John Sinard, MD, PhD
Biography
John H. Sinard, MD, PhD, is a pathologist who practices in many subspecialty areas but specializes in diagnosing eye diseases. When he is not examining tissue samples of patients, Dr. Sinard works closely with the pathology department’s technology team within Yale Pathology Informatics, a program that he helped build from the ground up. “We have developed in-house software that doesn’t exist anywhere else in the world,” Dr. Sinard says. “It helps facilitate the accuracy of patient specimens and provides important diagnostic information to the pathologist.”
Similar to this specialized software system, pathologists perform necessary roles in patient care behind the scenes, Dr. Sinard explains. “A specialty physician may see between five and 10 patients each day, while a pathologist may be treating 20 to 80 patients every day.”
At the Yale School of Medicine, Dr. Sinard currently serves as medical director of pathology informatics and professor of pathology and of ophthalmology.
Titles
- Professor of Pathology and of Ophthalmology and Visual Science
- Medical Director, Pathology Informatics, Pathology
Education & Training
- FellowYale University School of Medicine (1995)
- ResidentYale-New Haven Hospital (1993)
- MDJohns Hopkins University (1990)
- PhDJohns Hopkins University (1990)
- ABHarvard University (1982)
Additional Information
- Lifetime Achievement Award: College of American Pathologists (2018)
- Averill Liebow Resident Teaching Award: Yale Pathology (2018)
- F.K. Mostofi Distinguished Service Award: United States and Canadian Academy of Pathology (2017)
- Averill Liebow Resident Teaching Award: Yale Pathology (2003)
- Averill Liebow Resident Teaching Award: Yale Pathology (1999)
- AB of Pathology, Clinical Informatics (2014)
- AB of Pathology, Anatomic Pathology (1994)
- Association of Pathology Chairs (2021 - Present): Clinical Service Leaders Committee
- College of American Pathologists (2019 - Present): Information Technology Leadership Committee
- College of American Pathologists (2017 - 2020): Vice Chair, Informatics Committee
- Yale Medical School (2017 - 2019): Senior Appointments and Promotions Committee
- College of American Pathologists (2015 - 2020): Council on Education
- Yale University (2015 - Present): University Safety Committee
- United States and Canadian Academy of Pathology (2014 - 2020): Secretary and Executive Committee Member
- Yale-New Haven Hospital (2014 - 2022): Perioperative Patient Safety and Quality Committee
- College of American Pathologists (2014 - 2017): Clinical Informatics Steering Committee
- College of American Pathologists (2013 - 2018): Council on Scientific Affairs
- Weiss M, Perzia B, Sinard J, Tran T, Maeng M. Primary Treatment of Eyelid Conjunctival Melanoma with Immunotherapy: A Case Report. Ophthalmic Plastic And Reconstructive Surgery 2024 PMID: 39240220, DOI: 10.1097/iop.0000000000002776.
- Obstfeld A, Brodsky V, Carter A, Gershkovich P, Haymond S, Levy B, Sinard J, Sellers D, Stoffel M, Jackups R. Proceedings of the Association for Pathology Informatics Bootcamp 2022. Journal Of Pathology Informatics 2023, 14: 100331. PMID: 37705688, PMCID: PMC10495674, DOI: 10.1016/j.jpi.2023.100331.
- Spadaro J, Chow R, Sinard J, Watsky K, Habib L. Chronic Lymphocytic Leukemia Presenting as Bilateral Periorbital Edema Treated With Low-dose Radiation Therapy. Ophthalmic Plastic And Reconstructive Surgery 2023, 39: e78-e81. PMID: 36852835, DOI: 10.1097/iop.0000000000002338.
- Dhodapkar R, Spadaro J, Heng J, Sinard J, Lee Y, Habib L, Pointdujour-Lim R. NK/T-cell Lymphoma With Orbital Involvement: A Case Report and Systematic Review of the Literature. Ophthalmic Plastic And Reconstructive Surgery 2023, 39: 316-327. PMID: 36692957, DOI: 10.1097/iop.0000000000002317.
- Berbís M, McClintock D, Bychkov A, Van der Laak J, Pantanowitz L, Lennerz J, Cheng J, Delahunt B, Egevad L, Eloy C, Farris A, Fraggetta F, del Moral R, Hartman D, Herrmann M, Hollemans E, Iczkowski K, Karsan A, Kriegsmann M, Salama M, Sinard J, Tuthill J, Williams B, Casado-Sánchez C, Sánchez-Turrión V, Luna A, Aneiros-Fernández J, Shen J. Computational pathology in 2030: a Delphi study forecasting the role of AI in pathology within the next decade. EBioMedicine 2023, 88: 104427. PMID: 36603288, PMCID: PMC9823157, DOI: 10.1016/j.ebiom.2022.104427.
- Darbinian N, Darbinyan A, Sinard J, Tatevosian G, Merabova N, D’Amico F, Khader T, Bajwa A, Martirosyan D, Gawlinski A, Pursnani R, Zhao H, Amini S, Morrison M, Goetzl L, Selzer M. Molecular Markers in Maternal Blood Exosomes Allow Early Detection of Fetal Alcohol Spectrum Disorders. International Journal Of Molecular Sciences 2022, 24: 135. PMID: 36613580, PMCID: PMC9820501, DOI: 10.3390/ijms24010135.
- Singh V, Mezzacappa C, Gershkovich P, Di Giovanna J, Ganzak A, Gibson J, Sinard J, Xicola RM, Llor X. Systems approach to enhance Lynch syndrome diagnosis through tumour testing. Journal Of Medical Genetics 2022, 60: 533-539. PMID: 36115663, PMCID: PMC10020126, DOI: 10.1136/jmg-2022-108770.
- Spadaro JZ, Sinard J, Habib L. Bilateral dacryoadenitis as the initial presentation of ANCA-associated vasculitis in a pediatric patient. Orbit 2022, 43: 231-235. PMID: 35801829, DOI: 10.1080/01676830.2022.2093920.
- Heng JS, Perzia BM, Sinard JH, Pointdujour-Lim R. Local recurrence of uveal melanoma and concomitant brain metastases associated with an activating telomerase promoter mutation seven years after secondary enucleation. American Journal Of Ophthalmology Case Reports 2022, 27: 101607. PMID: 35707052, PMCID: PMC9189986, DOI: 10.1016/j.ajoc.2022.101607.
- Zhang L, Lubin D, Sinard JH, Dickson BC, Antonescu CR, Wu H, Panni RZ, Dogan S, Untch BR, Ghossein RA, Xu B. Primary Mesenchymal Tumors of the Thyroid Gland: A Modern Retrospective Cohort Including the First Case of TFE3-Translocated Malignant Perivascular Epithelioid Cell Tumor (PEComa). Head And Neck Pathology 2022, 16: 716-727. PMID: 35218514, PMCID: PMC9424363, DOI: 10.1007/s12105-022-01428-7.
- Abdel-Aty A, Linderman WL, Kombo N, Sinard J, Pointdujour-Lim R. Necrotic Uveal Melanoma Mimics Orbital Cellulitis: A Review. Ocular Oncology And Pathology 2021, 8: 1-8. PMID: 35356597, PMCID: PMC8914239, DOI: 10.1159/000515558.
- Mir T, Megalla M, Sinard J, Wang J. Cilioretinal Artery Occlusion as the Presenting Manifestation of Left Atrial Myxoma. Journal Of VitreoRetinal Diseases 2021, 6: 320-323. PMID: 37007931, PMCID: PMC9976024, DOI: 10.1177/24741264211034114.
- Perincheri S, Levi AW, Celli R, Gershkovich P, Rimm D, Morrow JS, Rothrock B, Raciti P, Klimstra D, Sinard J. An independent assessment of an artificial intelligence system for prostate cancer detection shows strong diagnostic accuracy. Modern Pathology 2021, 34: 1588-1595. PMID: 33782551, PMCID: PMC8295034, DOI: 10.1038/s41379-021-00794-x.
- Morrow JS, Gershkovich P, Gibson J, Gilshannon M, Kowalski D, Levi AW, Nguyen DX, Rimm DL, Xu ML, Sinard J. Measuring Faculty Effort: A Quantitative Approach That Aligns Personal and Institutional Goals in Pathology at Yale. Academic Pathology 2021, 8: 23742895211047985. PMID: 34646939, PMCID: PMC8504692, DOI: 10.1177/23742895211047985.
- McGuone D, Sinard J, Gill JR, Masters A, Liu C, Morotti R, Parkash V. Autopsy Services and Emergency Preparedness of a Tertiary Academic Hospital Mortuary for the COVID-19 Public Health Emergency: The Yale Plan. Advances In Anatomic Pathology 2020, 27: 355-362. PMID: 32649315, DOI: 10.1097/pap.0000000000000274.
