Samuel Katz, MD, PhD
Biography
Samuel G. Katz, MD, is a pathologist who specializes in diagnosing diseases and cancers of the blood, including lymphoma, leukemia and myeloma. During medical school, Dr. Katz was strongly drawn to scientific research, especially the study of disease origin. He is driven by a need “to understand what’s happening within cells, and a desire to reprogram the immune system to fight cancer,” he says.
Dr. Katz appreciates the opportunity to discuss patient samples with colleagues in order to determine—with the most accuracy possible—how a patient’s therapy might move forward. “There’s an art to pathology,” he says.
At Yale School of Medicine, Dr. Katz is an associate professor of pathology and studies the basic mechanisms of cell death.
Titles
- Associate Professor of Pathology
Education & Training
- FellowshipBrigham & Women's Hospital (2008)
- ResidencyBrigham & Women's Hospital (2006)
- MDHarvard Medical School (2004)
- PhDHarvard Medical School (2004)
- BSYale University, Molecular Biophysics & Biochemistry (1995)
- MSYale University, Molecular Biophysics & Biochemistry (1995)
Additional Information
- Mantle Cell Lymphoma Consortium Member: Lymphoma Research Foundation (2011)
- Career Development Award, Mentored (K08): NIH, National Heart, Lung, and Blood Institute (2010)
- Post-Doctoral Fellow, Career Development Award: Leukemia and Lymphoma Society (2008)
- Yamaguchi Award in Hematology Research: Children's Hospital, Boston MA (1999)
- Pre-Doctoral Fellow Award: Howard Hughes Medical Institute (1998)
- cum laude: Yale University (1995)
- Distinction in the major: Yale University, MB&B (1995)
- AB of Pathology, Hematology (Pathology) (2020)
- AB of Pathology, Anatomic Pathology (2009, recertified: 2020)
- MD/PhD Faculty Committee (2012 - Present): Member
- Larrayoz M, Garcia-Barchino M, Celay J, Etxebeste A, Jimenez M, Perez C, Ordoñez R, Cobaleda C, Chesi M, Bergsagel L, Rodríguez-Otero P, Takahashi S, Katz S, Walensky L, Ruppert S, Lasater E, Amann M, Lasarte J, Kurilovich A, Cerchietti L, Agirre X, San-Miguel J, Paiva B, Prosper F, Martinez-Climent J. OAB-033: Pre-clinical models of genetically heterogeneous multiple myeloma reveal mechanisms of immune escape and predict clinical immunotherapy outcomes. Clinical Lymphoma Myeloma & Leukemia 2022, 22: s19-s20. DOI: 10.1016/s2152-2650(22)00306-8.
- Boisvert E, Means R, Michaud M, Thomson J, Madri J, Katz S. A Static Self-Directed Method for Generating Brain Organoids from Human Embryonic Stem Cells. Journal Of Visualized Experiments 2020 DOI: 10.3791/60379-v.
- Rabinovich PM, Zhang J, Kerr SR, Cheng BH, Komarovskaya M, Bersenev A, Hurwitz ME, Krause DS, Weissman SM, Katz SG. A versatile flow-based assay for immunocyte-mediated cytotoxicity. Journal Of Immunological Methods 2019, 474: 112668. PMID: 31525367, PMCID: PMC6891822, DOI: 10.1016/j.jim.2019.112668.
- Wang JD, Katz SG, Morgan EA, Yang DT, Pan X, Xu ML. Proapoptotic protein BIM as a novel prognostic marker in mantle cell lymphoma. Human Pathology 2019, 93: 54-64. PMID: 31425695, PMCID: PMC7038910, DOI: 10.1016/j.humpath.2019.08.008.
- Kang SH, Perales O, Michaud M, Katz SG. BOK promotes erythropoiesis in a mouse model of myelodysplastic syndrome. Annals Of Hematology 2019, 98: 2089-2096. PMID: 31203423, PMCID: PMC6702064, DOI: 10.1007/s00277-019-03726-7.
- Boisvert EM, Means RE, Michaud M, Madri JA, Katz SG. Minocycline mitigates the effect of neonatal hypoxic insult on human brain organoids. Cell Death & Disease 2019, 10: 325. PMID: 30975982, PMCID: PMC6459920, DOI: 10.1038/s41419-019-1553-x.
