Dennis G Moledina, MD, PhD, FASN
Nephrology, Internal Medicine
Biography
Dennis Moledina, MD, PhD, is a nephrologist (kidney specialist) who directs the Yale Kidney BioBank, which collects samples of kidney tissue, DNA, plasma, and urine to better understand kidney diseases and develop treatments.
Dr. Moledina's work revolves around evaluating biomarkers for acute interstitial nephritis, a lesion that causes a decline in kidney function, and acute kidney injury. He is the recipient of several National Institutes of Health (NIH) research awards and enrolls study participants in NIH-funded consortia, including the Kidney Precision Medicine Program (KPMP) and care of outpatients with acute kidney injury (COPE-AKI).
He obtained clinical training through a clinical fellowship in nephrology and research training through postdoctoral fellowship and an investigative medicine doctorate at Yale University. Notably, his research experience includes leading the enrollment of a group of more than 750 participants concurrent with their kidney biopsy to create the Yale Kidney BioBank. In this group, he has identified diagnostic and prognostic biomarkers of acute interstitial nephritis.
Dr. Moledina is a fellow of the American Society of Nephrology. This designation honors members who have distinguished themselves through excellent work and clinical practice.
Titles
- Associate Professor of Medicine (Nephrology)
- Director, Kidney BioBank, Internal Medicine
Education & Training
- PhDYale Graduate School of Arts and Sciences, Investigative Medicine (2018)
- Postdoctoral FellowYale School of Medicine (2018)
- Clinical FellowYale School of Medicine (2015)
- Resident PhysicianNYU Grossman Long Island School of Medicine (2013)
- MDM.P. Shah Medical College (2009)
Languages Spoken
- English
- ગુજરાતી (Gujarati)
- हिन्दी (Hindi)
Additional Information
Honors & Recognitions
- Top -rated abstract: National Kidney Foundation (2024)
- Fellow: American Society of Nephrology (2021)
- K23 Mentored Patient-Oriented Career Development Award: NIH/NIDDK (2018)
- KPMP Opportunity Pool Travel Grant: Kidney Precision Medicine Program (KPMP) (2018)
- American Heart Association Career Development Award: (2018)
- Patterson Trust Mentored Research Award: (2017)
- Top Oral Abstract by a Trainee: American Society of Nephrology (2015)
- Outstanding Renal Fellow: Faculty and Fellows of Yale Nephrology (2015)
- John F Aloia Award for Academic Excellence: NYU Grossman Long Island School of Medicine (2013)
- Outstanding Second Year Medical Resident: NYU Grossman Long Island School of Medicine (2012)
Professional Service
- ASN Journals Editorial Board (2024 - 2026): Editorial Board Member
- National Kidney Foundation: 2025 Spring Clinical Meetings (2024 - 2025): Committee Member
- 2025 Patterson Mentored Research Review Committee (2024): Review Panel Member
- National Kidney Foundation Spring Clinical Meetings 2025 (2024): Abstract Reviewer
- National Institutes of Health (2024): Special Emphasis panel: Topics in Nephrology and Urology
- Fundamentals and Updates in Critical Care Nephrology and Acute Kidney Injury: National Kidney Foundation: Spring Clinical Meeting 2024 Planning Committee (2024): Chair
- AKI Syndromes: Special Considerations: National Kidney Foundation 2024 Spring Clinical Meetings (2024): Chair
- National Kidney Foundation: 2024 Spring Clinical Meetings (2023 - 2024): Committee Member
- National Kidney Foundation Spring Clinical Meeting 2024 (2023): Abstract Reviewer
- American Society of Nephrology: Kidney Week 2023 (2023): Coronavirus (COVID-19): 000 Coronavirus (COVID-19)
Publications
- Moledina D, Obeid W, Smith R, Rosales I, Sise M, Moeckel G, Kashgarian M, Kuperman M, Campbell K, Lefferts S, Meliambro K, Bitzer M, Perazella M, Luciano R, Pober J, Cantley L, Colvin R, Wilson F, Parikh C. Identification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis. Journal Of Clinical Investigation 2023, 133: e168950. PMID: 37395276, PMCID: PMC10313360, DOI: 10.1172/jci168950.
- Moledina DG, Wilson FP, Pober JS, Perazella MA, Singh N, Luciano RL, Obeid W, Lin H, Kuperman M, Moeckel GW, Kashgarian M, Cantley LG, Parikh CR. Urine TNF-α and IL-9 for clinical diagnosis of acute interstitial nephritis. JCI Insight 2019, 4: e127456. PMID: 31092735, PMCID: PMC6542610, DOI: 10.1172/jci.insight.127456.