- Mazer BL, Paulson N, Sinard JH. Protecting the Pathology Commons in the Digital Era. Archives Of Pathology & Laboratory Medicine 2020, 144: 1037-1040. PMID: 32579394, DOI: 10.5858/arpa.2020-0022-ed.
- Maslin JS, Chen PP, Sinard J, Nguyen AT, Noecker R. Histopathologic changes in cadaver eyes after MicroPulse and continuous wave transscleral cyclophotocoagulation. Canadian Journal Of Ophthalmology 2020, 55: 330-335. PMID: 32446502, DOI: 10.1016/j.jcjo.2020.03.010.
- Li E, Sinard J, Sohrab M. Pulmonary Adenocarcinoma Metastatic to Periocular Skin and Orbital Tissue Presenting as Orbital Cellulitis. Ophthalmic Plastic And Reconstructive Surgery 2020, 36: e28-e30. PMID: 31789787, DOI: 10.1097/iop.0000000000001534.
- Sinard JH. An Analysis of the Effect of the COVID-19 Pandemic on Case Volumes in an Academic Subspecialty-Based Anatomic Pathology Practice. Academic Pathology 2020, 7: 2374289520959788. PMID: 33088911, PMCID: PMC7545513, DOI: 10.1177/2374289520959788.
- Stram M, Seheult J, Sinard JH, Campbell WS, Carter AB, de Baca ME, Quinn AM, Luu HS, Pathologists O. A Survey of LOINC Code Selection Practices Among Participants of the College of American Pathologists Coagulation (CGL) and Cardiac Markers (CRT) Proficiency Testing Programs. Archives Of Pathology & Laboratory Medicine 2019, 144: 586-596. PMID: 31603714, DOI: 10.5858/arpa.2019-0276-oa.
- Baine MK, Sinard JH, Cai G, Homer RJ. A Semiquantitative Scoring System May Allow Biopsy Diagnosis of Pulmonary Large Cell Neuroendocrine Carcinoma. American Journal Of Clinical Pathology 2019, 153: 165-174. PMID: 31593583, PMCID: PMC7571487, DOI: 10.1093/ajcp/aqz149.
- Kim JM, Weiss S, Sinard JH, Pointdujour-Lim R. Dabrafenib and Trametinib for BRAF-Mutated Conjunctival Melanoma. Ocular Oncology And Pathology 2019, 6: 35-38. PMID: 32002403, PMCID: PMC6984155, DOI: 10.1159/000497473.
- Li E, Sinard J, Distefano A, Sohrab M. Angiolymphoid Hyperplasia with Eosinophilia with Clinical Presentation Concerning for Juvenile Temporal Arteritis. Ocular Oncology And Pathology 2019, 6: 25-30. PMID: 32002401, PMCID: PMC6984143, DOI: 10.1159/000500361.
- Altan M, Toki MI, Gettinger SN, Carvajal-Hausdorf DE, Zugazagoitia J, Sinard JH, Herbst RS, Rimm DL. Immune Checkpoint Inhibitor–Associated Pericarditis. Journal Of Thoracic Oncology 2019, 14: 1102-1108. PMID: 30851443, PMCID: PMC6617516, DOI: 10.1016/j.jtho.2019.02.026.
- Li E, Silbert J, Sinard J. Pleomorphic lipoma of the bulbar conjunctiva. BMJ Case Reports 2018, 11: e226548. PMID: 30567236, PMCID: PMC6301450, DOI: 10.1136/bcr-2018-226548.
- Li E, Distefano A, Sinard J, Wong A, Pointdujour-Lim R. Epithelial–Myoepithelial Carcinoma Presenting as a Pseudo Veno-Lymphatic Malformation. Ophthalmic Plastic And Reconstructive Surgery 2018, 34: e157-e160. PMID: 30080758, DOI: 10.1097/iop.0000000000001179.
- Kim JM, Megalla M, Howard M, Sinard J, Pointdujour-Lim R. Orbital cellulitis with choroidal detachment following strabismus surgery in an adult. Journal Of American Association For Pediatric Ophthalmology And Strabismus 2018, 22: 477-480. PMID: 30171895, DOI: 10.1016/j.jaapos.2018.04.016.
- Celli R, Barbieri AL, Colunga M, Sinard J, Gibson JA. Optimal Intraoperative Assessment of Gastric Margins. American Journal Of Clinical Pathology 2018, 150: 353-363. PMID: 30020407, DOI: 10.1093/ajcp/aqy062.
- Apostolopoulos N, Sinard J, Kombo N. Bilateral Cicatrizing Conjunctivitis in a Middle-aged Man. JAMA Ophthalmology 2018, 136: 706-707. PMID: 29596593, DOI: 10.1001/jamaophthalmol.2017.5490.
- Kim JM, Hall LB, Elia M, Ehrlich MS, Materin MA, Sinard JH. Acute Presentation of Mesectodermal Leiomyoma of the Ciliary Body. Ocular Oncology And Pathology 2017, 3: 304-309. PMID: 29344486, PMCID: PMC5757584, DOI: 10.1159/000464466.
- Tainsh LT, Coady PA, Sinard JH, Neparidze N, Meskin SW, Adelman RA, Chow J. Asymmetric Deep Stromal Keratopathy in a Patient With Multiple Myeloma. Cornea 2017, 36: 372-374. PMID: 28079685, DOI: 10.1097/ico.0000000000001139.
- Gaudio PA, Sinard J, Shield DR, Huang JJ, King BA. Repeat Conjunctival Biopsy after Immunomodulatory Therapy for Ocular Mucous Membrane Pemphigoid. Ocular Immunology And Inflammation 2016, 26: 70-73. PMID: 27437791, DOI: 10.1080/09273948.2016.1194435.
- Henricks WH, Karcher DS, Harrison JH, Sinard JH, Riben MW, Boyer PJ, Plath S, Thompson A, Pantanowitz L. Pathology Informatics Essentials for Residents: A Flexible Informatics Curriculum Linked to Accreditation Council for Graduate Medical Education Milestones. Archives Of Pathology & Laboratory Medicine 2016, 141: 113-124. PMID: 27383543, DOI: 10.5858/arpa.2016-0199-oa.
- Henricks WH, Karcher DS, Harrison JH, Sinard JH, Riben MW, Boyer PJ, Plath S, Thompson A, Pantanowitz L. Pathology Informatics Essentials for Residents: A flexible informatics curriculum linked to Accreditation Council for Graduate Medical Education milestones. Journal Of Pathology Informatics 2016, 7: 27. PMID: 27563486, PMCID: PMC4977974, DOI: 10.4103/2153-3539.185673.
- Henricks WH, Karcher DS, Harrison JH, Sinard JH, Riben MW, Boyer PJ, Plath S, Thompson A, Pantanowitz L. Pathology Informatics Essentials for Residents. Academic Pathology 2016, 3: 2374289516659051. PMID: 28725772, PMCID: PMC5497905, DOI: 10.1177/2374289516659051.
- Gershkovich P, Sinard JH. Customizing Laboratory Information Systems. Advances In Anatomic Pathology 2015, 22: 323-330. PMID: 26262515, DOI: 10.1097/pap.0000000000000088.
- Louis DN, Feldman M, Carter AB, Dighe AS, Pfeifer JD, Bry L, Almeida JS, Saltz J, Braun J, Tomaszewski JE, Gilbertson JR, Sinard JH, Gerber GK, Galli SJ, Golden JA, Becich MJ. Computational Pathology. Archives Of Pathology & Laboratory Medicine 2015, 140: 41-50. PMID: 26098131, PMCID: PMC4996078, DOI: 10.5858/arpa.2015-0093-sa.
- Henricks WH, Wilkerson ML, Castellani WJ, Whitsitt MS, Sinard JH. Pathologists' Place in the Electronic Health Record Landscape. Archives Of Pathology & Laboratory Medicine 2015, 139: 307-10. PMID: 25724026, DOI: 10.5858/arpa.2013-0709-so.
- Henricks WH, Wilkerson ML, Castellani WJ, Whitsitt MS, Sinard JH. Pathologists as Stewards of Laboratory Information. Archives Of Pathology & Laboratory Medicine 2015, 139: 332-7. PMID: 25724030, DOI: 10.5858/arpa.2013-0714-so.
- Wilkerson ML, Henricks WH, Castellani WJ, Whitsitt MS, Sinard JH. Management of Laboratory Data and Information Exchange in the Electronic Health Record. Archives Of Pathology & Laboratory Medicine 2015, 139: 319-27. PMID: 25724028, DOI: 10.5858/arpa.2013-0712-so.