- Carpio MA, Katz SG. Methods to Probe Calcium Regulation by BCL-2 Family Members. Methods In Molecular Biology 2018, 1877: 173-183. PMID: 30536006, DOI: 10.1007/978-1-4939-8861-7_12.
- Kang S, Perales O, Michuad M, Katz S. Bok Promotes Erythropoiesis in a Mouse Model of Myelodysplastic Syndrome. Blood 2017, 130: 922. DOI: 10.1182/blood.v130.suppl_1.922.922.
- Katz SG. EZH! The IRE of DLBCL gets an UPR hand. Blood 2017, 129: 2340-2342. PMID: 28450573, DOI: 10.1182/blood-2017-02-769067.
- Gross A, Katz SG. Non-apoptotic functions of BCL-2 family proteins. Cell Death & Differentiation 2017, 24: 1348-1358. PMID: 28234359, PMCID: PMC5520452, DOI: 10.1038/cdd.2017.22.
- Xu ML, Acevedo-Gadea C, Seropian S, Katz SG. Expression of CD30 as a biomarker to predict response to brentuximab vedotin. Histopathology 2016, 69: 155-158. PMID: 26648051, PMCID: PMC7064871, DOI: 10.1111/his.12914.
- Kuo P, Jiang Z, Perumal D, Leshchenko V, Lagana' A, Katz S, Walensky L, Shaknovich R, Ye B, Parekh S. SOX11 Cooperates with CCND1 in Mantle Cell Lymphoma Pathogenesis. Blood 2015, 126: 1253. DOI: 10.1182/blood.v126.23.1253.1253.
- Carpio MA, Michaud M, Zhou W, Fisher JK, Walensky LD, Katz SG. BCL-2 family member BOK promotes apoptosis in response to endoplasmic reticulum stress. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: 7201-7206. PMID: 26015568, PMCID: PMC4466744, DOI: 10.1073/pnas.1421063112.
- Bernal F, Katz SG. Synthesis of Stabilized Alpha-Helical Peptides. Methods In Molecular Biology 2014, 1176: 107-114. PMID: 25030922, PMCID: PMC6333094, DOI: 10.1007/978-1-4939-0992-6_9.
- Bird GH, Gavathiotis E, LaBelle JL, Katz SG, Walensky LD. Distinct BimBH3 (BimSAHB) Stapled Peptides for Structural and Cellular Studies. ACS Chemical Biology 2014, 9: 831-837. PMID: 24358963, PMCID: PMC4131438, DOI: 10.1021/cb4003305.
- Katz SG, LaBelle JL, Meng H, Valeriano RP, Fisher JK, Sun H, Rodig SJ, Kleinstein SH, Walensky LD. Mantle cell lymphoma in cyclin D1 transgenic mice with Bim-deficient B cells. Blood 2013, 123: 884-893. PMID: 24352880, PMCID: PMC3916879, DOI: 10.1182/blood-2013-04-499079.
- Katz SG, Fisher JK, Correll M, Bronson RT, Ligon KL, Walensky LD. Brain and testicular tumors in mice with progenitor cells lacking BAX and BAK. Oncogene 2012, 32: 4078-4085. PMID: 22986529, PMCID: PMC3529761, DOI: 10.1038/onc.2012.421.
- LaBelle JL, Katz SG, Bird GH, Gavathiotis E, Stewart ML, Lawrence C, Fisher JK, Godes M, Pitter K, Kung AL, Walensky LD. A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers. Journal Of Clinical Investigation 2012, 122: 2018-2031. PMID: 22622039, PMCID: PMC3366394, DOI: 10.1172/jci46231.
- Katz S, Labelle J, Godes M, Fisher J, Bird G, Walensky L. A Stapled BIM BH3 Helix Restores Apoptosis In Bim-Null Mantle Cell Lymphoma. Blood 2010, 116: 437. DOI: 10.1182/blood.v116.21.437.437.
- Gavathiotis E, Suzuki M, Davis M, Pitter K, Bird G, Katz S, Tu H, Kim H, Cheng E, Tjandra N, Walensky L. Structural Analysis of a BAX-BIM SAHB Complex Reveals a Novel BH3 Interaction Site on BAX for Therapeutic Activation of Apoptosis. Blood 2008, 112: 300. DOI: 10.1182/blood.v112.11.300.300.
