Classical Hematology
Smilow Cancer Hospital Care Center - Spring Brook Common
240 Indian River Road
Orange, CT 06477
- Classical HematologySmilow Cancer Hospital Care Center - Spring Brook Common240 Indian River RoadOrange, CT 06477
Alfred Lee, MD, PhD
Hematology, Hematology & Oncology
Telehealth is available
Patient type treated
Adult
Accepting new patients
Yes
Referral required
From patients or physicians
Board Certified in
Internal Medicine and Hematology (Internal Medicine)
Biography
Alfred Ian Lee, MD, PhD, is Professor of Medicine (Hematology) and Program Director for the hematology/oncology fellowship program. He received his MD/PhD from the Yale School of Medicine in 2004. Dr. Lee completed residency in internal medicine at Brigham & Women’s Hospital, where he served as Chief Medical Resident, followed by a fellowship in hematology/oncology at Dana-Farber Cancer Institute. His primary academic interests are classical hematology, thrombosis, and medical education.
He has received such honors as the Charles W. Bohmfalk Prize for teaching in the basic sciences, the Leah M. Lowenstein Award for excellence in the promotion of humane and egalitarian medical education, the Yale Cancer Center Award for Mentorship Excellence, and the David J. Lefell Prize for Clinical Excellence.
Titles
- Professor of Medicine (Hematology)
- Director, Hematology/Oncology Fellowship Program
- Chief, Classical Hematology Program
Education & Training
- FellowshipDana Farber Cancer Institute (2011)
- Chief Medical ResidentBrigham & Women's Hospital (2010)
- ResidencyBrigham & Women's Hospital (2007)
- MDYale School of Medicine (2004)
- PhDYale University (2003)
Additional Information
Honors & Recognitions
- Yale Cancer Center Award for Mentorship Excellence: Yale Cancer Center (2022)
- David J. Lefell Prize for clinical excellence: Yale Medicine (2020)
- Fred Kantor Teacher of the Year Award: Yale Internal Medicine Traditional Residency Program (2018)
- Inspiring Yale Award: Yale University Graduate & Professional Student Senate (2018)
- Leah M. Lowenstein Award for excellence in the promotion of humane and egalitarian medical education: Yale School of Medicine (2017)
- Connecticut Top Doc: Connecticut Magazine (2017), (2019), (2020), (2021)
- Charles W. Bohmfalk Prize for teaching in the basic sciences: Yale School of Medicine (2016)
- David S. Fischer Annual Award for outstanding teaching and mentoring of fellows in Hematology: Yale Cancer Center (2012), (2015), (2019)
- Faculty Teacher of the Year Award: Yale Internal Medicine Traditional Residency Program (2012)
Professional Service
- Guideline Panel on the Use of Anticoagulation in Patients with COVID-19, American Society of Hematology (2020 - Present): Member
- NIH ClinGen Hemostasis/Thrombosis Variant Curation Expert Panel (2020 - Present): Member
- Medical Educators Institute, American Society of Hematology (2019 - Present): Faculty Member
- NIH ClinGen Hemostasis/Thrombosis Expert Panel (2019 - Present): Member
- Recruitment & Retention Working Group, American Society of Hematology (2017 - Present): Chair
- Committee on Training, American Society of Hematology (2015 - Present): Member
- National Comprehensive Cancer Network Cancer-Associated Venous Thromboembolic Disease Panel (2015 - Present): Member
Publications
- Ito S, Chetlapalli K, Wang D, Potnis K, Richmond R, Krumholz H, Lee A, Cuker A, Goshua G. Cost-effectiveness of iptacopan in paroxysmal nocturnal hemoglobinuria. Blood 2024 PMID: 39374533, DOI: 10.1182/blood.2024025176.
- Gu S, Butt A, Schulz V, Rinder H, Lee A, Gallagher P, Hwa J, Bona R. Phenotypic and genotypic evaluation of bleeding diagnostic dilemmas: Two case studies. Blood Cells Molecules And Diseases 2024, 110: 102893. PMID: 39260211, DOI: 10.1016/j.bcmd.2024.102893.
- Allen C, Heskel M, Butt A, Tormey C, Pine A, Lee A, Gautam S. Factor VIII Levels and ISTH Disseminated Intravascular Coagulation Scores Do Not Distinguish Disseminated Intravascular Coagulation from the Coagulopathy of Liver Disease. Acta Haematologica 2024, 1-5. PMID: 39004080, DOI: 10.1159/000540239.
- Srikumar T, Stempel J, Goldberg S, Podoltsev N, Braun D, Lee A, Sanft T. Longitudinal Curriculum to Address Wellness and Professional Development in a Hematology/Oncology Fellowship Program. EMJ Oncology 2024, 1: 37-39. DOI: 10.33590/oncolamj/zgwb5064.
- Srikumar T, Stempel J, Goldberg S, Podoltsev N, Braun D, Lee A, Sanft T. Longitudinal curriculum to address wellness and professional development in a hematology/oncology fellowship program. Journal Of Clinical Oncology 2024, 42: 9004-9004. DOI: 10.1200/jco.2024.42.16_suppl.9004.
- Roy A, Bakouny Z, Dizman N, Ozay Z, Mohan Lal B, Nawfal R, Eid M, El Hajj Chehade R, Machaalani M, Butt A, Aggarwal C, Bekaii-Saab T, Chavez-MacGregor M, Lopes G, Marshall A, Murphy M, Owonikoko T, Lee A, CHOUEIRI T. International medical graduates (IMG) representation at international oncology conference meetings. Journal Of Clinical Oncology 2024, 42: 9000-9000. DOI: 10.1200/jco.2024.42.16_suppl.9000.
- Ito S, Wang D, Purcell A, Chetlapalli K, Lee A, Cuker A, Goshua G. Cost‐effectiveness of sutimlimab in cold agglutinin disease. American Journal Of Hematology 2024, 99: 1475-1484. PMID: 38733355, DOI: 10.1002/ajh.27358.
- Butt A, Christian J, Kress A, Lu B, Hurwitz M, Goldberg S, Podoltsev N, Gilkes L, Lee A. Providing 0.1 Full-Time Equivalent (FTE) Support to Fellowship Core Faculty Improves Faculty Involvement in Fellowship Education and Recruitment. Journal Of Cancer Education 2024, 39: 325-334. PMID: 38430454, DOI: 10.1007/s13187-024-02414-z.
- Pine A, Butt A, Garcia-Milian R, Gu S, Restrepo V, Chock Y, Hwa J, Tormey C, Rinder H, Goshua G, Belmont H, Bertolaccini M, Branch D, Erhan D, Kello N, Knight J, Petri M, Willis R, Lee A, Sharda A. Proteomic Profiling of Different Antiphospholipid Antibody-Positive Phenotypes: Results from Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking (APS ACTION) Registry. Blood 2023, 142: 2575. DOI: 10.1182/blood-2023-185232.
- Restrepo V, Pine A, Butt A, Chang E, Bar N, Baluha A, Brooks A, Chirico G, Curran J, Dumont A, Obura-Wilkes P, Rinder H, Tormey C, Nassiri N, Lee A, Prozora S. Comprehensive Characterization of Coagulation Parameters in Venous Malformations. Blood 2023, 142: 27. DOI: 10.1182/blood-2023-190609.
- Kewan T, Mirza S, Pine A, Rasheed Y, Hamouche R, Leveille E, Goshua G, Gu S, Liu Y, Vanoudenhove J, Bar N, Neparidze N, Foss F, Gowda L, Isufi I, Halene S, Lee A, Seropian S. CAR T-Related Toxicities Based on Dynamic Proteomic Profiles Identifies Risk Factors for Cytokine Release Syndrome (CRS) and Immune Effector Cell -Associated Neurotoxicity Syndrome (ICANS). Blood 2023, 142: 2132. DOI: 10.1182/blood-2023-187295.
- Muradashvili T, Restrepo V, Alameddine D, Soliman S, Feinn R, Chaar C, Lee A, Pine A. The Choice of Anticoagulant at First Recurrence Does Not Alter the Risk for the Second Recurrence. Blood 2023, 142: 5540. DOI: 10.1182/blood-2023-191084.
- Gu S, Gallagher P, Butt A, Gu V, Lezon-Geyda K, Schulz V, Prozora S, Lee A, Neparidze N, Bar N, Martin K, Cornell J, Chirico G, Chakraborty R, Rinder H, Hwa J, Bona R. Multimodality Platelet Evaluation By Mass Cytometry and Genetic Analysis in Patients with Bleeding Disorders. Blood 2023, 142: 1197. DOI: 10.1182/blood-2023-177946.
