- Yale Dermatology New HavenDoctors Building2 Church Street SouthNew Haven, CT 06519
William Damsky, MD, PhD
Biography
William Damsky, MD, PhD, is a dermatologist at Yale Medicine specializing in skin conditions such as psoriasis, eczema, acne, skin cancer, and such rare skin conditions as sarcoidosis, granuloma annulare, necrobiosis lipoidica, and others . He also conducts research on new treatments for these conditions, especially a new class of medications called JAK inhibitors, which inhibit a specific protein responsible for the immune reactions that cause certain rashes.
As a clinician, Dr. Damsky’s goal is to guide patients through the decision-making process to choose an effective therapy that is right for them. While conservative by nature, he also utilizes more aggressive approaches when needed, as long as the patient is comfortable with the decision and is a candidate for the treatment.
Dr. Damsky first became interested in skin conditions when he conducted research on skin cancer and learned about rare skin diseases. “I really like trying to understand rashes and skin conditions that most people haven’t even heard of. Finding treatments for patients who have been told that nothing can be done is really gratifying,” he says.
Titles
- Assistant Professor in Dermatology and Dermatopathology
Education & Training
- FellowYale School of Medicine (2020)
- ResidentYale New Haven Hospital / Yale School of Medicine (2017)
- InternshipYale New Haven Hospital (2014)
- MDUniversity of Vermont, College of Medicine (2013)
- PhDUniversity of Vermont College of Medicine (2011)
- BSUniversity of Vermont (2005)
Additional Information
- Young Investigator Award: American Society for Clinical Investigation (2022)
- 2022 Young Physician-Scientist Award: American Society for Clinical Investigation (2022)
- Young Investigator Award: American Academy of Dermatology (2020)
- Todd Nagel Memorial Award: Skin Cancer Foundation (2018)
- Career Development Award: Dermatology Foundation (2017)
- Physician Scientist Career Development Award: Dermatology Foundation (2017)
- Dermatologist Investigator Research Fellowship: Dermatology Foundation (2016)
- Joseph B Warshaw Award: University of Vermont College of Medicine (2012)
- Research Scholar Award: Joanna Nicolay Melanoma Research Foundation (2010)
- Lyman S Rowell Award: University of Vermont, Department of Biology (2004)
- AB of Dermatology, Dermatopathology (2020)
- AB of Dermatology, Dermatology (2017)
- Spaulding S, Wride A, Slade M, Damsky W, Cohen J. Cutaneous fungal infections in the United States: A cross-sectional analysis of the National Ambulatory Medical Care Survey (NAMCS) and National Hospital Ambulatory Medical Care Survey (NHAMCS), 2005–2016. Journal Of The American Academy Of Dermatology 2024 PMID: 39486764, DOI: 10.1016/j.jaad.2024.10.035.
- Lin Y, Xie M, Lau H, Zeng R, Zhang R, Wang L, Li Q, Wang Y, Chen D, Jiang L, Damsky W, Yu J. Effects of gut microbiota on immune checkpoint inhibitors in multi-cancer and as microbial biomarkers for predicting therapeutic response. Med 2024 PMID: 39515321, DOI: 10.1016/j.medj.2024.10.007.
- Wride A, Chen G, Fan R, Leasure A, Jones S, Levey D, Damsky W, Cohen J. Bipolar disorder among individuals with atopic dermatitis: A case-control study in the All of Us Research Program. Clinical And Experimental Dermatology 2024, llae451. PMID: 39425681, DOI: 10.1093/ced/llae451.
- Bassir F, Valido K, Maciejewski K, Damsky W, Nelson C. Validation of the Delphi Consensus Diagnostic Criteria for Necrobiotic Xanthogranuloma. JAMA Dermatology 2024, 160 PMID: 39356540, PMCID: PMC11447626, DOI: 10.1001/jamadermatol.2024.3198.
- Wride M, Chen G, Fan R, Leasure A, Levey D, Damsky W, Cohen J. 54712 Bipolar disorder among patients with atopic dermatitis: A case-control study in the All of Us research program. Journal Of The American Academy Of Dermatology 2024, 91: ab147. DOI: 10.1016/j.jaad.2024.07.584.
- Chang J, Shin K, Lewis J, Suh H, Lee J, Damsky W, Xu S, Bosenberg M, Saltzman W, Girardi M. Enhanced intratumoral delivery of immunomodulator MPLA via hyperbranched polyglycerol-coated biodegradable nanoparticles. Journal Of Investigative Dermatology 2024 PMID: 39122142, DOI: 10.1016/j.jid.2024.07.019.
- Sand J, Jessen H, Leeming D, Yu S, Lee C, Hu B, Sun Y, Adams T, Pivarnik T, Liu A, Woo S, McGovern J, Fiorini V, Saber T, Higuero-Sevilla J, Gulati M, Kaminski N, Damsky W, Shaw A, Mohanty S, Goobie G, Zhang Y, Herzog E, Ryu C. Plasma collagen neoepitopes are associated with multiorgan disease in the ACCESS and GRADS sarcoidosis cohorts. Thorax 2024, 79: thorax-2023-221095. PMID: 39117421, DOI: 10.1136/thorax-2023-221095.
- Daccache J, Park E, Junejo M, Abdelghaffar M, Hwang E, Mohanty C, Singh C, Wang G, Wheeler J, Shields B, Nelson C, Wang Y, Damsky W. Spatial transcriptomics reveals organized and distinct immune activation in cutaneous granulomatous disorders. Journal Of Allergy And Clinical Immunology 2024, 154: 1216-1231. PMID: 39098508, PMCID: PMC11560686, DOI: 10.1016/j.jaci.2024.07.021.
- Daccache J, Park E, Junejo M, Abdelghaffar M, Hwang E, Mohanty C, Singh C, Wang G, Wheeler J, Shields B, Nelson C, Wang Y, Damsky W. LB863 Spatial transcriptomics reveals structurally organized and distinct immune polarization in inflammatory cutaneous granulomatous disorders. Journal Of Investigative Dermatology 2024, 144: s150. DOI: 10.1016/j.jid.2024.06.1243.
- Bangert C, Alkon N, Chennareddy S, Arnoldner T, Levine J, Pilz M, Ruggiero J, Cohenour E, Jonak C, Damsky W, Griss J, Brunner P. 795 Dupilumab-associated head and neck dermatitis shows a pronounced type 22 immune signature mediated by oligoclonally expanded T cells. Journal Of Investigative Dermatology 2024, 144: s139. DOI: 10.1016/j.jid.2024.06.811.
- Wang Y, Yu W, Micevic G, Daccache J, Wang A, Park K, Wang G, Palmatier M, Wheeler J, King B, Damsky W. 057 Single cell RNA and TCR sequencing reveals hyperexpansion of T cell clones and novel regulatory mechanisms of CD8+ T cells in murine alopcecia areata skin and draining lymph nodes. Journal Of Investigative Dermatology 2024, 144: s10. DOI: 10.1016/j.jid.2024.06.073.
- McKay G, Liu L, Shaw K, Shakshouk H, Murphy M, Damsky W, Ortega‐Loayza A, Caplan A, Arkin L, Shields B. Pediatric cutaneous Crohn disease: A case series of 89 patients and review. Pediatric Dermatology 2024, 41: 807-813. PMID: 39011834, DOI: 10.1111/pde.15689.
- Cohen J, Damsky W. Anti-Interleukin-23 Autoantibodies in Adult-Onset Immunodeficiency. New England Journal Of Medicine 2024, 391: 188-189. PMID: 38986070, DOI: 10.1056/nejmc2404977.
- Mohanty C, Singh C, Daccache J, Damsky W, Kendziorski C, Yan D, Prasad A, Zhang D, Keenan T, Drolet B, Ahmad N, Shields B. Granuloma Annulare Exhibits Mixed Immune and Macrophage Polarization Profiles with Spatial Transcriptomics. Journal Of Investigative Dermatology 2024 PMID: 38844128, DOI: 10.1016/j.jid.2024.04.024.
- Valido K, Murphy M, Leventhal J, Damsky W. Successful treatment of pityriasis rubra pilaris with brodalumab after nonresponse to IL-17A inhibition: A role for the innate cytokine IL-17C. JAAD Case Reports 2024, 48: 85-87. PMID: 38783931, PMCID: PMC11111584, DOI: 10.1016/j.jdcr.2024.04.010.
- Shaw V, Damsky W, Homer R, Cohen J. Characterizing interstitial lung disease in patients with psoriasis: a cross-sectional analysis in the National Institutes of Health’s All of Us Research Program. Clinical And Experimental Dermatology 2024, 49: 1083-1084. PMID: 38618708, DOI: 10.1093/ced/llae132.
