- Winchester Center for Lung DiseaseFitkin Memorial Pavilion789 Howard AvenueNew Haven, CT 06519
- Winchester Center for Lung Disease6 Devine StreetNorth Haven, CT 06473
Jose Gomez Villalobos, MD, MS
Biography
Jose L. Gomez-Villalobos, MD, MS, works to connect patients with state-of-the-art resources for asthma and chronic obstructive pulmonary disease (COPD). He shares with his patients that there are an increasing number of resources to help them control their disease and improve their lives. “We have have established a program to improve our understanding of the disease and help develop novel therapies to decrease the time from discovery to treatment,” he says.
An assistant professor of medicine (pulmonary) at Yale School of Medicine, Dr. Gomez-Villalobos also studies the biological mechanisms behind secondhand smoke and severe asthma.
Titles
- Associate Professor of Medicine (Pulmonary, Critical Care and Sleep Medicine)
- Affiliated Faculty, Yale Institute for Global Health
Education & Training
- MSYale University Graduate School of Arts and Sciences, Computational Biology and Bioinformatics (2012)
- FellowYale University School of Medicine (2012)
- ResidencyHospital of Saint Raphael, New Haven, CT (2007)
- Graduate Teaching AssistantPontificia Universidad Javeriana (1999)
- MDPontificia Universidad Javeriana (1999)
Languages Spoken
- English
- Español (Spanish)
Additional Information
- Fellow: American Thoracic Society (2019)
- Outstanding PGY-1 Resident: Hospital of Saint Raphael (2005)
- AB of Internal Medicine, Critical Care Medicine (Internal Medicine) (2012, recertified: 2023)
- AB of Internal Medicine, Pulmonary Disease (2011, recertified: 2021)
- AB of Internal Medicine, Internal Medicine (2007, recertified: 2017)
- National Institutes of Health-Therapeutic Approaches to Genetic Diseases Study Section (2023 - Present): Member
- American Thoracic Society, Allergy, Immunology and Inflammation Assembly (2019 - 2021): Executive Committee Member
- American Thoracic Society (2019 - Present): Research Committee Member
- American Thoracic Society, Genetics and Genomics Section (2016 - 2018): Executive Committee Member
- Spanish National Agency for Scientific Evaluation (ANEP) (2015): Reviewer
- American Thoracic Society, Web Committee, Allergy, Immunology and Inflammation Assembly (2015 - Present): Committee Member
- Pulmonary and Critical Care Fellowship Journal Club (2014 - 2022): Coordinator
- Pulmonary and Critical Care Fellowship Curriculum (2009 - 2012): Committee Member
- Chest, American Journal of Respiratory and Critical Care Medicine, BMC Pulmonary Medicine, Journal of Preventive Medicine, Thorax, AJP Lung, Nature Communications, European Respiratory Journal, Respiratory Research (2009 - Present): Reviewer
- Unterman A, Zhao A, Neumark N, Schupp J, Ahangari F, Cosme C, Sharma P, Flint J, Stein Y, Ryu C, Ishikawa G, Sumida T, Gomez J, Herazo-Maya J, Dela Cruz C, Herzog E, Kaminski N. Single-Cell Profiling Reveals Immune Aberrations in Progressive Idiopathic Pulmonary Fibrosis. American Journal Of Respiratory And Critical Care Medicine 2024, 210: 484-496. PMID: 38717443, PMCID: PMC11351796, DOI: 10.1164/rccm.202306-0979oc.
- Yin H, Kockar Kizilirmak T, Li N, Adams T, Sauler M, Gomez J, Britto-Leon C. CFTR Modulators Reprogram Sex-Specific Airway Neutrophil Signaling. 2024, a7454-a7454. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a7454.
- Gautam S, Chu J, Cohen A, Kaur R, Lee S, Wilson G, Liu Q, Gomez J, Rajaveen H, Yan X, Cohn L, Clark B, Chupp G. Sputum alarmins delineate distinct T2 cytokine pathways and unique subtypes of patients with asthma. Allergy 2023, 78: 3274-3277. PMID: 37874609, PMCID: PMC10842366, DOI: 10.1111/all.15915.
- Li B, Wang Y, Wang Z, Li X, Kay S, Chupp G, Zhao H, Gomez J. Shared genetic architecture of blood eosinophil counts and asthma in UK Biobank. ERJ Open Research 2023, 9: 00291-2023. PMID: 37650091, PMCID: PMC10463033, DOI: 10.1183/23120541.00291-2023.
- Liu Y, Rajeevan H, Simonov M, Wilson F, Desir G, Vinetz J, Yan X, Wang Z, Clark B, Possick J, Price C, Lutchmansingh D, Gomez J, Cohn L, Gautam S, Chupp G. Mortality Differences Among Patients With Airway Disease Hospitalized With COVID-19. 2023, a6297-a6297. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6297.
- Li H, Lopez K, Lipkin-Moore Z, Kay S, Rajeevan H, Davis J, Wilson F, Rochester C, Gomez J. Machine Learning Prediction of Severe Asthma and COPD Hospital Readmission. 2023, a4831-a4831. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a4831.
- Lopez K, Li H, Lipkin-Moore Z, Kay S, Rajeevan H, Davis J, Wilson F, Rochester C, Gomez J. Deep learning prediction of hospital readmissions for asthma and COPD. Respiratory Research 2023, 24: 311. PMID: 38093373, PMCID: PMC10720134, DOI: 10.1186/s12931-023-02628-7.
- Cui H, Xie N, Banerjee S, Dey T, Liu RM, Antony VB, Sanders YY, Adams TS, Gomez JL, Thannickal VJ, Kaminski N, Liu G. CD38 Mediates Lung Fibrosis by Promoting Alveolar Epithelial Cell Aging. American Journal Of Respiratory And Critical Care Medicine 2022, 206: 459-475. PMID: 35687485, DOI: 10.1164/rccm.202109-2151oc.