- Ito S, Chetlapalli K, Potnis K, Richmond R, Wang D, Lee A, Goshua G. Setting Cost-Effective Price Thresholds before FDA Approval: Cost-Effectiveness of Iptacopan Monotherapy Versus Standard-of-Care Anti-C5 Therapy in Transfusion-Dependent, Treatment-Experienced Adult Patients with Paroxysmal Nocturnal Hemoglobinuria in the United States. Blood 2023, 142: 5042. DOI: 10.1182/blood-2023-188063.
- Chang E, Kress A, Ackermann F, Fradkin M, Halene S, Herbert E, Shomsky L, Sudhakar L, Lee A, Bona R. Characterizing Outpatient Classical Hematology Referrals at an Academic Healthcare System. Blood 2023, 142: 7196. DOI: 10.1182/blood-2023-186065.
- Ito S, Wang D, Purcell A, Chetlapalli K, Lee A, Cuker A, Goshua G. Cost-Effectiveness of Sutimlimab Versus Standard-of-Care in Transfusion Dependent Patients with Primary Cold Agglutinin Disease in the United States. Blood 2023, 142: 2316. DOI: 10.1182/blood-2023-187270.
- Lee A, Masselink LE, De Castro LM, Marshall AL, Connell NT, Dent GA, Fritz J, Homer M, Lucas TL, Naik RP, Nelson M, O’Connell C, Rajasekhar A, Reynolds R, Sharma D, Smith M, Weeks LD, Erikson CE. Burnout in US hematologists and oncologists: impact of compensation models and advanced practice provider support. Blood Advances 2023, 7: 3058-3068. PMID: 35476017, PMCID: PMC10331414, DOI: 10.1182/bloodadvances.2021006140.
- Allen C, Gautam S, Cheng W, Pine A, Podoltsev N, Zeidan A, Lee A, Shallis R. Impact of Prophylactic Antibacterials on Coagulation Profiles and Bleeding in Patients with Acute Myeloid Leukemia/Myelodysplastic Syndrome. Acta Haematologica 2023, 146: 287-292. PMID: 37166332, DOI: 10.1159/000530153.
- Goshua G, Lee A. Summiting thrombotic hazards in glioma. Blood 2023, 141: 1245-1246. PMID: 36929442, DOI: 10.1182/blood.2022019020.
- Goshua G, Bendapudi P, Lee A. Thrombosis questions from the inpatient wards. Hematology 2022, 2022: 481-490. PMID: 36485139, PMCID: PMC9819989, DOI: 10.1182/hematology.2022000384.
- Allen C, Butt A, Zhao X, Li F, Bahel P, Chang C, Chun H, Gu S, Hwa J, Jakab S, Chen B, Garcia-Tsao G, Rinder H, To U, McConnell M, Lee A, Pine A. Plasma Proteomic Profiling Illustrates Endothelial and Complement Signature in Patients with Alcohol-Associated Cirrhosis. Blood 2022, 140: 8382-8383. DOI: 10.1182/blood-2022-162633.
- Mirza A, Pine A, Rasheed Y, Hamouche R, Leveille E, Goshua G, Gu S, Liu Y, VanOudenhove J, Bar N, Neparidze N, Foss F, Gowda L, Isufi I, Halene S, Lee A, Seropian S. Proteomic Profiles of Cytokine Release Syndromes Following Lisocabtagene Maraleucel and Idecabtagene Vicleucel. Blood 2022, 140: 10410-10412. DOI: 10.1182/blood-2022-168374.
- Nassar A, Groha S, El-am E, Bejjani A, Zarif T, Mouhieddine T, Alaiwi S, Adib E, Ng K, Connors J, Lee A, Gusev A. Monogenic and Polygenic Contributions to Venous Thromboembolism (VTE) and Splanchnic Thrombosis in Patients (pts) with Pancreatic Cancer (PC). Blood 2022, 140: 5525-5526. DOI: 10.1182/blood-2022-163804.
- Butt A, Mankbadi M, Erikson C, Marshall A, Masselink LE, Tong G, Hafler J, Podoltsev N, Lee AI. Bias Against International Medical Graduates in the Hematology/Oncology Fellowship Recruitment Process: Findings From a Nationwide Survey of Fellowship Program Directors. JCO Oncology Practice 2022, 18: 783-787. PMID: 36108253, DOI: 10.1200/op.22.00219.
- Butt A, Erkan D, Lee A. COVID-19 and antiphospholipid antibodies. Best Practice & Research Clinical Haematology 2022, 35: 101402. PMID: 36494152, PMCID: PMC9568270, DOI: 10.1016/j.beha.2022.101402.
- Ali S, Chan S, Brahmandam A, Xu Y, Deng Y, Elbadawy A, Lee A, Chaar C. The Incidence and Significance of Iliac Vein Stenosis in Patients With Deep Vein Thrombosis. Journal Of Vascular Surgery 2022, 76: e32-e33. DOI: 10.1016/j.jvs.2022.06.059.
- Stempel JM, Podoltsev NA, Zeidan AM, Lee AI, Shallis RM. Concealed by the convenient: acquired von Willebrand syndrome in myeloproliferative neoplasm requires a thorough evaluation. Annals Of Hematology 2022, 101: 2559-2561. PMID: 35984499, DOI: 10.1007/s00277-022-04943-3.
- Butt A, Muradashvili T, Soliman S, Li F, Burns AJ, Brooks A, Browning S, Bar N, Borgman G, Goshua G, Hwa J, Martin K, Rinder H, Tormey C, Pine AB, Bona RD, Lee AI, Neparidze N. Association of iron infusion reactions with ABO blood type. European Journal Of Haematology 2022, 109: 519-525. PMID: 35871468, DOI: 10.1111/ejh.13838.
- Al-Samkari H, Loren AW, Lee AI. The case for classical haematology: the impact of a name and the future of a field. The Lancet Haematology 2022, 9: e455-e459. PMID: 35500590, DOI: 10.1016/s2352-3026(22)00096-5.
- Tyagi T, Jain K, Gu S, Qiu M, Gu V, Melchinger H, Rinder H, Martin K, Gardiner E, Lee A, Tang W, Hwa J. A guide to molecular and functional investigations of platelets to bridge basic and clinical sciences. Nature Cardiovascular Research 2022, 1: 223-237. PMID: 37502132, PMCID: PMC10373053, DOI: 10.1038/s44161-022-00021-z.
- Goshua G, Sinha P, Pischel L, Lee A, Cuker A. Cost-Effectiveness of Second-Line Therapies in Adult Patients with Chronic Immune Thrombocytopenia. Blood 2021, 138: 751. DOI: 10.1182/blood-2021-144819.
- Lee E, Moreira M, Al-Samkari H, Cuker A, DiRaimo J, Gernsheimer T, Kruse A, Kessler C, Kruse C, Leavitt A, Lee A, Liebman H, Newland A, Ray A, Tarantino M, Thachil J, Kuter D, Cines D, Bussel J. Sars-Cov-2 Vaccination in Patients with Pre-Existing Immune Thrombocytopenia. Blood 2021, 138: 586. PMCID: PMC8701617, DOI: 10.1182/blood-2021-152918.
- Christian J, Gilkes L, Goldberg S, Hurwitz M, Podoltsev N, Lee A. Implementing a Full Time Equivalent-Supported Hematology/Oncology Fellowship Core Faculty Program May Improve Faculty Engagement in Education, Mentorship, and Recruitment. Blood 2021, 138: 2974. DOI: 10.1182/blood-2021-154326.
- Madeeva D, Borges K, Shallow M, Juthani P, Wang S, Gupta A, Chun H, Lee A, Pine A. Proteomic Profiles in Patients with Thrombosis Due to COVID-19 Are Distinct from Non-COVID-19 Thrombosis. Blood 2021, 138: 777. PMCID: PMC8701622, DOI: 10.1182/blood-2021-153959.
- Butt A, Muradashvili T, Soliman S, Goshua G, Burns A, Bar N, Martin K, Borgman G, Bona R, Lee A, Neparidze N. Iron Infusion Reactions: Risk Factors and Real-World Experience. Blood 2021, 138: 4154. DOI: 10.1182/blood-2021-151048.
- Lee EJ, Lee AI. Cerebral venous sinus thrombosis after vaccination: the UK experience. The Lancet 2021, 398: 1107-1109. PMID: 34370974, PMCID: PMC8346246, DOI: 10.1016/s0140-6736(21)01788-8.
