- Yale Dermatology New HavenDoctors Building2 Church Street SouthNew Haven, CT 06519
William Damsky, MD, PhD
Biography
William Damsky, MD, PhD, is a dermatologist at Yale Medicine specializing in skin conditions such as psoriasis, eczema, acne, skin cancer, and such rare skin conditions as sarcoidosis, granuloma annulare, necrobiosis lipoidica, and others . He also conducts research on new treatments for these conditions, especially a new class of medications called JAK inhibitors, which inhibit a specific protein responsible for the immune reactions that cause certain rashes.
As a clinician, Dr. Damsky’s goal is to guide patients through the decision-making process to choose an effective therapy that is right for them. While conservative by nature, he also utilizes more aggressive approaches when needed, as long as the patient is comfortable with the decision and is a candidate for the treatment.
Dr. Damsky first became interested in skin conditions when he conducted research on skin cancer and learned about rare skin diseases. “I really like trying to understand rashes and skin conditions that most people haven’t even heard of. Finding treatments for patients who have been told that nothing can be done is really gratifying,” he says.
Titles
- Associate Professor of Dermatology and Dermatopathology
Education & Training
- FellowYale School of Medicine (2020)
- ResidentYale New Haven Hospital / Yale School of Medicine (2017)
- InternshipYale New Haven Hospital (2014)
- MDUniversity of Vermont, College of Medicine (2013)
- PhDUniversity of Vermont College of Medicine (2011)
- BSUniversity of Vermont (2005)
Additional Information
- Young Investigator Award: American Society for Clinical Investigation (2022)
- 2022 Young Physician-Scientist Award: American Society for Clinical Investigation (2022)
- Young Investigator Award: American Academy of Dermatology (2020)
- Todd Nagel Memorial Award: Skin Cancer Foundation (2018)
- Career Development Award: Dermatology Foundation (2017)
- Physician Scientist Career Development Award: Dermatology Foundation (2017)
- Dermatologist Investigator Research Fellowship: Dermatology Foundation (2016)
- Joseph B Warshaw Award: University of Vermont College of Medicine (2012)
- Research Scholar Award: Joanna Nicolay Melanoma Research Foundation (2010)
- Lyman S Rowell Award: University of Vermont, Department of Biology (2004)
- AB of Dermatology, Dermatopathology (2020)
- AB of Dermatology, Dermatology (2017)
- Hong S, Valido K, Antaya R, Choate K, Cohen J, Damsky W, Tomayko M, Bolognia J, Nelson C. Pustular Dermatoses. Part I. Inflammatory and Autoimmune. Journal Of The American Academy Of Dermatology 2026 PMID: 42176709, DOI: 10.1016/j.jaad.2026.05.049.
- Hong S, Valido K, Antaya R, Choate K, Cohen J, Damsky W, Tomayko M, Bolognia J, Nelson C. Pustular Dermatoses. Part II. Infectious, Genetic, and Transient Neonatal. Journal Of The American Academy Of Dermatology 2026 PMID: 42176705, DOI: 10.1016/j.jaad.2026.05.050.
- Gehlhausen J, Cohen J, Baker E, Luyten S, Gipson W, Ko C, McNiff J, Damsky W. RNA in situ hybridization for ISG15 and IFI6 highlights IFN-I activity in discoid lupus erythematosus. JID Innovations 2026, 6: 100472. PMID: 42199555, PMCID: PMC13199983, DOI: 10.1016/j.xjidi.2026.100472.
- Sun Q, Damsky W, Cohen J. Cost Consequences Associated With Biologic Therapy Switching in Publicly Insured Psoriasis Individuals in the United States. International Journal Of Dermatology 2026 PMID: 41649376, DOI: 10.1111/ijd.70325.
- Gehlhausen J, Luyten S, Deng J, Micevic G, Cohen J, Damsky W, Cowper S, McNiff J, Ko C. Leveraging Interpretable AI for Deciphering Signature Histopathologic Patterns. Journal Of Cutaneous Pathology 2026, 53: 370-376. PMID: 41479397, DOI: 10.1111/cup.70048.
- Valido K, Hong S, Damsky W, Nelson C. Dermal Hypersensitivity Reaction Masquerading as Cellulitis: An Underrecognized Diagnostic Pitfall in the Inpatient Setting. International Journal Of Dermatology 2025 PMID: 41266937, DOI: 10.1111/ijd.70169.
- Wang Y, Hernandez E, Junejo M, Damsky W. Patients with granuloma annulare treated with Jak inhibitors show Cutibacterium acnes expansion: A clue to the mechanism underlying acneiform eruptions seen with Jak inhibitors. Journal Of Investigative Dermatology 2025, 146: 1424-1427.e4. PMID: 41203008, DOI: 10.1016/j.jid.2025.10.600.
- Spaulding S, Wride A, Murphy M, Junejo M, Damsky W. Reactive granulomatous dermatitis arising in the setting of interleukin-17 inhibition successfully treated with tofacitinib. JAAD Case Reports 2025, 69: 194-197. PMID: 41782736, PMCID: PMC12955564, DOI: 10.1016/j.jdcr.2025.09.043.
- Sun Q, Damsky W, Cohen J. Dermatologist prescribing patterns for androgenetic alopecia therapies among Medicare beneficiaries. Archives Of Dermatological Research 2025, 317: 872. DOI: 10.1007/s00403-025-04374-w.
- Flem-Karlsen K, Talty R, McGeary M, Park K, Thakral D, Brooks V, Daniels A, Damsky W, Roy S, Micevic G, Bosenberg M. Cytotoxic CD8+ T Cells Downregulate GPX4 to Promote Ferroptosis in Melanoma That Drives Antitumor Immunity. Cancer Research 2025, 85: 4139-4150. PMID: 40828991, DOI: 10.1158/0008-5472.can-24-1952.
- Gehlhausen J, Kong Y, Baker E, Ramachandran S, Koumpouras F, Ko C, Vesely M, Little A, Damsky W, King B, Iwasaki A. Cutaneous Lupus Features Specialized Stromal Niches and Altered Retroelement Expression. Journal Of Investigative Dermatology 2025, 145: 3011-3024.e11. PMID: 40409678, PMCID: PMC12354343, DOI: 10.1016/j.jid.2025.04.033.
- Junejo M, Hwang E, Rufin O, Shields B, Rosenbach M, Wang Y, King B, Damsky W. Jak1 Inhibition Is Sufficient for Treatment of Granuloma Annulare. Journal Of Investigative Dermatology 2025, 145: 3206-3209.e9. PMID: 40383463, PMCID: PMC12641425, DOI: 10.1016/j.jid.2025.04.030.
- Kidacki M, Cho C, Lopez-Giraldez F, Breidbart R, Jaiswal A, Lee M, Chowdhury S, Damsky W, Chen L, Vesely M. Spatial Transcriptomics Reveals Differential Inflammatory Pathways in Discoid Lupus Erythematosus and Lichen Planus. Journal Of Investigative Dermatology 2025, 145: 2344-2348.e7. PMID: 40113031, PMCID: PMC12353771, DOI: 10.1016/j.jid.2025.02.148.
- McKay G, Coromilas A, Liu L, Shaw K, Murphy M, Punyamurthy N, Soltero K, Damsky W, Wanat K, Charrow A, Rosenbach M, Caplan A, LaSenna C, Arkin L, Shields B. Interleukin‐12/23 and Interleukin‐23 Inhibitors for the Treatment of Cutaneous Crohn's Disease: A Case Series From a Multi‐Institutional Registry. JEADV Clinical Practice 2025, 4: 458-462. DOI: 10.1002/jvc2.615.
- Murphy M, Junejo M, Rufin O, Cohen J, Nelson C, Damsky W. Grover disease shows type 2 immune activation and improves with dupilumab. British Journal Of Dermatology 2025, 192: 939-941. PMID: 39775460, DOI: 10.1093/bjd/ljaf005.
- Damsky W, King B. Cutaneous sarcoidosis: clinical and pathologic features, molecular pathogenesis, and treatment. Clinics In Dermatology 2024, 43: 177-190. PMID: 39694198, DOI: 10.1016/j.clindermatol.2024.12.017.
- Bassir F, Valido K, Maciejewski K, Damsky W, Nelson C. Validation of the Delphi Consensus Diagnostic Criteria for Necrobiotic Xanthogranuloma. JAMA Dermatology 2024, 160: 1361-1362. PMID: 39356540, PMCID: PMC11447626, DOI: 10.1001/jamadermatol.2024.3198.
- McGeary M, Damsky W, Daniels A, Lang S, Xu Q, Song E, Huet-Calderwood C, Lou H, Paradkar S, Micevic G, Kaech S, Calderwood D, Turk B, Yan Q, Iwasaki A, Bosenberg M. Setdb1 Loss Induces Type I Interferons and Immune Clearance of Melanoma. Cancer Immunology Research 2024, 13: 245-257. PMID: 39589394, DOI: 10.1158/2326-6066.cir-23-0514.