- Abdelghaffar M, Kottilil S, Murphy M, Cohen J, Damsky W. Paradoxical Psoriasis. Dermatologic Clinics 2024, 42: 471-480. PMID: 38796276, DOI: 10.1016/j.det.2024.02.011.
- Valido K, Patel V, Murphy M, Junejo M, Patel D, Deutsch A, Turner N, Zaki T, King B, Damsky W, Nelson C. Treatment of prolonged drug reaction with eosinophilia and systemic symptoms syndrome with dupilumab using a molecularly-guided approach. JAAD Case Reports 2024, 48: 49-53. PMID: 38774671, PMCID: PMC11107093, DOI: 10.1016/j.jdcr.2024.03.020.
- Bangert C, Alkon N, Chennareddy S, Arnoldner T, Levine J, Pilz M, Medjimorec M, Ruggiero J, Cohenour E, Jonak C, Damsky W, Griss J, Brunner P. Dupilumab-associated head and neck dermatitis shows a pronounced type 22 immune signature mediated by oligoclonally expanded T cells. Nature Communications 2024, 15: 2839. PMID: 38565563, PMCID: PMC10987549, DOI: 10.1038/s41467-024-46540-0.
- Garate D, Thang C, Damsky W, Rosenbach M, Golovko G, Wilkerson M, Barbieri J. Granuloma annulare is associated with an increased risk of hematologic malignancies: A multicenter cohort study using TriNetX. Journal Of The American Academy Of Dermatology 2023, 90: 862-864. PMID: 38147901, DOI: 10.1016/j.jaad.2023.12.028.
- Hwang E, Lee T, Okifo K, Murphy M, Damsky W. Retrospective assessment of immunologic and histologic heterogeneity in granuloma annulare by cytokine staining. International Journal Of Dermatology 2023, 63: 655-659. PMID: 38135676, PMCID: PMC11055676, DOI: 10.1111/ijd.16998.
- Chen G, Fan R, Leasure A, Levey D, Damsky W, Cohen J. Obsessive–compulsive disorder among patients with atopic dermatitis: a case–control study in the All of Us research program. Archives Of Dermatological Research 2023, 316: 11. PMID: 38038754, DOI: 10.1007/s00403-023-02767-3.
- Joel M, Damsky W, Cohen J, Wride M. Association between atopic dermatitis and inflammatory bowel disease among US adults in the All of Us Research Program. Clinical And Experimental Dermatology 2023, 49: 390-392. PMID: 37967342, PMCID: PMC10957220, DOI: 10.1093/ced/llad397.
- Djureinovic D, Weiss S, Krykbaeva I, Qu R, Vathiotis I, Moutafi M, Zhang L, Perdigoto A, Wei W, Anderson G, Damsky W, Hurwitz M, Johnson B, Schoenfeld D, Mahajan A, Hsu F, Miller-Jensen K, Kluger Y, Sznol M, Kaech S, Bosenberg M, Jilaveanu L, Kluger H. A bedside to bench study of anti-PD-1, anti-CD40, and anti-CSF1R indicates that more is not necessarily better. Molecular Cancer 2023, 22: 182. PMID: 37964379, PMCID: PMC10644655, DOI: 10.1186/s12943-023-01884-x.
- Shipman W, Singh K, Cohen J, Leventhal J, Damsky W, Tomayko M. Targeting interleukin (IL)-4/IL-13 in immune checkpoint inhibitor-induced bullous pemphigoid: a cautionary note on the beneficial effect of T helper 2 immunity in melanoma and immunotherapy: reply from the authors. British Journal Of Dermatology 2023, 190: 138-138. PMID: 37947404, DOI: 10.1093/bjd/ljad342.
- Abdelghaffar M, Hwang E, Damsky W. Cutaneous Sarcoidosis. Clinics In Chest Medicine 2023, 45: 71-89. PMID: 38245372, DOI: 10.1016/j.ccm.2023.08.004.
- Murphy M, Hwang E, Singh K, Lee T, Cohen J, Damsky W. Machine learning analysis of pretreatment skin biopsies predicts nonresponse to dupilumab in patients with eczematous dermatitis. British Journal Of Dermatology 2023, 190: 132-134. PMID: 37818837, DOI: 10.1093/bjd/ljad389.
- Nihal A, Caplan A, Rosenbach M, Damsky W, Mangold A, Shields B. Treatment options for necrobiosis lipoidica: a systematic review. International Journal Of Dermatology 2023, 62: 1529-1537. PMID: 37772666, DOI: 10.1111/ijd.16856.
- Chen G, Fan R, Leasure A, Damsky W, Cohen J. 44140 Obsessive-Compulsive Disorder Among Patients with Atopic Dermatitis: A Case-Control Study in the All of Us Research Program. Journal Of The American Academy Of Dermatology 2023, 89: ab69. DOI: 10.1016/j.jaad.2023.07.279.
- McKay G, Coromilas A, Liu L, Murphy M, Punyamurthy N, Damsky W, Wanat K, Rosenbach M, Caplan A, LaSenna C, Shields B. 43437 Ustekinumab for the Treatment of Metastatic Crohn Disease. Journal Of The American Academy Of Dermatology 2023, 89: ab103. DOI: 10.1016/j.jaad.2023.07.414.
- Kimball K, Damsky W, Richmond J. Lichen Nitidus: A Case of Tiny, Shiny, Skin Bumps. Frontiers For Young Minds 2023, 11: 1033760. DOI: 10.3389/frym.2023.1033760.
- Hwang E, Abdelghaffar M, Shields B, Damsky W. Molecularly Targeted Therapies for Inflammatory Cutaneous Granulomatous Disorders: A Review of the Evidence and Implications for Understanding Disease Pathogenesis. JID Innovations 2023, 3: 100220. PMID: 37719661, PMCID: PMC10500476, DOI: 10.1016/j.xjidi.2023.100220.
- Wei B, Fox L, Kaffenberger B, Korman A, Micheletti R, Mostaghimi A, Noe M, Rosenbach M, Shinkai K, Kwah J, Phillips E, Bolognia J, Damsky W, Nelson C. Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms. Part II diagnosis and management. Journal Of The American Academy Of Dermatology 2023, 90: 911-926. PMID: 37516356, DOI: 10.1016/j.jaad.2023.02.073.
- Wei B, Fox L, Kaffenberger B, Korman A, Micheletti R, Mostaghimi A, Noe M, Rosenbach M, Shinkai K, Kwah J, Phillips E, Bolognia J, Damsky W, Nelson C. Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms. Part I. Epidemiology, pathogenesis, clinicopathological features, and prognosis. Journal Of The American Academy Of Dermatology 2023, 90: 885-908. PMID: 37516359, DOI: 10.1016/j.jaad.2023.02.072.
- Fan R, Chen G, Leasure A, Johnson M, Damsky W, Cohen J. Association of atopic dermatitis with schizophrenia and schizoaffective disorder. Archives Of Dermatological Research 2023, 315: 2731-2733. PMID: 37495709, DOI: 10.1007/s00403-023-02674-7.
- Murphy M, Heyang M, Fan R, Leasure A, Damsky W, Cohen J. Association between uveitis and Lichen planus in the all of us research program. Archives Of Dermatological Research 2023, 315: 2729-2730. PMID: 37488318, DOI: 10.1007/s00403-023-02675-6.
- Krykbaeva I, Bridges K, Damsky W, Pizzurro G, Alexander A, McGeary M, Park K, Muthusamy V, Eyles J, Luheshi N, Turner N, Weiss S, Olino K, Kaech S, Kluger H, Miller-Jensen K, Bosenberg M. Combinatorial Immunotherapy with Agonistic CD40 Activates Dendritic Cells to Express IL12 and Overcomes PD-1 Resistance. Cancer Immunology Research 2023, 11: 1332-1350. PMID: 37478171, DOI: 10.1158/2326-6066.cir-22-0699.
- Damo M, Hornick N, Venkat A, William I, Clulo K, Venkatesan S, He J, Fagerberg E, Loza J, Kwok D, Tal A, Buck J, Cui C, Singh J, Damsky W, Leventhal J, Krishnaswamy S, Joshi N. PD-1 maintains CD8 T cell tolerance towards cutaneous neoantigens. Nature 2023, 619: 151-159. PMID: 37344588, PMCID: PMC10989189, DOI: 10.1038/s41586-023-06217-y.
- Mortlock R, Ma E, Cohen J, Damsky W. Assessment of Treatment-Relevant Immune Biomarkers in Psoriasis and Atopic Dermatitis: Toward Personalized Medicine in Dermatology. Journal Of Investigative Dermatology 2023, 143: 1412-1422. PMID: 37341663, PMCID: PMC10830170, DOI: 10.1016/j.jid.2023.04.005.