- Pischel L, Geirsson A, Magaldi J, Martinello RA, Lee AI. A Brewing Back Pain. New England Journal Of Medicine 2021, 385: 66-72. PMID: 34192434, PMCID: PMC9273048, DOI: 10.1056/nejmcps2034802.
- McConnell MJ, Kawaguchi N, Kondo R, Sonzogni A, Licini L, Valle C, Bonaffini PA, Sironi S, Alessio MG, Previtali G, Seghezzi M, Zhang X, Lee A, Pine AB, Chun HJ, Zhang X, Fernandez-Hernando C, Qing H, Wang A, Price C, Sun Z, Utsumi T, Hwa J, Strazzabosco M, Iwakiri Y. Liver injury in COVID-19 and IL-6 trans-signaling-induced endotheliopathy. Journal Of Hepatology 2021, 75: 647-658. PMID: 33991637, PMCID: PMC8285256, DOI: 10.1016/j.jhep.2021.04.050.
- Wang S, Pine A, Mankbadi M, Chang C, Madeeva D, Zhang H, Dajani A, Crandall I, Sugeng L, Lee A, Chun H. PRO-THROMBOTIC SIGNATURE FROM NEUTROPHIL ACTIVATION AND DECREASED ADAMTS13 TO VWF RATIO IS A KEY DRIVER OF CARDIAC INJURY IN HOSPITALIZED PATIENTS WITH COVID-19. Journal Of The American College Of Cardiology 2021, 77: 3193. PMID: 34167644, PMCID: PMC8091195, DOI: 10.1016/s0735-1097(21)04548-4.
- McAlpine L, Zubair A, Maran I, Chojecka P, Lleva P, Jasne A, Navaratnam D, Matouk C, Schindler J, Chun H, Lee A, Spudich S, Sharma R, Sansing L. Ischemic Stroke, Inflammation, and Endotheliopathy in COVID-19 Patients (2402). Neurology 2021, 96 DOI: 10.1212/wnl.96.15_supplement.2402.
- Brahmandam A, Lee A, Chaar C. Endovascular Treatment of Renal Vein Thrombosis in a Young Patient With Lung Transplant. Journal Of Vascular Surgery Venous And Lymphatic Disorders 2021, 9: 542-543. DOI: 10.1016/j.jvsv.2020.12.022.
- Brahmandam A, Chan S, Aspegren-Valcarce M, Zhuo H, Zhang Y, Tonnessen B, Lee A, Chaar C. Sex Differences in Long-Term Outcomes of Patients with Deep Vein Thrombosis. Journal Of Vascular Surgery Venous And Lymphatic Disorders 2021, 9: 546-547. DOI: 10.1016/j.jvsv.2020.12.033.
- Goshua G, Sinha P, Hendrickson J, Tormey C, Bendapudi PK, Lee AI. Cost effectiveness of caplacizumab in acquired thrombotic thrombocytopenic purpura. Blood 2021, 137: 969-976. PMID: 33280030, PMCID: PMC7918179, DOI: 10.1182/blood.2020006052.
- Bewersdorf J, Parmar N, Gettinger S, Israel G, Lee A. Clinical Characteristics and Outcomes of Splenic Infarction in Cancer Patients - a Retrospective, Single Center Report of 206 Cases. Blood 2020, 136: 22-23. DOI: 10.1182/blood-2020-136646.
- Durani U, Manana A, May J, Nelson M, Zheng Z, Gollapudi A, Alam S, Reynolds R, Thompson J, Kumbamu A, Das D, Murphy M, Henry E, Lee A, Marshall A, Wun T, Weeks L. Measuring the Impact of COVID-19 on Hematology-Oncology Trainees: A Quantitative and Qualitative Assessment. Blood 2020, 136: 20-21. PMCID: PMC8330314, DOI: 10.1182/blood-2020-143347.
- Manana A, Durani U, Reynolds R, Kumbamu A, Das D, Murphy M, Henry E, Lee A, Marshall A. The Impact of COVID-19 on Hematology-Oncology Fellowship Programs: Program Director Perspectives. Blood 2020, 136: 24-25. PMCID: PMC8544190, DOI: 10.1182/blood-2020-141514.
- Masselink L, Lee A, Erikson C. Factors Associated with Burnout Among Hematology & Oncology Physicians. Blood 2020, 136: 41-42. DOI: 10.1182/blood-2020-139798.
- Goshua G, Sinha P, Hendrickson J, Tormey C, Bendapudi P, Lee A. Cost Effectiveness of Caplacizumab in Acquired Thrombotic Thrombocytopenic Purpura. Blood 2020, 136: 18-19. DOI: 10.1182/blood-2020-138515.
- Madeeva D, Christian J, Goshua G, Chun H, Lee A, Pine A. VWF/ADAMTS13 Ratios Are Potential Markers of Immunothrombotic Complications in Patients with COVID-19: A Cross-Sectional Study. Blood 2020, 136: 34-35. PMCID: PMC8330245, DOI: 10.1182/blood-2020-142917.
- Goshua G, Liu Y, Meizlish M, Fine R, Amin K, Chang E, Liu Y, McManus D, Petrosan A, Chaar C, Chun H, Defilippo N, Neuberg D, Owusu K, Lee A. Admission Rothman Index, Aspirin, and Intermediate Dose Anticoagulation Effects on Outcomes in COVID-19: A Multi-Site Propensity Matched Analysis. Blood 2020, 136: 23-24. PMCID: PMC8330288, DOI: 10.1182/blood-2020-143349.
- Odio CD, O'Brien CR, Jacox J, Jain D, Lee AI. Cryptic Cachexia. New England Journal Of Medicine 2020, 383: 68-74. PMID: 32609985, DOI: 10.1056/nejmcps1817531.
- Goshua G, Pine AB, Meizlish ML, Chang CH, Zhang H, Bahel P, Baluha A, Bar N, Bona RD, Burns AJ, Dela Cruz CS, Dumont A, Halene S, Hwa J, Koff J, Menninger H, Neparidze N, Price C, Siner JM, Tormey C, Rinder HM, Chun HJ, Lee AI. Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study. The Lancet Haematology 2020, 7: e575-e582. PMID: 32619411, PMCID: PMC7326446, DOI: 10.1016/s2352-3026(20)30216-7.
- Schwartz AR, Siegel MD, Lee AI. A novel approach to the program evaluation committee. BMC Medical Education 2019, 19: 465. PMID: 31842868, PMCID: PMC6916454, DOI: 10.1186/s12909-019-1899-x.
- Lee AI, Connors JM. The next(gen) step in coagulation testing. Blood 2019, 134: 2002-2003. PMID: 31805193, DOI: 10.1182/blood.2019001414.
- Sharma D, Wallace N, Levinsohn EA, Marshall AL, Kayoumi K, Madero J, Homer M, Reynolds R, Hafler J, Podoltsev NA, Lee AI. Trends and factors affecting the US adult hematology workforce: a mixed methods study. Blood Advances 2019, 3: 3550-3561. PMID: 31738829, PMCID: PMC6880914, DOI: 10.1182/bloodadvances.2019000307.
- Naik R, Montana M, Kersun L, Nagalla S, Lee A. Perceptions and Attitudes Toward Single-Board Hematology Training in the United States: A Program Director Survey. Blood 2019, 134: 3392. DOI: 10.1182/blood-2019-126310.
- Masselink L, Lee A, Erikson C. Hematology/Oncology Fellows' Future Plans and Job Expectations: Findings from the 2019 Hematology/Oncology Fellows Survey. Blood 2019, 134: 5780. DOI: 10.1182/blood-2019-126899.
- Lee A, Masselink L, Bass E, Connell N, Marshall A, Erikson C. Mentorship Experiences Among Second-Year U.S. Hematology/Oncology Fellows in the 2019 ASH Hematology/Oncology Fellows Survey. Blood 2019, 134: 2124. DOI: 10.1182/blood-2019-132252.
- Browning S, Parker T, Bar N, Seropian S, Lee A, Anderson T, Neparidze N. Daratumumab in the Clinic, a Real-Word Experience at Yale Cancer Center. Blood 2019, 134: 5569. DOI: 10.1182/blood-2019-130134.
- Pine A, Lee A. Providers Increased the Use of Direct Oral Anticoagulants in Patients with Cancer-Associated Thromboembolism without Gaining Complete Confidence: A Health System-Wide Retrospective Registry Study and a Providers' Survey. Blood 2019, 134: 2097. DOI: 10.1182/blood-2019-130200.