- Moledina DG, Eadon MT, Calderon F, Yamamoto Y, Shaw M, Perazella MA, Simonov M, Luciano R, Schwantes-An TH, Moeckel G, Kashgarian M, Kuperman M, Obeid W, Cantley LG, Parikh CR, Wilson FP. Development and external validation of a diagnostic model for biopsy-proven acute interstitial nephritis using electronic health record data. Nephrology Dialysis Transplantation 2021, 37: 2214-2222. PMID: 34865148, PMCID: PMC9755995, DOI: 10.1093/ndt/gfab346.
- Baker ML, Yamamoto Y, Perazella MA, Dizman N, Shirali AC, Hafez N, Weinstein J, Simonov M, Testani JM, Kluger HM, Cantley LG, Parikh CR, Wilson FP, Moledina DG. Mortality after acute kidney injury and acute interstitial nephritis in patients prescribed immune checkpoint inhibitor therapy. Journal For ImmunoTherapy Of Cancer 2022, 10: e004421. PMID: 35354588, PMCID: PMC8968986, DOI: 10.1136/jitc-2021-004421.
- Moledina DG, Wilson FP, Kukova L, Obeid W, Luciano R, Kuperman M, Moeckel GW, Kashgarian M, Perazella MA, Cantley LG, Parikh CR. Urine interleukin-9 and tumor necrosis factor-α for prognosis of human acute interstitial nephritis. Nephrology Dialysis Transplantation 2020, 36: 1851-1858. PMID: 33125471, PMCID: PMC8476079, DOI: 10.1093/ndt/gfaa169.
- Moledina DG, Simonov M, Yamamoto Y, Alausa J, Arora T, Biswas A, Cantley LG, Ghazi L, Greenberg JH, Hinchcliff M, Huang C, Mansour SG, Martin M, Peixoto A, Schulz W, Subair L, Testani JM, Ugwuowo U, Young P, Wilson FP. The Association of COVID-19 With Acute Kidney Injury Independent of Severity of Illness: A Multicenter Cohort Study. American Journal Of Kidney Diseases 2021, 77: 490-499.e1. PMID: 33422598, PMCID: PMC7791318, DOI: 10.1053/j.ajkd.2020.12.007.
- Melchinger H, Calderon-Gutierrez F, Obeid W, Xu L, Shaw MM, Luciano RL, Kuperman M, Moeckel GW, Kashgarian M, Wilson FP, Parikh CR, Moledina DG. Urine Uromodulin as a Biomarker of Kidney Tubulointerstitial Fibrosis. Clinical Journal Of The American Society Of Nephrology 2022, 17: 1284-1292. PMID: 35948365, PMCID: PMC9625093, DOI: 10.2215/cjn.04360422.
- Moledina D, Shelton K, Menez S, Aklilu A, Yamamoto Y, Kadhim B, Shaw M, Kent C, Makhijani A, Hu D, Simonov M, O'Connor K, Bitzel J, Thiessen-Philbrook H, Wilson F, Parikh C. External Validation of an Electronic Health Record-Based Diagnostic Model for Histological Acute Tubulointerstitial Nephritis. Journal Of The American Society Of Nephrology 2024 PMID: 39500309, DOI: 10.1681/asn.0000000556.
- Mistry K, Sadarangani S, Moreno D, Mejia S, Moledina D, Sise M. Novel Biomarkers and Imaging Tests for AKI Diagnosis in Patients with Cancer. Kidney360 2024 PMID: 39575585, DOI: 10.34067/kid.0000000660.
- Aklilu A, Menez S, Baker M, Brown D, Dircksen K, Dunkley K, Gaviria S, Farrokh S, Faulkner S, Jones C, Kadhim B, Le D, Li F, Makhijani A, Martin M, Moledina D, Coronel-Moreno C, O’Connor K, Shelton K, Shvets K, Srialluri N, Tan J, Testani J, Corona-Villalobos C, Yamamoto Y, Parikh C, Wilson F, Sundararajan A, Wang A, Schretlen C, Singel D, Moss E, Aune F, Iantosca G, Zou G, Chernova I, Bitzel J, Hernandez J, Lindsley J, Dane K, Orias M, Mehta P, Zassman-Isner S, Wen Y, Freeman N. Early, Individualized Recommendations for Hospitalized Patients With Acute Kidney Injury. JAMA 2024, 332 PMID: 39454050, DOI: 10.1001/jama.2024.22718.