- Castellani WJ, Sinard JH, Wilkerson ML, Whitsitt MS, Henricks WH. Accreditation and Regulatory Implications of Electronic Health Records for Laboratory Reporting. Archives Of Pathology & Laboratory Medicine 2015, 139: 328-31. PMID: 25724029, DOI: 10.5858/arpa.2013-0713-so.
- Sinard JH, Castellani WJ, Wilkerson ML, Henricks WH. Stand-alone Laboratory Information Systems Versus Laboratory Modules Incorporated in the Electronic Health Record. Archives Of Pathology & Laboratory Medicine 2015, 139: 311-8. PMID: 25724027, DOI: 10.5858/arpa.2013-0711-so.
- Sinard J. Review of “digital pathology” by Yves Sucaet and Wim Waelput Y Sucaet W Waelput Review of “digital pathology” by Yves Sucaet and Wim Waelput 2015 Springer New York 83 10:978-3-319-08779-5. Journal Of Pathology Informatics 2015, 6: 12. PMCID: PMC4355838, DOI: 10.1016/s2153-3539(22)00467-9.
- Sinard JH, Powell SZ, Karcher DS. Pathology Training in Informatics: Evolving to Meet a Growing Need. Archives Of Pathology & Laboratory Medicine 2014, 138: 505-11. PMID: 24678681, DOI: 10.5858/arpa.2013-0328-ra.
- Sinard JH. In Response: It's All About What is Typical. Archives Of Pathology & Laboratory Medicine 2014, 138: 869-70. PMID: 24491222, DOI: 10.5858/arpa.2013-0427-edi.
- Oatts JT, Zhang Z, Tseng H, Shields MB, Sinard JH, Loewen NA. In Vitro and In Vivo Comparison of Two Suprachoroidal ShuntsComparison of Two Suprachoroidal Shunts. Investigative Ophthalmology & Visual Science 2013, 54: 5416-5423. PMID: 23847318, PMCID: PMC4141703, DOI: 10.1167/iovs.13-11853.
- Niccolai LM, Russ C, Julian PJ, Hariri S, Sinard J, Meek JI, McBride V, Markowitz LE, Unger ER, Hadler JL, Sosa LE. Individual and geographic disparities in human papillomavirus types 16/18 in high‐grade cervical lesions. Cancer 2013, 119: 3052-3058. PMID: 23661284, DOI: 10.1002/cncr.28038.
- Pantanowitz L, Mackinnon AC, Sinard JH. Tracking in Anatomic Pathology. Archives Of Pathology & Laboratory Medicine 2013, 137: 1798-810. PMID: 23634908, DOI: 10.5858/arpa.2013-0125-sa.
- Pantanowitz L, Sinard JH, Henricks WH, Fatheree LA, Carter AB, Contis L, Beckwith BA, Evans AJ, Lal A, Parwani AV. Validating Whole Slide Imaging for Diagnostic Purposes in Pathology: Guideline from the College of American Pathologists Pathology and Laboratory Quality Center. Archives Of Pathology & Laboratory Medicine 2013, 137: 1710-22. PMID: 23634907, PMCID: PMC7240346, DOI: 10.5858/arpa.2013-0093-cp.
- Salchow DJ, Sinard J. Management of lens dislocation and iris cyst after iris sutured intraocular lens implantation in children with Marfan syndrome. Journal Of Pediatric Ophthalmology And Strabismus 2013, 50 Online: e8-10. PMID: 23429576, DOI: 10.3928/01913913-20130219-02.
- Sinard JH. Accounting for the Professional Work of Pathologists Performing Autopsies. Archives Of Pathology & Laboratory Medicine 2013, 137: 228-32. PMID: 23368865, DOI: 10.5858/arpa.2012-0012-cp.
- Mohsenin A, Sinard J, Huang JJ. Necrobiotic xanthogranuloma and chronic lymphocytic leukemia of the conjunctiva masquerading as scleritis and uveitis. Clinical Ophthalmology 2012, Volume 6: 2045-2047. PMID: 23271884, PMCID: PMC3526909, DOI: 10.2147/opth.s35743.
- Pantanowitz L, Sinard J, Fatheree L, Henricks W, Carter A, Contis L, Beckwith B, Evans A, Otis C, MacDonald J, Parwani A. Recommendations for Validating Whole Slide Imaging in Pathology: College of American Pathologists Pathology and Laboratory Quality Center. American Journal Of Clinical Pathology 2012, 138: a194-a194. DOI: 10.1093/ajcp/138.suppl1.178.
- Servat JJ, Williamson JE, Piepmeier J, Sinard J, Bernardino CR. Giant myofibroma of the orbit in an adult male. Orbit (Amsterdam, Netherlands) 2012, 31: 21-3. PMID: 22007896, DOI: 10.3109/01676830.2011.605501.
- Sinard JH, Gershkovich P. Custom software development for use in a clinical laboratory. Journal Of Pathology Informatics 2012, 3: 44. PMID: 23372985, PMCID: PMC3551490, DOI: 10.4103/2153-3539.104906.
- Lee RE, McClintock DS, Balis UJ, Baron JM, Becich MJ, Beckwith BA, Brodsky VB, Carter AB, Dighe AS, Haghighi M, Hipp JD, Henricks WH, Kim JY, Klepseis VE, Kuo FC, Lane WJ, Levy BP, Onozato ML, Park SL, Sinard JH, Tuthill MJ, Gilbertson JR. Pathology informatics fellowship retreats: The use of interactive scenarios and case studies as pathology informatics teaching tools. Journal Of Pathology Informatics 2012, 3: 41. PMID: 23248762, PMCID: PMC3519095, DOI: 10.4103/2153-3539.103995.
- Hardwick DF, Sinard J, Silva F. Development and evolution of The Knowledge Hub for Pathology and related electronic resources. Human Pathology 2011, 42: 795-801. PMID: 21316077, DOI: 10.1016/j.humpath.2010.10.019.
- Lu F, Hu Z, Sinard J, Garen A, Adelman RA. Factor VII–Verteporfin for Targeted Photodynamic Therapy in a Rat Model of Choroidal Neovascularization. Investigative Ophthalmology & Visual Science 2009, 50: 3890-3896. PMID: 19357351, DOI: 10.1167/iovs.08-2833.
- Sinard J. Book Review: Virtual Microscopy. Pediatric And Developmental Pathology 2008, 11: 69-69. DOI: 10.2350/07-08-0320.1.
- Iyer A, Mathur R, Deepak BV, Sinard J. Fatal adenoviral hepatitis after rituximab therapy. Archives Of Pathology & Laboratory Medicine 2006, 130: 1557-60. PMID: 17090202, DOI: 10.5858/2006-130-1557-FAHART.
- Sinard J. Practical Pathology Informatics, Demstifying informatics for the practicing anatomic pathologist. 2006 DOI: 10.1007/0-387-28058-8.
- Practical Pathology Informatics: demystifying informatics for the practicing anatomic pathologistSinard, J.H. (2006) Practical Pathology Informatics: demystifying informatics for the practicing anatomic pathologist. Springer-Verlag, London. 380pp.
- Sinard JH, Mattie ME. Overcoming the limitations of integrated clinical digital imaging solutions. Archives Of Pathology & Laboratory Medicine 2005, 129: 1118-26. PMID: 16119983, DOI: 10.5858/2005-129-1118-otloic.
- Diaz VA, DeBroff BM, Sinard J. Comparison of Histopathologic Features, Clinical Symptoms, and Erythrocyte Sedimentation Rates in Biopsy-Positive Temporal Arteritis. Ophthalmology 2005, 112: 1293-1298. PMID: 15921755, DOI: 10.1016/j.ophtha.2005.02.016.
- Landi K, Sinard J, Crawford JM, Topazian M. Cholesterol crystal morphology in acalculous gallbladder disease. Journal Of Clinical Gastroenterology 2003, 36: 364-6. PMID: 12642747, DOI: 10.1097/00004836-200304000-00017.
- Fadare O, Sinard J. Glandular patterns in a thyroid carcinoma with insular and anaplastic features: A case with possible implications for the classification of thyroid carcinomas. Annals Of Diagnostic Pathology 2002, 6: 389-398. PMID: 12478492, DOI: 10.1053/adpa.2002.37012.
- Hui P, Glusac EJ, Sinard JH, Perkins AS. Clonal analysis of cutaneous fibrous histiocytoma (dermatofibroma). Journal Of Cutaneous Pathology 2002, 29: 385-389. PMID: 12139632, DOI: 10.1034/j.1600-0560.2002.290701.x.