- Masselink LE, Erikson CE, Connell NT, De Castro LM, Dent GA, Marshall AL, Naik RP, Nelson M, O’Connell C, Rajasekhar A, Sharma D, Smith M, Lee AI. Associations between hematology/oncology fellows' training and mentorship experiences and hematology-only career plans. Blood Advances 2019, 3: 3278-3286. PMID: 31698456, PMCID: PMC6855099, DOI: 10.1182/bloodadvances.2019000569.
- Gu S, Shevell L, Tormey C, Rinder H, Lee A. Whole-Exome Sequencing in Evaluation of Thrombophilia: Characterization of Novel Genetic Variants. American Journal Of Clinical Pathology 2019, 152: s35-s35. DOI: 10.1093/ajcp/aqz112.066.
- Effendi M, Stutsky M, Curran C, Owusu K, Lee A. Impact of a Pharmacist Driven Anti-Xa Level Monitoring Protocol on Therapeutic Drug Monitoring Practice Patterns. Blood 2018, 132: 2284. DOI: 10.1182/blood-2018-99-119379.
- Juthani P, Ahmed D, Ahmed O, Bona R, Neparidze N, Lee A. Venous Thromboembolism (VTE) Education Preferences Amongst Physicians and Patients: A Qualitative Needs Assessment. Blood 2018, 132: 5810. DOI: 10.1182/blood-2018-99-119418.
- Hsu C, Brahmandam A, Brownson K, Huynh N, Reynolds J, Lee A, Fares W, Chaar C. The Effects of Statin Therapy on Thrombus Resolution in Patients with Deep Venous Thrombosis. Journal Of Vascular Surgery Venous And Lymphatic Disorders 2018, 6: 291-292. DOI: 10.1016/j.jvsv.2017.12.034.
- Djulbegovic M, Dugdale LS, Lee AI. Evaluation of Polycythemia: A Teachable Moment. JAMA Internal Medicine 2018, 178: 128-130. PMID: 29131894, DOI: 10.1001/jamainternmed.2017.6213.
- Lee A, Lee E. Anticoagulation for Proximal Deep Vein Thrombosis. 2017, 299-313. DOI: 10.1007/978-3-319-65226-9_23.
- Lee EJ, Dykas DJ, Leavitt AD, Camire RM, Ebberink E, García de Frutos P, Gnanasambandan K, Gu SX, Huntington JA, Lentz SR, Mertens K, Parish CR, Rezaie AR, Sayeski PP, Cromwell C, Bar N, Halene S, Neparidze N, Parker TL, Burns AJ, Dumont A, Yao X, Chaar CIO, Connors JM, Bale AE, Lee AI. Whole-exome sequencing in evaluation of patients with venous thromboembolism. Blood Advances 2017, 1: 1224-1237. PMID: 29296762, PMCID: PMC5728544, DOI: 10.1182/bloodadvances.2017005249.
- Levinsohn E, DiGiovanna M, Encandela J, Takizawa P, Hafler J, Lee A. A Novel Approach to the Medical Student Hematology Curriculum. Blood 2016, 128: 3537. DOI: 10.1182/blood.v128.22.3537.3537.
- Wallace N, Hafler J, Hurwitz M, Podoltsev N, Lacy J, Lee A. Factors Influencing Hematology Career Choice in Hematology and Oncology Fellows at a Major Academic Institution. Blood 2016, 128: 3538. DOI: 10.1182/blood.v128.22.3538.3538.
- Wallace N, Dumont A, Burns A, Christopher T, Rinder H, Kriegel M, Buckley L, Erkan D, Lee A. Thromboelastography in the Characterization of Coagulation Status in Antiphospholipid Syndrome. Blood 2016, 128: 4983. DOI: 10.1182/blood.v128.22.4983.4983.
- Lee AI, Chaar C. The Hidden Lesion. New England Journal Of Medicine 2016, 374: 2160-2165. PMID: 27248622, DOI: 10.1056/nejmcps1406615.
- Brownson K, Satoskar S, Reynolds J, Sumpio B, Sarac T, Scoutt L, Lee A. Thrombus Resolution as Guide to Anticoagulation Therapy for Provoked Deep Vein Thrombosis: TRUDVT Pilot Study. Journal Of Vascular Surgery Venous And Lymphatic Disorders 2016, 4: 149. DOI: 10.1016/j.jvsv.2015.10.040.
- Stutsky M, Reardon D, Lee A. Clinical Practice Patterns of Anti-Xa Monitoring During Low Molecular Weight Heparin Therapy. Blood 2015, 126: 3275. DOI: 10.1182/blood.v126.23.3275.3275.
- Lee E, Smith B, Merrey J, Lee A, Podoltsev N, Barbarotta L, Litzow M, Prebet T, Luger S, Gore S, Streiff M, Zeidan A. Patterns of Venous Thromboembolism Prophylaxis during Inpatient Treatment of Acute Leukemia: Results of a North American Web-Based Survey. Blood 2015, 126: 4455. DOI: 10.1182/blood.v126.23.4455.4455.
- Pine A, Lee E, Sekeres M, Steensma D, Prebet T, DeZern A, Komrokji R, Litzow M, Luger S, Stone R, Erba H, Garcia-Manero G, Lee A, Podoltsev N, Barbarotta L, Hendrickson J, Gore S, Zeidan A. North American Cooperative Group Members' Patterns of Blood Products Transfusion for Patients with Acute Leukemia. Blood 2015, 126: 1138. DOI: 10.1182/blood.v126.23.1138.1138.
- Catanzaro J, Lee A, Price C. Profoundly Low Immunoglobulins, Lymphopenia, Thymoma and No Infections. Journal Of Allergy And Clinical Immunology 2015, 135: ab15. DOI: 10.1016/j.jaci.2014.12.982.
- Kim R, Yao X, Longley P, Rimar J, Kournioti C, Lee A. Using the Rothman Index to Predict Discharge and Readmission Rates in an Inpatient Hematology Unit. Blood 2014, 124: 1302. DOI: 10.1182/blood.v124.21.1302.1302.
- Varughese N, Duong A, Emre S, Xu M, Lee AI. Venting the Spleen. New England Journal Of Medicine 2013, 369: 1357-1363. PMID: 24088096, DOI: 10.1056/nejmcps1210943.
- Lee A, Sylvester K, Rawn J, Fanikos J, Berliner N. Heparin-Induced Thrombocytopenia and Cardiac Surgery: A Role for Hematologists in Critical Care Units. Blood 2011, 118: 2062. DOI: 10.1182/blood.v118.21.2062.2062.
- Lee A, Campigotto F, Rawn J, Neuberg D, Kaufman R, Berliner N. Clinical Significance of Coagulation Studies in Predicting Response to Recombinant Factor VIIa in Cardiac Surgery Patients. Blood 2011, 118: 4351. DOI: 10.1182/blood.v118.21.4351.4351.
- Lee AI, Koo S, Vaidya A, Katz JT, Loscalzo J. A Bird's-Eye View of Fever. New England Journal Of Medicine 2011, 365: 1727-1732. PMID: 22047564, DOI: 10.1056/nejmcps1012518.
- Toomey C, Muzikanksy A, Lee A, Barnes J, Michaelson J, Abramson J, Hochberg E. Treatment Choice and Outcome In Diffuse Large B Cell Lymphoma (DLBCL) Patients 75 Years and Older. Blood 2010, 116: 733. DOI: 10.1182/blood.v116.21.733.733.
- Hochberg E, Birrer N, Toomey C, Barnes J, Lee A, LaCasce A, Abramson J. Rituximab Does Not Improve Progression Free (PFS) or Overall Survival (OS) in Patients with Limited Stage Diffuse Large B Cell Lymphoma (DLBCL). Blood 2009, 114: 3755. DOI: 10.1182/blood.v114.22.3755.3755.
- Barnes J, LaCasce A, Toomey C, Hochberg E, Lee A, Canellos G, Abramson J. Early Interim FDG-PET Scan Predicts Outcome in Non-Bulky Limited Stage Hodgkin Lymphoma, but may Not Guide Use of Consolidative Radiotherapy. Blood 2008, 112: 1453. DOI: 10.1182/blood.v112.11.1453.1453.
- Fugmann S, Lee A, Shockett P, Villey I, Schatz D. The RAG Proteins and V(D)J Recombination: Complexes, Ends, and Transposition. Annual Review Of Immunology 2000, 18: 495-527. PMID: 10837067, DOI: 10.1146/annurev.immunol.18.1.495.