- Horowitch B, Lee D, Ding M, Martinez-Morilla S, Aung T, Ouerghi F, Wang X, Wei W, Damsky W, Sznol M, Kluger H, Rimm D, Ishizuka J. Subsets of IFN Signaling Predict Response to Immune Checkpoint Blockade in Patients with Melanoma. Clinical Cancer Research 2023, 29: 2908-2918. PMID: 37233452, PMCID: PMC10524955, DOI: 10.1158/1078-0432.ccr-23-0215.
- Park J, Park E, Damsky W, Vesely M. Pembrolizumab-induced lichenoid dermatitis treated with dupilumab. JAAD Case Reports 2023, 37: 13-15. PMID: 37332364, PMCID: PMC10275729, DOI: 10.1016/j.jdcr.2023.05.004.
- Shipman W, Singh K, Cohen J, Leventhal J, Damsky W, Tomayko M. Immune checkpoint inhibitor-induced bullous pemphigoid is characterized by interleukin (IL)-4 and IL-13 expression and responds to dupilumab treatment. British Journal Of Dermatology 2023, 189: 339-341. PMID: 37140007, PMCID: PMC10947518, DOI: 10.1093/bjd/ljad149.
- Singh I, Leitner B, Wang Y, Zhang H, Joseph P, Lutchmansingh D, Gulati M, Possick J, Damsky W, Hwa J, Heerdt P, Chun H. Proteomic profiling demonstrates inflammatory and endotheliopathy signatures associated with impaired cardiopulmonary exercise hemodynamic profile in Post Acute Sequelae of SARS‐CoV‐2 infection (PASC) syndrome. Pulmonary Circulation 2023, 13: e12220. PMID: 37091121, PMCID: PMC10113513, DOI: 10.1002/pul2.12220.
- Murphy M, Edemobi P, Leasure A, Gulati M, Miller E, Damsky W, Cohen J. Autoimmune comorbidities associated with sarcoidosis: a case-control study in the All of Us research program. Rheumatology Advances In Practice 2023, 7: rkad030. PMID: 38606002, PMCID: PMC11007907, DOI: 10.1093/rap/rkad030.
- Fan R, Chen G, Leasure A, Johnson M, Damsky W, Cohen J. Association of atopic dermatitis with schizophrenia and schizoaffective disorder: A case-control study in the All of Us Research Program. 2023 DOI: 10.21203/rs.3.rs-2782847/v1.
- Xu S, Weiss E, Singh K, Damsky W, Girardi M. A case of bullous lesions in cutaneous T-cell lymphoma. JAAD Case Reports 2023, 35: 90-93. PMID: 37223111, PMCID: PMC10201206, DOI: 10.1016/j.jdcr.2023.02.026.
- Singh K, Valido K, Swallow M, Okifo K, Wang A, Cohen J, Damsky W. Baseline skin cytokine profiles determined by RNA in situ hybridization correlate with response to dupilumab in patients with eczematous dermatitis. Journal Of The American Academy Of Dermatology 2023, 88: 1094-1100. PMID: 36780951, DOI: 10.1016/j.jaad.2022.12.052.
- Chen J, Murphy M, Singh K, Wang A, Chow R, Kim R, Cohen J, Ko C, Damsky W. IL17A mRNA Staining Distinguishes Palmoplantar Psoriasis from Hyperkeratotic Palmoplantar Eczema in Diagnostic Skin Biopsies. JID Innovations 2023, 3: 100189. PMID: 37205304, PMCID: PMC10186614, DOI: 10.1016/j.xjidi.2023.100189.
- Ren J, Qu R, Rahman N, Lewis J, King A, Liao X, Mirza F, Carlson K, Huang Y, Gigante S, Evans B, Rajendran B, Xu S, Wang G, Foss F, Damsky W, Kluger Y, Krishnaswamy S, Girardi M. Integrated transcriptome and trajectory analysis of cutaneous T-cell lymphoma identifies putative precancer populations. Blood Advances 2023, 7: 445-457. PMID: 35947128, PMCID: PMC9979716, DOI: 10.1182/bloodadvances.2022008168.
- Joel M, Fan R, Damsky W, Cohen J. Psoriasis associated with asthma and allergic rhinitis: a US-based cross-sectional study using the All of US Research Program. Archives Of Dermatological Research 2023, 315: 1823-1826. PMID: 36707438, DOI: 10.1007/s00403-023-02539-z.
- Hodelin C, Fan R, Damsky W, Cohen J. The association of atopic dermatitis and chronic rhinosinusitis in adults: a cross‐sectional study using the All of Us research program. International Journal Of Dermatology 2022, 62: e430-e431. PMID: 36468789, DOI: 10.1111/ijd.16544.
- Ahmad M, Murphy M, Damsky W, Leventhal J. Dupilumab‐induced psoriasis in the setting of pembrolizumab therapy: an analysis of cytokine expression. International Journal Of Dermatology 2022, 62: e424-e426. PMID: 36468831, DOI: 10.1111/ijd.16538.
- Belzer A, Leasure A, Damsky W, Cohen J. The association of anxiety with granuloma annulare: a case–control study of the National Institutes of Health ‘All of Us’ research programme. British Journal Of Dermatology 2022, 188: 558-560. PMID: 36715356, DOI: 10.1093/bjd/ljac114.
- Association of sarcoidosis with psoriasis: a cross-sectional study in the All of Us research programMurphy M, Leasure A, Damsky W, Cohen J. Association of sarcoidosis with psoriasis: a cross-sectional study in the All of Us research program. Archives Of Dermatological Research 2022, 315: 1439-1441. PMID: 36436011, DOI: 10.1007/s00403-022-02488-z.
- Fan R, Leasure A, Damsky W, Cohen J. Migraine among adults with atopic dermatitis: a cross-sectional study in the All of Us research programme. Clinical And Experimental Dermatology 2022, 48: 24-26. PMID: 36669173, DOI: 10.1093/ced/llac004.
- Clark A, Murphy M, King B, Cohen J, Rosenbach M, Barbieri J, Damsky W. Patient perspectives on the lived experience of granuloma annulare. British Journal Of Dermatology 2022, 188: 134-136. PMID: 36689498, DOI: 10.1093/bjd/ljac004.
- A case of eosinophilic dermatosis of hematologic malignancy with tissue-based Th2 cytokine profilingXu S, Singh K, McNiff J, Damsky W, Gehlhausen J. A case of eosinophilic dermatosis of hematologic malignancy with tissue-based Th2 cytokine profiling. JAAD Case Reports 2022, 30: 5-7. PMID: 36345409, PMCID: PMC9636011, DOI: 10.1016/j.jdcr.2022.09.020.
- Belzer A, Leasure A, Damsky W. 35151 The association of major depressive disorder and anxiety with granuloma annulare: A case-control study of the NIH All of Us database. Journal Of The American Academy Of Dermatology 2022, 87: ab116. DOI: 10.1016/j.jaad.2022.06.498.
- Fan R, Leasure A, Damsky W, Cohen J. 187 Mental health comorbidities and alcohol use disorder in atopic dermatitis: A case-control study in the All of Us research program. Journal Of Investigative Dermatology 2022, 142: s32. DOI: 10.1016/j.jid.2022.05.194.
- Choi R, Wang J, Damsky W, Wang A, Galan A, Leventhal J. 103 JAK-STAT activation in anti-PD-1 therapy-associated granuloma annulare. Journal Of Investigative Dermatology 2022, 142: s18. DOI: 10.1016/j.jid.2022.05.038.
- Singh K, Valido K, Swallow M, Cohen J, Damsky W. 814 Correlation between skin cytokine profile and response to dupilumab in atopic dermatitis. Journal Of Investigative Dermatology 2022, 142: s141. DOI: 10.1016/j.jid.2022.05.828.
- Ricardo-Gonzalez R, Kotas M, O’Leary C, Tenvooren I, Marquez D, Singh K, Damsky W, Liao C, Schroeder A, Cohen J, Fassett M, Lee J, Daniel S, Bittinger K, Diaz R, Fraser J, Ansel K, Spitzer M, Liang H, Locksley R. Innate type 2 immunity controls hair follicle commensalism by Demodex mites. The Journal Of Immunology 2022, 208: 50.39-50.39. DOI: 10.4049/jimmunol.208.supp.50.39.