- Gavathiotis E, Suzuki M, Davis ML, Pitter K, Bird GH, Katz SG, Tu HC, Kim H, Cheng E, Tjandra N, Walensky LD. BAX activation is initiated at a novel interaction site. Nature 2008, 455: 1076-1081. PMID: 18948948, PMCID: PMC2597110, DOI: 10.1038/nature07396.
- Beuling E, Bosse T, de Kerk D, Piaseckyj CM, Fujiwara Y, Katz SG, Orkin SH, Grand RJ, Krasinski SD. GATA4 mediates gene repression in the mature mouse small intestine through interactions with friend of GATA (FOG) cofactors. Developmental Biology 2008, 322: 179-189. PMID: 18692040, PMCID: PMC3031907, DOI: 10.1016/j.ydbio.2008.07.022.
- LaBelle J, Fisher J, Katz S, Bird G, Lawrence C, Silverstein A, Walensky L. Pharmacologic Replacement of BIM BH3 Reactivates Apoptosis in Hematologic Cancer and Lymphoproliferative Disease. Blood 2007, 110: 524. DOI: 10.1182/blood.v110.11.524.524.
- Katz SG, Williams A, Yang J, Fujiwara Y, Tsang AP, Epstein JA, Orkin SH. Endothelial lineage-mediated loss of the GATA cofactor Friend of GATA 1 impairs cardiac development. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 14030-14035. PMID: 14614148, PMCID: PMC283540, DOI: 10.1073/pnas.1936250100.
- Katz SG, Cantor AB, Orkin SH. Interaction between FOG-1 and the Corepressor C-Terminal Binding Protein Is Dispensable for Normal Erythropoiesis In Vivo. Molecular And Cellular Biology 2002, 22: 3121-3128. PMID: 11940669, PMCID: PMC133767, DOI: 10.1128/mcb.22.9.3121-3128.2002.
- Zhou M, Ouyang W, Gong Q, Katz S, White J, Orkin S, Murphy K. Friend of GATA-1 Represses GATA-3–dependent Activity in CD4+ T Cells. Journal Of Experimental Medicine 2001, 194: 1461-1471. PMID: 11714753, PMCID: PMC2193678, DOI: 10.1084/jem.194.10.1461.
- Hematopathology
- Pathology
- Surgical Pathology
- Yale Cancer Center
Biography
Samuel G. Katz, MD, is a pathologist who specializes in diagnosing diseases and cancers of the blood, including lymphoma, leukemia and myeloma. During medical school, Dr. Katz was strongly drawn to scientific research, especially the study of disease origin. He is driven by a need “to understand what’s happening within cells, and a desire to reprogram the immune system to fight cancer,” he says.
Dr. Katz appreciates the opportunity to discuss patient samples with colleagues in order to determine—with the most accuracy possible—how a patient’s therapy might move forward. “There’s an art to pathology,” he says.
At Yale School of Medicine, Dr. Katz is an associate professor of pathology and studies the basic mechanisms of cell death.
Titles
- Associate Professor of Pathology
Education & Training
- FellowshipBrigham & Women's Hospital (2008)
- ResidencyBrigham & Women's Hospital (2006)
- MDHarvard Medical School (2004)
- PhDHarvard Medical School (2004)
- BSYale University, Molecular Biophysics & Biochemistry (1995)
- MSYale University, Molecular Biophysics & Biochemistry (1995)
Additional Information
- Mantle Cell Lymphoma Consortium Member: Lymphoma Research Foundation (2011)
- Career Development Award, Mentored (K08): NIH, National Heart, Lung, and Blood Institute (2010)
- Post-Doctoral Fellow, Career Development Award: Leukemia and Lymphoma Society (2008)
- Yamaguchi Award in Hematology Research: Children's Hospital, Boston MA (1999)
- Pre-Doctoral Fellow Award: Howard Hughes Medical Institute (1998)
- cum laude: Yale University (1995)
- Distinction in the major: Yale University, MB&B (1995)
- AB of Pathology, Hematology (Pathology) (2020)
- AB of Pathology, Anatomic Pathology (2009, recertified: 2020)
- MD/PhD Faculty Committee (2012 - Present): Member
- Larrayoz M, Garcia-Barchino M, Celay J, Etxebeste A, Jimenez M, Perez C, Ordoñez R, Cobaleda C, Chesi M, Bergsagel L, Rodríguez-Otero P, Takahashi S, Katz S, Walensky L, Ruppert S, Lasater E, Amann M, Lasarte J, Kurilovich A, Cerchietti L, Agirre X, San-Miguel J, Paiva B, Prosper F, Martinez-Climent J. OAB-033: Pre-clinical models of genetically heterogeneous multiple myeloma reveal mechanisms of immune escape and predict clinical immunotherapy outcomes. Clinical Lymphoma Myeloma & Leukemia 2022, 22: s19-s20. DOI: 10.1016/s2152-2650(22)00306-8.