Locations
Classical Hematology
Smilow Cancer Hospital Care Center - Spring Brook Common
240 Indian River Road
Orange, CT 06477
- Classical HematologySmilow Cancer Hospital Care Center - Spring Brook Common240 Indian River RoadOrange, CT 06477
Biography
Alfred Ian Lee, MD, PhD, is Professor of Medicine (Hematology) and Program Director for the hematology/oncology fellowship program. He received his MD/PhD from the Yale School of Medicine in 2004. Dr. Lee completed residency in internal medicine at Brigham & Women’s Hospital, where he served as Chief Medical Resident, followed by a fellowship in hematology/oncology at Dana-Farber Cancer Institute. His primary academic interests are classical hematology, thrombosis, and medical education.
He has received such honors as the Charles W. Bohmfalk Prize for teaching in the basic sciences, the Leah M. Lowenstein Award for excellence in the promotion of humane and egalitarian medical education, the Yale Cancer Center Award for Mentorship Excellence, and the David J. Lefell Prize for Clinical Excellence.
Titles
- Professor of Medicine (Hematology)
- Director, Hematology/Oncology Fellowship Program
- Chief, Classical Hematology Program
Education & Training
- FellowshipDana Farber Cancer Institute (2011)
- Chief Medical ResidentBrigham & Women's Hospital (2010)
- ResidencyBrigham & Women's Hospital (2007)
- MDYale School of Medicine (2004)
- PhDYale University (2003)
Additional Information
Honors & Recognitions
- Yale Cancer Center Award for Mentorship Excellence: Yale Cancer Center (2022)
- David J. Lefell Prize for clinical excellence: Yale Medicine (2020)
- Fred Kantor Teacher of the Year Award: Yale Internal Medicine Traditional Residency Program (2018)
- Inspiring Yale Award: Yale University Graduate & Professional Student Senate (2018)
- Leah M. Lowenstein Award for excellence in the promotion of humane and egalitarian medical education: Yale School of Medicine (2017)
- Connecticut Top Doc: Connecticut Magazine (2017), (2019), (2020), (2021)
- Charles W. Bohmfalk Prize for teaching in the basic sciences: Yale School of Medicine (2016)
- David S. Fischer Annual Award for outstanding teaching and mentoring of fellows in Hematology: Yale Cancer Center (2012), (2015), (2019)
- Faculty Teacher of the Year Award: Yale Internal Medicine Traditional Residency Program (2012)
Professional Service
- Guideline Panel on the Use of Anticoagulation in Patients with COVID-19, American Society of Hematology (2020 - Present): Member
- NIH ClinGen Hemostasis/Thrombosis Variant Curation Expert Panel (2020 - Present): Member
- Medical Educators Institute, American Society of Hematology (2019 - Present): Faculty Member
- NIH ClinGen Hemostasis/Thrombosis Expert Panel (2019 - Present): Member
- Recruitment & Retention Working Group, American Society of Hematology (2017 - Present): Chair
- Committee on Training, American Society of Hematology (2015 - Present): Member
- National Comprehensive Cancer Network Cancer-Associated Venous Thromboembolic Disease Panel (2015 - Present): Member
Publications
- Ito S, Chetlapalli K, Wang D, Potnis K, Richmond R, Krumholz H, Lee A, Cuker A, Goshua G. Cost-effectiveness of iptacopan in paroxysmal nocturnal hemoglobinuria. Blood 2024 PMID: 39374533, DOI: 10.1182/blood.2024025176.
- Gu S, Butt A, Schulz V, Rinder H, Lee A, Gallagher P, Hwa J, Bona R. Phenotypic and genotypic evaluation of bleeding diagnostic dilemmas: Two case studies. Blood Cells Molecules And Diseases 2024, 110: 102893. PMID: 39260211, DOI: 10.1016/j.bcmd.2024.102893.
- Allen C, Heskel M, Butt A, Tormey C, Pine A, Lee A, Gautam S. Factor VIII Levels and ISTH Disseminated Intravascular Coagulation Scores Do Not Distinguish Disseminated Intravascular Coagulation from the Coagulopathy of Liver Disease. Acta Haematologica 2024, 1-5. PMID: 39004080, DOI: 10.1159/000540239.
- Srikumar T, Stempel J, Goldberg S, Podoltsev N, Braun D, Lee A, Sanft T. Longitudinal Curriculum to Address Wellness and Professional Development in a Hematology/Oncology Fellowship Program. EMJ Oncology 2024, 1: 37-39. DOI: 10.33590/oncolamj/zgwb5064.
- Srikumar T, Stempel J, Goldberg S, Podoltsev N, Braun D, Lee A, Sanft T. Longitudinal curriculum to address wellness and professional development in a hematology/oncology fellowship program. Journal Of Clinical Oncology 2024, 42: 9004-9004. DOI: 10.1200/jco.2024.42.16_suppl.9004.
- Roy A, Bakouny Z, Dizman N, Ozay Z, Mohan Lal B, Nawfal R, Eid M, El Hajj Chehade R, Machaalani M, Butt A, Aggarwal C, Bekaii-Saab T, Chavez-MacGregor M, Lopes G, Marshall A, Murphy M, Owonikoko T, Lee A, CHOUEIRI T. International medical graduates (IMG) representation at international oncology conference meetings. Journal Of Clinical Oncology 2024, 42: 9000-9000. DOI: 10.1200/jco.2024.42.16_suppl.9000.
- Ito S, Wang D, Purcell A, Chetlapalli K, Lee A, Cuker A, Goshua G. Cost‐effectiveness of sutimlimab in cold agglutinin disease. American Journal Of Hematology 2024, 99: 1475-1484. PMID: 38733355, DOI: 10.1002/ajh.27358.
- Butt A, Christian J, Kress A, Lu B, Hurwitz M, Goldberg S, Podoltsev N, Gilkes L, Lee A. Providing 0.1 Full-Time Equivalent (FTE) Support to Fellowship Core Faculty Improves Faculty Involvement in Fellowship Education and Recruitment. Journal Of Cancer Education 2024, 39: 325-334. PMID: 38430454, DOI: 10.1007/s13187-024-02414-z.
- Pine A, Butt A, Garcia-Milian R, Gu S, Restrepo V, Chock Y, Hwa J, Tormey C, Rinder H, Goshua G, Belmont H, Bertolaccini M, Branch D, Erhan D, Kello N, Knight J, Petri M, Willis R, Lee A, Sharda A. Proteomic Profiling of Different Antiphospholipid Antibody-Positive Phenotypes: Results from Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking (APS ACTION) Registry. Blood 2023, 142: 2575. DOI: 10.1182/blood-2023-185232.
- Restrepo V, Pine A, Butt A, Chang E, Bar N, Baluha A, Brooks A, Chirico G, Curran J, Dumont A, Obura-Wilkes P, Rinder H, Tormey C, Nassiri N, Lee A, Prozora S. Comprehensive Characterization of Coagulation Parameters in Venous Malformations. Blood 2023, 142: 27. DOI: 10.1182/blood-2023-190609.
- Kewan T, Mirza S, Pine A, Rasheed Y, Hamouche R, Leveille E, Goshua G, Gu S, Liu Y, Vanoudenhove J, Bar N, Neparidze N, Foss F, Gowda L, Isufi I, Halene S, Lee A, Seropian S. CAR T-Related Toxicities Based on Dynamic Proteomic Profiles Identifies Risk Factors for Cytokine Release Syndrome (CRS) and Immune Effector Cell -Associated Neurotoxicity Syndrome (ICANS). Blood 2023, 142: 2132. DOI: 10.1182/blood-2023-187295.
- Muradashvili T, Restrepo V, Alameddine D, Soliman S, Feinn R, Chaar C, Lee A, Pine A. The Choice of Anticoagulant at First Recurrence Does Not Alter the Risk for the Second Recurrence. Blood 2023, 142: 5540. DOI: 10.1182/blood-2023-191084.
- Gu S, Gallagher P, Butt A, Gu V, Lezon-Geyda K, Schulz V, Prozora S, Lee A, Neparidze N, Bar N, Martin K, Cornell J, Chirico G, Chakraborty R, Rinder H, Hwa J, Bona R. Multimodality Platelet Evaluation By Mass Cytometry and Genetic Analysis in Patients with Bleeding Disorders. Blood 2023, 142: 1197. DOI: 10.1182/blood-2023-177946.
- Ito S, Chetlapalli K, Potnis K, Richmond R, Wang D, Lee A, Goshua G. Setting Cost-Effective Price Thresholds before FDA Approval: Cost-Effectiveness of Iptacopan Monotherapy Versus Standard-of-Care Anti-C5 Therapy in Transfusion-Dependent, Treatment-Experienced Adult Patients with Paroxysmal Nocturnal Hemoglobinuria in the United States. Blood 2023, 142: 5042. DOI: 10.1182/blood-2023-188063.