- Gehlhausen JR, Little AJ, Ko CJ, Emmenegger M, Lucas C, Wong P, Klein J, Lu P, Mao T, Jaycox J, Wang E, Ugwu N, Muenker C, Mekael D, Klein R, Patrignelli R, Antaya R, McNiff J, Damsky W, Kamath K, Shon J, Ring A, Yildirim I, Omer S, Ko A, Aguzzi A, Iwasaki A, Obaid A, Lu-Culligan A, Nelson A, Brito A, Nunez A, Martin A, Watkins A, Geng B, Kalinich C, Harden C, Todeasa C, Jensen C, Kim D, McDonald D, Shepard D, Courchaine E, White E, Song E, Silva E, Kudo E, DeIuliis G, Rahming H, Park H, Matos I, Nouws J, Valdez J, Fauver J, Lim J, Rose K, Anastasio K, Brower K, Glick L, Sharma L, Sewanan L, Knaggs L, Minasyan M, Batsu M, Petrone M, Kuang M, Nakahata M, Campbell M, Linehan M, Askenase M, Simonov M, Smolgovsky M, Sonnert N, Naushad N, Vijayakumar P, Martinello R, Datta R, Handoko R, Bermejo S, Prophet S, Bickerton S, Velazquez S, Alpert T, Rice T, Khoury-Hanold W, Peng X, Yang Y, Cao Y, Strong Y. Lack of association between pandemic chilblains and SARS-CoV-2 infection. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2122090119. PMID: 35217624, PMCID: PMC8892496, DOI: 10.1073/pnas.2122090119.
- Zhang SM, Cai WL, Liu X, Thakral D, Luo J, Chan LH, McGeary MK, Song E, Blenman KRM, Micevic G, Jessel S, Zhang Y, Yin M, Booth CJ, Jilaveanu LB, Damsky W, Sznol M, Kluger HM, Iwasaki A, Bosenberg MW, Yan Q. KDM5B promotes immune evasion by recruiting SETDB1 to silence retroelements. Nature 2021, 598: 682-687. PMID: 34671158, PMCID: PMC8555464, DOI: 10.1038/s41586-021-03994-2.
- Mirza F, Wang A, Ramachandran S, Damsky W, Cohen J. Dupilumab‐induced phenotype switch from atopic dermatitis to psoriasis is characterized by de novo interleukin‐17A expression: a case report. British Journal Of Dermatology 2021, 185: 432-434. PMID: 33730377, DOI: 10.1111/bjd.20064.
- Wang A, King B, Damsky W. 674 Single-cell RNA sequencing (scRNA-seq) of sarcoidosis skin biopsies reveals key pathogenic cytokines and potential treatment targets. Journal Of Investigative Dermatology 2021, 141: s117. DOI: 10.1016/j.jid.2021.02.704.
- Zhou T, Damsky W, Weizman OE, McGeary MK, Hartmann KP, Rosen CE, Fischer S, Jackson R, Flavell RA, Wang J, Sanmamed MF, Bosenberg MW, Ring AM. IL-18BP is a secreted immune checkpoint and barrier to IL-18 immunotherapy. Nature 2020, 583: 609-614. PMID: 32581358, PMCID: PMC7381364, DOI: 10.1038/s41586-020-2422-6.
- Damsky W, Wang A, Olamiju B, Peterson D, Galan A, King B. Treatment of severe lichen planus with the JAK inhibitor tofacitinib. Journal Of Allergy And Clinical Immunology 2020, 145: 1708-1710.e2. PMID: 32018031, DOI: 10.1016/j.jaci.2020.01.031.
- Damsky W, Patel D, Garelli CJ, Garg M, Wang A, Dresser K, Deng A, Harris JE, Richmond J, King B. JAK inhibition prevents bleomycin-induced fibrosis in mice and is effective in morphea patients. Journal Of Investigative Dermatology 2020, 140: 1446-1449.e4. PMID: 31954727, DOI: 10.1016/j.jid.2019.12.019.
- Krykbaeva I, Damsky W, Turner N, Perry C, Kluger H, Bosenberg M. LB1122 Myeloid targeting in combination with PD1 inhibition boosts anti-tumor immunity in melanoma. Journal Of Investigative Dermatology 2019, 139: b19. DOI: 10.1016/j.jid.2019.06.089.
- Damsky W, Thakral D, McGeary MK, Leventhal J, Galan A, King B. Janus kinase inhibition induces disease remission in cutaneous sarcoidosis and granuloma annulare. Journal Of The American Academy Of Dermatology 2019, 82: 612-621. PMID: 31185230, PMCID: PMC7590533, DOI: 10.1016/j.jaad.2019.05.098.
- Ferreira M, Krykbaeva I, Damsky W, Kluger H, Bosenberg M. Evaluating the role of the COX2/PGE2 pathway in anti-melanoma immunity. Journal Of Clinical Oncology 2019, 37: e14114-e14114. DOI: 10.1200/jco.2019.37.15_suppl.e14114.
- Ferreira M, Damsky W, Bosenberg M. 783 Evaluating the impact of high-dose steroids on checkpoint inhibitor efficacy in a murine model of melanoma. Journal Of Investigative Dermatology 2019, 139: s135. DOI: 10.1016/j.jid.2019.03.859.
- Ramseier J, Thakral D, Damsky W, Bosenberg M. 789 Immune checkpoint therapy polarizes fibroblasts into a proinflammatory state. Journal Of Investigative Dermatology 2019, 139: s136. DOI: 10.1016/j.jid.2019.03.865.
- Damsky W, Thakral D, Emeagwali N, Galan A, King B. Tofacitinib Treatment and Molecular Analysis of Cutaneous Sarcoidosis. New England Journal Of Medicine 2018, 379: 2540-2546. PMID: 30586518, PMCID: PMC6351852, DOI: 10.1056/nejmoa1805958.
- Turner N, Damsky W, Wang J, Meeth K, Blenman K, Bosenberg M. 1245 PD-1 blockade impedes tumor growth in the immunogenic YUMMER1.7 mouse melanoma model. Journal Of Investigative Dermatology 2018, 138: s211. DOI: 10.1016/j.jid.2018.03.1260.
- Wang J, Perry CJ, Meeth K, Thakral D, Damsky W, Micevic G, Kaech S, Blenman K, Bosenberg M. UV‐induced somatic mutations elicit a functional T cell response in the YUMMER1.7 mouse melanoma model. Pigment Cell & Melanoma Research 2017, 30: 428-435. PMID: 28379630, PMCID: PMC5820096, DOI: 10.1111/pcmr.12591.
- Damsky W, Wang J, Perry C, Meeth K, Kaech S, Bosenberg M. 766 Exposure to ultraviolet light enhances anti-tumor immunity and response to immunotherapy in a mouse model of melanoma. Journal Of Investigative Dermatology 2017, 137: s132. DOI: 10.1016/j.jid.2017.02.791.
- Damsky W, King BA. JAK inhibitors in dermatology: The promise of a new drug class. Journal Of The American Academy Of Dermatology 2017, 76: 736-744. PMID: 28139263, PMCID: PMC6035868, DOI: 10.1016/j.jaad.2016.12.005.
- Meeth K, Wang JX, Micevic G, Damsky W, Bosenberg MW. The YUMM lines: a series of congenic mouse melanoma cell lines with defined genetic alterations. Pigment Cell & Melanoma Research 2016, 29: 590-597. PMID: 27287723, PMCID: PMC5331933, DOI: 10.1111/pcmr.12498.
- Bosenberg M, Meeth K, Damsky W. A comprehensive system of congenic mouse melanoma models for evaluation of immune therapies. The Journal Of Immunology 2016, 196: 144.19-144.19. DOI: 10.4049/jimmunol.196.supp.144.19.
- Damsky W, Micevic G, Meeth K, Muthusamy V, Curley DP, Santhanakrishnan M, Erdelyi I, Platt JT, Huang L, Theodosakis N, Zaidi MR, Tighe S, Davies MA, Dankort D, McMahon M, Merlino G, Bardeesy N, Bosenberg M. mTORC1 Activation Blocks Braf V600E -Induced Growth Arrest but Is Insufficient for Melanoma Formation. Cancer Cell 2015, 27: 41-56. PMID: 25584893, PMCID: PMC4295062, DOI: 10.1016/j.ccell.2014.11.014.
- Damsky WE, Curley DP, Santhanakrishnan M, Rosenbaum LE, Platt JT, Rothberg BE, Taketo MM, Dankort D, Rimm DL, McMahon M, Bosenberg M. β-Catenin Signaling Controls Metastasis in Braf-Activated Pten-Deficient Melanomas. Cancer Cell 2011, 20: 741-754. PMID: 22172720, PMCID: PMC3241928, DOI: 10.1016/j.ccr.2011.10.030.