- Boisvert E, Means R, Michaud M, Thomson J, Madri J, Katz S. A Static Self-Directed Method for Generating Brain Organoids from Human Embryonic Stem Cells. Journal Of Visualized Experiments 2020 DOI: 10.3791/60379-v.
- Rabinovich PM, Zhang J, Kerr SR, Cheng BH, Komarovskaya M, Bersenev A, Hurwitz ME, Krause DS, Weissman SM, Katz SG. A versatile flow-based assay for immunocyte-mediated cytotoxicity. Journal Of Immunological Methods 2019, 474: 112668. PMID: 31525367, PMCID: PMC6891822, DOI: 10.1016/j.jim.2019.112668.
- Wang JD, Katz SG, Morgan EA, Yang DT, Pan X, Xu ML. Proapoptotic protein BIM as a novel prognostic marker in mantle cell lymphoma. Human Pathology 2019, 93: 54-64. PMID: 31425695, PMCID: PMC7038910, DOI: 10.1016/j.humpath.2019.08.008.
- Kang SH, Perales O, Michaud M, Katz SG. BOK promotes erythropoiesis in a mouse model of myelodysplastic syndrome. Annals Of Hematology 2019, 98: 2089-2096. PMID: 31203423, PMCID: PMC6702064, DOI: 10.1007/s00277-019-03726-7.
- Boisvert EM, Means RE, Michaud M, Madri JA, Katz SG. Minocycline mitigates the effect of neonatal hypoxic insult on human brain organoids. Cell Death & Disease 2019, 10: 325. PMID: 30975982, PMCID: PMC6459920, DOI: 10.1038/s41419-019-1553-x.
- Carpio MA, Katz SG. Methods to Probe Calcium Regulation by BCL-2 Family Members. Methods In Molecular Biology 2018, 1877: 173-183. PMID: 30536006, DOI: 10.1007/978-1-4939-8861-7_12.
- Kang S, Perales O, Michuad M, Katz S. Bok Promotes Erythropoiesis in a Mouse Model of Myelodysplastic Syndrome. Blood 2017, 130: 922. DOI: 10.1182/blood.v130.suppl_1.922.922.
- Katz SG. EZH! The IRE of DLBCL gets an UPR hand. Blood 2017, 129: 2340-2342. PMID: 28450573, DOI: 10.1182/blood-2017-02-769067.
- Gross A, Katz SG. Non-apoptotic functions of BCL-2 family proteins. Cell Death & Differentiation 2017, 24: 1348-1358. PMID: 28234359, PMCID: PMC5520452, DOI: 10.1038/cdd.2017.22.
- Xu ML, Acevedo-Gadea C, Seropian S, Katz SG. Expression of CD30 as a biomarker to predict response to brentuximab vedotin. Histopathology 2016, 69: 155-158. PMID: 26648051, PMCID: PMC7064871, DOI: 10.1111/his.12914.
- Kuo P, Jiang Z, Perumal D, Leshchenko V, Lagana' A, Katz S, Walensky L, Shaknovich R, Ye B, Parekh S. SOX11 Cooperates with CCND1 in Mantle Cell Lymphoma Pathogenesis. Blood 2015, 126: 1253. DOI: 10.1182/blood.v126.23.1253.1253.
- Carpio MA, Michaud M, Zhou W, Fisher JK, Walensky LD, Katz SG. BCL-2 family member BOK promotes apoptosis in response to endoplasmic reticulum stress. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: 7201-7206. PMID: 26015568, PMCID: PMC4466744, DOI: 10.1073/pnas.1421063112.
- Bernal F, Katz SG. Synthesis of Stabilized Alpha-Helical Peptides. Methods In Molecular Biology 2014, 1176: 107-114. PMID: 25030922, PMCID: PMC6333094, DOI: 10.1007/978-1-4939-0992-6_9.