- Sauler M, McDonough JE, Adams TS, Kothapalli N, Barnthaler T, Werder RB, Schupp JC, Nouws J, Robertson MJ, Coarfa C, Yang T, Chioccioli M, Omote N, Cosme C, Poli S, Ayaub EA, Chu SG, Jensen KH, Gomez JL, Britto CJ, Raredon MSB, Niklason LE, Wilson AA, Timshel PN, Kaminski N, Rosas IO. Characterization of the COPD alveolar niche using single-cell RNA sequencing. Nature Communications 2022, 13: 494. PMID: 35078977, PMCID: PMC8789871, DOI: 10.1038/s41467-022-28062-9.
- Kumar A, Elko E, Bruno SR, Mark ZF, Chamberlain N, Mihavics BK, Chandrasekaran R, Walzer J, Ruban M, Gold C, Lam YW, Ghandikota S, Jegga AG, Gomez JL, Janssen-Heininger YM, Anathy V. Inhibition of PDIA3 in club cells attenuates osteopontin production and lung fibrosis. Thorax 2021, 77: 669-678. PMID: 34400514, PMCID: PMC8847543, DOI: 10.1136/thoraxjnl-2021-216882.
- Gutierrez MJ, Perez GF, Gomez JL, Rodriguez‐Martinez C, Castro‐Rodriguez J, Nino G. Genes, environment, and developmental timing: New insights from translational approaches to understand early origins of respiratory diseases. Pediatric Pulmonology 2021, 56: 3157-3165. PMID: 34388306, PMCID: PMC8858026, DOI: 10.1002/ppul.25598.
- Khanal S, Webster M, Niu N, Zielonka J, Nunez M, Chupp G, Slade MD, Cohn L, Sauler M, Gomez JL, Tarran R, Sharma L, Dela Cruz CS, Egan M, Laguna T, Britto CJ. SPLUNC1: a novel marker of cystic fibrosis exacerbations. European Respiratory Journal 2021, 58: 2000507. PMID: 33958427, PMCID: PMC8571118, DOI: 10.1183/13993003.00507-2020.
- Kumar A, Elko E, Bruno S, Mark Z, Chamberlain N, Korwin-Mihavics B, Chandrasekaran R, walzer J, Ruban M, Gold C, Lam Y, Gomez J, Janssen-Heininger Y, Anathy V. Ablation or Inhibition of Protein Disulfide Isomerase A3 (PDIA3) in Club Cells Attenuates Osteopontin (SPP1) Production and Lung Fibrosis. 2021, a4241-a4241. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4241.
- Alapaty S, Siner J, Sauler M, Baldassarri S, Davis J, Gomez J. Lung Compliance Clusters of COVID-ARDS Identify Distinct Subgroups with Increased Mortality. 2021, a2492-a2492. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a2492.
- Chen A, Diaz-Soto MP, Sanmamed MF, Adams T, Schupp JC, Gupta A, Britto C, Sauler M, Yan X, Liu Q, Nino G, Cruz CSD, Chupp GL, Gomez JL. Single-cell characterization of a model of poly I:C-stimulated peripheral blood mononuclear cells in severe asthma. Respiratory Research 2021, 22: 122. PMID: 33902571, PMCID: PMC8074196, DOI: 10.1186/s12931-021-01709-9.
- Salka K, Abutaleb K, Chorvinsky E, Thiruvengadam G, Arroyo M, Gomez JL, Gutierrez MJ, Pillai DK, Jaiswal JK, Nino G. IFN Stimulates ACE2 Expression in Pediatric Airway Epithelial Cells. American Journal Of Respiratory Cell And Molecular Biology 2021, 64: 515-518. PMID: 33544656, PMCID: PMC8008803, DOI: 10.1165/rcmb.2020-0352le.
- Nouws J, Wan F, Finnemore E, Roque W, Kim SJ, Bazan IS, Li CX, Sköld C, Dai Q, Yan X, Chioccioli M, Neumeister V, Britto CJ, Sweasy J, Bindra RS, Wheelock ÅM, Gomez JL, Kaminski N, Lee PJ, Sauler M. MicroRNA miR-24-3p reduces DNA damage responses, apoptosis, and susceptibility to chronic obstructive pulmonary disease. JCI Insight 2021, 6: e134218. PMID: 33290275, PMCID: PMC7934877, DOI: 10.1172/jci.insight.134218.
- Gao R, Peng X, Perry C, Sun H, Ntokou A, Ryu C, Gomez JL, Reeves BC, Walia A, Kaminski N, Neumark N, Ishikawa G, Black KE, Hariri LP, Moore MW, Gulati M, Homer RJ, Greif DM, Eltzschig HK, Herzog EL. Macrophage-derived netrin-1 drives adrenergic nerve–associated lung fibrosis. Journal Of Clinical Investigation 2021, 131: e136542. PMID: 33393489, PMCID: PMC7773383, DOI: 10.1172/jci136542.
- Schupp JC, Khanal S, Gomez JL, Sauler M, Adams TS, Chupp GL, Yan X, Poli S, Zhao Y, Montgomery RR, Rosas IO, Dela Cruz CS, Bruscia EM, Egan ME, Kaminski N, Britto CJ. Single-Cell Transcriptional Archetypes of Airway Inflammation in Cystic Fibrosis. American Journal Of Respiratory And Critical Care Medicine 2020, 202: 1419-1429. PMID: 32603604, PMCID: PMC7667912, DOI: 10.1164/rccm.202004-0991oc.
- Ryu C, Walia A, Ortiz V, Perry C, Woo S, Reeves BC, Sun H, Winkler J, Kanyo JE, Wang W, Vukmirovic M, Ristic N, Stratton EA, Meena SR, Minasyan M, Kurbanov D, Liu X, Lam TT, Farina G, Gomez JL, Gulati M, Herzog EL. Bioactive Plasma Mitochondrial DNA Is Associated With Disease Progression in Scleroderma‐Associated Interstitial Lung Disease. Arthritis & Rheumatology 2020, 72: 1905-1915. PMID: 32602227, PMCID: PMC8081728, DOI: 10.1002/art.41418.
- Spakowicz D, Lou S, Barron B, Gomez JL, Li T, Liu Q, Grant N, Yan X, Hoyd R, Weinstock G, Chupp GL, Gerstein M. Approaches for integrating heterogeneous RNA-seq data reveal cross-talk between microbes and genes in asthmatic patients. Genome Biology 2020, 21: 150. PMID: 32571363, PMCID: PMC7310008, DOI: 10.1186/s13059-020-02033-z.