- Yale Dermatology New HavenDoctors Building2 Church Street SouthNew Haven, CT 06519
Biography
William Damsky, MD, PhD, is a dermatologist at Yale Medicine specializing in skin conditions such as psoriasis, eczema, acne, skin cancer, and such rare skin conditions as sarcoidosis, granuloma annulare, necrobiosis lipoidica, and others . He also conducts research on new treatments for these conditions, especially a new class of medications called JAK inhibitors, which inhibit a specific protein responsible for the immune reactions that cause certain rashes.
As a clinician, Dr. Damsky’s goal is to guide patients through the decision-making process to choose an effective therapy that is right for them. While conservative by nature, he also utilizes more aggressive approaches when needed, as long as the patient is comfortable with the decision and is a candidate for the treatment.
Dr. Damsky first became interested in skin conditions when he conducted research on skin cancer and learned about rare skin diseases. “I really like trying to understand rashes and skin conditions that most people haven’t even heard of. Finding treatments for patients who have been told that nothing can be done is really gratifying,” he says.
Titles
- Assistant Professor in Dermatology and Dermatopathology
Education & Training
- FellowYale School of Medicine (2020)
- ResidentYale New Haven Hospital / Yale School of Medicine (2017)
- InternshipYale New Haven Hospital (2014)
- MDUniversity of Vermont, College of Medicine (2013)
- PhDUniversity of Vermont College of Medicine (2011)
- BSUniversity of Vermont (2005)
Additional Information
- Young Investigator Award: American Society for Clinical Investigation (2022)
- 2022 Young Physician-Scientist Award: American Society for Clinical Investigation (2022)
- Young Investigator Award: American Academy of Dermatology (2020)
- Todd Nagel Memorial Award: Skin Cancer Foundation (2018)
- Career Development Award: Dermatology Foundation (2017)
- Physician Scientist Career Development Award: Dermatology Foundation (2017)
- Dermatologist Investigator Research Fellowship: Dermatology Foundation (2016)
- Joseph B Warshaw Award: University of Vermont College of Medicine (2012)
- Research Scholar Award: Joanna Nicolay Melanoma Research Foundation (2010)
- Lyman S Rowell Award: University of Vermont, Department of Biology (2004)
- AB of Dermatology, Dermatopathology (2020)
- AB of Dermatology, Dermatology (2017)
- Spaulding S, Wride A, Slade M, Damsky W, Cohen J. Cutaneous fungal infections in the United States: A cross-sectional analysis of the National Ambulatory Medical Care Survey (NAMCS) and National Hospital Ambulatory Medical Care Survey (NHAMCS), 2005–2016. Journal Of The American Academy Of Dermatology 2024 PMID: 39486764, DOI: 10.1016/j.jaad.2024.10.035.
- Lin Y, Xie M, Lau H, Zeng R, Zhang R, Wang L, Li Q, Wang Y, Chen D, Jiang L, Damsky W, Yu J. Effects of gut microbiota on immune checkpoint inhibitors in multi-cancer and as microbial biomarkers for predicting therapeutic response. Med 2024 PMID: 39515321, DOI: 10.1016/j.medj.2024.10.007.
- Wride A, Chen G, Fan R, Leasure A, Jones S, Levey D, Damsky W, Cohen J. Bipolar disorder among individuals with atopic dermatitis: A case-control study in the All of Us Research Program. Clinical And Experimental Dermatology 2024, llae451. PMID: 39425681, DOI: 10.1093/ced/llae451.
- Bassir F, Valido K, Maciejewski K, Damsky W, Nelson C. Validation of the Delphi Consensus Diagnostic Criteria for Necrobiotic Xanthogranuloma. JAMA Dermatology 2024, 160 PMID: 39356540, PMCID: PMC11447626, DOI: 10.1001/jamadermatol.2024.3198.
- Wride M, Chen G, Fan R, Leasure A, Levey D, Damsky W, Cohen J. 54712 Bipolar disorder among patients with atopic dermatitis: A case-control study in the All of Us research program. Journal Of The American Academy Of Dermatology 2024, 91: ab147. DOI: 10.1016/j.jaad.2024.07.584.
- Chang J, Shin K, Lewis J, Suh H, Lee J, Damsky W, Xu S, Bosenberg M, Saltzman W, Girardi M. Enhanced intratumoral delivery of immunomodulator MPLA via hyperbranched polyglycerol-coated biodegradable nanoparticles. Journal Of Investigative Dermatology 2024 PMID: 39122142, DOI: 10.1016/j.jid.2024.07.019.
- Sand J, Jessen H, Leeming D, Yu S, Lee C, Hu B, Sun Y, Adams T, Pivarnik T, Liu A, Woo S, McGovern J, Fiorini V, Saber T, Higuero-Sevilla J, Gulati M, Kaminski N, Damsky W, Shaw A, Mohanty S, Goobie G, Zhang Y, Herzog E, Ryu C. Plasma collagen neoepitopes are associated with multiorgan disease in the ACCESS and GRADS sarcoidosis cohorts. Thorax 2024, 79: thorax-2023-221095. PMID: 39117421, DOI: 10.1136/thorax-2023-221095.
- Daccache J, Park E, Junejo M, Abdelghaffar M, Hwang E, Mohanty C, Singh C, Wang G, Wheeler J, Shields B, Nelson C, Wang Y, Damsky W. Spatial transcriptomics reveals organized and distinct immune activation in cutaneous granulomatous disorders. Journal Of Allergy And Clinical Immunology 2024, 154: 1216-1231. PMID: 39098508, PMCID: PMC11560686, DOI: 10.1016/j.jaci.2024.07.021.
- Daccache J, Park E, Junejo M, Abdelghaffar M, Hwang E, Mohanty C, Singh C, Wang G, Wheeler J, Shields B, Nelson C, Wang Y, Damsky W. LB863 Spatial transcriptomics reveals structurally organized and distinct immune polarization in inflammatory cutaneous granulomatous disorders. Journal Of Investigative Dermatology 2024, 144: s150. DOI: 10.1016/j.jid.2024.06.1243.
- Bangert C, Alkon N, Chennareddy S, Arnoldner T, Levine J, Pilz M, Ruggiero J, Cohenour E, Jonak C, Damsky W, Griss J, Brunner P. 795 Dupilumab-associated head and neck dermatitis shows a pronounced type 22 immune signature mediated by oligoclonally expanded T cells. Journal Of Investigative Dermatology 2024, 144: s139. DOI: 10.1016/j.jid.2024.06.811.
- Wang Y, Yu W, Micevic G, Daccache J, Wang A, Park K, Wang G, Palmatier M, Wheeler J, King B, Damsky W. 057 Single cell RNA and TCR sequencing reveals hyperexpansion of T cell clones and novel regulatory mechanisms of CD8+ T cells in murine alopcecia areata skin and draining lymph nodes. Journal Of Investigative Dermatology 2024, 144: s10. DOI: 10.1016/j.jid.2024.06.073.
- McKay G, Liu L, Shaw K, Shakshouk H, Murphy M, Damsky W, Ortega‐Loayza A, Caplan A, Arkin L, Shields B. Pediatric cutaneous Crohn disease: A case series of 89 patients and review. Pediatric Dermatology 2024, 41: 807-813. PMID: 39011834, DOI: 10.1111/pde.15689.
- Cohen J, Damsky W. Anti-Interleukin-23 Autoantibodies in Adult-Onset Immunodeficiency. New England Journal Of Medicine 2024, 391: 188-189. PMID: 38986070, DOI: 10.1056/nejmc2404977.
- Mohanty C, Singh C, Daccache J, Damsky W, Kendziorski C, Yan D, Prasad A, Zhang D, Keenan T, Drolet B, Ahmad N, Shields B. Granuloma Annulare Exhibits Mixed Immune and Macrophage Polarization Profiles with Spatial Transcriptomics. Journal Of Investigative Dermatology 2024 PMID: 38844128, DOI: 10.1016/j.jid.2024.04.024.
- Valido K, Murphy M, Leventhal J, Damsky W. Successful treatment of pityriasis rubra pilaris with brodalumab after nonresponse to IL-17A inhibition: A role for the innate cytokine IL-17C. JAAD Case Reports 2024, 48: 85-87. PMID: 38783931, PMCID: PMC11111584, DOI: 10.1016/j.jdcr.2024.04.010.
- Shaw V, Damsky W, Homer R, Cohen J. Characterizing interstitial lung disease in patients with psoriasis: a cross-sectional analysis in the National Institutes of Health’s All of Us Research Program. Clinical And Experimental Dermatology 2024, 49: 1083-1084. PMID: 38618708, DOI: 10.1093/ced/llae132.