- Lin Y, Xie M, Lau H, Zeng R, Zhang R, Wang L, Li Q, Wang Y, Chen D, Jiang L, Damsky W, Yu J. Effects of gut microbiota on immune checkpoint inhibitors in multi-cancer and as microbial biomarkers for predicting therapeutic response. Med 2024, 6: 100530. PMID: 39515321, DOI: 10.1016/j.medj.2024.10.007.
- Spaulding S, Wride A, Slade M, Damsky W, Cohen J. Cutaneous fungal infections in the United States: A cross-sectional analysis of the National Ambulatory Medical Care Survey and National Hospital Ambulatory Medical Care Survey, 2005-2016. Journal Of The American Academy Of Dermatology 2024, 92: 572-574. PMID: 39486764, DOI: 10.1016/j.jaad.2024.10.035.
- Wride A, Chen G, Fan R, Leasure A, Jones S, Levey D, Damsky W, Cohen J. Bipolar disorder among individuals with atopic dermatitis: a case–control study in the All of Us Research Program. Clinical And Experimental Dermatology 2024, 50: 760-763. PMID: 39425681, DOI: 10.1093/ced/llae451.
- Peterson D, Damsky W, King B. JAK Inhibitors as Immunomodulators. 2024, 57-71. DOI: 10.1007/978-3-031-66590-5_5.
- Chang J, Shin K, Lewis J, Suh H, Lee J, Damsky W, Xu S, Bosenberg M, Saltzman W, Girardi M. Enhanced Intratumoral Delivery of Immunomodulator Monophosphoryl Lipid A through Hyperbranched Polyglycerol–Coated Biodegradable Nanoparticles. Journal Of Investigative Dermatology 2024, 145: 593-604. PMID: 39122142, DOI: 10.1016/j.jid.2024.07.019.
- Sand J, Jessen H, Leeming D, Yu S, Lee C, Hu B, Sun Y, Adams T, Pivarnik T, Liu A, Woo S, McGovern J, Fiorini V, Saber T, Higuero-Sevilla J, Gulati M, Kaminski N, Damsky W, Shaw A, Mohanty S, Goobie G, Zhang Y, Herzog E, Ryu C. Plasma collagen neoepitopes are associated with multiorgan disease in the ACCESS and GRADS sarcoidosis cohorts. Thorax 2024, 79: 1136-1144. PMID: 39117421, PMCID: PMC12147189, DOI: 10.1136/thorax-2023-221095.
- Daccache J, Park E, Junejo M, Abdelghaffar M, Hwang E, Mohanty C, Singh C, Wang G, Wheeler J, Shields B, Nelson C, Wang Y, Damsky W. Spatial transcriptomics reveals organized and distinct immune activation in cutaneous granulomatous disorders. The Journal Of Allergy And Clinical Immunology 2024, 154: 1216-1231. PMID: 39098508, PMCID: PMC11560686, DOI: 10.1016/j.jaci.2024.07.021.
- McKay G, Liu L, Shaw K, Shakshouk H, Murphy M, Damsky W, Ortega‐Loayza A, Caplan A, Arkin L, Shields B. Pediatric cutaneous Crohn disease: A case series of 89 patients and review. Pediatric Dermatology 2024, 41: 807-813. PMID: 39011834, PMCID: PMC11949095, DOI: 10.1111/pde.15689.
- Cohen J, Damsky W. Anti-Interleukin-23 Autoantibodies in Adult-Onset Immunodeficiency. The New England Journal Of Medicine 2024, 391: 188-189. PMID: 38986070, DOI: 10.1056/nejmc2404977.
- Mohanty C, Singh C, Daccache J, Damsky W, Kendziorski C, Yan D, Prasad A, Zhang D, Keenan T, Drolet B, Ahmad N, Shields B. Granuloma Annulare Exhibits Mixed Immune and Macrophage Polarization Profiles with Spatial Transcriptomics. Journal Of Investigative Dermatology 2024, 145: 109-121. PMID: 38844128, DOI: 10.1016/j.jid.2024.04.024.
- Singh K, Breidbart R, Jaiswal A, Damsky W, Choate K, Vesely M. Intravenous immunoglobulin-induced eczematous dermatitis treated with dupilumab. JAAD Case Reports 2024, 49: 102-105. PMID: 38952857, PMCID: PMC11214983, DOI: 10.1016/j.jdcr.2024.05.002.
- Valido K, Murphy M, Leventhal J, Damsky W. Successful treatment of pityriasis rubra pilaris with brodalumab after nonresponse to IL-17A inhibition: A role for the innate cytokine IL-17C. JAAD Case Reports 2024, 48: 85-87. PMID: 38783931, PMCID: PMC11111584, DOI: 10.1016/j.jdcr.2024.04.010.
- Shaw V, Damsky W, Homer R, Cohen J. Characterizing interstitial lung disease in patients with psoriasis: a cross-sectional analysis in the National Institutes of Health’s All of Us Research Program. Clinical And Experimental Dermatology 2024, 49: 1083-1084. PMID: 38618708, DOI: 10.1093/ced/llae132.
- Abdelghaffar M, Kottilil S, Murphy M, Cohen J, Damsky W. Paradoxical Psoriasis. Dermatologic Clinics 2024, 42: 471-480. PMID: 38796276, DOI: 10.1016/j.det.2024.02.011.
- Valido K, Patel V, Murphy M, Junejo M, Patel D, Deutsch A, Turner N, Zaki T, King B, Damsky W, Nelson C. Treatment of prolonged drug reaction with eosinophilia and systemic symptoms syndrome with dupilumab using a molecularly-guided approach. JAAD Case Reports 2024, 48: 49-53. PMID: 38774671, PMCID: PMC11107093, DOI: 10.1016/j.jdcr.2024.03.020.
- Bangert C, Alkon N, Chennareddy S, Arnoldner T, Levine J, Pilz M, Medjimorec M, Ruggiero J, Cohenour E, Jonak C, Damsky W, Griss J, Brunner P. Dupilumab-associated head and neck dermatitis shows a pronounced type 22 immune signature mediated by oligoclonally expanded T cells. Nature Communications 2024, 15: 2839. PMID: 38565563, PMCID: PMC10987549, DOI: 10.1038/s41467-024-46540-0.
- Pozniak J, Pedri D, Landeloos E, Van Herck Y, Antoranz A, Vanwynsberghe L, Nowosad A, Roda N, Makhzami S, Bervoets G, Maciel L, Pulido-Vicuña C, Pollaris L, Seurinck R, Zhao F, Flem-Karlsen K, Damsky W, Chen L, Karagianni D, Cinque S, Kint S, Vandereyken K, Rombaut B, Voet T, Vernaillen F, Annaert W, Lambrechts D, Boecxstaens V, Saeys Y, van den Oord J, Bosisio F, Karras P, Shain A, Bosenberg M, Leucci E, Paschen A, Rambow F, Bechter O, Marine J. A TCF4-dependent gene regulatory network confers resistance to immunotherapy in melanoma. Cell 2024, 187: 166-183.e25. PMID: 38181739, DOI: 10.1016/j.cell.2023.11.037.
- Garate D, Thang C, Damsky W, Rosenbach M, Golovko G, Wilkerson M, Barbieri J. Granuloma annulare is associated with an increased risk of hematologic malignancies: A multicenter cohort study using TriNetX. Journal Of The American Academy Of Dermatology 2023, 90: 862-864. PMID: 38147901, DOI: 10.1016/j.jaad.2023.12.028.
- Hwang E, Lee T, Okifo K, Murphy M, Damsky W. Retrospective assessment of immunologic and histologic heterogeneity in granuloma annulare by cytokine staining. International Journal Of Dermatology 2023, 63: 655-659. PMID: 38135676, PMCID: PMC11055676, DOI: 10.1111/ijd.16998.
- Chen G, Fan R, Leasure A, Levey D, Damsky W, Cohen J. Obsessive–compulsive disorder among patients with atopic dermatitis: a case–control study in the All of Us research program. Archives Of Dermatological Research 2023, 316: 11. PMID: 38038754, DOI: 10.1007/s00403-023-02767-3.
- Joel M, Damsky W, Cohen J, Wride M. Association between atopic dermatitis and inflammatory bowel disease among US adults in the All of Us Research Program. Clinical And Experimental Dermatology 2023, 49: 390-392. PMID: 37967342, PMCID: PMC10957220, DOI: 10.1093/ced/llad397.
- Djureinovic D, Weiss S, Krykbaeva I, Qu R, Vathiotis I, Moutafi M, Zhang L, Perdigoto A, Wei W, Anderson G, Damsky W, Hurwitz M, Johnson B, Schoenfeld D, Mahajan A, Hsu F, Miller-Jensen K, Kluger Y, Sznol M, Kaech S, Bosenberg M, Jilaveanu L, Kluger H. A bedside to bench study of anti-PD-1, anti-CD40, and anti-CSF1R indicates that more is not necessarily better. Molecular Cancer 2023, 22: 182. PMID: 37964379, PMCID: PMC10644655, DOI: 10.1186/s12943-023-01884-x.