- Schmidt I, Surapaneni A, Zhao R, Upadhyay D, Yeo W, Schlosser P, Huynh C, Srivastava A, Palsson R, Kim T, Stillman I, Barwinska D, Barasch J, Eadon M, El-Achkar T, Henderson J, Moledina D, Rosas S, Claudel S, Verma A, Wen Y, Lindenmayer M, Huber T, Parikh S, Shapiro J, Rovin B, Stanaway I, Sathe N, Bhatraju P, Coresh J, Rhee E, Grams M, Waikar S. Plasma proteomics of acute tubular injury. Nature Communications 2024, 15: 7368. PMID: 39191768, PMCID: PMC11349760, DOI: 10.1038/s41467-024-51304-x.
- D Souza S, Obeid W, Hernandez J, Hu D, Wen Y, Moledina D, Albert A, Gregg A, Wheeler A, Philbrook H, Parikh C. The development of lateral flow devices for urinary biomarkers to assess kidney health. Scientific Reports 2024, 14: 8516. PMID: 38609491, PMCID: PMC11014899, DOI: 10.1038/s41598-024-59104-5.
- Aklilu A, Kumar S, Nugent J, Yamamoto Y, Coronel-Moreno C, Kadhim B, Faulkner S, O’Connor K, Yasmin F, Greenberg J, Moledina D, Testani J, Wilson F. COVID-19−Associated Acute Kidney Injury and Longitudinal Kidney Outcomes. JAMA Internal Medicine 2024, 184: 414-423. PMID: 38407862, PMCID: PMC10897825, DOI: 10.1001/jamainternmed.2023.8225.
- de Cos M, Mosoyan G, Chauhan K, Troost J, Wong J, Lefferts S, Morgan P, Meliambro K, Egerman M, Ray J, Parker T, Levine D, Seshan S, Bardash Y, Horowitz B, Kent C, Shaw M, Perlman A, Moledina D, Coca S, Campbell K. Urinary Plasminogen as a Marker of Disease Progression in Human Glomerular Disease. American Journal Of Kidney Diseases 2024, 84: 205-214.e1. PMID: 38452919, PMCID: PMC11260534, DOI: 10.1053/j.ajkd.2024.01.520.
- Barsotti G, Luciano R, Kumar A, Meliambro K, Kakade V, Tokita J, Naik A, Fu J, Peck E, Pell J, Reghuvaran A, Tanvir E, Patel P, Zhang W, Li F, Moeckel G, Perincheri S, Cantley L, Moledina D, Wilson F, He J, Menon M. Rationale and Design of a Phase 2, Double-blind, Placebo-Controlled, Randomized Trial Evaluating AMP Kinase-Activation by Metformin in Focal Segmental Glomerulosclerosis. Kidney International Reports 2024, 9: 1354-1368. PMID: 38707807, PMCID: PMC11068976, DOI: 10.1016/j.ekir.2024.02.006.
- Krishnan N, Moledina D, Perazella M. Toxic Nephropathies of the Tubulointerstitium: Core Curriculum 2024. American Journal Of Kidney Diseases 2024, 83: 659-676. PMID: 38243994, DOI: 10.1053/j.ajkd.2023.09.017.
- Guo X, Blanc V, Davidson N, Velazquez H, Chen T, Moledina D, Moeckel G, Safirstein R, Desir G. APOBEC-1 deletion enhances cisplatin-induced acute kidney injury. Scientific Reports 2023, 13: 22255. PMID: 38097707, PMCID: PMC10721635, DOI: 10.1038/s41598-023-49575-3.
- Wen Y, Su E, Xu L, Menez S, Moledina D, Obeid W, Palevsky P, Mansour S, Devarajan P, Cantley L, Cahan P, Parikh C, Project K, Injury T. Analysis of the human kidney transcriptome and plasma proteome identifies markers of proximal tubule maladaptation to injury. Science Translational Medicine 2023, 15: eade7287. PMID: 38091407, PMCID: PMC11405121, DOI: 10.1126/scitranslmed.ade7287.
- Kiernan E, Hu D, Philbrook H, Ix J, Bonventre J, Coca S, Moledina D, Fried L, Shlipak M, Parikh C. Urinary Biomarkers and Kidney Injury in VA NEPHRON-D: Phenotyping Acute Kidney Injury in Clinical Trials. American Journal Of Kidney Diseases 2023, 83: 151-161. PMID: 37726051, PMCID: PMC10841767, DOI: 10.1053/j.ajkd.2023.07.012.