- Abdelghaffar M, Kottilil S, Murphy M, Cohen J, Damsky W. Paradoxical Psoriasis. Dermatologic Clinics 2024, 42: 471-480. PMID: 38796276, DOI: 10.1016/j.det.2024.02.011.
- Valido K, Patel V, Murphy M, Junejo M, Patel D, Deutsch A, Turner N, Zaki T, King B, Damsky W, Nelson C. Treatment of prolonged drug reaction with eosinophilia and systemic symptoms syndrome with dupilumab using a molecularly-guided approach. JAAD Case Reports 2024, 48: 49-53. PMID: 38774671, PMCID: PMC11107093, DOI: 10.1016/j.jdcr.2024.03.020.
- Bangert C, Alkon N, Chennareddy S, Arnoldner T, Levine J, Pilz M, Medjimorec M, Ruggiero J, Cohenour E, Jonak C, Damsky W, Griss J, Brunner P. Dupilumab-associated head and neck dermatitis shows a pronounced type 22 immune signature mediated by oligoclonally expanded T cells. Nature Communications 2024, 15: 2839. PMID: 38565563, PMCID: PMC10987549, DOI: 10.1038/s41467-024-46540-0.
- Garate D, Thang C, Damsky W, Rosenbach M, Golovko G, Wilkerson M, Barbieri J. Granuloma annulare is associated with an increased risk of hematologic malignancies: A multicenter cohort study using TriNetX. Journal Of The American Academy Of Dermatology 2023, 90: 862-864. PMID: 38147901, DOI: 10.1016/j.jaad.2023.12.028.
- Hwang E, Lee T, Okifo K, Murphy M, Damsky W. Retrospective assessment of immunologic and histologic heterogeneity in granuloma annulare by cytokine staining. International Journal Of Dermatology 2023, 63: 655-659. PMID: 38135676, PMCID: PMC11055676, DOI: 10.1111/ijd.16998.
- Chen G, Fan R, Leasure A, Levey D, Damsky W, Cohen J. Obsessive–compulsive disorder among patients with atopic dermatitis: a case–control study in the All of Us research program. Archives Of Dermatological Research 2023, 316: 11. PMID: 38038754, DOI: 10.1007/s00403-023-02767-3.
- Joel M, Damsky W, Cohen J, Wride M. Association between atopic dermatitis and inflammatory bowel disease among US adults in the All of Us Research Program. Clinical And Experimental Dermatology 2023, 49: 390-392. PMID: 37967342, PMCID: PMC10957220, DOI: 10.1093/ced/llad397.
- Djureinovic D, Weiss S, Krykbaeva I, Qu R, Vathiotis I, Moutafi M, Zhang L, Perdigoto A, Wei W, Anderson G, Damsky W, Hurwitz M, Johnson B, Schoenfeld D, Mahajan A, Hsu F, Miller-Jensen K, Kluger Y, Sznol M, Kaech S, Bosenberg M, Jilaveanu L, Kluger H. A bedside to bench study of anti-PD-1, anti-CD40, and anti-CSF1R indicates that more is not necessarily better. Molecular Cancer 2023, 22: 182. PMID: 37964379, PMCID: PMC10644655, DOI: 10.1186/s12943-023-01884-x.
- Shipman W, Singh K, Cohen J, Leventhal J, Damsky W, Tomayko M. Targeting interleukin (IL)-4/IL-13 in immune checkpoint inhibitor-induced bullous pemphigoid: a cautionary note on the beneficial effect of T helper 2 immunity in melanoma and immunotherapy: reply from the authors. British Journal Of Dermatology 2023, 190: 138-138. PMID: 37947404, DOI: 10.1093/bjd/ljad342.
- Abdelghaffar M, Hwang E, Damsky W. Cutaneous Sarcoidosis. Clinics In Chest Medicine 2023, 45: 71-89. PMID: 38245372, DOI: 10.1016/j.ccm.2023.08.004.
- Murphy M, Hwang E, Singh K, Lee T, Cohen J, Damsky W. Machine learning analysis of pretreatment skin biopsies predicts nonresponse to dupilumab in patients with eczematous dermatitis. British Journal Of Dermatology 2023, 190: 132-134. PMID: 37818837, DOI: 10.1093/bjd/ljad389.
- Nihal A, Caplan A, Rosenbach M, Damsky W, Mangold A, Shields B. Treatment options for necrobiosis lipoidica: a systematic review. International Journal Of Dermatology 2023, 62: 1529-1537. PMID: 37772666, DOI: 10.1111/ijd.16856.
- Chen G, Fan R, Leasure A, Damsky W, Cohen J. 44140 Obsessive-Compulsive Disorder Among Patients with Atopic Dermatitis: A Case-Control Study in the All of Us Research Program. Journal Of The American Academy Of Dermatology 2023, 89: ab69. DOI: 10.1016/j.jaad.2023.07.279.
- McKay G, Coromilas A, Liu L, Murphy M, Punyamurthy N, Damsky W, Wanat K, Rosenbach M, Caplan A, LaSenna C, Shields B. 43437 Ustekinumab for the Treatment of Metastatic Crohn Disease. Journal Of The American Academy Of Dermatology 2023, 89: ab103. DOI: 10.1016/j.jaad.2023.07.414.
- Kimball K, Damsky W, Richmond J. Lichen Nitidus: A Case of Tiny, Shiny, Skin Bumps. Frontiers For Young Minds 2023, 11: 1033760. DOI: 10.3389/frym.2023.1033760.
- Hwang E, Abdelghaffar M, Shields B, Damsky W. Molecularly Targeted Therapies for Inflammatory Cutaneous Granulomatous Disorders: A Review of the Evidence and Implications for Understanding Disease Pathogenesis. JID Innovations 2023, 3: 100220. PMID: 37719661, PMCID: PMC10500476, DOI: 10.1016/j.xjidi.2023.100220.
- Wei B, Fox L, Kaffenberger B, Korman A, Micheletti R, Mostaghimi A, Noe M, Rosenbach M, Shinkai K, Kwah J, Phillips E, Bolognia J, Damsky W, Nelson C. Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms. Part II diagnosis and management. Journal Of The American Academy Of Dermatology 2023, 90: 911-926. PMID: 37516356, DOI: 10.1016/j.jaad.2023.02.073.
- Wei B, Fox L, Kaffenberger B, Korman A, Micheletti R, Mostaghimi A, Noe M, Rosenbach M, Shinkai K, Kwah J, Phillips E, Bolognia J, Damsky W, Nelson C. Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms. Part I. Epidemiology, pathogenesis, clinicopathological features, and prognosis. Journal Of The American Academy Of Dermatology 2023, 90: 885-908. PMID: 37516359, DOI: 10.1016/j.jaad.2023.02.072.
- Fan R, Chen G, Leasure A, Johnson M, Damsky W, Cohen J. Association of atopic dermatitis with schizophrenia and schizoaffective disorder. Archives Of Dermatological Research 2023, 315: 2731-2733. PMID: 37495709, DOI: 10.1007/s00403-023-02674-7.
- Murphy M, Heyang M, Fan R, Leasure A, Damsky W, Cohen J. Association between uveitis and Lichen planus in the all of us research program. Archives Of Dermatological Research 2023, 315: 2729-2730. PMID: 37488318, DOI: 10.1007/s00403-023-02675-6.
- Krykbaeva I, Bridges K, Damsky W, Pizzurro G, Alexander A, McGeary M, Park K, Muthusamy V, Eyles J, Luheshi N, Turner N, Weiss S, Olino K, Kaech S, Kluger H, Miller-Jensen K, Bosenberg M. Combinatorial Immunotherapy with Agonistic CD40 Activates Dendritic Cells to Express IL12 and Overcomes PD-1 Resistance. Cancer Immunology Research 2023, 11: 1332-1350. PMID: 37478171, DOI: 10.1158/2326-6066.cir-22-0699.
- Damo M, Hornick N, Venkat A, William I, Clulo K, Venkatesan S, He J, Fagerberg E, Loza J, Kwok D, Tal A, Buck J, Cui C, Singh J, Damsky W, Leventhal J, Krishnaswamy S, Joshi N. PD-1 maintains CD8 T cell tolerance towards cutaneous neoantigens. Nature 2023, 619: 151-159. PMID: 37344588, PMCID: PMC10989189, DOI: 10.1038/s41586-023-06217-y.
- Mortlock R, Ma E, Cohen J, Damsky W. Assessment of Treatment-Relevant Immune Biomarkers in Psoriasis and Atopic Dermatitis: Toward Personalized Medicine in Dermatology. Journal Of Investigative Dermatology 2023, 143: 1412-1422. PMID: 37341663, PMCID: PMC10830170, DOI: 10.1016/j.jid.2023.04.005.