- Sinard J. Factors Affecting Autopsy Rates, Autopsy Request Rates, and Autopsy Findings at a Large Academic Medical Center. Experimental And Molecular Pathology 2001, 70: 333-343. PMID: 11418012, DOI: 10.1006/exmp.2001.2371.
- Sinard JH. Y2k revisited: a human component? JAMA 2001, 285: 1706-7. PMID: 11277824, DOI: 10.1001/jama.285.13.1706.
- Sinard J, Morrow J. Informatics and anatomic pathology: Meeting challenges and charting the future. Human Pathology 2001, 32: 143-148. PMID: 11230700, DOI: 10.1053/hupa.2001.23057.
- Sinard J, Blood D. Quality improvement on an academic autopsy service. Archives Of Pathology & Laboratory Medicine 2001, 125: 237-45. PMID: 11175642, DOI: 10.5858/2001-125-0237-qioaaa.
- Belanger A, Lopes A, Sinard J. Implementation of a practical digital imaging system for routine gross photography in an autopsy environment. Archives Of Pathology & Laboratory Medicine 2000, 124: 160-5. PMID: 10629152, DOI: 10.5858/2000-124-0160-ioapdi.
- Sinard JH. Immunohistochemical distinction of ocular sebaceous carcinoma from basal cell and squamous cell carcinoma. Archives Of Ophthalmology (Chicago, Ill. : 1960) 1999, 117: 776-83. PMID: 10369589, DOI: 10.1001/archopht.117.6.776.
- Meyer D, Ge J, Blinder KJ, Sinard J, Xu S. Malignant transformation of an optic disk melanocytoma. American Journal Of Ophthalmology 1999, 127: 710-4. PMID: 10372881, DOI: 10.1016/s0002-9394(99)00065-3.
- Gloor P, Ansari I, Sinard J. Sebaceous carcinoma presenting as a unilateral papillary conjunctivitis. American Journal Of Ophthalmology 1999, 127: 458-9. PMID: 10218701, DOI: 10.1016/s0002-9394(98)00383-3.
- Innes D, Sinard J, Gilligan D, Snyder L, Gallagher P, Morrow J. Exclusion of the stomatin, α‐adducin and β‐adducin loci in a large kindred with dehydrated hereditary stomatocytosis. American Journal Of Hematology 1999, 60: 72-74. PMID: 9883810, DOI: 10.1002/(sici)1096-8652(199901)60:1<72::aid-ajh13>3.0.co;2-8.
- Bemporad JA, Chaloupka JC, Putman CM, Roth TC, Tarro J, Mitra S, Sinard JH, Sasaki CT. Pigmented villonodular synovitis of the temporomandibular joint: diagnostic imaging and endovascular therapeutic embolization of a rare head and neck tumor. AJNR. American Journal Of Neuroradiology 1999, 20: 159-62. PMID: 9974074.
- Foschini MP, Baccarini P, Dal Monte P, Sinard J, Eusebi V, Rosai J. Albumin gene expression in adenocarcinomas with hepatoid differentiation. Virchows Archiv 1998, 433: 537-541. PMID: 9870687, DOI: 10.1007/s004280050286.
- Fezza J, Chaudhry I, Kwon Y, Grannum E, Sinard J, Wolfley D. Orbital Melanoma Presenting as Orbital Cellulitis. Ophthalmic Plastic And Reconstructive Surgery 1998, 14: 286-289. PMID: 9700739, DOI: 10.1097/00002341-199807000-00012.
- Sinard J, Stewart G, Stabach P, Argent A, Gilligan D, Morrow J. Utilization of an 86bp exon generates a novel adducin isoform (β4) lacking the MARCKS homology domain1The first two authors contributed equally to this work.1. Biochimica Et Biophysica Acta 1998, 1396: 57-66. PMID: 9524222, DOI: 10.1016/s0167-4781(97)00167-x.
- Morrow J, Rimm D, Kennedy S, Cianci C, Sinard J, Weed S. Of Membrane Stability and Mosaics: The Spectrin Cytoskeleton. 1997, 485-540. DOI: 10.1002/cphy.cp140111.
- Fezza J, Sinard J. Metastatic Liposarcoma to the Orbit. American Journal Of Ophthalmology 1997, 123: 271-272. PMID: 9186144, DOI: 10.1016/s0002-9394(14)71055-4.
- Outlines in PathologySinard, J.H. Outlines in Pathology. W.B. Saunders Company, Philadephia. 229 pages (1996).
- Mani S, Haffty B, Sinard J, Fischer D, Papac R, Flynn S. DNA Ploidy as a Significant Predictor of Recurrence‐Free Survival in Male Patients with Breast Cancer. The Breast Journal 1995, 1: 356-361. DOI: 10.1111/j.1524-4741.1995.tb00262.x.
- Sinard J, Hedreen J. Neuronal loss from the subthalamic nuclei in a patient with progressive chorea. Movement Disorders 1995, 10: 305-311. PMID: 7651448, DOI: 10.1002/mds.870100313.
- Rimm DL, Sinard JH, Morrow JS. Reduced alpha-catenin and E-cadherin expression in breast cancer. Laboratory Investigation 1995, 72: 506-12. PMID: 7745946.
- Sinard J, Macleay L, Melamed J. Hepatoid adenocarcinoma in the urinary bladder. Unusual localization of a newly recognized tumor type. Cancer 1994, 73: 1919-1925. PMID: 7511041, DOI: 10.1002/1097-0142(19940401)73:7<1919::aid-cncr2820730724>3.0.co;2-l.
- COOPER D, SINARD J, EDELSON R, FLYNN S. Cardiogenic Shock Due to Progression of Cutaneous T-Cell Lymphoma. Southern Medical Journal 1994, 87: 89-94. PMID: 8284728, DOI: 10.1097/00007611-199401000-00021.
- Sinard JH, Rimm DL, Pollard TD. Identification of functional regions on the tail of Acanthamoeba myosin-II using recombinant fusion proteins. II. Assembly properties of tails with NH2- and COOH-terminal deletions. Journal Of Cell Biology 1990, 111: 2417-2426. PMID: 2177477, PMCID: PMC2116375, DOI: 10.1083/jcb.111.6.2417.
- Pollard T, Maupin P, Sinard J, Huxley H. A Stopped‐flow/rapid‐freezing machine with millisecond time resolution to prepare intermediates in biochemical reactions for electron microscopy. Microscopy Research And Technique 1990, 16: 160-166. PMID: 2213238, DOI: 10.1002/jemt.1060160206.
- Sinard JH, Pollard TD. Acanthamoeba myosin-II minifilaments assemble on a millisecond time scale with rate constants greater than those expected for a diffusion limited reaction. Journal Of Biological Chemistry 1990, 265: 3654-3660. PMID: 2303471, DOI: 10.1016/s0021-9258(19)39643-7.
- Sinard JH, Pollard TD. The effect of heavy chain phosphorylation and solution conditions on the assembly of Acanthamoeba myosin-II. Journal Of Cell Biology 1989, 109: 1529-1535. PMID: 2793932, PMCID: PMC2115825, DOI: 10.1083/jcb.109.4.1529.
- Sinard JH, Stafford WF, Pollard TD. The mechanism of assembly of Acanthamoeba myosin-II minifilaments: minifilaments assemble by three successive dimerization steps. Journal Of Cell Biology 1989, 109: 1537-1547. PMID: 2793933, PMCID: PMC2115822, DOI: 10.1083/jcb.109.4.1537.
- Rimm DL, Sinard JH, Pollard TD. Location of the head-tail junction of myosin. Journal Of Cell Biology 1989, 108: 1783-1789. PMID: 2715178, PMCID: PMC2115540, DOI: 10.1083/jcb.108.5.1783.
- Sinard J, Pollard T. Microinjection into Acanthamoeba castellanii of monoclonal antibodies to myosin‐II slows but does not stop cell locomotion. Cytoskeleton 1989, 12: 42-52. PMID: 2523248, DOI: 10.1002/cm.970120106.
- Pollard T, Tseng P, Rimm D, Bichell D, Williams R, Sinard J, Sato M. Characterization of alpha‐actinin from Acanthamoeba. Cytoskeleton 1986, 6: 649-661. PMID: 2948678, DOI: 10.1002/cm.970060613.
- Wu YJ, Parker LM, Binder NE, Beckett MA, Sinard JH, Griffiths CT, Rheinwald JG. The mesothelial keratins: a new family of cytoskeletal proteins identified in cultured mesothelial cells and nonkeratinizing epithelia. Cell 1982, 31: 693-703. PMID: 6186388, DOI: 10.1016/0092-8674(82)90324-5.