- Shipman W, Singh K, Cohen J, Leventhal J, Damsky W, Tomayko M. Targeting interleukin (IL)-4/IL-13 in immune checkpoint inhibitor-induced bullous pemphigoid: a cautionary note on the beneficial effect of T helper 2 immunity in melanoma and immunotherapy: reply from the authors. British Journal Of Dermatology 2023, 190: 138-138. PMID: 37947404, DOI: 10.1093/bjd/ljad342.
- Abdelghaffar M, Hwang E, Damsky W. Cutaneous Sarcoidosis. Clinics In Chest Medicine 2023, 45: 71-89. PMID: 38245372, DOI: 10.1016/j.ccm.2023.08.004.
- Murphy M, Hwang E, Singh K, Lee T, Cohen J, Damsky W. Machine learning analysis of pretreatment skin biopsies predicts nonresponse to dupilumab in patients with eczematous dermatitis. British Journal Of Dermatology 2023, 190: 132-134. PMID: 37818837, DOI: 10.1093/bjd/ljad389.
- Nihal A, Caplan A, Rosenbach M, Damsky W, Mangold A, Shields B. Treatment options for necrobiosis lipoidica: a systematic review. International Journal Of Dermatology 2023, 62: 1529-1537. PMID: 37772666, DOI: 10.1111/ijd.16856.
- Kimball K, Damsky W, Richmond J. Lichen Nitidus: A Case of Tiny, Shiny, Skin Bumps. Frontiers For Young Minds 2023, 11: 1033760. DOI: 10.3389/frym.2023.1033760.
- Hwang E, Abdelghaffar M, Shields B, Damsky W. Molecularly Targeted Therapies for Inflammatory Cutaneous Granulomatous Disorders: A Review of the Evidence and Implications for Understanding Disease Pathogenesis. JID Innovations 2023, 3: 100220. PMID: 37719661, PMCID: PMC10500476, DOI: 10.1016/j.xjidi.2023.100220.
- Wei B, Fox L, Kaffenberger B, Korman A, Micheletti R, Mostaghimi A, Noe M, Rosenbach M, Shinkai K, Kwah J, Phillips E, Bolognia J, Damsky W, Nelson C. Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms. Part II diagnosis and management. Journal Of The American Academy Of Dermatology 2023, 90: 911-926. PMID: 37516356, DOI: 10.1016/j.jaad.2023.02.073.
- Wei B, Fox L, Kaffenberger B, Korman A, Micheletti R, Mostaghimi A, Noe M, Rosenbach M, Shinkai K, Kwah J, Phillips E, Bolognia J, Damsky W, Nelson C. Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms. Part I. Epidemiology, pathogenesis, clinicopathological features, and prognosis. Journal Of The American Academy Of Dermatology 2023, 90: 885-908. PMID: 37516359, DOI: 10.1016/j.jaad.2023.02.072.
- Fan R, Chen G, Leasure A, Johnson M, Damsky W, Cohen J. Association of atopic dermatitis with schizophrenia and schizoaffective disorder. Archives Of Dermatological Research 2023, 315: 2731-2733. PMID: 37495709, DOI: 10.1007/s00403-023-02674-7.
- Murphy M, Heyang M, Fan R, Leasure A, Damsky W, Cohen J. Association between uveitis and Lichen planus in the all of us research program. Archives Of Dermatological Research 2023, 315: 2729-2730. PMID: 37488318, DOI: 10.1007/s00403-023-02675-6.
- Krykbaeva I, Bridges K, Damsky W, Pizzurro G, Alexander A, McGeary M, Park K, Muthusamy V, Eyles J, Luheshi N, Turner N, Weiss S, Olino K, Kaech S, Kluger H, Miller-Jensen K, Bosenberg M. Combinatorial Immunotherapy with Agonistic CD40 Activates Dendritic Cells to Express IL12 and Overcomes PD-1 Resistance. Cancer Immunology Research 2023, 11: 1332-1350. PMID: 37478171, PMCID: PMC12645833, DOI: 10.1158/2326-6066.cir-22-0699.
- Damo M, Hornick N, Venkat A, William I, Clulo K, Venkatesan S, He J, Fagerberg E, Loza J, Kwok D, Tal A, Buck J, Cui C, Singh J, Damsky W, Leventhal J, Krishnaswamy S, Joshi N. PD-1 maintains CD8 T cell tolerance towards cutaneous neoantigens. Nature 2023, 619: 151-159. PMID: 37344588, PMCID: PMC10989189, DOI: 10.1038/s41586-023-06217-y.
- Mortlock R, Ma E, Cohen J, Damsky W. Assessment of Treatment-Relevant Immune Biomarkers in Psoriasis and Atopic Dermatitis: Toward Personalized Medicine in Dermatology. Journal Of Investigative Dermatology 2023, 143: 1412-1422. PMID: 37341663, PMCID: PMC10830170, DOI: 10.1016/j.jid.2023.04.005.
- Horowitch B, Lee D, Ding M, Martinez-Morilla S, Aung T, Ouerghi F, Wang X, Wei W, Damsky W, Sznol M, Kluger H, Rimm D, Ishizuka J. Subsets of interferon signaling predict response to immune checkpoint blockade in melanoma patients. Clinical Cancer Research 2023, 29: 2908-2918. PMID: 37233452, PMCID: PMC10524955, DOI: 10.1158/1078-0432.ccr-23-0215.
- Park J, Park E, Damsky W, Vesely M. Pembrolizumab-induced lichenoid dermatitis treated with dupilumab. JAAD Case Reports 2023, 37: 13-15. PMID: 37332364, PMCID: PMC10275729, DOI: 10.1016/j.jdcr.2023.05.004.
- Shipman W, Singh K, Cohen J, Leventhal J, Damsky W, Tomayko M. Immune checkpoint inhibitor-induced bullous pemphigoid is characterized by interleukin (IL)-4 and IL-13 expression and responds to dupilumab treatment. British Journal Of Dermatology 2023, 189: 339-341. PMID: 37140007, PMCID: PMC10947518, DOI: 10.1093/bjd/ljad149.
- Singh I, Leitner B, Wang Y, Zhang H, Joseph P, Lutchmansingh D, Gulati M, Possick J, Damsky W, Hwa J, Heerdt P, Chun H. Proteomic profiling demonstrates inflammatory and endotheliopathy signatures associated with impaired cardiopulmonary exercise hemodynamic profile in Post Acute Sequelae of SARS‐CoV‐2 infection (PASC) syndrome. Pulmonary Circulation 2023, 13: e12220. PMID: 37091121, PMCID: PMC10113513, DOI: 10.1002/pul2.12220.
- Murphy M, Edemobi P, Leasure A, Gulati M, Miller E, Damsky W, Cohen J. Autoimmune comorbidities associated with sarcoidosis: a case-control study in the All of Us research program. Rheumatology Advances In Practice 2023, 7: rkad030. PMID: 38606002, PMCID: PMC11007907, DOI: 10.1093/rap/rkad030.
- Fan R, Chen G, Leasure A, Johnson M, Damsky W, Cohen J. Association of atopic dermatitis with schizophrenia and schizoaffective disorder: A case-control study in the All of Us Research Program. 2023 DOI: 10.21203/rs.3.rs-2782847/v1.
- Xu S, Weiss E, Singh K, Damsky W, Girardi M. A case of bullous lesions in cutaneous T-cell lymphoma. JAAD Case Reports 2023, 35: 90-93. PMID: 37223111, PMCID: PMC10201206, DOI: 10.1016/j.jdcr.2023.02.026.
- Singh K, Valido K, Swallow M, Okifo K, Wang A, Cohen J, Damsky W. Baseline skin cytokine profiles determined by RNA in situ hybridization correlate with response to dupilumab in patients with eczematous dermatitis. Journal Of The American Academy Of Dermatology 2023, 88: 1094-1100. PMID: 36780951, DOI: 10.1016/j.jaad.2022.12.052.
- Chen J, Murphy M, Singh K, Wang A, Chow R, Kim R, Cohen J, Ko C, Damsky W. IL17A mRNA Staining Distinguishes Palmoplantar Psoriasis from Hyperkeratotic Palmoplantar Eczema in Diagnostic Skin Biopsies. JID Innovations 2023, 3: 100189. PMID: 37205304, PMCID: PMC10186614, DOI: 10.1016/j.xjidi.2023.100189.
- Girardi M, Ren J, Qu R, Rahman N, Lewis J, King A, Liao X, Mirza F, Carlson K, Huang Y, Gigante S, Evans B, Rajendran B, Xu S, Wang G, Foss F, Damsky W, Kluger Y, Krishnaswamy S. Integrated transcriptome and trajectory analysis of cutaneous T-cell lymphoma identifies putative precancer populations. Blood Advances 2023, 7: 445-457. PMID: 35947128, PMCID: PMC9979716, DOI: 10.1182/bloodadvances.2022008168.