- Horowitch B, Lee D, Ding M, Martinez-Morilla S, Aung T, Ouerghi F, Wang X, Wei W, Damsky W, Sznol M, Kluger H, Rimm D, Ishizuka J. Subsets of IFN Signaling Predict Response to Immune Checkpoint Blockade in Patients with Melanoma. Clinical Cancer Research 2023, 29: 2908-2918. PMID: 37233452, PMCID: PMC10524955, DOI: 10.1158/1078-0432.ccr-23-0215.
- Park J, Park E, Damsky W, Vesely M. Pembrolizumab-induced lichenoid dermatitis treated with dupilumab. JAAD Case Reports 2023, 37: 13-15. PMID: 37332364, PMCID: PMC10275729, DOI: 10.1016/j.jdcr.2023.05.004.
- Shipman W, Singh K, Cohen J, Leventhal J, Damsky W, Tomayko M. Immune checkpoint inhibitor-induced bullous pemphigoid is characterized by interleukin (IL)-4 and IL-13 expression and responds to dupilumab treatment. British Journal Of Dermatology 2023, 189: 339-341. PMID: 37140007, PMCID: PMC10947518, DOI: 10.1093/bjd/ljad149.
- Singh I, Leitner B, Wang Y, Zhang H, Joseph P, Lutchmansingh D, Gulati M, Possick J, Damsky W, Hwa J, Heerdt P, Chun H. Proteomic profiling demonstrates inflammatory and endotheliopathy signatures associated with impaired cardiopulmonary exercise hemodynamic profile in Post Acute Sequelae of SARS‐CoV‐2 infection (PASC) syndrome. Pulmonary Circulation 2023, 13: e12220. PMID: 37091121, PMCID: PMC10113513, DOI: 10.1002/pul2.12220.
- Murphy M, Edemobi P, Leasure A, Gulati M, Miller E, Damsky W, Cohen J. Autoimmune comorbidities associated with sarcoidosis: a case-control study in the All of Us research program. Rheumatology Advances In Practice 2023, 7: rkad030. PMID: 38606002, PMCID: PMC11007907, DOI: 10.1093/rap/rkad030.
- Fan R, Chen G, Leasure A, Johnson M, Damsky W, Cohen J. Association of atopic dermatitis with schizophrenia and schizoaffective disorder: A case-control study in the All of Us Research Program. 2023 DOI: 10.21203/rs.3.rs-2782847/v1.
- Xu S, Weiss E, Singh K, Damsky W, Girardi M. A case of bullous lesions in cutaneous T-cell lymphoma. JAAD Case Reports 2023, 35: 90-93. PMID: 37223111, PMCID: PMC10201206, DOI: 10.1016/j.jdcr.2023.02.026.
- Singh K, Valido K, Swallow M, Okifo K, Wang A, Cohen J, Damsky W. Baseline skin cytokine profiles determined by RNA in situ hybridization correlate with response to dupilumab in patients with eczematous dermatitis. Journal Of The American Academy Of Dermatology 2023, 88: 1094-1100. PMID: 36780951, DOI: 10.1016/j.jaad.2022.12.052.
- Chen J, Murphy M, Singh K, Wang A, Chow R, Kim R, Cohen J, Ko C, Damsky W. IL17A mRNA Staining Distinguishes Palmoplantar Psoriasis from Hyperkeratotic Palmoplantar Eczema in Diagnostic Skin Biopsies. JID Innovations 2023, 3: 100189. PMID: 37205304, PMCID: PMC10186614, DOI: 10.1016/j.xjidi.2023.100189.
- Ren J, Qu R, Rahman N, Lewis J, King A, Liao X, Mirza F, Carlson K, Huang Y, Gigante S, Evans B, Rajendran B, Xu S, Wang G, Foss F, Damsky W, Kluger Y, Krishnaswamy S, Girardi M. Integrated transcriptome and trajectory analysis of cutaneous T-cell lymphoma identifies putative precancer populations. Blood Advances 2023, 7: 445-457. PMID: 35947128, PMCID: PMC9979716, DOI: 10.1182/bloodadvances.2022008168.
- Joel M, Fan R, Damsky W, Cohen J. Psoriasis associated with asthma and allergic rhinitis: a US-based cross-sectional study using the All of US Research Program. Archives Of Dermatological Research 2023, 315: 1823-1826. PMID: 36707438, DOI: 10.1007/s00403-023-02539-z.
- Hodelin C, Fan R, Damsky W, Cohen J. The association of atopic dermatitis and chronic rhinosinusitis in adults: a cross‐sectional study using the All of Us research program. International Journal Of Dermatology 2022, 62: e430-e431. PMID: 36468789, DOI: 10.1111/ijd.16544.
- Ahmad M, Murphy M, Damsky W, Leventhal J. Dupilumab‐induced psoriasis in the setting of pembrolizumab therapy: an analysis of cytokine expression. International Journal Of Dermatology 2022, 62: e424-e426. PMID: 36468831, DOI: 10.1111/ijd.16538.
- Belzer A, Leasure A, Damsky W, Cohen J. The association of anxiety with granuloma annulare: a case–control study of the National Institutes of Health ‘All of Us’ research programme. British Journal Of Dermatology 2022, 188: 558-560. PMID: 36715356, DOI: 10.1093/bjd/ljac114.
- Association of sarcoidosis with psoriasis: a cross-sectional study in the All of Us research programMurphy M, Leasure A, Damsky W, Cohen J. Association of sarcoidosis with psoriasis: a cross-sectional study in the All of Us research program. Archives Of Dermatological Research 2022, 315: 1439-1441. PMID: 36436011, DOI: 10.1007/s00403-022-02488-z.
- Fan R, Leasure A, Damsky W, Cohen J. Migraine among adults with atopic dermatitis: a cross-sectional study in the All of Us research programme. Clinical And Experimental Dermatology 2022, 48: 24-26. PMID: 36669173, DOI: 10.1093/ced/llac004.
- Clark A, Murphy M, King B, Cohen J, Rosenbach M, Barbieri J, Damsky W. Patient perspectives on the lived experience of granuloma annulare. British Journal Of Dermatology 2022, 188: 134-136. PMID: 36689498, DOI: 10.1093/bjd/ljac004.
- A case of eosinophilic dermatosis of hematologic malignancy with tissue-based Th2 cytokine profilingXu S, Singh K, McNiff J, Damsky W, Gehlhausen J. A case of eosinophilic dermatosis of hematologic malignancy with tissue-based Th2 cytokine profiling. JAAD Case Reports 2022, 30: 5-7. PMID: 36345409, PMCID: PMC9636011, DOI: 10.1016/j.jdcr.2022.09.020.
- Belzer A, Leasure A, Damsky W. 35151 The association of major depressive disorder and anxiety with granuloma annulare: A case-control study of the NIH All of Us database. Journal Of The American Academy Of Dermatology 2022, 87: ab116. DOI: 10.1016/j.jaad.2022.06.498.
- Fan R, Leasure A, Damsky W, Cohen J. 187 Mental health comorbidities and alcohol use disorder in atopic dermatitis: A case-control study in the All of Us research program. Journal Of Investigative Dermatology 2022, 142: s32. DOI: 10.1016/j.jid.2022.05.194.
- Choi R, Wang J, Damsky W, Wang A, Galan A, Leventhal J. 103 JAK-STAT activation in anti-PD-1 therapy-associated granuloma annulare. Journal Of Investigative Dermatology 2022, 142: s18. DOI: 10.1016/j.jid.2022.05.038.
- Singh K, Valido K, Swallow M, Cohen J, Damsky W. 814 Correlation between skin cytokine profile and response to dupilumab in atopic dermatitis. Journal Of Investigative Dermatology 2022, 142: s141. DOI: 10.1016/j.jid.2022.05.828.
- Ricardo-Gonzalez R, Kotas M, O’Leary C, Tenvooren I, Marquez D, Singh K, Damsky W, Liao C, Schroeder A, Cohen J, Fassett M, Lee J, Daniel S, Bittinger K, Diaz R, Fraser J, Ansel K, Spitzer M, Liang H, Locksley R. Innate type 2 immunity controls hair follicle commensalism by Demodex mites. The Journal Of Immunology 2022, 208: 50.39-50.39. DOI: 10.4049/jimmunol.208.supp.50.39.