- Chang E, Kress A, Ackermann F, Fradkin M, Halene S, Herbert E, Shomsky L, Sudhakar L, Lee A, Bona R. Characterizing Outpatient Classical Hematology Referrals at an Academic Healthcare System. Blood 2023, 142: 7196. DOI: 10.1182/blood-2023-186065.
- Ito S, Wang D, Purcell A, Chetlapalli K, Lee A, Cuker A, Goshua G. Cost-Effectiveness of Sutimlimab Versus Standard-of-Care in Transfusion Dependent Patients with Primary Cold Agglutinin Disease in the United States. Blood 2023, 142: 2316. DOI: 10.1182/blood-2023-187270.
- Lee A, Masselink LE, De Castro LM, Marshall AL, Connell NT, Dent GA, Fritz J, Homer M, Lucas TL, Naik RP, Nelson M, O’Connell C, Rajasekhar A, Reynolds R, Sharma D, Smith M, Weeks LD, Erikson CE. Burnout in US hematologists and oncologists: impact of compensation models and advanced practice provider support. Blood Advances 2023, 7: 3058-3068. PMID: 35476017, PMCID: PMC10331414, DOI: 10.1182/bloodadvances.2021006140.
- Allen C, Gautam S, Cheng W, Pine A, Podoltsev N, Zeidan A, Lee A, Shallis R. Impact of Prophylactic Antibacterials on Coagulation Profiles and Bleeding in Patients with Acute Myeloid Leukemia/Myelodysplastic Syndrome. Acta Haematologica 2023, 146: 287-292. PMID: 37166332, DOI: 10.1159/000530153.
- Goshua G, Lee A. Summiting thrombotic hazards in glioma. Blood 2023, 141: 1245-1246. PMID: 36929442, DOI: 10.1182/blood.2022019020.
- Goshua G, Bendapudi P, Lee A. Thrombosis questions from the inpatient wards. Hematology 2022, 2022: 481-490. PMID: 36485139, PMCID: PMC9819989, DOI: 10.1182/hematology.2022000384.
- Allen C, Butt A, Zhao X, Li F, Bahel P, Chang C, Chun H, Gu S, Hwa J, Jakab S, Chen B, Garcia-Tsao G, Rinder H, To U, McConnell M, Lee A, Pine A. Plasma Proteomic Profiling Illustrates Endothelial and Complement Signature in Patients with Alcohol-Associated Cirrhosis. Blood 2022, 140: 8382-8383. DOI: 10.1182/blood-2022-162633.
- Mirza A, Pine A, Rasheed Y, Hamouche R, Leveille E, Goshua G, Gu S, Liu Y, VanOudenhove J, Bar N, Neparidze N, Foss F, Gowda L, Isufi I, Halene S, Lee A, Seropian S. Proteomic Profiles of Cytokine Release Syndromes Following Lisocabtagene Maraleucel and Idecabtagene Vicleucel. Blood 2022, 140: 10410-10412. DOI: 10.1182/blood-2022-168374.
- Nassar A, Groha S, El-am E, Bejjani A, Zarif T, Mouhieddine T, Alaiwi S, Adib E, Ng K, Connors J, Lee A, Gusev A. Monogenic and Polygenic Contributions to Venous Thromboembolism (VTE) and Splanchnic Thrombosis in Patients (pts) with Pancreatic Cancer (PC). Blood 2022, 140: 5525-5526. DOI: 10.1182/blood-2022-163804.
- Butt A, Mankbadi M, Erikson C, Marshall A, Masselink LE, Tong G, Hafler J, Podoltsev N, Lee AI. Bias Against International Medical Graduates in the Hematology/Oncology Fellowship Recruitment Process: Findings From a Nationwide Survey of Fellowship Program Directors. JCO Oncology Practice 2022, 18: 783-787. PMID: 36108253, DOI: 10.1200/op.22.00219.
- Butt A, Erkan D, Lee A. COVID-19 and antiphospholipid antibodies. Best Practice & Research Clinical Haematology 2022, 35: 101402. PMID: 36494152, PMCID: PMC9568270, DOI: 10.1016/j.beha.2022.101402.
- Ali S, Chan S, Brahmandam A, Xu Y, Deng Y, Elbadawy A, Lee A, Chaar C. The Incidence and Significance of Iliac Vein Stenosis in Patients With Deep Vein Thrombosis. Journal Of Vascular Surgery 2022, 76: e32-e33. DOI: 10.1016/j.jvs.2022.06.059.
- Stempel JM, Podoltsev NA, Zeidan AM, Lee AI, Shallis RM. Concealed by the convenient: acquired von Willebrand syndrome in myeloproliferative neoplasm requires a thorough evaluation. Annals Of Hematology 2022, 101: 2559-2561. PMID: 35984499, DOI: 10.1007/s00277-022-04943-3.
- Butt A, Muradashvili T, Soliman S, Li F, Burns AJ, Brooks A, Browning S, Bar N, Borgman G, Goshua G, Hwa J, Martin K, Rinder H, Tormey C, Pine AB, Bona RD, Lee AI, Neparidze N. Association of iron infusion reactions with ABO blood type. European Journal Of Haematology 2022, 109: 519-525. PMID: 35871468, DOI: 10.1111/ejh.13838.
- Al-Samkari H, Loren AW, Lee AI. The case for classical haematology: the impact of a name and the future of a field. The Lancet Haematology 2022, 9: e455-e459. PMID: 35500590, DOI: 10.1016/s2352-3026(22)00096-5.
- Tyagi T, Jain K, Gu S, Qiu M, Gu V, Melchinger H, Rinder H, Martin K, Gardiner E, Lee A, Tang W, Hwa J. A guide to molecular and functional investigations of platelets to bridge basic and clinical sciences. Nature Cardiovascular Research 2022, 1: 223-237. PMID: 37502132, PMCID: PMC10373053, DOI: 10.1038/s44161-022-00021-z.
- Goshua G, Sinha P, Pischel L, Lee A, Cuker A. Cost-Effectiveness of Second-Line Therapies in Adult Patients with Chronic Immune Thrombocytopenia. Blood 2021, 138: 751. DOI: 10.1182/blood-2021-144819.
- Lee E, Moreira M, Al-Samkari H, Cuker A, DiRaimo J, Gernsheimer T, Kruse A, Kessler C, Kruse C, Leavitt A, Lee A, Liebman H, Newland A, Ray A, Tarantino M, Thachil J, Kuter D, Cines D, Bussel J. Sars-Cov-2 Vaccination in Patients with Pre-Existing Immune Thrombocytopenia. Blood 2021, 138: 586. PMCID: PMC8701617, DOI: 10.1182/blood-2021-152918.
- Christian J, Gilkes L, Goldberg S, Hurwitz M, Podoltsev N, Lee A. Implementing a Full Time Equivalent-Supported Hematology/Oncology Fellowship Core Faculty Program May Improve Faculty Engagement in Education, Mentorship, and Recruitment. Blood 2021, 138: 2974. DOI: 10.1182/blood-2021-154326.
- Madeeva D, Borges K, Shallow M, Juthani P, Wang S, Gupta A, Chun H, Lee A, Pine A. Proteomic Profiles in Patients with Thrombosis Due to COVID-19 Are Distinct from Non-COVID-19 Thrombosis. Blood 2021, 138: 777. PMCID: PMC8701622, DOI: 10.1182/blood-2021-153959.
- Butt A, Muradashvili T, Soliman S, Goshua G, Burns A, Bar N, Martin K, Borgman G, Bona R, Lee A, Neparidze N. Iron Infusion Reactions: Risk Factors and Real-World Experience. Blood 2021, 138: 4154. DOI: 10.1182/blood-2021-151048.
- Lee EJ, Lee AI. Cerebral venous sinus thrombosis after vaccination: the UK experience. The Lancet 2021, 398: 1107-1109. PMID: 34370974, PMCID: PMC8346246, DOI: 10.1016/s0140-6736(21)01788-8.
- Pischel L, Geirsson A, Magaldi J, Martinello RA, Lee AI. A Brewing Back Pain. New England Journal Of Medicine 2021, 385: 66-72. PMID: 34192434, PMCID: PMC9273048, DOI: 10.1056/nejmcps2034802.
