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Porphyria Cutanea Tarda

Definition

Porphyria cutanea tarda (PCT) is a type of porphyria characterized by photosensitivity, typically as blisters and increased skin fragility on sun-exposed skin. It is caused by a deficiency in the enzyme uroporphyrinogen decarboxylase, leading to the accumulation of porphyrins in the liver and skin.