- Bird GH, Gavathiotis E, LaBelle JL, Katz SG, Walensky LD. Distinct BimBH3 (BimSAHB) Stapled Peptides for Structural and Cellular Studies. ACS Chemical Biology 2014, 9: 831-837. PMID: 24358963, PMCID: PMC4131438, DOI: 10.1021/cb4003305.
- Katz SG, LaBelle JL, Meng H, Valeriano RP, Fisher JK, Sun H, Rodig SJ, Kleinstein SH, Walensky LD. Mantle cell lymphoma in cyclin D1 transgenic mice with Bim-deficient B cells. Blood 2013, 123: 884-893. PMID: 24352880, PMCID: PMC3916879, DOI: 10.1182/blood-2013-04-499079.
- Katz SG, Fisher JK, Correll M, Bronson RT, Ligon KL, Walensky LD. Brain and testicular tumors in mice with progenitor cells lacking BAX and BAK. Oncogene 2012, 32: 4078-4085. PMID: 22986529, PMCID: PMC3529761, DOI: 10.1038/onc.2012.421.
- LaBelle JL, Katz SG, Bird GH, Gavathiotis E, Stewart ML, Lawrence C, Fisher JK, Godes M, Pitter K, Kung AL, Walensky LD. A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers. Journal Of Clinical Investigation 2012, 122: 2018-2031. PMID: 22622039, PMCID: PMC3366394, DOI: 10.1172/jci46231.
- Katz S, Labelle J, Godes M, Fisher J, Bird G, Walensky L. A Stapled BIM BH3 Helix Restores Apoptosis In Bim-Null Mantle Cell Lymphoma. Blood 2010, 116: 437. DOI: 10.1182/blood.v116.21.437.437.
- Gavathiotis E, Suzuki M, Davis M, Pitter K, Bird G, Katz S, Tu H, Kim H, Cheng E, Tjandra N, Walensky L. Structural Analysis of a BAX-BIM SAHB Complex Reveals a Novel BH3 Interaction Site on BAX for Therapeutic Activation of Apoptosis. Blood 2008, 112: 300. DOI: 10.1182/blood.v112.11.300.300.
- Gavathiotis E, Suzuki M, Davis ML, Pitter K, Bird GH, Katz SG, Tu HC, Kim H, Cheng E, Tjandra N, Walensky LD. BAX activation is initiated at a novel interaction site. Nature 2008, 455: 1076-1081. PMID: 18948948, PMCID: PMC2597110, DOI: 10.1038/nature07396.
- Beuling E, Bosse T, de Kerk D, Piaseckyj CM, Fujiwara Y, Katz SG, Orkin SH, Grand RJ, Krasinski SD. GATA4 mediates gene repression in the mature mouse small intestine through interactions with friend of GATA (FOG) cofactors. Developmental Biology 2008, 322: 179-189. PMID: 18692040, PMCID: PMC3031907, DOI: 10.1016/j.ydbio.2008.07.022.
- LaBelle J, Fisher J, Katz S, Bird G, Lawrence C, Silverstein A, Walensky L. Pharmacologic Replacement of BIM BH3 Reactivates Apoptosis in Hematologic Cancer and Lymphoproliferative Disease. Blood 2007, 110: 524. DOI: 10.1182/blood.v110.11.524.524.
- Katz SG, Williams A, Yang J, Fujiwara Y, Tsang AP, Epstein JA, Orkin SH. Endothelial lineage-mediated loss of the GATA cofactor Friend of GATA 1 impairs cardiac development. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 14030-14035. PMID: 14614148, PMCID: PMC283540, DOI: 10.1073/pnas.1936250100.
- Katz SG, Cantor AB, Orkin SH. Interaction between FOG-1 and the Corepressor C-Terminal Binding Protein Is Dispensable for Normal Erythropoiesis In Vivo. Molecular And Cellular Biology 2002, 22: 3121-3128. PMID: 11940669, PMCID: PMC133767, DOI: 10.1128/mcb.22.9.3121-3128.2002.
- Zhou M, Ouyang W, Gong Q, Katz S, White J, Orkin S, Murphy K. Friend of GATA-1 Represses GATA-3–dependent Activity in CD4+ T Cells. Journal Of Experimental Medicine 2001, 194: 1461-1471. PMID: 11714753, PMCID: PMC2193678, DOI: 10.1084/jem.194.10.1461.
- Hematopathology
- Pathology
- Surgical Pathology
- Yale Cancer Center