- Gomez JL, Chen A, Diaz MP, Zirn N, Gupta A, Britto C, Sauler M, Yan X, Stewart E, Santerian K, Grant N, Liu Q, Fry R, Rager J, Cohn L, Alexis N, Chupp GL. A Network of Sputum MicroRNAs is Associated with Neutrophilic Airway Inflammation in Asthma. American Journal Of Respiratory And Critical Care Medicine 2020, 0: 51-64. PMID: 32255668, PMCID: PMC7328332, DOI: 10.1164/rccm.201912-2360oc.
- Wang Z, Shan N, Yan X, Mane S, Gomez J, Chupp G. Whole Exome Sequencing of Severe Asthma Identifies Novel Gene Association Candidates. 2020, a1336-a1336. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a1336.
- Kalra S, Rebaza A, Bermejo S, Gomez J, Dela Cruz C. Characteristics and Outcomes of Adults with Multiple Co-Occurring Respiratory Viral Infections. 2020, a2953-a2953. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2953.
- Nino CL, Perez GF, Isaza N, Gutierrez MJ, Gomez JL, Nino G. Author Correction: Characterization of Sex-Based Dna Methylation Signatures in the Airways During Early Life. Scientific Reports 2020, 10: 3877. PMID: 32099017, PMCID: PMC7042283, DOI: 10.1038/s41598-020-60913-7.
- Korde A, Ahangari F, Haslip M, Zhang X, Liu Q, Cohn L, Gomez JL, Chupp G, Pober JS, Gonzalez A, Takyar SS. An endothelial microRNA-1–regulated network controls eosinophil trafficking in asthma and chronic rhinosinusitis. Journal Of Allergy And Clinical Immunology 2020, 145: 550-562. PMID: 32035607, PMCID: PMC8440091, DOI: 10.1016/j.jaci.2019.10.031.
- Gomez J, Kaminski N, Himes B. Summary and Future Applications of Precision Medicine in Pulmonary, Critical Care, and Sleep Medicine. Respiratory Medicine 2020, 417-428. DOI: 10.1007/978-3-030-31507-8_28.
- Gomez J, Kaminski N, Himes B. Introduction. Respiratory Medicine 2020, 3-8. DOI: 10.1007/978-3-030-31507-8_1.
- Precision in Pulmonary, Critical Care and Sleep Medicine. A Clinical and Research Guide.Precision in Pulmonary, Critical Care and Sleep Medicine. A Clinical and Research Guide. Gomez JL, Himes BE, Kaminski N. Editor. First Edition. Springer Nature Switzerland, 2020.
- Gomez JL. Epigenetics in Asthma. Current Allergy And Asthma Reports 2019, 19: 56. PMID: 31776749, PMCID: PMC6986424, DOI: 10.1007/s11882-019-0886-y.
- Robertson NM, Kayongo A, Siddharthan T, Pollard SL, Villalobos JG, Ladd-Acosta C, Kirenga B, Checkley W. The role of epigenetics in respiratory health in urban populations in low and middle-income countries. Global Health, Epidemiology And Genomics 2019, 4: e8. PMID: 32047643, PMCID: PMC6983949, DOI: 10.1017/gheg.2019.7.
- Yan X, Liu Q, Mihaljinec A, Gomez J, Cohn L, Chupp G. Cell Lineage Defined by Single Cell Transcriptomics of the Sputum in Asthma. 2019, a6085-a6085. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a6085.
- Chu J, Yan X, Liang A, Hu B, Gomez J, Chupp G. Integration of Sputum eQTL and GWAS Indicates IL-27/EBI3 Pathway Is Associated with Severe Asthma. 2019, a6088-a6088. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a6088.
- Gomez J, Chen A, Yan X, Cohn L, Chupp G. MicroRNA miR-223 Is Associated with Lung Function Impairment and TH17 Inflammation in Asthma. 2019, a2929-a2929. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2929.
- Sauler M, Lamontagne M, Finnemore E, Herazo-Maya JD, Tedrow J, Zhang X, Morneau JE, Sciurba F, Timens W, Paré PD, Lee PJ, Kaminski N, Bossé Y, Gomez JL. The DNA repair transcriptome in severe COPD. European Respiratory Journal 2018, 52: 1701994. PMID: 30190272, PMCID: PMC6422831, DOI: 10.1183/13993003.01994-2017.
- Anathy V, Lahue KG, Chapman DG, Chia SB, Casey DT, Aboushousha R, van der Velden JLJ, Elko E, Hoffman SM, McMillan DH, Jones JT, Nolin JD, Abdalla S, Schneider R, Seward DJ, Roberson EC, Liptak MD, Cousins ME, Butnor KJ, Taatjes DJ, Budd RC, Irvin CG, Ho YS, Hakem R, Brown KK, Matsui R, Bachschmid MM, Gomez JL, Kaminski N, van der Vliet A, Janssen-Heininger YMW. Reducing protein oxidation reverses lung fibrosis. Nature Medicine 2018, 24: 1128-1135. PMID: 29988126, PMCID: PMC6204256, DOI: 10.1038/s41591-018-0090-y.
- Nino C, Perez G, Isaza N, Gutierrez M, Gomez J, Nino G. Characterization of Sex-Based Dna Methylation Signatures in the Airways During Early Life. Scientific Reports 2018, 8: 5526. PMID: 29615635, PMCID: PMC5882800, DOI: 10.1038/s41598-018-23063-5.
- Gomez JL, Diaz MP, Nino G, Britto CJ. Impaired type I interferon regulation in the blood transcriptome of recurrent asthma exacerbations. BMC Medical Genomics 2018, 11: 21. PMID: 29486764, PMCID: PMC5830339, DOI: 10.1186/s12920-018-0340-3.
- Gomez JL, Yan X, Holm CT, Grant N, Liu Q, Cohn L, Nezgovorova V, Meyers DA, Bleecker ER, Crisafi GM, Jarjour NN, Rogers L, Reibman J, Chupp GL. Characterisation of asthma subgroups associated with circulating YKL-40 levels. European Respiratory Journal 2017, 50: 1700800. PMID: 29025889, PMCID: PMC5967238, DOI: 10.1183/13993003.00800-2017.