- McConnell MJ, Kawaguchi N, Kondo R, Sonzogni A, Licini L, Valle C, Bonaffini PA, Sironi S, Alessio MG, Previtali G, Seghezzi M, Zhang X, Lee A, Pine AB, Chun HJ, Zhang X, Fernandez-Hernando C, Qing H, Wang A, Price C, Sun Z, Utsumi T, Hwa J, Strazzabosco M, Iwakiri Y. Liver injury in COVID-19 and IL-6 trans-signaling-induced endotheliopathy. Journal Of Hepatology 2021, 75: 647-658. PMID: 33991637, PMCID: PMC8285256, DOI: 10.1016/j.jhep.2021.04.050.
- Wang S, Pine A, Mankbadi M, Chang C, Madeeva D, Zhang H, Dajani A, Crandall I, Sugeng L, Lee A, Chun H. PRO-THROMBOTIC SIGNATURE FROM NEUTROPHIL ACTIVATION AND DECREASED ADAMTS13 TO VWF RATIO IS A KEY DRIVER OF CARDIAC INJURY IN HOSPITALIZED PATIENTS WITH COVID-19. Journal Of The American College Of Cardiology 2021, 77: 3193. PMID: 34167644, PMCID: PMC8091195, DOI: 10.1016/s0735-1097(21)04548-4.
- McAlpine L, Zubair A, Maran I, Chojecka P, Lleva P, Jasne A, Navaratnam D, Matouk C, Schindler J, Chun H, Lee A, Spudich S, Sharma R, Sansing L. Ischemic Stroke, Inflammation, and Endotheliopathy in COVID-19 Patients (2402). Neurology 2021, 96 DOI: 10.1212/wnl.96.15_supplement.2402.
- Brahmandam A, Lee A, Chaar C. Endovascular Treatment of Renal Vein Thrombosis in a Young Patient With Lung Transplant. Journal Of Vascular Surgery Venous And Lymphatic Disorders 2021, 9: 542-543. DOI: 10.1016/j.jvsv.2020.12.022.
- Brahmandam A, Chan S, Aspegren-Valcarce M, Zhuo H, Zhang Y, Tonnessen B, Lee A, Chaar C. Sex Differences in Long-Term Outcomes of Patients with Deep Vein Thrombosis. Journal Of Vascular Surgery Venous And Lymphatic Disorders 2021, 9: 546-547. DOI: 10.1016/j.jvsv.2020.12.033.
- Goshua G, Sinha P, Hendrickson J, Tormey C, Bendapudi PK, Lee AI. Cost effectiveness of caplacizumab in acquired thrombotic thrombocytopenic purpura. Blood 2021, 137: 969-976. PMID: 33280030, PMCID: PMC7918179, DOI: 10.1182/blood.2020006052.
- Bewersdorf J, Parmar N, Gettinger S, Israel G, Lee A. Clinical Characteristics and Outcomes of Splenic Infarction in Cancer Patients - a Retrospective, Single Center Report of 206 Cases. Blood 2020, 136: 22-23. DOI: 10.1182/blood-2020-136646.
- Durani U, Manana A, May J, Nelson M, Zheng Z, Gollapudi A, Alam S, Reynolds R, Thompson J, Kumbamu A, Das D, Murphy M, Henry E, Lee A, Marshall A, Wun T, Weeks L. Measuring the Impact of COVID-19 on Hematology-Oncology Trainees: A Quantitative and Qualitative Assessment. Blood 2020, 136: 20-21. PMCID: PMC8330314, DOI: 10.1182/blood-2020-143347.
- Manana A, Durani U, Reynolds R, Kumbamu A, Das D, Murphy M, Henry E, Lee A, Marshall A. The Impact of COVID-19 on Hematology-Oncology Fellowship Programs: Program Director Perspectives. Blood 2020, 136: 24-25. PMCID: PMC8544190, DOI: 10.1182/blood-2020-141514.
- Masselink L, Lee A, Erikson C. Factors Associated with Burnout Among Hematology & Oncology Physicians. Blood 2020, 136: 41-42. DOI: 10.1182/blood-2020-139798.
- Goshua G, Sinha P, Hendrickson J, Tormey C, Bendapudi P, Lee A. Cost Effectiveness of Caplacizumab in Acquired Thrombotic Thrombocytopenic Purpura. Blood 2020, 136: 18-19. DOI: 10.1182/blood-2020-138515.
- Madeeva D, Christian J, Goshua G, Chun H, Lee A, Pine A. VWF/ADAMTS13 Ratios Are Potential Markers of Immunothrombotic Complications in Patients with COVID-19: A Cross-Sectional Study. Blood 2020, 136: 34-35. PMCID: PMC8330245, DOI: 10.1182/blood-2020-142917.
- Goshua G, Liu Y, Meizlish M, Fine R, Amin K, Chang E, Liu Y, McManus D, Petrosan A, Chaar C, Chun H, Defilippo N, Neuberg D, Owusu K, Lee A. Admission Rothman Index, Aspirin, and Intermediate Dose Anticoagulation Effects on Outcomes in COVID-19: A Multi-Site Propensity Matched Analysis. Blood 2020, 136: 23-24. PMCID: PMC8330288, DOI: 10.1182/blood-2020-143349.
- Odio CD, O'Brien CR, Jacox J, Jain D, Lee AI. Cryptic Cachexia. New England Journal Of Medicine 2020, 383: 68-74. PMID: 32609985, DOI: 10.1056/nejmcps1817531.
- Goshua G, Pine AB, Meizlish ML, Chang CH, Zhang H, Bahel P, Baluha A, Bar N, Bona RD, Burns AJ, Dela Cruz CS, Dumont A, Halene S, Hwa J, Koff J, Menninger H, Neparidze N, Price C, Siner JM, Tormey C, Rinder HM, Chun HJ, Lee AI. Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study. The Lancet Haematology 2020, 7: e575-e582. PMID: 32619411, PMCID: PMC7326446, DOI: 10.1016/s2352-3026(20)30216-7.
- Schwartz AR, Siegel MD, Lee AI. A novel approach to the program evaluation committee. BMC Medical Education 2019, 19: 465. PMID: 31842868, PMCID: PMC6916454, DOI: 10.1186/s12909-019-1899-x.
- Lee AI, Connors JM. The next(gen) step in coagulation testing. Blood 2019, 134: 2002-2003. PMID: 31805193, DOI: 10.1182/blood.2019001414.
- Sharma D, Wallace N, Levinsohn EA, Marshall AL, Kayoumi K, Madero J, Homer M, Reynolds R, Hafler J, Podoltsev NA, Lee AI. Trends and factors affecting the US adult hematology workforce: a mixed methods study. Blood Advances 2019, 3: 3550-3561. PMID: 31738829, PMCID: PMC6880914, DOI: 10.1182/bloodadvances.2019000307.
- Naik R, Montana M, Kersun L, Nagalla S, Lee A. Perceptions and Attitudes Toward Single-Board Hematology Training in the United States: A Program Director Survey. Blood 2019, 134: 3392. DOI: 10.1182/blood-2019-126310.
- Masselink L, Lee A, Erikson C. Hematology/Oncology Fellows' Future Plans and Job Expectations: Findings from the 2019 Hematology/Oncology Fellows Survey. Blood 2019, 134: 5780. DOI: 10.1182/blood-2019-126899.
- Lee A, Masselink L, Bass E, Connell N, Marshall A, Erikson C. Mentorship Experiences Among Second-Year U.S. Hematology/Oncology Fellows in the 2019 ASH Hematology/Oncology Fellows Survey. Blood 2019, 134: 2124. DOI: 10.1182/blood-2019-132252.
- Browning S, Parker T, Bar N, Seropian S, Lee A, Anderson T, Neparidze N. Daratumumab in the Clinic, a Real-Word Experience at Yale Cancer Center. Blood 2019, 134: 5569. DOI: 10.1182/blood-2019-130134.
- Pine A, Lee A. Providers Increased the Use of Direct Oral Anticoagulants in Patients with Cancer-Associated Thromboembolism without Gaining Complete Confidence: A Health System-Wide Retrospective Registry Study and a Providers' Survey. Blood 2019, 134: 2097. DOI: 10.1182/blood-2019-130200.
- Masselink LE, Erikson CE, Connell NT, De Castro LM, Dent GA, Marshall AL, Naik RP, Nelson M, O’Connell C, Rajasekhar A, Sharma D, Smith M, Lee AI. Associations between hematology/oncology fellows' training and mentorship experiences and hematology-only career plans. Blood Advances 2019, 3: 3278-3286. PMID: 31698456, PMCID: PMC6855099, DOI: 10.1182/bloodadvances.2019000569.