Biography
John H. Sinard, MD, PhD, is a pathologist who practices in many subspecialty areas but specializes in diagnosing eye diseases. When he is not examining tissue samples of patients, Dr. Sinard works closely with the pathology department’s technology team within Yale Pathology Informatics, a program that he helped build from the ground up. “We have developed in-house software that doesn’t exist anywhere else in the world,” Dr. Sinard says. “It helps facilitate the accuracy of patient specimens and provides important diagnostic information to the pathologist.”
Similar to this specialized software system, pathologists perform necessary roles in patient care behind the scenes, Dr. Sinard explains. “A specialty physician may see between five and 10 patients each day, while a pathologist may be treating 20 to 80 patients every day.”
At the Yale School of Medicine, Dr. Sinard currently serves as medical director of pathology informatics and professor of pathology and of ophthalmology.
Titles
- Professor of Pathology and of Ophthalmology and Visual Science
- Medical Director, Pathology Informatics, Pathology
Education & Training
- FellowYale University School of Medicine (1995)
- ResidentYale-New Haven Hospital (1993)
- MDJohns Hopkins University (1990)
- PhDJohns Hopkins University (1990)
- ABHarvard University (1982)
Additional Information
- Lifetime Achievement Award: College of American Pathologists (2018)
- Averill Liebow Resident Teaching Award: Yale Pathology (2018)
- F.K. Mostofi Distinguished Service Award: United States and Canadian Academy of Pathology (2017)
- Averill Liebow Resident Teaching Award: Yale Pathology (2003)
- Averill Liebow Resident Teaching Award: Yale Pathology (1999)
- AB of Pathology, Clinical Informatics (2014)
- AB of Pathology, Anatomic Pathology (1994)
- Association of Pathology Chairs (2021 - Present): Clinical Service Leaders Committee
- College of American Pathologists (2019 - Present): Information Technology Leadership Committee
- College of American Pathologists (2017 - 2020): Vice Chair, Informatics Committee
- Yale Medical School (2017 - 2019): Senior Appointments and Promotions Committee
- College of American Pathologists (2015 - 2020): Council on Education
- Yale University (2015 - Present): University Safety Committee
- United States and Canadian Academy of Pathology (2014 - 2020): Secretary and Executive Committee Member
- Yale-New Haven Hospital (2014 - 2022): Perioperative Patient Safety and Quality Committee
- College of American Pathologists (2014 - 2017): Clinical Informatics Steering Committee
- College of American Pathologists (2013 - 2018): Council on Scientific Affairs
- Weiss M, Perzia B, Sinard J, Tran T, Maeng M. Primary Treatment of Eyelid Conjunctival Melanoma with Immunotherapy: A Case Report. Ophthalmic Plastic And Reconstructive Surgery 2024 PMID: 39240220, DOI: 10.1097/iop.0000000000002776.
- Obstfeld A, Brodsky V, Carter A, Gershkovich P, Haymond S, Levy B, Sinard J, Sellers D, Stoffel M, Jackups R. Proceedings of the Association for Pathology Informatics Bootcamp 2022. Journal Of Pathology Informatics 2023, 14: 100331. PMID: 37705688, PMCID: PMC10495674, DOI: 10.1016/j.jpi.2023.100331.
- Spadaro J, Chow R, Sinard J, Watsky K, Habib L. Chronic Lymphocytic Leukemia Presenting as Bilateral Periorbital Edema Treated With Low-dose Radiation Therapy. Ophthalmic Plastic And Reconstructive Surgery 2023, 39: e78-e81. PMID: 36852835, DOI: 10.1097/iop.0000000000002338.
- Dhodapkar R, Spadaro J, Heng J, Sinard J, Lee Y, Habib L, Pointdujour-Lim R. NK/T-cell Lymphoma With Orbital Involvement: A Case Report and Systematic Review of the Literature. Ophthalmic Plastic And Reconstructive Surgery 2023, 39: 316-327. PMID: 36692957, DOI: 10.1097/iop.0000000000002317.
- Berbís M, McClintock D, Bychkov A, Van der Laak J, Pantanowitz L, Lennerz J, Cheng J, Delahunt B, Egevad L, Eloy C, Farris A, Fraggetta F, del Moral R, Hartman D, Herrmann M, Hollemans E, Iczkowski K, Karsan A, Kriegsmann M, Salama M, Sinard J, Tuthill J, Williams B, Casado-Sánchez C, Sánchez-Turrión V, Luna A, Aneiros-Fernández J, Shen J. Computational pathology in 2030: a Delphi study forecasting the role of AI in pathology within the next decade. EBioMedicine 2023, 88: 104427. PMID: 36603288, PMCID: PMC9823157, DOI: 10.1016/j.ebiom.2022.104427.
- Darbinian N, Darbinyan A, Sinard J, Tatevosian G, Merabova N, D’Amico F, Khader T, Bajwa A, Martirosyan D, Gawlinski A, Pursnani R, Zhao H, Amini S, Morrison M, Goetzl L, Selzer M. Molecular Markers in Maternal Blood Exosomes Allow Early Detection of Fetal Alcohol Spectrum Disorders. International Journal Of Molecular Sciences 2022, 24: 135. PMID: 36613580, PMCID: PMC9820501, DOI: 10.3390/ijms24010135.
- Singh V, Mezzacappa C, Gershkovich P, Di Giovanna J, Ganzak A, Gibson J, Sinard J, Xicola RM, Llor X. Systems approach to enhance Lynch syndrome diagnosis through tumour testing. Journal Of Medical Genetics 2022, 60: 533-539. PMID: 36115663, PMCID: PMC10020126, DOI: 10.1136/jmg-2022-108770.
- Spadaro JZ, Sinard J, Habib L. Bilateral dacryoadenitis as the initial presentation of ANCA-associated vasculitis in a pediatric patient. Orbit 2022, 43: 231-235. PMID: 35801829, DOI: 10.1080/01676830.2022.2093920.
- Heng JS, Perzia BM, Sinard JH, Pointdujour-Lim R. Local recurrence of uveal melanoma and concomitant brain metastases associated with an activating telomerase promoter mutation seven years after secondary enucleation. American Journal Of Ophthalmology Case Reports 2022, 27: 101607. PMID: 35707052, PMCID: PMC9189986, DOI: 10.1016/j.ajoc.2022.101607.
- Zhang L, Lubin D, Sinard JH, Dickson BC, Antonescu CR, Wu H, Panni RZ, Dogan S, Untch BR, Ghossein RA, Xu B. Primary Mesenchymal Tumors of the Thyroid Gland: A Modern Retrospective Cohort Including the First Case of TFE3-Translocated Malignant Perivascular Epithelioid Cell Tumor (PEComa). Head And Neck Pathology 2022, 16: 716-727. PMID: 35218514, PMCID: PMC9424363, DOI: 10.1007/s12105-022-01428-7.
- Abdel-Aty A, Linderman WL, Kombo N, Sinard J, Pointdujour-Lim R. Necrotic Uveal Melanoma Mimics Orbital Cellulitis: A Review. Ocular Oncology And Pathology 2021, 8: 1-8. PMID: 35356597, PMCID: PMC8914239, DOI: 10.1159/000515558.
- Mir T, Megalla M, Sinard J, Wang J. Cilioretinal Artery Occlusion as the Presenting Manifestation of Left Atrial Myxoma. Journal Of VitreoRetinal Diseases 2021, 6: 320-323. PMID: 37007931, PMCID: PMC9976024, DOI: 10.1177/24741264211034114.
- Perincheri S, Levi AW, Celli R, Gershkovich P, Rimm D, Morrow JS, Rothrock B, Raciti P, Klimstra D, Sinard J. An independent assessment of an artificial intelligence system for prostate cancer detection shows strong diagnostic accuracy. Modern Pathology 2021, 34: 1588-1595. PMID: 33782551, PMCID: PMC8295034, DOI: 10.1038/s41379-021-00794-x.
- Morrow JS, Gershkovich P, Gibson J, Gilshannon M, Kowalski D, Levi AW, Nguyen DX, Rimm DL, Xu ML, Sinard J. Measuring Faculty Effort: A Quantitative Approach That Aligns Personal and Institutional Goals in Pathology at Yale. Academic Pathology 2021, 8: 23742895211047985. PMID: 34646939, PMCID: PMC8504692, DOI: 10.1177/23742895211047985.
- McGuone D, Sinard J, Gill JR, Masters A, Liu C, Morotti R, Parkash V. Autopsy Services and Emergency Preparedness of a Tertiary Academic Hospital Mortuary for the COVID-19 Public Health Emergency: The Yale Plan. Advances In Anatomic Pathology 2020, 27: 355-362. PMID: 32649315, DOI: 10.1097/pap.0000000000000274.