- A novel pathway-based distance score enhances assessment of disease heterogeneity in gene expressionYan X, Liang A, Gomez J, Cohn L, Zhao H, Chupp GL. A novel pathway-based distance score enhances assessment of disease heterogeneity in gene expression. BMC Bioinformatics 2017, 18: 309. PMID: 28637421, PMCID: PMC5480187, DOI: 10.1186/s12859-017-1727-4.
- Rinne ST, Castaneda J, Lindenauer PK, Cleary PD, Paz HL, Gomez JL. Chronic Obstructive Pulmonary Disease Readmissions and Other Measures of Hospital Quality. American Journal Of Respiratory And Critical Care Medicine 2017, 196: 47-55. PMID: 28145726, PMCID: PMC5519962, DOI: 10.1164/rccm.201609-1944oc.
- Gomez JL, Kaminski N. Toward Precision Medicine of Symptom Control in Asthma. American Journal Of Respiratory And Critical Care Medicine 2017, 195: 147-148. PMID: 28084831, PMCID: PMC5394790, DOI: 10.1164/rccm.201608-1600ed.
- Gutierrez M, Gomez J, Perez G, Pancham K, Val S, Pillai D, Giri M, Ferrante S, Freishtat R, Rose M, Preciado D, Nino G. Airway Secretory microRNAome Changes during Rhinovirus Infection in Early Childhood. PLOS ONE 2016, 11: e0162244. PMID: 27643599, PMCID: PMC5028059, DOI: 10.1371/journal.pone.0162244.
- Duncan G, Lockett A, Villegas L, Almodovar S, Gomez J, Flores S, Wilkes D, Tigno X. National Heart, Lung, and Blood Institute Workshop Summary: Enhancing Opportunities for Training and Retention of a Diverse Biomedical Workforce. Annals Of The American Thoracic Society 2016, 13: 562-7. PMID: 27058184, PMCID: PMC5012697, DOI: 10.1513/annalsats.201509-624ot.
- Yan X, Chu JH, Gomez J, Koenigs M, Holm C, He X, Perez MF, Zhao H, Mane S, Martinez FD, Ober C, Nicolae DL, Barnes KC, London SJ, Gilliland F, Weiss ST, Raby BA, Cohn L, Chupp GL. Noninvasive Analysis of the Sputum Transcriptome Discriminates Clinical Phenotypes of Asthma. Annals Of The American Thoracic Society 2016, 13 Suppl 1: s104-5. PMID: 27027945, PMCID: PMC5015745, DOI: 10.1513/annalsats.201510-681mg.
- Yan X, Chu JH, Gomez J, Koenigs M, Holm C, He X, Perez MF, Zhao H, Mane S, Martinez FD, Ober C, Nicolae DL, Barnes KC, London SJ, Gilliland F, Weiss ST, Raby BA, Cohn L, Chupp GL. Noninvasive Analysis of the Sputum Transcriptome Discriminates Clinical Phenotypes of Asthma. American Journal Of Respiratory And Critical Care Medicine 2015, 191: 1116-1125. PMID: 25763605, PMCID: PMC4451618, DOI: 10.1164/rccm.201408-1440oc.
- Gomez JL, Crisafi GM, Holm CT, Meyers DA, Hawkins GA, Bleecker ER, Jarjour N, Investigators S, Cohn L, Chupp GL. Genetic variation in chitinase 3-like 1 (CHI3L1) contributes to asthma severity and airway expression of YKL-40. Journal Of Allergy And Clinical Immunology 2015, 136: 51-58.e10. PMID: 25592985, PMCID: PMC4494869, DOI: 10.1016/j.jaci.2014.11.027.
- Guillain–Barré syndrome mimics primary biliary cirrhosis-related myopathyMunday WR, DiCapua D, Vortmeyer A, Gomez JL. Guillain–Barré syndrome mimics primary biliary cirrhosis-related myopathy. Oxf Med Case Rep 2015;4: 272-275
- Aspirin- and Exercise-Induced AsthmaGomez JL, Chupp GL, Geba G. Aspirin- and Exercise-Induced Asthma. In: Fishman’s Pulmonary Diseases and Disorders, Fifth Edition, by Drs. Michael A. Grippi, Jack A. Elias, Jay A. Fishman, Allan I. Pack and Robert M. Senior., McGraw-Hill Co., New York, NY, 2015, pp. 715-729.
- Acid-Base State: The Stewart Approach. In: Nefrologia Critica (Critical Care Nephrology).Kellum JA, Hoste E, Gomez JL. Acid-Base State: The Stewart Approach. In: Nefrologia Critica (Critical Care Nephrology). 1st ed. Buenos Aires, Argentina. Ediciones Journal. Chapter 16.
- Definition of Acute Renal FailureKellum JA, Hoste E, Gomez JL. Definition of Acute Renal Failure. In: Nefrologia Critica (Critical Care Nephrology). 1st ed. Buenos Aires, Argentina. Ediciones Journal. Chapter 1.
- Roundtable: Adult Asthma and AllergiesGorin A, Gomez JL. Roundtable: Adult Asthma and Allergies. Journal of Asthma and Allergy Educators. 2013, 4:87-89
- Gomez J, Perez M, He X, Mitchell A, Holm C, Chupp G. Characterization Of Chitinase Activity And YKL-40 Expression In Induced Sputum From Asthmatics: Correlations With Inflammation And Cell Viability And Gene Expression. 2010, a4279-a4279. DOI: 10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a4279.
- Gómez JL, Gunnerson KJ, Song M, Li J, Kellum JA. Effects of hypercapnia on BP in hypoalbuminemic and Nagase analbuminemic rats. Chest 2007, 131: 1295-300. PMID: 17494780, DOI: 10.1378/chest.06-2069.