- Joel M, Fan R, Damsky W, Cohen J. Psoriasis associated with asthma and allergic rhinitis: a US-based cross-sectional study using the All of US Research Program. Archives Of Dermatological Research 2023, 315: 1823-1826. PMID: 36707438, DOI: 10.1007/s00403-023-02539-z.
- Hodelin C, Fan R, Damsky W, Cohen J. The association of atopic dermatitis and chronic rhinosinusitis in adults: a cross‐sectional study using the All of Us research program. International Journal Of Dermatology 2022, 62: e430-e431. PMID: 36468789, DOI: 10.1111/ijd.16544.
- Ahmad M, Murphy M, Damsky W, Leventhal J. Dupilumab‐induced psoriasis in the setting of pembrolizumab therapy: an analysis of cytokine expression. International Journal Of Dermatology 2022, 62: e424-e426. PMID: 36468831, DOI: 10.1111/ijd.16538.
- Belzer A, Leasure A, Damsky W, Cohen J. The association of anxiety with granuloma annulare: a case–control study of the National Institutes of Health ‘All of Us’ research programme. British Journal Of Dermatology 2022, 188: 558-560. PMID: 36715356, DOI: 10.1093/bjd/ljac114.
- Association of sarcoidosis with psoriasis: a cross-sectional study in the All of Us research programMurphy M, Leasure A, Damsky W, Cohen J. Association of sarcoidosis with psoriasis: a cross-sectional study in the All of Us research program. Archives Of Dermatological Research 2022, 315: 1439-1441. PMID: 36436011, DOI: 10.1007/s00403-022-02488-z.
- Fan R, Leasure A, Damsky W, Cohen J. Migraine among adults with atopic dermatitis: a cross-sectional study in the All of Us research programme. Clinical And Experimental Dermatology 2022, 48: 24-26. PMID: 36669173, DOI: 10.1093/ced/llac004.
- Clark A, Murphy M, King B, Cohen J, Rosenbach M, Barbieri J, Damsky W. Patient perspectives on the lived experience of granuloma annulare. British Journal Of Dermatology 2022, 188: 134-136. PMID: 36689498, DOI: 10.1093/bjd/ljac004.
- A case of eosinophilic dermatosis of hematologic malignancy with tissue-based Th2 cytokine profilingXu S, Singh K, McNiff J, Damsky W, Gehlhausen J. A case of eosinophilic dermatosis of hematologic malignancy with tissue-based Th2 cytokine profiling. JAAD Case Reports 2022, 30: 5-7. PMID: 36345409, PMCID: PMC9636011, DOI: 10.1016/j.jdcr.2022.09.020.
- Gehlhausen JR, Little AJ, Ko CJ, Emmenegger M, Lucas C, Wong P, Klein J, Lu P, Mao T, Jaycox J, Wang E, Ugwu N, Muenker C, Mekael D, Klein R, Patrignelli R, Antaya R, McNiff J, Damsky W, Kamath K, Shon J, Ring A, Yildirim I, Omer S, Ko A, Aguzzi A, Iwasaki A, Obaid A, Lu-Culligan A, Nelson A, Brito A, Nunez A, Martin A, Watkins A, Geng B, Kalinich C, Harden C, Todeasa C, Jensen C, Kim D, McDonald D, Shepard D, Courchaine E, White E, Song E, Silva E, Kudo E, DeIuliis G, Rahming H, Park H, Matos I, Nouws J, Valdez J, Fauver J, Lim J, Rose K, Anastasio K, Brower K, Glick L, Sharma L, Sewanan L, Knaggs L, Minasyan M, Batsu M, Petrone M, Kuang M, Nakahata M, Campbell M, Linehan M, Askenase M, Simonov M, Smolgovsky M, Sonnert N, Naushad N, Vijayakumar P, Martinello R, Datta R, Handoko R, Bermejo S, Prophet S, Bickerton S, Velazquez S, Alpert T, Rice T, Khoury-Hanold W, Peng X, Yang Y, Cao Y, Strong Y. Lack of association between pandemic chilblains and SARS-CoV-2 infection. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2122090119. PMID: 35217624, PMCID: PMC8892496, DOI: 10.1073/pnas.2122090119.
- Zhang SM, Cai WL, Liu X, Thakral D, Luo J, Chan LH, McGeary MK, Song E, Blenman KRM, Micevic G, Jessel S, Zhang Y, Yin M, Booth CJ, Jilaveanu LB, Damsky W, Sznol M, Kluger HM, Iwasaki A, Bosenberg MW, Yan Q. KDM5B promotes immune evasion by recruiting SETDB1 to silence retroelements. Nature 2021, 598: 682-687. PMID: 34671158, PMCID: PMC8555464, DOI: 10.1038/s41586-021-03994-2.
- Mirza F, Wang A, Ramachandran S, Damsky W, Cohen J. Dupilumab‐induced phenotype switch from atopic dermatitis to psoriasis is characterized by de novo interleukin‐17A expression: a case report. British Journal Of Dermatology 2021, 185: 432-434. PMID: 33730377, DOI: 10.1111/bjd.20064.
- Zhou T, Damsky W, Weizman OE, McGeary MK, Hartmann KP, Rosen CE, Fischer S, Jackson R, Flavell RA, Wang J, Sanmamed MF, Bosenberg MW, Ring AM. IL-18BP is a secreted immune checkpoint and barrier to IL-18 immunotherapy. Nature 2020, 583: 609-614. PMID: 32581358, PMCID: PMC7381364, DOI: 10.1038/s41586-020-2422-6.
- Damsky W, Wang A, Olamiju B, Peterson D, Galan A, King B. Treatment of severe lichen planus with the JAK inhibitor tofacitinib. The Journal Of Allergy And Clinical Immunology 2020, 145: 1708-1710.e2. PMID: 32018031, DOI: 10.1016/j.jaci.2020.01.031.
- Damsky W, Patel D, Garelli CJ, Garg M, Wang A, Dresser K, Deng A, Harris JE, Richmond J, King B. JAK inhibition prevents bleomycin-induced fibrosis in mice and is effective in morphea patients. Journal Of Investigative Dermatology 2020, 140: 1446-1449.e4. PMID: 31954727, DOI: 10.1016/j.jid.2019.12.019.
- Damsky W, Thakral D, McGeary MK, Leventhal J, Galan A, King B. Janus kinase inhibition induces disease remission in cutaneous sarcoidosis and granuloma annulare. Journal Of The American Academy Of Dermatology 2019, 82: 612-621. PMID: 31185230, PMCID: PMC7590533, DOI: 10.1016/j.jaad.2019.05.098.
- Damsky W, Thakral D, Emeagwali N, Galan A, King B. Tofacitinib Treatment and Molecular Analysis of Cutaneous Sarcoidosis. The New England Journal Of Medicine 2018, 379: 2540-2546. PMID: 30586518, PMCID: PMC6351852, DOI: 10.1056/nejmoa1805958.
- Wang J, Perry CJ, Meeth K, Thakral D, Damsky W, Micevic G, Kaech S, Blenman K, Bosenberg M. UV‐induced somatic mutations elicit a functional T cell response in the YUMMER1.7 mouse melanoma model. Pigment Cell & Melanoma Research 2017, 30: 428-435. PMID: 28379630, PMCID: PMC5820096, DOI: 10.1111/pcmr.12591.
- Damsky W, King BA. JAK inhibitors in dermatology: The promise of a new drug class. Journal Of The American Academy Of Dermatology 2017, 76: 736-744. PMID: 28139263, PMCID: PMC6035868, DOI: 10.1016/j.jaad.2016.12.005.
- Meeth K, Wang JX, Micevic G, Damsky W, Bosenberg MW. The YUMM lines: a series of congenic mouse melanoma cell lines with defined genetic alterations. Pigment Cell & Melanoma Research 2016, 29: 590-597. PMID: 27287723, PMCID: PMC5331933, DOI: 10.1111/pcmr.12498.
- Damsky W, Micevic G, Meeth K, Muthusamy V, Curley DP, Santhanakrishnan M, Erdelyi I, Platt JT, Huang L, Theodosakis N, Zaidi MR, Tighe S, Davies MA, Dankort D, McMahon M, Merlino G, Bardeesy N, Bosenberg M. mTORC1 Activation Blocks Braf V600E -Induced Growth Arrest but Is Insufficient for Melanoma Formation. Cancer Cell 2015, 27: 41-56. PMID: 25584893, PMCID: PMC4295062, DOI: 10.1016/j.ccell.2014.11.014.
- Damsky WE, Curley DP, Santhanakrishnan M, Rosenbaum LE, Platt JT, Rothberg BE, Taketo MM, Dankort D, Rimm DL, McMahon M, Bosenberg M. β-Catenin Signaling Controls Metastasis in Braf-Activated Pten-Deficient Melanomas. Cancer Cell 2011, 20: 741-754. PMID: 22172720, PMCID: PMC3241928, DOI: 10.1016/j.ccr.2011.10.030.