- Mazer BL, Paulson N, Sinard JH. Protecting the Pathology Commons in the Digital Era. Archives Of Pathology & Laboratory Medicine 2020, 144: 1037-1040. PMID: 32579394, DOI: 10.5858/arpa.2020-0022-ed.
- Maslin JS, Chen PP, Sinard J, Nguyen AT, Noecker R. Histopathologic changes in cadaver eyes after MicroPulse and continuous wave transscleral cyclophotocoagulation. Canadian Journal Of Ophthalmology 2020, 55: 330-335. PMID: 32446502, DOI: 10.1016/j.jcjo.2020.03.010.
- Li E, Sinard J, Sohrab M. Pulmonary Adenocarcinoma Metastatic to Periocular Skin and Orbital Tissue Presenting as Orbital Cellulitis. Ophthalmic Plastic And Reconstructive Surgery 2020, 36: e28-e30. PMID: 31789787, DOI: 10.1097/iop.0000000000001534.
- Sinard JH. An Analysis of the Effect of the COVID-19 Pandemic on Case Volumes in an Academic Subspecialty-Based Anatomic Pathology Practice. Academic Pathology 2020, 7: 2374289520959788. PMID: 33088911, PMCID: PMC7545513, DOI: 10.1177/2374289520959788.
- Stram M, Seheult J, Sinard JH, Campbell WS, Carter AB, de Baca ME, Quinn AM, Luu HS, Pathologists O. A Survey of LOINC Code Selection Practices Among Participants of the College of American Pathologists Coagulation (CGL) and Cardiac Markers (CRT) Proficiency Testing Programs. Archives Of Pathology & Laboratory Medicine 2019, 144: 586-596. PMID: 31603714, DOI: 10.5858/arpa.2019-0276-oa.
- Baine MK, Sinard JH, Cai G, Homer RJ. A Semiquantitative Scoring System May Allow Biopsy Diagnosis of Pulmonary Large Cell Neuroendocrine Carcinoma. American Journal Of Clinical Pathology 2019, 153: 165-174. PMID: 31593583, PMCID: PMC7571487, DOI: 10.1093/ajcp/aqz149.
- Kim JM, Weiss S, Sinard JH, Pointdujour-Lim R. Dabrafenib and Trametinib for BRAF-Mutated Conjunctival Melanoma. Ocular Oncology And Pathology 2019, 6: 35-38. PMID: 32002403, PMCID: PMC6984155, DOI: 10.1159/000497473.
- Li E, Sinard J, Distefano A, Sohrab M. Angiolymphoid Hyperplasia with Eosinophilia with Clinical Presentation Concerning for Juvenile Temporal Arteritis. Ocular Oncology And Pathology 2019, 6: 25-30. PMID: 32002401, PMCID: PMC6984143, DOI: 10.1159/000500361.
- Altan M, Toki MI, Gettinger SN, Carvajal-Hausdorf DE, Zugazagoitia J, Sinard JH, Herbst RS, Rimm DL. Immune Checkpoint Inhibitor–Associated Pericarditis. Journal Of Thoracic Oncology 2019, 14: 1102-1108. PMID: 30851443, PMCID: PMC6617516, DOI: 10.1016/j.jtho.2019.02.026.
- Li E, Silbert J, Sinard J. Pleomorphic lipoma of the bulbar conjunctiva. BMJ Case Reports 2018, 11: e226548. PMID: 30567236, PMCID: PMC6301450, DOI: 10.1136/bcr-2018-226548.
- Li E, Distefano A, Sinard J, Wong A, Pointdujour-Lim R. Epithelial–Myoepithelial Carcinoma Presenting as a Pseudo Veno-Lymphatic Malformation. Ophthalmic Plastic And Reconstructive Surgery 2018, 34: e157-e160. PMID: 30080758, DOI: 10.1097/iop.0000000000001179.
- Kim JM, Megalla M, Howard M, Sinard J, Pointdujour-Lim R. Orbital cellulitis with choroidal detachment following strabismus surgery in an adult. Journal Of American Association For Pediatric Ophthalmology And Strabismus 2018, 22: 477-480. PMID: 30171895, DOI: 10.1016/j.jaapos.2018.04.016.
- Celli R, Barbieri AL, Colunga M, Sinard J, Gibson JA. Optimal Intraoperative Assessment of Gastric Margins. American Journal Of Clinical Pathology 2018, 150: 353-363. PMID: 30020407, DOI: 10.1093/ajcp/aqy062.
- Apostolopoulos N, Sinard J, Kombo N. Bilateral Cicatrizing Conjunctivitis in a Middle-aged Man. JAMA Ophthalmology 2018, 136: 706-707. PMID: 29596593, DOI: 10.1001/jamaophthalmol.2017.5490.
- Kim JM, Hall LB, Elia M, Ehrlich MS, Materin MA, Sinard JH. Acute Presentation of Mesectodermal Leiomyoma of the Ciliary Body. Ocular Oncology And Pathology 2017, 3: 304-309. PMID: 29344486, PMCID: PMC5757584, DOI: 10.1159/000464466.
- Tainsh LT, Coady PA, Sinard JH, Neparidze N, Meskin SW, Adelman RA, Chow J. Asymmetric Deep Stromal Keratopathy in a Patient With Multiple Myeloma. Cornea 2017, 36: 372-374. PMID: 28079685, DOI: 10.1097/ico.0000000000001139.
- Gaudio PA, Sinard J, Shield DR, Huang JJ, King BA. Repeat Conjunctival Biopsy after Immunomodulatory Therapy for Ocular Mucous Membrane Pemphigoid. Ocular Immunology And Inflammation 2016, 26: 70-73. PMID: 27437791, DOI: 10.1080/09273948.2016.1194435.
- Henricks WH, Karcher DS, Harrison JH, Sinard JH, Riben MW, Boyer PJ, Plath S, Thompson A, Pantanowitz L. Pathology Informatics Essentials for Residents: A Flexible Informatics Curriculum Linked to Accreditation Council for Graduate Medical Education Milestones. Archives Of Pathology & Laboratory Medicine 2016, 141: 113-124. PMID: 27383543, DOI: 10.5858/arpa.2016-0199-oa.
- Henricks WH, Karcher DS, Harrison JH, Sinard JH, Riben MW, Boyer PJ, Plath S, Thompson A, Pantanowitz L. Pathology Informatics Essentials for Residents: A flexible informatics curriculum linked to Accreditation Council for Graduate Medical Education milestones. Journal Of Pathology Informatics 2016, 7: 27. PMID: 27563486, PMCID: PMC4977974, DOI: 10.4103/2153-3539.185673.
- Henricks WH, Karcher DS, Harrison JH, Sinard JH, Riben MW, Boyer PJ, Plath S, Thompson A, Pantanowitz L. Pathology Informatics Essentials for Residents. Academic Pathology 2016, 3: 2374289516659051. PMID: 28725772, PMCID: PMC5497905, DOI: 10.1177/2374289516659051.
- Gershkovich P, Sinard JH. Customizing Laboratory Information Systems. Advances In Anatomic Pathology 2015, 22: 323-330. PMID: 26262515, DOI: 10.1097/pap.0000000000000088.
- Louis DN, Feldman M, Carter AB, Dighe AS, Pfeifer JD, Bry L, Almeida JS, Saltz J, Braun J, Tomaszewski JE, Gilbertson JR, Sinard JH, Gerber GK, Galli SJ, Golden JA, Becich MJ. Computational Pathology. Archives Of Pathology & Laboratory Medicine 2015, 140: 41-50. PMID: 26098131, PMCID: PMC4996078, DOI: 10.5858/arpa.2015-0093-sa.
- Henricks WH, Wilkerson ML, Castellani WJ, Whitsitt MS, Sinard JH. Pathologists' Place in the Electronic Health Record Landscape. Archives Of Pathology & Laboratory Medicine 2015, 139: 307-10. PMID: 25724026, DOI: 10.5858/arpa.2013-0709-so.
- Henricks WH, Wilkerson ML, Castellani WJ, Whitsitt MS, Sinard JH. Pathologists as Stewards of Laboratory Information. Archives Of Pathology & Laboratory Medicine 2015, 139: 332-7. PMID: 25724030, DOI: 10.5858/arpa.2013-0714-so.
- Wilkerson ML, Henricks WH, Castellani WJ, Whitsitt MS, Sinard JH. Management of Laboratory Data and Information Exchange in the Electronic Health Record. Archives Of Pathology & Laboratory Medicine 2015, 139: 319-27. PMID: 25724028, DOI: 10.5858/arpa.2013-0712-so.