- Winchester Center for Lung DiseaseFitkin Memorial Pavilion789 Howard AvenueNew Haven, CT 06519
- Winchester Center for Lung Disease6 Devine StreetNorth Haven, CT 06473
Biography
Jose L. Gomez-Villalobos, MD, MS, works to connect patients with state-of-the-art resources for asthma and chronic obstructive pulmonary disease (COPD). He shares with his patients that there are an increasing number of resources to help them control their disease and improve their lives. “We have have established a program to improve our understanding of the disease and help develop novel therapies to decrease the time from discovery to treatment,” he says.
An assistant professor of medicine (pulmonary) at Yale School of Medicine, Dr. Gomez-Villalobos also studies the biological mechanisms behind secondhand smoke and severe asthma.
Titles
- Associate Professor of Medicine (Pulmonary, Critical Care and Sleep Medicine)
- Affiliated Faculty, Yale Institute for Global Health
Education & Training
- MSYale University Graduate School of Arts and Sciences, Computational Biology and Bioinformatics (2012)
- FellowYale University School of Medicine (2012)
- ResidencyHospital of Saint Raphael, New Haven, CT (2007)
- Graduate Teaching AssistantPontificia Universidad Javeriana (1999)
- MDPontificia Universidad Javeriana (1999)
Languages Spoken
- English
- Español (Spanish)
Additional Information
- Fellow: American Thoracic Society (2019)
- Outstanding PGY-1 Resident: Hospital of Saint Raphael (2005)
- AB of Internal Medicine, Critical Care Medicine (Internal Medicine) (2012, recertified: 2023)
- AB of Internal Medicine, Pulmonary Disease (2011, recertified: 2021)
- AB of Internal Medicine, Internal Medicine (2007, recertified: 2017)
- National Institutes of Health-Therapeutic Approaches to Genetic Diseases Study Section (2023 - Present): Member
- American Thoracic Society, Allergy, Immunology and Inflammation Assembly (2019 - 2021): Executive Committee Member
- American Thoracic Society (2019 - Present): Research Committee Member
- American Thoracic Society, Genetics and Genomics Section (2016 - 2018): Executive Committee Member
- Spanish National Agency for Scientific Evaluation (ANEP) (2015): Reviewer
- American Thoracic Society, Web Committee, Allergy, Immunology and Inflammation Assembly (2015 - Present): Committee Member
- Pulmonary and Critical Care Fellowship Journal Club (2014 - 2022): Coordinator
- Pulmonary and Critical Care Fellowship Curriculum (2009 - 2012): Committee Member
- Chest, American Journal of Respiratory and Critical Care Medicine, BMC Pulmonary Medicine, Journal of Preventive Medicine, Thorax, AJP Lung, Nature Communications, European Respiratory Journal, Respiratory Research (2009 - Present): Reviewer
- Unterman A, Zhao A, Neumark N, Schupp J, Ahangari F, Cosme C, Sharma P, Flint J, Stein Y, Ryu C, Ishikawa G, Sumida T, Gomez J, Herazo-Maya J, Dela Cruz C, Herzog E, Kaminski N. Single-Cell Profiling Reveals Immune Aberrations in Progressive Idiopathic Pulmonary Fibrosis. American Journal Of Respiratory And Critical Care Medicine 2024, 210: 484-496. PMID: 38717443, PMCID: PMC11351796, DOI: 10.1164/rccm.202306-0979oc.
- Yin H, Kockar Kizilirmak T, Li N, Adams T, Sauler M, Gomez J, Britto-Leon C. CFTR Modulators Reprogram Sex-Specific Airway Neutrophil Signaling. 2024, a7454-a7454. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a7454.
- Gautam S, Chu J, Cohen A, Kaur R, Lee S, Wilson G, Liu Q, Gomez J, Rajaveen H, Yan X, Cohn L, Clark B, Chupp G. Sputum alarmins delineate distinct T2 cytokine pathways and unique subtypes of patients with asthma. Allergy 2023, 78: 3274-3277. PMID: 37874609, PMCID: PMC10842366, DOI: 10.1111/all.15915.
- Li B, Wang Y, Wang Z, Li X, Kay S, Chupp G, Zhao H, Gomez J. Shared genetic architecture of blood eosinophil counts and asthma in UK Biobank. ERJ Open Research 2023, 9: 00291-2023. PMID: 37650091, PMCID: PMC10463033, DOI: 10.1183/23120541.00291-2023.
- Liu Y, Rajeevan H, Simonov M, Wilson F, Desir G, Vinetz J, Yan X, Wang Z, Clark B, Possick J, Price C, Lutchmansingh D, Gomez J, Cohn L, Gautam S, Chupp G. Mortality Differences Among Patients With Airway Disease Hospitalized With COVID-19. 2023, a6297-a6297. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6297.
- Li H, Lopez K, Lipkin-Moore Z, Kay S, Rajeevan H, Davis J, Wilson F, Rochester C, Gomez J. Machine Learning Prediction of Severe Asthma and COPD Hospital Readmission. 2023, a4831-a4831. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a4831.
- Lopez K, Li H, Lipkin-Moore Z, Kay S, Rajeevan H, Davis J, Wilson F, Rochester C, Gomez J. Deep learning prediction of hospital readmissions for asthma and COPD. Respiratory Research 2023, 24: 311. PMID: 38093373, PMCID: PMC10720134, DOI: 10.1186/s12931-023-02628-7.
- Cui H, Xie N, Banerjee S, Dey T, Liu RM, Antony VB, Sanders YY, Adams TS, Gomez JL, Thannickal VJ, Kaminski N, Liu G. CD38 Mediates Lung Fibrosis by Promoting Alveolar Epithelial Cell Aging. American Journal Of Respiratory And Critical Care Medicine 2022, 206: 459-475. PMID: 35687485, DOI: 10.1164/rccm.202109-2151oc.
- Sauler M, McDonough JE, Adams TS, Kothapalli N, Barnthaler T, Werder RB, Schupp JC, Nouws J, Robertson MJ, Coarfa C, Yang T, Chioccioli M, Omote N, Cosme C, Poli S, Ayaub EA, Chu SG, Jensen KH, Gomez JL, Britto CJ, Raredon MSB, Niklason LE, Wilson AA, Timshel PN, Kaminski N, Rosas IO. Characterization of the COPD alveolar niche using single-cell RNA sequencing. Nature Communications 2022, 13: 494. PMID: 35078977, PMCID: PMC8789871, DOI: 10.1038/s41467-022-28062-9.