- Gehlhausen JR, Little AJ, Ko CJ, Emmenegger M, Lucas C, Wong P, Klein J, Lu P, Mao T, Jaycox J, Wang E, Ugwu N, Muenker C, Mekael D, Klein R, Patrignelli R, Antaya R, McNiff J, Damsky W, Kamath K, Shon J, Ring A, Yildirim I, Omer S, Ko A, Aguzzi A, Iwasaki A, Obaid A, Lu-Culligan A, Nelson A, Brito A, Nunez A, Martin A, Watkins A, Geng B, Kalinich C, Harden C, Todeasa C, Jensen C, Kim D, McDonald D, Shepard D, Courchaine E, White E, Song E, Silva E, Kudo E, DeIuliis G, Rahming H, Park H, Matos I, Nouws J, Valdez J, Fauver J, Lim J, Rose K, Anastasio K, Brower K, Glick L, Sharma L, Sewanan L, Knaggs L, Minasyan M, Batsu M, Petrone M, Kuang M, Nakahata M, Campbell M, Linehan M, Askenase M, Simonov M, Smolgovsky M, Sonnert N, Naushad N, Vijayakumar P, Martinello R, Datta R, Handoko R, Bermejo S, Prophet S, Bickerton S, Velazquez S, Alpert T, Rice T, Khoury-Hanold W, Peng X, Yang Y, Cao Y, Strong Y. Lack of association between pandemic chilblains and SARS-CoV-2 infection. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2122090119. PMID: 35217624, PMCID: PMC8892496, DOI: 10.1073/pnas.2122090119.
- Zhang SM, Cai WL, Liu X, Thakral D, Luo J, Chan LH, McGeary MK, Song E, Blenman KRM, Micevic G, Jessel S, Zhang Y, Yin M, Booth CJ, Jilaveanu LB, Damsky W, Sznol M, Kluger HM, Iwasaki A, Bosenberg MW, Yan Q. KDM5B promotes immune evasion by recruiting SETDB1 to silence retroelements. Nature 2021, 598: 682-687. PMID: 34671158, PMCID: PMC8555464, DOI: 10.1038/s41586-021-03994-2.
- Mirza F, Wang A, Ramachandran S, Damsky W, Cohen J. Dupilumab‐induced phenotype switch from atopic dermatitis to psoriasis is characterized by de novo interleukin‐17A expression: a case report. British Journal Of Dermatology 2021, 185: 432-434. PMID: 33730377, DOI: 10.1111/bjd.20064.
- Wang A, King B, Damsky W. 674 Single-cell RNA sequencing (scRNA-seq) of sarcoidosis skin biopsies reveals key pathogenic cytokines and potential treatment targets. Journal Of Investigative Dermatology 2021, 141: s117. DOI: 10.1016/j.jid.2021.02.704.
- Zhou T, Damsky W, Weizman OE, McGeary MK, Hartmann KP, Rosen CE, Fischer S, Jackson R, Flavell RA, Wang J, Sanmamed MF, Bosenberg MW, Ring AM. IL-18BP is a secreted immune checkpoint and barrier to IL-18 immunotherapy. Nature 2020, 583: 609-614. PMID: 32581358, PMCID: PMC7381364, DOI: 10.1038/s41586-020-2422-6.
- Damsky W, Wang A, Olamiju B, Peterson D, Galan A, King B. Treatment of severe lichen planus with the JAK inhibitor tofacitinib. Journal Of Allergy And Clinical Immunology 2020, 145: 1708-1710.e2. PMID: 32018031, DOI: 10.1016/j.jaci.2020.01.031.
- Damsky W, Patel D, Garelli CJ, Garg M, Wang A, Dresser K, Deng A, Harris JE, Richmond J, King B. JAK inhibition prevents bleomycin-induced fibrosis in mice and is effective in morphea patients. Journal Of Investigative Dermatology 2020, 140: 1446-1449.e4. PMID: 31954727, DOI: 10.1016/j.jid.2019.12.019.
- Krykbaeva I, Damsky W, Turner N, Perry C, Kluger H, Bosenberg M. LB1122 Myeloid targeting in combination with PD1 inhibition boosts anti-tumor immunity in melanoma. Journal Of Investigative Dermatology 2019, 139: b19. DOI: 10.1016/j.jid.2019.06.089.
- Damsky W, Thakral D, McGeary MK, Leventhal J, Galan A, King B. Janus kinase inhibition induces disease remission in cutaneous sarcoidosis and granuloma annulare. Journal Of The American Academy Of Dermatology 2019, 82: 612-621. PMID: 31185230, PMCID: PMC7590533, DOI: 10.1016/j.jaad.2019.05.098.
- Ferreira M, Krykbaeva I, Damsky W, Kluger H, Bosenberg M. Evaluating the role of the COX2/PGE2 pathway in anti-melanoma immunity. Journal Of Clinical Oncology 2019, 37: e14114-e14114. DOI: 10.1200/jco.2019.37.15_suppl.e14114.
- Ferreira M, Damsky W, Bosenberg M. 783 Evaluating the impact of high-dose steroids on checkpoint inhibitor efficacy in a murine model of melanoma. Journal Of Investigative Dermatology 2019, 139: s135. DOI: 10.1016/j.jid.2019.03.859.
- Ramseier J, Thakral D, Damsky W, Bosenberg M. 789 Immune checkpoint therapy polarizes fibroblasts into a proinflammatory state. Journal Of Investigative Dermatology 2019, 139: s136. DOI: 10.1016/j.jid.2019.03.865.
- Damsky W, Thakral D, Emeagwali N, Galan A, King B. Tofacitinib Treatment and Molecular Analysis of Cutaneous Sarcoidosis. New England Journal Of Medicine 2018, 379: 2540-2546. PMID: 30586518, PMCID: PMC6351852, DOI: 10.1056/nejmoa1805958.
- Turner N, Damsky W, Wang J, Meeth K, Blenman K, Bosenberg M. 1245 PD-1 blockade impedes tumor growth in the immunogenic YUMMER1.7 mouse melanoma model. Journal Of Investigative Dermatology 2018, 138: s211. DOI: 10.1016/j.jid.2018.03.1260.
- Wang J, Perry CJ, Meeth K, Thakral D, Damsky W, Micevic G, Kaech S, Blenman K, Bosenberg M. UV‐induced somatic mutations elicit a functional T cell response in the YUMMER1.7 mouse melanoma model. Pigment Cell & Melanoma Research 2017, 30: 428-435. PMID: 28379630, PMCID: PMC5820096, DOI: 10.1111/pcmr.12591.
- Damsky W, Wang J, Perry C, Meeth K, Kaech S, Bosenberg M. 766 Exposure to ultraviolet light enhances anti-tumor immunity and response to immunotherapy in a mouse model of melanoma. Journal Of Investigative Dermatology 2017, 137: s132. DOI: 10.1016/j.jid.2017.02.791.
- Damsky W, King BA. JAK inhibitors in dermatology: The promise of a new drug class. Journal Of The American Academy Of Dermatology 2017, 76: 736-744. PMID: 28139263, PMCID: PMC6035868, DOI: 10.1016/j.jaad.2016.12.005.
- Meeth K, Wang JX, Micevic G, Damsky W, Bosenberg MW. The YUMM lines: a series of congenic mouse melanoma cell lines with defined genetic alterations. Pigment Cell & Melanoma Research 2016, 29: 590-597. PMID: 27287723, PMCID: PMC5331933, DOI: 10.1111/pcmr.12498.
- Bosenberg M, Meeth K, Damsky W. A comprehensive system of congenic mouse melanoma models for evaluation of immune therapies. The Journal Of Immunology 2016, 196: 144.19-144.19. DOI: 10.4049/jimmunol.196.supp.144.19.
- Damsky W, Micevic G, Meeth K, Muthusamy V, Curley DP, Santhanakrishnan M, Erdelyi I, Platt JT, Huang L, Theodosakis N, Zaidi MR, Tighe S, Davies MA, Dankort D, McMahon M, Merlino G, Bardeesy N, Bosenberg M. mTORC1 Activation Blocks Braf V600E -Induced Growth Arrest but Is Insufficient for Melanoma Formation. Cancer Cell 2015, 27: 41-56. PMID: 25584893, PMCID: PMC4295062, DOI: 10.1016/j.ccell.2014.11.014.
- Damsky WE, Curley DP, Santhanakrishnan M, Rosenbaum LE, Platt JT, Rothberg BE, Taketo MM, Dankort D, Rimm DL, McMahon M, Bosenberg M. β-Catenin Signaling Controls Metastasis in Braf-Activated Pten-Deficient Melanomas. Cancer Cell 2011, 20: 741-754. PMID: 22172720, PMCID: PMC3241928, DOI: 10.1016/j.ccr.2011.10.030.
- Yale Dermatology New HavenDoctors Building2 Church Street SouthNew Haven, CT 06519
- Yale Dermatology New HavenDoctors Building2 Church Street SouthNew Haven, CT 06519