- Castellani WJ, Sinard JH, Wilkerson ML, Whitsitt MS, Henricks WH. Accreditation and Regulatory Implications of Electronic Health Records for Laboratory Reporting. Archives Of Pathology & Laboratory Medicine 2015, 139: 328-31. PMID: 25724029, DOI: 10.5858/arpa.2013-0713-so.
- Sinard JH, Castellani WJ, Wilkerson ML, Henricks WH. Stand-alone Laboratory Information Systems Versus Laboratory Modules Incorporated in the Electronic Health Record. Archives Of Pathology & Laboratory Medicine 2015, 139: 311-8. PMID: 25724027, DOI: 10.5858/arpa.2013-0711-so.
- Sinard J. Review of “digital pathology” by Yves Sucaet and Wim Waelput Y Sucaet W Waelput Review of “digital pathology” by Yves Sucaet and Wim Waelput 2015 Springer New York 83 10:978-3-319-08779-5. Journal Of Pathology Informatics 2015, 6: 12. PMCID: PMC4355838, DOI: 10.1016/s2153-3539(22)00467-9.
- Sinard JH, Powell SZ, Karcher DS. Pathology Training in Informatics: Evolving to Meet a Growing Need. Archives Of Pathology & Laboratory Medicine 2014, 138: 505-11. PMID: 24678681, DOI: 10.5858/arpa.2013-0328-ra.
- Sinard JH. In Response: It's All About What is Typical. Archives Of Pathology & Laboratory Medicine 2014, 138: 869-70. PMID: 24491222, DOI: 10.5858/arpa.2013-0427-edi.
- Oatts JT, Zhang Z, Tseng H, Shields MB, Sinard JH, Loewen NA. In Vitro and In Vivo Comparison of Two Suprachoroidal ShuntsComparison of Two Suprachoroidal Shunts. Investigative Ophthalmology & Visual Science 2013, 54: 5416-5423. PMID: 23847318, PMCID: PMC4141703, DOI: 10.1167/iovs.13-11853.
- Niccolai LM, Russ C, Julian PJ, Hariri S, Sinard J, Meek JI, McBride V, Markowitz LE, Unger ER, Hadler JL, Sosa LE. Individual and geographic disparities in human papillomavirus types 16/18 in high‐grade cervical lesions. Cancer 2013, 119: 3052-3058. PMID: 23661284, DOI: 10.1002/cncr.28038.
- Pantanowitz L, Mackinnon AC, Sinard JH. Tracking in Anatomic Pathology. Archives Of Pathology & Laboratory Medicine 2013, 137: 1798-810. PMID: 23634908, DOI: 10.5858/arpa.2013-0125-sa.
- Pantanowitz L, Sinard JH, Henricks WH, Fatheree LA, Carter AB, Contis L, Beckwith BA, Evans AJ, Lal A, Parwani AV. Validating Whole Slide Imaging for Diagnostic Purposes in Pathology: Guideline from the College of American Pathologists Pathology and Laboratory Quality Center. Archives Of Pathology & Laboratory Medicine 2013, 137: 1710-22. PMID: 23634907, PMCID: PMC7240346, DOI: 10.5858/arpa.2013-0093-cp.
- Salchow DJ, Sinard J. Management of lens dislocation and iris cyst after iris sutured intraocular lens implantation in children with Marfan syndrome. Journal Of Pediatric Ophthalmology And Strabismus 2013, 50 Online: e8-10. PMID: 23429576, DOI: 10.3928/01913913-20130219-02.
- Sinard JH. Accounting for the Professional Work of Pathologists Performing Autopsies. Archives Of Pathology & Laboratory Medicine 2013, 137: 228-32. PMID: 23368865, DOI: 10.5858/arpa.2012-0012-cp.
- Mohsenin A, Sinard J, Huang JJ. Necrobiotic xanthogranuloma and chronic lymphocytic leukemia of the conjunctiva masquerading as scleritis and uveitis. Clinical Ophthalmology 2012, Volume 6: 2045-2047. PMID: 23271884, PMCID: PMC3526909, DOI: 10.2147/opth.s35743.
- Pantanowitz L, Sinard J, Fatheree L, Henricks W, Carter A, Contis L, Beckwith B, Evans A, Otis C, MacDonald J, Parwani A. Recommendations for Validating Whole Slide Imaging in Pathology: College of American Pathologists Pathology and Laboratory Quality Center. American Journal Of Clinical Pathology 2012, 138: a194-a194. DOI: 10.1093/ajcp/138.suppl1.178.
- Servat JJ, Williamson JE, Piepmeier J, Sinard J, Bernardino CR. Giant myofibroma of the orbit in an adult male. Orbit (Amsterdam, Netherlands) 2012, 31: 21-3. PMID: 22007896, DOI: 10.3109/01676830.2011.605501.
- Sinard JH, Gershkovich P. Custom software development for use in a clinical laboratory. Journal Of Pathology Informatics 2012, 3: 44. PMID: 23372985, PMCID: PMC3551490, DOI: 10.4103/2153-3539.104906.
- Lee RE, McClintock DS, Balis UJ, Baron JM, Becich MJ, Beckwith BA, Brodsky VB, Carter AB, Dighe AS, Haghighi M, Hipp JD, Henricks WH, Kim JY, Klepseis VE, Kuo FC, Lane WJ, Levy BP, Onozato ML, Park SL, Sinard JH, Tuthill MJ, Gilbertson JR. Pathology informatics fellowship retreats: The use of interactive scenarios and case studies as pathology informatics teaching tools. Journal Of Pathology Informatics 2012, 3: 41. PMID: 23248762, PMCID: PMC3519095, DOI: 10.4103/2153-3539.103995.
- Hardwick DF, Sinard J, Silva F. Development and evolution of The Knowledge Hub for Pathology and related electronic resources. Human Pathology 2011, 42: 795-801. PMID: 21316077, DOI: 10.1016/j.humpath.2010.10.019.
- Lu F, Hu Z, Sinard J, Garen A, Adelman RA. Factor VII–Verteporfin for Targeted Photodynamic Therapy in a Rat Model of Choroidal Neovascularization. Investigative Ophthalmology & Visual Science 2009, 50: 3890-3896. PMID: 19357351, DOI: 10.1167/iovs.08-2833.
- Sinard J. Book Review: Virtual Microscopy. Pediatric And Developmental Pathology 2008, 11: 69-69. DOI: 10.2350/07-08-0320.1.
- Iyer A, Mathur R, Deepak BV, Sinard J. Fatal adenoviral hepatitis after rituximab therapy. Archives Of Pathology & Laboratory Medicine 2006, 130: 1557-60. PMID: 17090202, DOI: 10.5858/2006-130-1557-FAHART.
- Sinard J. Practical Pathology Informatics, Demstifying informatics for the practicing anatomic pathologist. 2006 DOI: 10.1007/0-387-28058-8.
- Practical Pathology Informatics: demystifying informatics for the practicing anatomic pathologistSinard, J.H. (2006) Practical Pathology Informatics: demystifying informatics for the practicing anatomic pathologist. Springer-Verlag, London. 380pp.
- Sinard JH, Mattie ME. Overcoming the limitations of integrated clinical digital imaging solutions. Archives Of Pathology & Laboratory Medicine 2005, 129: 1118-26. PMID: 16119983, DOI: 10.5858/2005-129-1118-otloic.
- Diaz VA, DeBroff BM, Sinard J. Comparison of Histopathologic Features, Clinical Symptoms, and Erythrocyte Sedimentation Rates in Biopsy-Positive Temporal Arteritis. Ophthalmology 2005, 112: 1293-1298. PMID: 15921755, DOI: 10.1016/j.ophtha.2005.02.016.
- Landi K, Sinard J, Crawford JM, Topazian M. Cholesterol crystal morphology in acalculous gallbladder disease. Journal Of Clinical Gastroenterology 2003, 36: 364-6. PMID: 12642747, DOI: 10.1097/00004836-200304000-00017.
- Fadare O, Sinard J. Glandular patterns in a thyroid carcinoma with insular and anaplastic features: A case with possible implications for the classification of thyroid carcinomas. Annals Of Diagnostic Pathology 2002, 6: 389-398. PMID: 12478492, DOI: 10.1053/adpa.2002.37012.
- Hui P, Glusac EJ, Sinard JH, Perkins AS. Clonal analysis of cutaneous fibrous histiocytoma (dermatofibroma). Journal Of Cutaneous Pathology 2002, 29: 385-389. PMID: 12139632, DOI: 10.1034/j.1600-0560.2002.290701.x.