- Kumar A, Elko E, Bruno SR, Mark ZF, Chamberlain N, Mihavics BK, Chandrasekaran R, Walzer J, Ruban M, Gold C, Lam YW, Ghandikota S, Jegga AG, Gomez JL, Janssen-Heininger YM, Anathy V. Inhibition of PDIA3 in club cells attenuates osteopontin production and lung fibrosis. Thorax 2021, 77: 669-678. PMID: 34400514, PMCID: PMC8847543, DOI: 10.1136/thoraxjnl-2021-216882.
- Gutierrez MJ, Perez GF, Gomez JL, Rodriguez‐Martinez C, Castro‐Rodriguez J, Nino G. Genes, environment, and developmental timing: New insights from translational approaches to understand early origins of respiratory diseases. Pediatric Pulmonology 2021, 56: 3157-3165. PMID: 34388306, PMCID: PMC8858026, DOI: 10.1002/ppul.25598.
- Khanal S, Webster M, Niu N, Zielonka J, Nunez M, Chupp G, Slade MD, Cohn L, Sauler M, Gomez JL, Tarran R, Sharma L, Dela Cruz CS, Egan M, Laguna T, Britto CJ. SPLUNC1: a novel marker of cystic fibrosis exacerbations. European Respiratory Journal 2021, 58: 2000507. PMID: 33958427, PMCID: PMC8571118, DOI: 10.1183/13993003.00507-2020.
- Kumar A, Elko E, Bruno S, Mark Z, Chamberlain N, Korwin-Mihavics B, Chandrasekaran R, walzer J, Ruban M, Gold C, Lam Y, Gomez J, Janssen-Heininger Y, Anathy V. Ablation or Inhibition of Protein Disulfide Isomerase A3 (PDIA3) in Club Cells Attenuates Osteopontin (SPP1) Production and Lung Fibrosis. 2021, a4241-a4241. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4241.
- Alapaty S, Siner J, Sauler M, Baldassarri S, Davis J, Gomez J. Lung Compliance Clusters of COVID-ARDS Identify Distinct Subgroups with Increased Mortality. 2021, a2492-a2492. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a2492.
- Chen A, Diaz-Soto MP, Sanmamed MF, Adams T, Schupp JC, Gupta A, Britto C, Sauler M, Yan X, Liu Q, Nino G, Cruz CSD, Chupp GL, Gomez JL. Single-cell characterization of a model of poly I:C-stimulated peripheral blood mononuclear cells in severe asthma. Respiratory Research 2021, 22: 122. PMID: 33902571, PMCID: PMC8074196, DOI: 10.1186/s12931-021-01709-9.
- Salka K, Abutaleb K, Chorvinsky E, Thiruvengadam G, Arroyo M, Gomez JL, Gutierrez MJ, Pillai DK, Jaiswal JK, Nino G. IFN Stimulates ACE2 Expression in Pediatric Airway Epithelial Cells. American Journal Of Respiratory Cell And Molecular Biology 2021, 64: 515-518. PMID: 33544656, PMCID: PMC8008803, DOI: 10.1165/rcmb.2020-0352le.
- Nouws J, Wan F, Finnemore E, Roque W, Kim SJ, Bazan IS, Li CX, Sköld C, Dai Q, Yan X, Chioccioli M, Neumeister V, Britto CJ, Sweasy J, Bindra RS, Wheelock ÅM, Gomez JL, Kaminski N, Lee PJ, Sauler M. MicroRNA miR-24-3p reduces DNA damage responses, apoptosis, and susceptibility to chronic obstructive pulmonary disease. JCI Insight 2021, 6: e134218. PMID: 33290275, PMCID: PMC7934877, DOI: 10.1172/jci.insight.134218.
- Gao R, Peng X, Perry C, Sun H, Ntokou A, Ryu C, Gomez JL, Reeves BC, Walia A, Kaminski N, Neumark N, Ishikawa G, Black KE, Hariri LP, Moore MW, Gulati M, Homer RJ, Greif DM, Eltzschig HK, Herzog EL. Macrophage-derived netrin-1 drives adrenergic nerve–associated lung fibrosis. Journal Of Clinical Investigation 2021, 131: e136542. PMID: 33393489, PMCID: PMC7773383, DOI: 10.1172/jci136542.
- Schupp JC, Khanal S, Gomez JL, Sauler M, Adams TS, Chupp GL, Yan X, Poli S, Zhao Y, Montgomery RR, Rosas IO, Dela Cruz CS, Bruscia EM, Egan ME, Kaminski N, Britto CJ. Single-Cell Transcriptional Archetypes of Airway Inflammation in Cystic Fibrosis. American Journal Of Respiratory And Critical Care Medicine 2020, 202: 1419-1429. PMID: 32603604, PMCID: PMC7667912, DOI: 10.1164/rccm.202004-0991oc.
- Ryu C, Walia A, Ortiz V, Perry C, Woo S, Reeves BC, Sun H, Winkler J, Kanyo JE, Wang W, Vukmirovic M, Ristic N, Stratton EA, Meena SR, Minasyan M, Kurbanov D, Liu X, Lam TT, Farina G, Gomez JL, Gulati M, Herzog EL. Bioactive Plasma Mitochondrial DNA Is Associated With Disease Progression in Scleroderma‐Associated Interstitial Lung Disease. Arthritis & Rheumatology 2020, 72: 1905-1915. PMID: 32602227, PMCID: PMC8081728, DOI: 10.1002/art.41418.
- Spakowicz D, Lou S, Barron B, Gomez JL, Li T, Liu Q, Grant N, Yan X, Hoyd R, Weinstock G, Chupp GL, Gerstein M. Approaches for integrating heterogeneous RNA-seq data reveal cross-talk between microbes and genes in asthmatic patients. Genome Biology 2020, 21: 150. PMID: 32571363, PMCID: PMC7310008, DOI: 10.1186/s13059-020-02033-z.