- Yale Dermatology New HavenDoctors Building2 Church Street SouthNew Haven, CT 06519
Biography
William Damsky, MD, PhD, is a dermatologist at Yale Medicine specializing in skin conditions such as psoriasis, eczema, acne, skin cancer, and such rare skin conditions as sarcoidosis, granuloma annulare, necrobiosis lipoidica, and others . He also conducts research on new treatments for these conditions, especially a new class of medications called JAK inhibitors, which inhibit a specific protein responsible for the immune reactions that cause certain rashes.
As a clinician, Dr. Damsky’s goal is to guide patients through the decision-making process to choose an effective therapy that is right for them. While conservative by nature, he also utilizes more aggressive approaches when needed, as long as the patient is comfortable with the decision and is a candidate for the treatment.
Dr. Damsky first became interested in skin conditions when he conducted research on skin cancer and learned about rare skin diseases. “I really like trying to understand rashes and skin conditions that most people haven’t even heard of. Finding treatments for patients who have been told that nothing can be done is really gratifying,” he says.
Titles
- Associate Professor of Dermatology and Dermatopathology
Education & Training
- FellowYale School of Medicine (2020)
- ResidentYale New Haven Hospital / Yale School of Medicine (2017)
- InternshipYale New Haven Hospital (2014)
- MDUniversity of Vermont, College of Medicine (2013)
- PhDUniversity of Vermont College of Medicine (2011)
- BSUniversity of Vermont (2005)
Additional Information
- Young Investigator Award: American Society for Clinical Investigation (2022)
- 2022 Young Physician-Scientist Award: American Society for Clinical Investigation (2022)
- Young Investigator Award: American Academy of Dermatology (2020)
- Todd Nagel Memorial Award: Skin Cancer Foundation (2018)
- Career Development Award: Dermatology Foundation (2017)
- Physician Scientist Career Development Award: Dermatology Foundation (2017)
- Dermatologist Investigator Research Fellowship: Dermatology Foundation (2016)
- Joseph B Warshaw Award: University of Vermont College of Medicine (2012)
- Research Scholar Award: Joanna Nicolay Melanoma Research Foundation (2010)
- Lyman S Rowell Award: University of Vermont, Department of Biology (2004)
- AB of Dermatology, Dermatopathology (2020)
- AB of Dermatology, Dermatology (2017)
- Hong S, Valido K, Antaya R, Choate K, Cohen J, Damsky W, Tomayko M, Bolognia J, Nelson C. Pustular Dermatoses. Part I. Inflammatory and Autoimmune. Journal Of The American Academy Of Dermatology 2026 PMID: 42176709, DOI: 10.1016/j.jaad.2026.05.049.
- Hong S, Valido K, Antaya R, Choate K, Cohen J, Damsky W, Tomayko M, Bolognia J, Nelson C. Pustular Dermatoses. Part II. Infectious, Genetic, and Transient Neonatal. Journal Of The American Academy Of Dermatology 2026 PMID: 42176705, DOI: 10.1016/j.jaad.2026.05.050.
- Gehlhausen J, Cohen J, Baker E, Luyten S, Gipson W, Ko C, McNiff J, Damsky W. RNA in situ hybridization for ISG15 and IFI6 highlights IFN-I activity in discoid lupus erythematosus. JID Innovations 2026, 6: 100472. PMID: 42199555, PMCID: PMC13199983, DOI: 10.1016/j.xjidi.2026.100472.
- Sun Q, Damsky W, Cohen J. Cost Consequences Associated With Biologic Therapy Switching in Publicly Insured Psoriasis Individuals in the United States. International Journal Of Dermatology 2026 PMID: 41649376, DOI: 10.1111/ijd.70325.
- Gehlhausen J, Luyten S, Deng J, Micevic G, Cohen J, Damsky W, Cowper S, McNiff J, Ko C. Leveraging Interpretable AI for Deciphering Signature Histopathologic Patterns. Journal Of Cutaneous Pathology 2026, 53: 370-376. PMID: 41479397, DOI: 10.1111/cup.70048.
- Valido K, Hong S, Damsky W, Nelson C. Dermal Hypersensitivity Reaction Masquerading as Cellulitis: An Underrecognized Diagnostic Pitfall in the Inpatient Setting. International Journal Of Dermatology 2025 PMID: 41266937, DOI: 10.1111/ijd.70169.
- Wang Y, Hernandez E, Junejo M, Damsky W. Patients with granuloma annulare treated with Jak inhibitors show Cutibacterium acnes expansion: A clue to the mechanism underlying acneiform eruptions seen with Jak inhibitors. Journal Of Investigative Dermatology 2025, 146: 1424-1427.e4. PMID: 41203008, DOI: 10.1016/j.jid.2025.10.600.
- Spaulding S, Wride A, Murphy M, Junejo M, Damsky W. Reactive granulomatous dermatitis arising in the setting of interleukin-17 inhibition successfully treated with tofacitinib. JAAD Case Reports 2025, 69: 194-197. PMID: 41782736, PMCID: PMC12955564, DOI: 10.1016/j.jdcr.2025.09.043.
- Sun Q, Damsky W, Cohen J. Dermatologist prescribing patterns for androgenetic alopecia therapies among Medicare beneficiaries. Archives Of Dermatological Research 2025, 317: 872. DOI: 10.1007/s00403-025-04374-w.
- Flem-Karlsen K, Talty R, McGeary M, Park K, Thakral D, Brooks V, Daniels A, Damsky W, Roy S, Micevic G, Bosenberg M. Cytotoxic CD8+ T Cells Downregulate GPX4 to Promote Ferroptosis in Melanoma That Drives Antitumor Immunity. Cancer Research 2025, 85: 4139-4150. PMID: 40828991, DOI: 10.1158/0008-5472.can-24-1952.
- Gehlhausen J, Kong Y, Baker E, Ramachandran S, Koumpouras F, Ko C, Vesely M, Little A, Damsky W, King B, Iwasaki A. Cutaneous Lupus Features Specialized Stromal Niches and Altered Retroelement Expression. Journal Of Investigative Dermatology 2025, 145: 3011-3024.e11. PMID: 40409678, PMCID: PMC12354343, DOI: 10.1016/j.jid.2025.04.033.
- Junejo M, Hwang E, Rufin O, Shields B, Rosenbach M, Wang Y, King B, Damsky W. Jak1 Inhibition Is Sufficient for Treatment of Granuloma Annulare. Journal Of Investigative Dermatology 2025, 145: 3206-3209.e9. PMID: 40383463, PMCID: PMC12641425, DOI: 10.1016/j.jid.2025.04.030.
- Kidacki M, Cho C, Lopez-Giraldez F, Breidbart R, Jaiswal A, Lee M, Chowdhury S, Damsky W, Chen L, Vesely M. Spatial Transcriptomics Reveals Differential Inflammatory Pathways in Discoid Lupus Erythematosus and Lichen Planus. Journal Of Investigative Dermatology 2025, 145: 2344-2348.e7. PMID: 40113031, PMCID: PMC12353771, DOI: 10.1016/j.jid.2025.02.148.
- McKay G, Coromilas A, Liu L, Shaw K, Murphy M, Punyamurthy N, Soltero K, Damsky W, Wanat K, Charrow A, Rosenbach M, Caplan A, LaSenna C, Arkin L, Shields B. Interleukin‐12/23 and Interleukin‐23 Inhibitors for the Treatment of Cutaneous Crohn's Disease: A Case Series From a Multi‐Institutional Registry. JEADV Clinical Practice 2025, 4: 458-462. DOI: 10.1002/jvc2.615.
- Murphy M, Junejo M, Rufin O, Cohen J, Nelson C, Damsky W. Grover disease shows type 2 immune activation and improves with dupilumab. British Journal Of Dermatology 2025, 192: 939-941. PMID: 39775460, DOI: 10.1093/bjd/ljaf005.
- Damsky W, King B. Cutaneous sarcoidosis: clinical and pathologic features, molecular pathogenesis, and treatment. Clinics In Dermatology 2024, 43: 177-190. PMID: 39694198, DOI: 10.1016/j.clindermatol.2024.12.017.
- Bassir F, Valido K, Maciejewski K, Damsky W, Nelson C. Validation of the Delphi Consensus Diagnostic Criteria for Necrobiotic Xanthogranuloma. JAMA Dermatology 2024, 160: 1361-1362. PMID: 39356540, PMCID: PMC11447626, DOI: 10.1001/jamadermatol.2024.3198.
- McGeary M, Damsky W, Daniels A, Lang S, Xu Q, Song E, Huet-Calderwood C, Lou H, Paradkar S, Micevic G, Kaech S, Calderwood D, Turk B, Yan Q, Iwasaki A, Bosenberg M. Setdb1 Loss Induces Type I Interferons and Immune Clearance of Melanoma. Cancer Immunology Research 2024, 13: 245-257. PMID: 39589394, DOI: 10.1158/2326-6066.cir-23-0514.