- Gu S, Shevell L, Tormey C, Rinder H, Lee A. Whole-Exome Sequencing in Evaluation of Thrombophilia: Characterization of Novel Genetic Variants. American Journal Of Clinical Pathology 2019, 152: s35-s35. DOI: 10.1093/ajcp/aqz112.066.
- Effendi M, Stutsky M, Curran C, Owusu K, Lee A. Impact of a Pharmacist Driven Anti-Xa Level Monitoring Protocol on Therapeutic Drug Monitoring Practice Patterns. Blood 2018, 132: 2284. DOI: 10.1182/blood-2018-99-119379.
- Juthani P, Ahmed D, Ahmed O, Bona R, Neparidze N, Lee A. Venous Thromboembolism (VTE) Education Preferences Amongst Physicians and Patients: A Qualitative Needs Assessment. Blood 2018, 132: 5810. DOI: 10.1182/blood-2018-99-119418.
- Hsu C, Brahmandam A, Brownson K, Huynh N, Reynolds J, Lee A, Fares W, Chaar C. The Effects of Statin Therapy on Thrombus Resolution in Patients with Deep Venous Thrombosis. Journal Of Vascular Surgery Venous And Lymphatic Disorders 2018, 6: 291-292. DOI: 10.1016/j.jvsv.2017.12.034.
- Djulbegovic M, Dugdale LS, Lee AI. Evaluation of Polycythemia: A Teachable Moment. JAMA Internal Medicine 2018, 178: 128-130. PMID: 29131894, DOI: 10.1001/jamainternmed.2017.6213.
- Lee A, Lee E. Anticoagulation for Proximal Deep Vein Thrombosis. 2017, 299-313. DOI: 10.1007/978-3-319-65226-9_23.
- Lee EJ, Dykas DJ, Leavitt AD, Camire RM, Ebberink E, García de Frutos P, Gnanasambandan K, Gu SX, Huntington JA, Lentz SR, Mertens K, Parish CR, Rezaie AR, Sayeski PP, Cromwell C, Bar N, Halene S, Neparidze N, Parker TL, Burns AJ, Dumont A, Yao X, Chaar CIO, Connors JM, Bale AE, Lee AI. Whole-exome sequencing in evaluation of patients with venous thromboembolism. Blood Advances 2017, 1: 1224-1237. PMID: 29296762, PMCID: PMC5728544, DOI: 10.1182/bloodadvances.2017005249.
- Levinsohn E, DiGiovanna M, Encandela J, Takizawa P, Hafler J, Lee A. A Novel Approach to the Medical Student Hematology Curriculum. Blood 2016, 128: 3537. DOI: 10.1182/blood.v128.22.3537.3537.
- Wallace N, Hafler J, Hurwitz M, Podoltsev N, Lacy J, Lee A. Factors Influencing Hematology Career Choice in Hematology and Oncology Fellows at a Major Academic Institution. Blood 2016, 128: 3538. DOI: 10.1182/blood.v128.22.3538.3538.
- Wallace N, Dumont A, Burns A, Christopher T, Rinder H, Kriegel M, Buckley L, Erkan D, Lee A. Thromboelastography in the Characterization of Coagulation Status in Antiphospholipid Syndrome. Blood 2016, 128: 4983. DOI: 10.1182/blood.v128.22.4983.4983.
- Lee AI, Chaar C. The Hidden Lesion. New England Journal Of Medicine 2016, 374: 2160-2165. PMID: 27248622, DOI: 10.1056/nejmcps1406615.
- Brownson K, Satoskar S, Reynolds J, Sumpio B, Sarac T, Scoutt L, Lee A. Thrombus Resolution as Guide to Anticoagulation Therapy for Provoked Deep Vein Thrombosis: TRUDVT Pilot Study. Journal Of Vascular Surgery Venous And Lymphatic Disorders 2016, 4: 149. DOI: 10.1016/j.jvsv.2015.10.040.
- Stutsky M, Reardon D, Lee A. Clinical Practice Patterns of Anti-Xa Monitoring During Low Molecular Weight Heparin Therapy. Blood 2015, 126: 3275. DOI: 10.1182/blood.v126.23.3275.3275.
- Lee E, Smith B, Merrey J, Lee A, Podoltsev N, Barbarotta L, Litzow M, Prebet T, Luger S, Gore S, Streiff M, Zeidan A. Patterns of Venous Thromboembolism Prophylaxis during Inpatient Treatment of Acute Leukemia: Results of a North American Web-Based Survey. Blood 2015, 126: 4455. DOI: 10.1182/blood.v126.23.4455.4455.
- Pine A, Lee E, Sekeres M, Steensma D, Prebet T, DeZern A, Komrokji R, Litzow M, Luger S, Stone R, Erba H, Garcia-Manero G, Lee A, Podoltsev N, Barbarotta L, Hendrickson J, Gore S, Zeidan A. North American Cooperative Group Members' Patterns of Blood Products Transfusion for Patients with Acute Leukemia. Blood 2015, 126: 1138. DOI: 10.1182/blood.v126.23.1138.1138.
- Catanzaro J, Lee A, Price C. Profoundly Low Immunoglobulins, Lymphopenia, Thymoma and No Infections. Journal Of Allergy And Clinical Immunology 2015, 135: ab15. DOI: 10.1016/j.jaci.2014.12.982.
- Kim R, Yao X, Longley P, Rimar J, Kournioti C, Lee A. Using the Rothman Index to Predict Discharge and Readmission Rates in an Inpatient Hematology Unit. Blood 2014, 124: 1302. DOI: 10.1182/blood.v124.21.1302.1302.
- Varughese N, Duong A, Emre S, Xu M, Lee AI. Venting the Spleen. New England Journal Of Medicine 2013, 369: 1357-1363. PMID: 24088096, DOI: 10.1056/nejmcps1210943.
- Lee A, Sylvester K, Rawn J, Fanikos J, Berliner N. Heparin-Induced Thrombocytopenia and Cardiac Surgery: A Role for Hematologists in Critical Care Units. Blood 2011, 118: 2062. DOI: 10.1182/blood.v118.21.2062.2062.
- Lee A, Campigotto F, Rawn J, Neuberg D, Kaufman R, Berliner N. Clinical Significance of Coagulation Studies in Predicting Response to Recombinant Factor VIIa in Cardiac Surgery Patients. Blood 2011, 118: 4351. DOI: 10.1182/blood.v118.21.4351.4351.
- Lee AI, Koo S, Vaidya A, Katz JT, Loscalzo J. A Bird's-Eye View of Fever. New England Journal Of Medicine 2011, 365: 1727-1732. PMID: 22047564, DOI: 10.1056/nejmcps1012518.
- Toomey C, Muzikanksy A, Lee A, Barnes J, Michaelson J, Abramson J, Hochberg E. Treatment Choice and Outcome In Diffuse Large B Cell Lymphoma (DLBCL) Patients 75 Years and Older. Blood 2010, 116: 733. DOI: 10.1182/blood.v116.21.733.733.
- Hochberg E, Birrer N, Toomey C, Barnes J, Lee A, LaCasce A, Abramson J. Rituximab Does Not Improve Progression Free (PFS) or Overall Survival (OS) in Patients with Limited Stage Diffuse Large B Cell Lymphoma (DLBCL). Blood 2009, 114: 3755. DOI: 10.1182/blood.v114.22.3755.3755.
- Barnes J, LaCasce A, Toomey C, Hochberg E, Lee A, Canellos G, Abramson J. Early Interim FDG-PET Scan Predicts Outcome in Non-Bulky Limited Stage Hodgkin Lymphoma, but may Not Guide Use of Consolidative Radiotherapy. Blood 2008, 112: 1453. DOI: 10.1182/blood.v112.11.1453.1453.
- Fugmann S, Lee A, Shockett P, Villey I, Schatz D. The RAG Proteins and V(D)J Recombination: Complexes, Ends, and Transposition. Annual Review Of Immunology 2000, 18: 495-527. PMID: 10837067, DOI: 10.1146/annurev.immunol.18.1.495.
Locations
Classical Hematology
Smilow Cancer Hospital Care Center - Spring Brook Common
240 Indian River Road
Orange, CT 06477
- Classical HematologySmilow Cancer Hospital Care Center - Spring Brook Common240 Indian River RoadOrange, CT 06477
Classical Hematology
Smilow Cancer Hospital Care Center - Spring Brook Common
240 Indian River Road
Orange, CT 06477
- Classical HematologySmilow Cancer Hospital Care Center - Spring Brook Common240 Indian River RoadOrange, CT 06477