- Gomez JL, Chen A, Diaz MP, Zirn N, Gupta A, Britto C, Sauler M, Yan X, Stewart E, Santerian K, Grant N, Liu Q, Fry R, Rager J, Cohn L, Alexis N, Chupp GL. A Network of Sputum MicroRNAs is Associated with Neutrophilic Airway Inflammation in Asthma. American Journal Of Respiratory And Critical Care Medicine 2020, 0: 51-64. PMID: 32255668, PMCID: PMC7328332, DOI: 10.1164/rccm.201912-2360oc.
- Wang Z, Shan N, Yan X, Mane S, Gomez J, Chupp G. Whole Exome Sequencing of Severe Asthma Identifies Novel Gene Association Candidates. 2020, a1336-a1336. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a1336.
- Kalra S, Rebaza A, Bermejo S, Gomez J, Dela Cruz C. Characteristics and Outcomes of Adults with Multiple Co-Occurring Respiratory Viral Infections. 2020, a2953-a2953. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2953.
- Nino CL, Perez GF, Isaza N, Gutierrez MJ, Gomez JL, Nino G. Author Correction: Characterization of Sex-Based Dna Methylation Signatures in the Airways During Early Life. Scientific Reports 2020, 10: 3877. PMID: 32099017, PMCID: PMC7042283, DOI: 10.1038/s41598-020-60913-7.
- Korde A, Ahangari F, Haslip M, Zhang X, Liu Q, Cohn L, Gomez JL, Chupp G, Pober JS, Gonzalez A, Takyar SS. An endothelial microRNA-1–regulated network controls eosinophil trafficking in asthma and chronic rhinosinusitis. Journal Of Allergy And Clinical Immunology 2020, 145: 550-562. PMID: 32035607, PMCID: PMC8440091, DOI: 10.1016/j.jaci.2019.10.031.
- Gomez J, Kaminski N, Himes B. Summary and Future Applications of Precision Medicine in Pulmonary, Critical Care, and Sleep Medicine. Respiratory Medicine 2020, 417-428. DOI: 10.1007/978-3-030-31507-8_28.
- Gomez J, Kaminski N, Himes B. Introduction. Respiratory Medicine 2020, 3-8. DOI: 10.1007/978-3-030-31507-8_1.
- Precision in Pulmonary, Critical Care and Sleep Medicine. A Clinical and Research Guide.Precision in Pulmonary, Critical Care and Sleep Medicine. A Clinical and Research Guide. Gomez JL, Himes BE, Kaminski N. Editor. First Edition. Springer Nature Switzerland, 2020.
- Gomez JL. Epigenetics in Asthma. Current Allergy And Asthma Reports 2019, 19: 56. PMID: 31776749, PMCID: PMC6986424, DOI: 10.1007/s11882-019-0886-y.
- Robertson NM, Kayongo A, Siddharthan T, Pollard SL, Villalobos JG, Ladd-Acosta C, Kirenga B, Checkley W. The role of epigenetics in respiratory health in urban populations in low and middle-income countries. Global Health, Epidemiology And Genomics 2019, 4: e8. PMID: 32047643, PMCID: PMC6983949, DOI: 10.1017/gheg.2019.7.
- Yan X, Liu Q, Mihaljinec A, Gomez J, Cohn L, Chupp G. Cell Lineage Defined by Single Cell Transcriptomics of the Sputum in Asthma. 2019, a6085-a6085. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a6085.
- Chu J, Yan X, Liang A, Hu B, Gomez J, Chupp G. Integration of Sputum eQTL and GWAS Indicates IL-27/EBI3 Pathway Is Associated with Severe Asthma. 2019, a6088-a6088. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a6088.
- Gomez J, Chen A, Yan X, Cohn L, Chupp G. MicroRNA miR-223 Is Associated with Lung Function Impairment and TH17 Inflammation in Asthma. 2019, a2929-a2929. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2929.
- Sauler M, Lamontagne M, Finnemore E, Herazo-Maya JD, Tedrow J, Zhang X, Morneau JE, Sciurba F, Timens W, Paré PD, Lee PJ, Kaminski N, Bossé Y, Gomez JL. The DNA repair transcriptome in severe COPD. European Respiratory Journal 2018, 52: 1701994. PMID: 30190272, PMCID: PMC6422831, DOI: 10.1183/13993003.01994-2017.
- Anathy V, Lahue KG, Chapman DG, Chia SB, Casey DT, Aboushousha R, van der Velden JLJ, Elko E, Hoffman SM, McMillan DH, Jones JT, Nolin JD, Abdalla S, Schneider R, Seward DJ, Roberson EC, Liptak MD, Cousins ME, Butnor KJ, Taatjes DJ, Budd RC, Irvin CG, Ho YS, Hakem R, Brown KK, Matsui R, Bachschmid MM, Gomez JL, Kaminski N, van der Vliet A, Janssen-Heininger YMW. Reducing protein oxidation reverses lung fibrosis. Nature Medicine 2018, 24: 1128-1135. PMID: 29988126, PMCID: PMC6204256, DOI: 10.1038/s41591-018-0090-y.
- Nino C, Perez G, Isaza N, Gutierrez M, Gomez J, Nino G. Characterization of Sex-Based Dna Methylation Signatures in the Airways During Early Life. Scientific Reports 2018, 8: 5526. PMID: 29615635, PMCID: PMC5882800, DOI: 10.1038/s41598-018-23063-5.
- Gomez JL, Diaz MP, Nino G, Britto CJ. Impaired type I interferon regulation in the blood transcriptome of recurrent asthma exacerbations. BMC Medical Genomics 2018, 11: 21. PMID: 29486764, PMCID: PMC5830339, DOI: 10.1186/s12920-018-0340-3.
- Gomez JL, Yan X, Holm CT, Grant N, Liu Q, Cohn L, Nezgovorova V, Meyers DA, Bleecker ER, Crisafi GM, Jarjour NN, Rogers L, Reibman J, Chupp GL. Characterisation of asthma subgroups associated with circulating YKL-40 levels. European Respiratory Journal 2017, 50: 1700800. PMID: 29025889, PMCID: PMC5967238, DOI: 10.1183/13993003.00800-2017.