- Lin Y, Xie M, Lau H, Zeng R, Zhang R, Wang L, Li Q, Wang Y, Chen D, Jiang L, Damsky W, Yu J. Effects of gut microbiota on immune checkpoint inhibitors in multi-cancer and as microbial biomarkers for predicting therapeutic response. Med 2024, 6: 100530. PMID: 39515321, DOI: 10.1016/j.medj.2024.10.007.
- Spaulding S, Wride A, Slade M, Damsky W, Cohen J. Cutaneous fungal infections in the United States: A cross-sectional analysis of the National Ambulatory Medical Care Survey and National Hospital Ambulatory Medical Care Survey, 2005-2016. Journal Of The American Academy Of Dermatology 2024, 92: 572-574. PMID: 39486764, DOI: 10.1016/j.jaad.2024.10.035.
- Wride A, Chen G, Fan R, Leasure A, Jones S, Levey D, Damsky W, Cohen J. Bipolar disorder among individuals with atopic dermatitis: a case–control study in the All of Us Research Program. Clinical And Experimental Dermatology 2024, 50: 760-763. PMID: 39425681, DOI: 10.1093/ced/llae451.
- Peterson D, Damsky W, King B. JAK Inhibitors as Immunomodulators. 2024, 57-71. DOI: 10.1007/978-3-031-66590-5_5.
- Chang J, Shin K, Lewis J, Suh H, Lee J, Damsky W, Xu S, Bosenberg M, Saltzman W, Girardi M. Enhanced Intratumoral Delivery of Immunomodulator Monophosphoryl Lipid A through Hyperbranched Polyglycerol–Coated Biodegradable Nanoparticles. Journal Of Investigative Dermatology 2024, 145: 593-604. PMID: 39122142, DOI: 10.1016/j.jid.2024.07.019.
- Sand J, Jessen H, Leeming D, Yu S, Lee C, Hu B, Sun Y, Adams T, Pivarnik T, Liu A, Woo S, McGovern J, Fiorini V, Saber T, Higuero-Sevilla J, Gulati M, Kaminski N, Damsky W, Shaw A, Mohanty S, Goobie G, Zhang Y, Herzog E, Ryu C. Plasma collagen neoepitopes are associated with multiorgan disease in the ACCESS and GRADS sarcoidosis cohorts. Thorax 2024, 79: 1136-1144. PMID: 39117421, PMCID: PMC12147189, DOI: 10.1136/thorax-2023-221095.
- Daccache J, Park E, Junejo M, Abdelghaffar M, Hwang E, Mohanty C, Singh C, Wang G, Wheeler J, Shields B, Nelson C, Wang Y, Damsky W. Spatial transcriptomics reveals organized and distinct immune activation in cutaneous granulomatous disorders. The Journal Of Allergy And Clinical Immunology 2024, 154: 1216-1231. PMID: 39098508, PMCID: PMC11560686, DOI: 10.1016/j.jaci.2024.07.021.
- McKay G, Liu L, Shaw K, Shakshouk H, Murphy M, Damsky W, Ortega‐Loayza A, Caplan A, Arkin L, Shields B. Pediatric cutaneous Crohn disease: A case series of 89 patients and review. Pediatric Dermatology 2024, 41: 807-813. PMID: 39011834, PMCID: PMC11949095, DOI: 10.1111/pde.15689.
- Cohen J, Damsky W. Anti-Interleukin-23 Autoantibodies in Adult-Onset Immunodeficiency. The New England Journal Of Medicine 2024, 391: 188-189. PMID: 38986070, DOI: 10.1056/nejmc2404977.
- Mohanty C, Singh C, Daccache J, Damsky W, Kendziorski C, Yan D, Prasad A, Zhang D, Keenan T, Drolet B, Ahmad N, Shields B. Granuloma Annulare Exhibits Mixed Immune and Macrophage Polarization Profiles with Spatial Transcriptomics. Journal Of Investigative Dermatology 2024, 145: 109-121. PMID: 38844128, DOI: 10.1016/j.jid.2024.04.024.
- Singh K, Breidbart R, Jaiswal A, Damsky W, Choate K, Vesely M. Intravenous immunoglobulin-induced eczematous dermatitis treated with dupilumab. JAAD Case Reports 2024, 49: 102-105. PMID: 38952857, PMCID: PMC11214983, DOI: 10.1016/j.jdcr.2024.05.002.
- Valido K, Murphy M, Leventhal J, Damsky W. Successful treatment of pityriasis rubra pilaris with brodalumab after nonresponse to IL-17A inhibition: A role for the innate cytokine IL-17C. JAAD Case Reports 2024, 48: 85-87. PMID: 38783931, PMCID: PMC11111584, DOI: 10.1016/j.jdcr.2024.04.010.
- Shaw V, Damsky W, Homer R, Cohen J. Characterizing interstitial lung disease in patients with psoriasis: a cross-sectional analysis in the National Institutes of Health’s All of Us Research Program. Clinical And Experimental Dermatology 2024, 49: 1083-1084. PMID: 38618708, DOI: 10.1093/ced/llae132.
- Abdelghaffar M, Kottilil S, Murphy M, Cohen J, Damsky W. Paradoxical Psoriasis. Dermatologic Clinics 2024, 42: 471-480. PMID: 38796276, DOI: 10.1016/j.det.2024.02.011.
- Valido K, Patel V, Murphy M, Junejo M, Patel D, Deutsch A, Turner N, Zaki T, King B, Damsky W, Nelson C. Treatment of prolonged drug reaction with eosinophilia and systemic symptoms syndrome with dupilumab using a molecularly-guided approach. JAAD Case Reports 2024, 48: 49-53. PMID: 38774671, PMCID: PMC11107093, DOI: 10.1016/j.jdcr.2024.03.020.
- Bangert C, Alkon N, Chennareddy S, Arnoldner T, Levine J, Pilz M, Medjimorec M, Ruggiero J, Cohenour E, Jonak C, Damsky W, Griss J, Brunner P. Dupilumab-associated head and neck dermatitis shows a pronounced type 22 immune signature mediated by oligoclonally expanded T cells. Nature Communications 2024, 15: 2839. PMID: 38565563, PMCID: PMC10987549, DOI: 10.1038/s41467-024-46540-0.
- Pozniak J, Pedri D, Landeloos E, Van Herck Y, Antoranz A, Vanwynsberghe L, Nowosad A, Roda N, Makhzami S, Bervoets G, Maciel L, Pulido-Vicuña C, Pollaris L, Seurinck R, Zhao F, Flem-Karlsen K, Damsky W, Chen L, Karagianni D, Cinque S, Kint S, Vandereyken K, Rombaut B, Voet T, Vernaillen F, Annaert W, Lambrechts D, Boecxstaens V, Saeys Y, van den Oord J, Bosisio F, Karras P, Shain A, Bosenberg M, Leucci E, Paschen A, Rambow F, Bechter O, Marine J. A TCF4-dependent gene regulatory network confers resistance to immunotherapy in melanoma. Cell 2024, 187: 166-183.e25. PMID: 38181739, DOI: 10.1016/j.cell.2023.11.037.
- Garate D, Thang C, Damsky W, Rosenbach M, Golovko G, Wilkerson M, Barbieri J. Granuloma annulare is associated with an increased risk of hematologic malignancies: A multicenter cohort study using TriNetX. Journal Of The American Academy Of Dermatology 2023, 90: 862-864. PMID: 38147901, DOI: 10.1016/j.jaad.2023.12.028.
- Hwang E, Lee T, Okifo K, Murphy M, Damsky W. Retrospective assessment of immunologic and histologic heterogeneity in granuloma annulare by cytokine staining. International Journal Of Dermatology 2023, 63: 655-659. PMID: 38135676, PMCID: PMC11055676, DOI: 10.1111/ijd.16998.
- Chen G, Fan R, Leasure A, Levey D, Damsky W, Cohen J. Obsessive–compulsive disorder among patients with atopic dermatitis: a case–control study in the All of Us research program. Archives Of Dermatological Research 2023, 316: 11. PMID: 38038754, DOI: 10.1007/s00403-023-02767-3.
- Joel M, Damsky W, Cohen J, Wride M. Association between atopic dermatitis and inflammatory bowel disease among US adults in the All of Us Research Program. Clinical And Experimental Dermatology 2023, 49: 390-392. PMID: 37967342, PMCID: PMC10957220, DOI: 10.1093/ced/llad397.
- Djureinovic D, Weiss S, Krykbaeva I, Qu R, Vathiotis I, Moutafi M, Zhang L, Perdigoto A, Wei W, Anderson G, Damsky W, Hurwitz M, Johnson B, Schoenfeld D, Mahajan A, Hsu F, Miller-Jensen K, Kluger Y, Sznol M, Kaech S, Bosenberg M, Jilaveanu L, Kluger H. A bedside to bench study of anti-PD-1, anti-CD40, and anti-CSF1R indicates that more is not necessarily better. Molecular Cancer 2023, 22: 182. PMID: 37964379, PMCID: PMC10644655, DOI: 10.1186/s12943-023-01884-x.