- Sinard J. Factors Affecting Autopsy Rates, Autopsy Request Rates, and Autopsy Findings at a Large Academic Medical Center. Experimental And Molecular Pathology 2001, 70: 333-343. PMID: 11418012, DOI: 10.1006/exmp.2001.2371.
- Sinard JH. Y2k revisited: a human component? JAMA 2001, 285: 1706-7. PMID: 11277824, DOI: 10.1001/jama.285.13.1706.
- Sinard J, Morrow J. Informatics and anatomic pathology: Meeting challenges and charting the future. Human Pathology 2001, 32: 143-148. PMID: 11230700, DOI: 10.1053/hupa.2001.23057.
- Sinard J, Blood D. Quality improvement on an academic autopsy service. Archives Of Pathology & Laboratory Medicine 2001, 125: 237-45. PMID: 11175642, DOI: 10.5858/2001-125-0237-qioaaa.
- Belanger A, Lopes A, Sinard J. Implementation of a practical digital imaging system for routine gross photography in an autopsy environment. Archives Of Pathology & Laboratory Medicine 2000, 124: 160-5. PMID: 10629152, DOI: 10.5858/2000-124-0160-ioapdi.
- Sinard JH. Immunohistochemical distinction of ocular sebaceous carcinoma from basal cell and squamous cell carcinoma. Archives Of Ophthalmology (Chicago, Ill. : 1960) 1999, 117: 776-83. PMID: 10369589, DOI: 10.1001/archopht.117.6.776.
- Meyer D, Ge J, Blinder KJ, Sinard J, Xu S. Malignant transformation of an optic disk melanocytoma. American Journal Of Ophthalmology 1999, 127: 710-4. PMID: 10372881, DOI: 10.1016/s0002-9394(99)00065-3.
- Gloor P, Ansari I, Sinard J. Sebaceous carcinoma presenting as a unilateral papillary conjunctivitis. American Journal Of Ophthalmology 1999, 127: 458-9. PMID: 10218701, DOI: 10.1016/s0002-9394(98)00383-3.
- Innes D, Sinard J, Gilligan D, Snyder L, Gallagher P, Morrow J. Exclusion of the stomatin, α‐adducin and β‐adducin loci in a large kindred with dehydrated hereditary stomatocytosis. American Journal Of Hematology 1999, 60: 72-74. PMID: 9883810, DOI: 10.1002/(sici)1096-8652(199901)60:1<72::aid-ajh13>3.0.co;2-8.
- Bemporad JA, Chaloupka JC, Putman CM, Roth TC, Tarro J, Mitra S, Sinard JH, Sasaki CT. Pigmented villonodular synovitis of the temporomandibular joint: diagnostic imaging and endovascular therapeutic embolization of a rare head and neck tumor. AJNR. American Journal Of Neuroradiology 1999, 20: 159-62. PMID: 9974074.
- Foschini MP, Baccarini P, Dal Monte P, Sinard J, Eusebi V, Rosai J. Albumin gene expression in adenocarcinomas with hepatoid differentiation. Virchows Archiv 1998, 433: 537-541. PMID: 9870687, DOI: 10.1007/s004280050286.
- Fezza J, Chaudhry I, Kwon Y, Grannum E, Sinard J, Wolfley D. Orbital Melanoma Presenting as Orbital Cellulitis. Ophthalmic Plastic And Reconstructive Surgery 1998, 14: 286-289. PMID: 9700739, DOI: 10.1097/00002341-199807000-00012.
- Sinard J, Stewart G, Stabach P, Argent A, Gilligan D, Morrow J. Utilization of an 86bp exon generates a novel adducin isoform (β4) lacking the MARCKS homology domain1The first two authors contributed equally to this work.1. Biochimica Et Biophysica Acta 1998, 1396: 57-66. PMID: 9524222, DOI: 10.1016/s0167-4781(97)00167-x.
- Morrow J, Rimm D, Kennedy S, Cianci C, Sinard J, Weed S. Of Membrane Stability and Mosaics: The Spectrin Cytoskeleton. 1997, 485-540. DOI: 10.1002/cphy.cp140111.
- Fezza J, Sinard J. Metastatic Liposarcoma to the Orbit. American Journal Of Ophthalmology 1997, 123: 271-272. PMID: 9186144, DOI: 10.1016/s0002-9394(14)71055-4.
- Outlines in PathologySinard, J.H. Outlines in Pathology. W.B. Saunders Company, Philadephia. 229 pages (1996).
- Mani S, Haffty B, Sinard J, Fischer D, Papac R, Flynn S. DNA Ploidy as a Significant Predictor of Recurrence‐Free Survival in Male Patients with Breast Cancer. The Breast Journal 1995, 1: 356-361. DOI: 10.1111/j.1524-4741.1995.tb00262.x.
- Sinard J, Hedreen J. Neuronal loss from the subthalamic nuclei in a patient with progressive chorea. Movement Disorders 1995, 10: 305-311. PMID: 7651448, DOI: 10.1002/mds.870100313.
- Rimm DL, Sinard JH, Morrow JS. Reduced alpha-catenin and E-cadherin expression in breast cancer. Laboratory Investigation 1995, 72: 506-12. PMID: 7745946.
- Sinard J, Macleay L, Melamed J. Hepatoid adenocarcinoma in the urinary bladder. Unusual localization of a newly recognized tumor type. Cancer 1994, 73: 1919-1925. PMID: 7511041, DOI: 10.1002/1097-0142(19940401)73:7<1919::aid-cncr2820730724>3.0.co;2-l.
- COOPER D, SINARD J, EDELSON R, FLYNN S. Cardiogenic Shock Due to Progression of Cutaneous T-Cell Lymphoma. Southern Medical Journal 1994, 87: 89-94. PMID: 8284728, DOI: 10.1097/00007611-199401000-00021.
- Sinard JH, Rimm DL, Pollard TD. Identification of functional regions on the tail of Acanthamoeba myosin-II using recombinant fusion proteins. II. Assembly properties of tails with NH2- and COOH-terminal deletions. Journal Of Cell Biology 1990, 111: 2417-2426. PMID: 2177477, PMCID: PMC2116375, DOI: 10.1083/jcb.111.6.2417.
- Pollard T, Maupin P, Sinard J, Huxley H. A Stopped‐flow/rapid‐freezing machine with millisecond time resolution to prepare intermediates in biochemical reactions for electron microscopy. Microscopy Research And Technique 1990, 16: 160-166. PMID: 2213238, DOI: 10.1002/jemt.1060160206.
- Sinard JH, Pollard TD. Acanthamoeba myosin-II minifilaments assemble on a millisecond time scale with rate constants greater than those expected for a diffusion limited reaction. Journal Of Biological Chemistry 1990, 265: 3654-3660. PMID: 2303471, DOI: 10.1016/s0021-9258(19)39643-7.
- Sinard JH, Pollard TD. The effect of heavy chain phosphorylation and solution conditions on the assembly of Acanthamoeba myosin-II. Journal Of Cell Biology 1989, 109: 1529-1535. PMID: 2793932, PMCID: PMC2115825, DOI: 10.1083/jcb.109.4.1529.
- Sinard JH, Stafford WF, Pollard TD. The mechanism of assembly of Acanthamoeba myosin-II minifilaments: minifilaments assemble by three successive dimerization steps. Journal Of Cell Biology 1989, 109: 1537-1547. PMID: 2793933, PMCID: PMC2115822, DOI: 10.1083/jcb.109.4.1537.
- Rimm DL, Sinard JH, Pollard TD. Location of the head-tail junction of myosin. Journal Of Cell Biology 1989, 108: 1783-1789. PMID: 2715178, PMCID: PMC2115540, DOI: 10.1083/jcb.108.5.1783.
- Sinard J, Pollard T. Microinjection into Acanthamoeba castellanii of monoclonal antibodies to myosin‐II slows but does not stop cell locomotion. Cytoskeleton 1989, 12: 42-52. PMID: 2523248, DOI: 10.1002/cm.970120106.
- Pollard T, Tseng P, Rimm D, Bichell D, Williams R, Sinard J, Sato M. Characterization of alpha‐actinin from Acanthamoeba. Cytoskeleton 1986, 6: 649-661. PMID: 2948678, DOI: 10.1002/cm.970060613.
- Wu YJ, Parker LM, Binder NE, Beckett MA, Sinard JH, Griffiths CT, Rheinwald JG. The mesothelial keratins: a new family of cytoskeletal proteins identified in cultured mesothelial cells and nonkeratinizing epithelia. Cell 1982, 31: 693-703. PMID: 6186388, DOI: 10.1016/0092-8674(82)90324-5.