- A novel pathway-based distance score enhances assessment of disease heterogeneity in gene expressionYan X, Liang A, Gomez J, Cohn L, Zhao H, Chupp GL. A novel pathway-based distance score enhances assessment of disease heterogeneity in gene expression. BMC Bioinformatics 2017, 18: 309. PMID: 28637421, PMCID: PMC5480187, DOI: 10.1186/s12859-017-1727-4.
- Rinne ST, Castaneda J, Lindenauer PK, Cleary PD, Paz HL, Gomez JL. Chronic Obstructive Pulmonary Disease Readmissions and Other Measures of Hospital Quality. American Journal Of Respiratory And Critical Care Medicine 2017, 196: 47-55. PMID: 28145726, PMCID: PMC5519962, DOI: 10.1164/rccm.201609-1944oc.
- Gomez JL, Kaminski N. Toward Precision Medicine of Symptom Control in Asthma. American Journal Of Respiratory And Critical Care Medicine 2017, 195: 147-148. PMID: 28084831, PMCID: PMC5394790, DOI: 10.1164/rccm.201608-1600ed.
- Gutierrez M, Gomez J, Perez G, Pancham K, Val S, Pillai D, Giri M, Ferrante S, Freishtat R, Rose M, Preciado D, Nino G. Airway Secretory microRNAome Changes during Rhinovirus Infection in Early Childhood. PLOS ONE 2016, 11: e0162244. PMID: 27643599, PMCID: PMC5028059, DOI: 10.1371/journal.pone.0162244.
- Duncan G, Lockett A, Villegas L, Almodovar S, Gomez J, Flores S, Wilkes D, Tigno X. National Heart, Lung, and Blood Institute Workshop Summary: Enhancing Opportunities for Training and Retention of a Diverse Biomedical Workforce. Annals Of The American Thoracic Society 2016, 13: 562-7. PMID: 27058184, PMCID: PMC5012697, DOI: 10.1513/annalsats.201509-624ot.
- Yan X, Chu JH, Gomez J, Koenigs M, Holm C, He X, Perez MF, Zhao H, Mane S, Martinez FD, Ober C, Nicolae DL, Barnes KC, London SJ, Gilliland F, Weiss ST, Raby BA, Cohn L, Chupp GL. Noninvasive Analysis of the Sputum Transcriptome Discriminates Clinical Phenotypes of Asthma. Annals Of The American Thoracic Society 2016, 13 Suppl 1: s104-5. PMID: 27027945, PMCID: PMC5015745, DOI: 10.1513/annalsats.201510-681mg.
- Yan X, Chu JH, Gomez J, Koenigs M, Holm C, He X, Perez MF, Zhao H, Mane S, Martinez FD, Ober C, Nicolae DL, Barnes KC, London SJ, Gilliland F, Weiss ST, Raby BA, Cohn L, Chupp GL. Noninvasive Analysis of the Sputum Transcriptome Discriminates Clinical Phenotypes of Asthma. American Journal Of Respiratory And Critical Care Medicine 2015, 191: 1116-1125. PMID: 25763605, PMCID: PMC4451618, DOI: 10.1164/rccm.201408-1440oc.
- Gomez JL, Crisafi GM, Holm CT, Meyers DA, Hawkins GA, Bleecker ER, Jarjour N, Investigators S, Cohn L, Chupp GL. Genetic variation in chitinase 3-like 1 (CHI3L1) contributes to asthma severity and airway expression of YKL-40. Journal Of Allergy And Clinical Immunology 2015, 136: 51-58.e10. PMID: 25592985, PMCID: PMC4494869, DOI: 10.1016/j.jaci.2014.11.027.
- Guillain–Barré syndrome mimics primary biliary cirrhosis-related myopathyMunday WR, DiCapua D, Vortmeyer A, Gomez JL. Guillain–Barré syndrome mimics primary biliary cirrhosis-related myopathy. Oxf Med Case Rep 2015;4: 272-275
- Aspirin- and Exercise-Induced AsthmaGomez JL, Chupp GL, Geba G. Aspirin- and Exercise-Induced Asthma. In: Fishman’s Pulmonary Diseases and Disorders, Fifth Edition, by Drs. Michael A. Grippi, Jack A. Elias, Jay A. Fishman, Allan I. Pack and Robert M. Senior., McGraw-Hill Co., New York, NY, 2015, pp. 715-729.
- Acid-Base State: The Stewart Approach. In: Nefrologia Critica (Critical Care Nephrology).Kellum JA, Hoste E, Gomez JL. Acid-Base State: The Stewart Approach. In: Nefrologia Critica (Critical Care Nephrology). 1st ed. Buenos Aires, Argentina. Ediciones Journal. Chapter 16.
- Definition of Acute Renal FailureKellum JA, Hoste E, Gomez JL. Definition of Acute Renal Failure. In: Nefrologia Critica (Critical Care Nephrology). 1st ed. Buenos Aires, Argentina. Ediciones Journal. Chapter 1.
- Roundtable: Adult Asthma and AllergiesGorin A, Gomez JL. Roundtable: Adult Asthma and Allergies. Journal of Asthma and Allergy Educators. 2013, 4:87-89
- Gomez J, Perez M, He X, Mitchell A, Holm C, Chupp G. Characterization Of Chitinase Activity And YKL-40 Expression In Induced Sputum From Asthmatics: Correlations With Inflammation And Cell Viability And Gene Expression. 2010, a4279-a4279. DOI: 10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a4279.
- Gómez JL, Gunnerson KJ, Song M, Li J, Kellum JA. Effects of hypercapnia on BP in hypoalbuminemic and Nagase analbuminemic rats. Chest 2007, 131: 1295-300. PMID: 17494780, DOI: 10.1378/chest.06-2069.
- Winchester Center for Lung DiseaseFitkin Memorial Pavilion789 Howard AvenueNew Haven, CT 06519
- Winchester Center for Lung Disease6 Devine StreetNorth Haven, CT 06473
- Winchester Center for Lung DiseaseFitkin Memorial Pavilion789 Howard AvenueNew Haven, CT 06519
- Winchester Center for Lung Disease6 Devine StreetNorth Haven, CT 06473