- Shipman W, Singh K, Cohen J, Leventhal J, Damsky W, Tomayko M. Targeting interleukin (IL)-4/IL-13 in immune checkpoint inhibitor-induced bullous pemphigoid: a cautionary note on the beneficial effect of T helper 2 immunity in melanoma and immunotherapy: reply from the authors. British Journal Of Dermatology 2023, 190: 138-138. PMID: 37947404, DOI: 10.1093/bjd/ljad342.
- Abdelghaffar M, Hwang E, Damsky W. Cutaneous Sarcoidosis. Clinics In Chest Medicine 2023, 45: 71-89. PMID: 38245372, DOI: 10.1016/j.ccm.2023.08.004.
- Murphy M, Hwang E, Singh K, Lee T, Cohen J, Damsky W. Machine learning analysis of pretreatment skin biopsies predicts nonresponse to dupilumab in patients with eczematous dermatitis. British Journal Of Dermatology 2023, 190: 132-134. PMID: 37818837, DOI: 10.1093/bjd/ljad389.
- Nihal A, Caplan A, Rosenbach M, Damsky W, Mangold A, Shields B. Treatment options for necrobiosis lipoidica: a systematic review. International Journal Of Dermatology 2023, 62: 1529-1537. PMID: 37772666, DOI: 10.1111/ijd.16856.
- Kimball K, Damsky W, Richmond J. Lichen Nitidus: A Case of Tiny, Shiny, Skin Bumps. Frontiers For Young Minds 2023, 11: 1033760. DOI: 10.3389/frym.2023.1033760.
- Hwang E, Abdelghaffar M, Shields B, Damsky W. Molecularly Targeted Therapies for Inflammatory Cutaneous Granulomatous Disorders: A Review of the Evidence and Implications for Understanding Disease Pathogenesis. JID Innovations 2023, 3: 100220. PMID: 37719661, PMCID: PMC10500476, DOI: 10.1016/j.xjidi.2023.100220.
- Wei B, Fox L, Kaffenberger B, Korman A, Micheletti R, Mostaghimi A, Noe M, Rosenbach M, Shinkai K, Kwah J, Phillips E, Bolognia J, Damsky W, Nelson C. Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms. Part II diagnosis and management. Journal Of The American Academy Of Dermatology 2023, 90: 911-926. PMID: 37516356, DOI: 10.1016/j.jaad.2023.02.073.
- Wei B, Fox L, Kaffenberger B, Korman A, Micheletti R, Mostaghimi A, Noe M, Rosenbach M, Shinkai K, Kwah J, Phillips E, Bolognia J, Damsky W, Nelson C. Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms. Part I. Epidemiology, pathogenesis, clinicopathological features, and prognosis. Journal Of The American Academy Of Dermatology 2023, 90: 885-908. PMID: 37516359, DOI: 10.1016/j.jaad.2023.02.072.
- Fan R, Chen G, Leasure A, Johnson M, Damsky W, Cohen J. Association of atopic dermatitis with schizophrenia and schizoaffective disorder. Archives Of Dermatological Research 2023, 315: 2731-2733. PMID: 37495709, DOI: 10.1007/s00403-023-02674-7.
- Murphy M, Heyang M, Fan R, Leasure A, Damsky W, Cohen J. Association between uveitis and Lichen planus in the all of us research program. Archives Of Dermatological Research 2023, 315: 2729-2730. PMID: 37488318, DOI: 10.1007/s00403-023-02675-6.
- Krykbaeva I, Bridges K, Damsky W, Pizzurro G, Alexander A, McGeary M, Park K, Muthusamy V, Eyles J, Luheshi N, Turner N, Weiss S, Olino K, Kaech S, Kluger H, Miller-Jensen K, Bosenberg M. Combinatorial Immunotherapy with Agonistic CD40 Activates Dendritic Cells to Express IL12 and Overcomes PD-1 Resistance. Cancer Immunology Research 2023, 11: 1332-1350. PMID: 37478171, PMCID: PMC12645833, DOI: 10.1158/2326-6066.cir-22-0699.
- Damo M, Hornick N, Venkat A, William I, Clulo K, Venkatesan S, He J, Fagerberg E, Loza J, Kwok D, Tal A, Buck J, Cui C, Singh J, Damsky W, Leventhal J, Krishnaswamy S, Joshi N. PD-1 maintains CD8 T cell tolerance towards cutaneous neoantigens. Nature 2023, 619: 151-159. PMID: 37344588, PMCID: PMC10989189, DOI: 10.1038/s41586-023-06217-y.
- Mortlock R, Ma E, Cohen J, Damsky W. Assessment of Treatment-Relevant Immune Biomarkers in Psoriasis and Atopic Dermatitis: Toward Personalized Medicine in Dermatology. Journal Of Investigative Dermatology 2023, 143: 1412-1422. PMID: 37341663, PMCID: PMC10830170, DOI: 10.1016/j.jid.2023.04.005.
- Horowitch B, Lee D, Ding M, Martinez-Morilla S, Aung T, Ouerghi F, Wang X, Wei W, Damsky W, Sznol M, Kluger H, Rimm D, Ishizuka J. Subsets of interferon signaling predict response to immune checkpoint blockade in melanoma patients. Clinical Cancer Research 2023, 29: 2908-2918. PMID: 37233452, PMCID: PMC10524955, DOI: 10.1158/1078-0432.ccr-23-0215.
- Park J, Park E, Damsky W, Vesely M. Pembrolizumab-induced lichenoid dermatitis treated with dupilumab. JAAD Case Reports 2023, 37: 13-15. PMID: 37332364, PMCID: PMC10275729, DOI: 10.1016/j.jdcr.2023.05.004.
- Shipman W, Singh K, Cohen J, Leventhal J, Damsky W, Tomayko M. Immune checkpoint inhibitor-induced bullous pemphigoid is characterized by interleukin (IL)-4 and IL-13 expression and responds to dupilumab treatment. British Journal Of Dermatology 2023, 189: 339-341. PMID: 37140007, PMCID: PMC10947518, DOI: 10.1093/bjd/ljad149.
- Singh I, Leitner B, Wang Y, Zhang H, Joseph P, Lutchmansingh D, Gulati M, Possick J, Damsky W, Hwa J, Heerdt P, Chun H. Proteomic profiling demonstrates inflammatory and endotheliopathy signatures associated with impaired cardiopulmonary exercise hemodynamic profile in Post Acute Sequelae of SARS‐CoV‐2 infection (PASC) syndrome. Pulmonary Circulation 2023, 13: e12220. PMID: 37091121, PMCID: PMC10113513, DOI: 10.1002/pul2.12220.
- Murphy M, Edemobi P, Leasure A, Gulati M, Miller E, Damsky W, Cohen J. Autoimmune comorbidities associated with sarcoidosis: a case-control study in the All of Us research program. Rheumatology Advances In Practice 2023, 7: rkad030. PMID: 38606002, PMCID: PMC11007907, DOI: 10.1093/rap/rkad030.
- Fan R, Chen G, Leasure A, Johnson M, Damsky W, Cohen J. Association of atopic dermatitis with schizophrenia and schizoaffective disorder: A case-control study in the All of Us Research Program. 2023 DOI: 10.21203/rs.3.rs-2782847/v1.
- Xu S, Weiss E, Singh K, Damsky W, Girardi M. A case of bullous lesions in cutaneous T-cell lymphoma. JAAD Case Reports 2023, 35: 90-93. PMID: 37223111, PMCID: PMC10201206, DOI: 10.1016/j.jdcr.2023.02.026.
- Singh K, Valido K, Swallow M, Okifo K, Wang A, Cohen J, Damsky W. Baseline skin cytokine profiles determined by RNA in situ hybridization correlate with response to dupilumab in patients with eczematous dermatitis. Journal Of The American Academy Of Dermatology 2023, 88: 1094-1100. PMID: 36780951, DOI: 10.1016/j.jaad.2022.12.052.
- Chen J, Murphy M, Singh K, Wang A, Chow R, Kim R, Cohen J, Ko C, Damsky W. IL17A mRNA Staining Distinguishes Palmoplantar Psoriasis from Hyperkeratotic Palmoplantar Eczema in Diagnostic Skin Biopsies. JID Innovations 2023, 3: 100189. PMID: 37205304, PMCID: PMC10186614, DOI: 10.1016/j.xjidi.2023.100189.
- Girardi M, Ren J, Qu R, Rahman N, Lewis J, King A, Liao X, Mirza F, Carlson K, Huang Y, Gigante S, Evans B, Rajendran B, Xu S, Wang G, Foss F, Damsky W, Kluger Y, Krishnaswamy S. Integrated transcriptome and trajectory analysis of cutaneous T-cell lymphoma identifies putative precancer populations. Blood Advances 2023, 7: 445-457. PMID: 35947128, PMCID: PMC9979716, DOI: 10.1182/bloodadvances.2022008168.
- Joel M, Fan R, Damsky W, Cohen J. Psoriasis associated with asthma and allergic rhinitis: a US-based cross-sectional study using the All of US Research Program. Archives Of Dermatological Research 2023, 315: 1823-1826. PMID: 36707438, DOI: 10.1007/s00403-023-02539-z.
- Hodelin C, Fan R, Damsky W, Cohen J. The association of atopic dermatitis and chronic rhinosinusitis in adults: a cross‐sectional study using the All of Us research program. International Journal Of Dermatology 2022, 62: e430-e431. PMID: 36468789, DOI: 10.1111/ijd.16544.
- Ahmad M, Murphy M, Damsky W, Leventhal J. Dupilumab‐induced psoriasis in the setting of pembrolizumab therapy: an analysis of cytokine expression. International Journal Of Dermatology 2022, 62: e424-e426. PMID: 36468831, DOI: 10.1111/ijd.16538.
- Belzer A, Leasure A, Damsky W, Cohen J. The association of anxiety with granuloma annulare: a case–control study of the National Institutes of Health ‘All of Us’ research programme. British Journal Of Dermatology 2022, 188: 558-560. PMID: 36715356, DOI: 10.1093/bjd/ljac114.
- Association of sarcoidosis with psoriasis: a cross-sectional study in the All of Us research programMurphy M, Leasure A, Damsky W, Cohen J. Association of sarcoidosis with psoriasis: a cross-sectional study in the All of Us research program. Archives Of Dermatological Research 2022, 315: 1439-1441. PMID: 36436011, DOI: 10.1007/s00403-022-02488-z.
- Fan R, Leasure A, Damsky W, Cohen J. Migraine among adults with atopic dermatitis: a cross-sectional study in the All of Us research programme. Clinical And Experimental Dermatology 2022, 48: 24-26. PMID: 36669173, DOI: 10.1093/ced/llac004.
- Clark A, Murphy M, King B, Cohen J, Rosenbach M, Barbieri J, Damsky W. Patient perspectives on the lived experience of granuloma annulare. British Journal Of Dermatology 2022, 188: 134-136. PMID: 36689498, DOI: 10.1093/bjd/ljac004.
- A case of eosinophilic dermatosis of hematologic malignancy with tissue-based Th2 cytokine profilingXu S, Singh K, McNiff J, Damsky W, Gehlhausen J. A case of eosinophilic dermatosis of hematologic malignancy with tissue-based Th2 cytokine profiling. JAAD Case Reports 2022, 30: 5-7. PMID: 36345409, PMCID: PMC9636011, DOI: 10.1016/j.jdcr.2022.09.020.
- Gehlhausen JR, Little AJ, Ko CJ, Emmenegger M, Lucas C, Wong P, Klein J, Lu P, Mao T, Jaycox J, Wang E, Ugwu N, Muenker C, Mekael D, Klein R, Patrignelli R, Antaya R, McNiff J, Damsky W, Kamath K, Shon J, Ring A, Yildirim I, Omer S, Ko A, Aguzzi A, Iwasaki A, Obaid A, Lu-Culligan A, Nelson A, Brito A, Nunez A, Martin A, Watkins A, Geng B, Kalinich C, Harden C, Todeasa C, Jensen C, Kim D, McDonald D, Shepard D, Courchaine E, White E, Song E, Silva E, Kudo E, DeIuliis G, Rahming H, Park H, Matos I, Nouws J, Valdez J, Fauver J, Lim J, Rose K, Anastasio K, Brower K, Glick L, Sharma L, Sewanan L, Knaggs L, Minasyan M, Batsu M, Petrone M, Kuang M, Nakahata M, Campbell M, Linehan M, Askenase M, Simonov M, Smolgovsky M, Sonnert N, Naushad N, Vijayakumar P, Martinello R, Datta R, Handoko R, Bermejo S, Prophet S, Bickerton S, Velazquez S, Alpert T, Rice T, Khoury-Hanold W, Peng X, Yang Y, Cao Y, Strong Y. Lack of association between pandemic chilblains and SARS-CoV-2 infection. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2122090119. PMID: 35217624, PMCID: PMC8892496, DOI: 10.1073/pnas.2122090119.
- Zhang SM, Cai WL, Liu X, Thakral D, Luo J, Chan LH, McGeary MK, Song E, Blenman KRM, Micevic G, Jessel S, Zhang Y, Yin M, Booth CJ, Jilaveanu LB, Damsky W, Sznol M, Kluger HM, Iwasaki A, Bosenberg MW, Yan Q. KDM5B promotes immune evasion by recruiting SETDB1 to silence retroelements. Nature 2021, 598: 682-687. PMID: 34671158, PMCID: PMC8555464, DOI: 10.1038/s41586-021-03994-2.
- Mirza F, Wang A, Ramachandran S, Damsky W, Cohen J. Dupilumab‐induced phenotype switch from atopic dermatitis to psoriasis is characterized by de novo interleukin‐17A expression: a case report. British Journal Of Dermatology 2021, 185: 432-434. PMID: 33730377, DOI: 10.1111/bjd.20064.
- Zhou T, Damsky W, Weizman OE, McGeary MK, Hartmann KP, Rosen CE, Fischer S, Jackson R, Flavell RA, Wang J, Sanmamed MF, Bosenberg MW, Ring AM. IL-18BP is a secreted immune checkpoint and barrier to IL-18 immunotherapy. Nature 2020, 583: 609-614. PMID: 32581358, PMCID: PMC7381364, DOI: 10.1038/s41586-020-2422-6.
- Damsky W, Wang A, Olamiju B, Peterson D, Galan A, King B. Treatment of severe lichen planus with the JAK inhibitor tofacitinib. The Journal Of Allergy And Clinical Immunology 2020, 145: 1708-1710.e2. PMID: 32018031, DOI: 10.1016/j.jaci.2020.01.031.
- Damsky W, Patel D, Garelli CJ, Garg M, Wang A, Dresser K, Deng A, Harris JE, Richmond J, King B. JAK inhibition prevents bleomycin-induced fibrosis in mice and is effective in morphea patients. Journal Of Investigative Dermatology 2020, 140: 1446-1449.e4. PMID: 31954727, DOI: 10.1016/j.jid.2019.12.019.
- Damsky W, Thakral D, McGeary MK, Leventhal J, Galan A, King B. Janus kinase inhibition induces disease remission in cutaneous sarcoidosis and granuloma annulare. Journal Of The American Academy Of Dermatology 2019, 82: 612-621. PMID: 31185230, PMCID: PMC7590533, DOI: 10.1016/j.jaad.2019.05.098.
- Damsky W, Thakral D, Emeagwali N, Galan A, King B. Tofacitinib Treatment and Molecular Analysis of Cutaneous Sarcoidosis. The New England Journal Of Medicine 2018, 379: 2540-2546. PMID: 30586518, PMCID: PMC6351852, DOI: 10.1056/nejmoa1805958.
- Wang J, Perry CJ, Meeth K, Thakral D, Damsky W, Micevic G, Kaech S, Blenman K, Bosenberg M. UV‐induced somatic mutations elicit a functional T cell response in the YUMMER1.7 mouse melanoma model. Pigment Cell & Melanoma Research 2017, 30: 428-435. PMID: 28379630, PMCID: PMC5820096, DOI: 10.1111/pcmr.12591.
- Damsky W, King BA. JAK inhibitors in dermatology: The promise of a new drug class. Journal Of The American Academy Of Dermatology 2017, 76: 736-744. PMID: 28139263, PMCID: PMC6035868, DOI: 10.1016/j.jaad.2016.12.005.
- Meeth K, Wang JX, Micevic G, Damsky W, Bosenberg MW. The YUMM lines: a series of congenic mouse melanoma cell lines with defined genetic alterations. Pigment Cell & Melanoma Research 2016, 29: 590-597. PMID: 27287723, PMCID: PMC5331933, DOI: 10.1111/pcmr.12498.
- Damsky W, Micevic G, Meeth K, Muthusamy V, Curley DP, Santhanakrishnan M, Erdelyi I, Platt JT, Huang L, Theodosakis N, Zaidi MR, Tighe S, Davies MA, Dankort D, McMahon M, Merlino G, Bardeesy N, Bosenberg M. mTORC1 Activation Blocks Braf V600E -Induced Growth Arrest but Is Insufficient for Melanoma Formation. Cancer Cell 2015, 27: 41-56. PMID: 25584893, PMCID: PMC4295062, DOI: 10.1016/j.ccell.2014.11.014.
- Damsky WE, Curley DP, Santhanakrishnan M, Rosenbaum LE, Platt JT, Rothberg BE, Taketo MM, Dankort D, Rimm DL, McMahon M, Bosenberg M. β-Catenin Signaling Controls Metastasis in Braf-Activated Pten-Deficient Melanomas. Cancer Cell 2011, 20: 741-754. PMID: 22172720, PMCID: PMC3241928, DOI: 10.1016/j.ccr.2011.10.030.
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