- Aklilu A, Kumar S, Yamamoto Y, Moledina D, Sinha F, Testani J, Wilson F. Outcomes Associated with Sodium-Glucose Cotransporter-2 Inhibitor Use in Acute Heart Failure Hospitalizations Complicated by AKI. Kidney360 2023, 4: 1371-1381. PMID: 37644648, PMCID: PMC10615381, DOI: 10.34067/kid.0000000000000250.
- Menez S, Wen Y, Xu L, Moledina D, Thiessen-Philbrook H, Hu D, Obeid W, Bhatraju P, Ikizler T, Siew E, Chinchilli V, Garg A, Go A, Liu K, Kaufman J, Kimmel P, Himmelfarb J, Coca S, Cantley L, Parikh C. The ASSESS-AKI Study found urinary epidermal growth factor is associated with reduced risk of major adverse kidney events. Kidney International 2023, 104: 1194-1205. PMID: 37652206, PMCID: PMC10840723, DOI: 10.1016/j.kint.2023.08.007.
- Reghuvaran A, Lin Q, Basgen J, Banu K, Shi H, Vashist A, Pell J, Perinchery S, He J, Moledina D, Wilson F, Menon M. Comparative evaluation of glomerular morphometric techniques reveals differential technical artifacts between focal segmental glomerulosclerosis and normal glomeruli. Physiological Reports 2023, 11: e15688. PMID: 37423891, PMCID: PMC10329935, DOI: 10.14814/phy2.15688.
- Menez S, Coca S, Moledina D, Wen Y, Chan L, Thiessen-Philbrook H, Obeid W, Garibaldi B, Azeloglu E, Ugwuowo U, Sperati C, Arend L, Rosenberg A, Kaushal M, Jain S, Wilson F, Parikh C, Consortium T, Deng J, Atta M, Bagnasco S, Ko A, Iwasaki A, Farhadian S, Nelson A, Casanovas-Massana A, White E, Schulz W, Coppi A, Young P, Nunez A, Shepard D, Matos I, Strong Y, Anastasio K, Brower K, Kuang M, Chiorazzi M, Bermejo S, Vijayakumar P, Geng B, Fournier J, Minasyan M, Muenker M, Moore A, Nadkarni G. Evaluation of Plasma Biomarkers to Predict Major Adverse Kidney Events in Hospitalized Patients With COVID-19. American Journal Of Kidney Diseases 2023, 82: 322-332.e1. PMID: 37263570, PMCID: PMC10229201, DOI: 10.1053/j.ajkd.2023.03.010.
- Wilson F, Yamamoto Y, Martin M, Coronel-Moreno C, Li F, Cheng C, Aklilu A, Ghazi L, Greenberg J, Latham S, Melchinger H, Mansour S, Moledina D, Parikh C, Partridge C, Testani J, Ugwuowo U. A randomized clinical trial assessing the effect of automated medication-targeted alerts on acute kidney injury outcomes. Nature Communications 2023, 14: 2826. PMID: 37198160, PMCID: PMC10192367, DOI: 10.1038/s41467-023-38532-3.
- Wen Y, Xu L, Melchinger I, Thiessen-Philbrook H, Moledina D, Coca S, Hsu C, Go A, Liu K, Siew E, Ikizler T, Chinchilli V, Kaufman J, Kimmel P, Himmelfarb J, Cantley L, Parikh C, Consortium T. Longitudinal biomarkers and kidney disease progression after acute kidney injury. JCI Insight 2023, 8: e167731. PMID: 36951957, PMCID: PMC10243801, DOI: 10.1172/jci.insight.167731.
- Moledina DG, Perazella, MA. Acute interstitial nephritis. 04 Apr 2023. https://bestpractice.bmj.com/topics/en-gb/938. Last accessed 04 October 2024.
- Vasquez-Rios G, Oh W, Lee S, Bhatraju P, Mansour S, Moledina D, Gulamali F, Siew E, Garg A, Sarder P, Chinchilli V, Kaufman J, Hsu C, Liu K, Kimmel P, Go A, Wurfel M, Himmelfarb J, Parikh C, Coca S, Nadkarni G. Joint Modeling of Clinical and Biomarker Data in Acute Kidney Injury Defines Unique Subphenotypes with Differing Outcomes. Clinical Journal Of The American Society Of Nephrology 2023, 18: 716-726. PMID: 36975209, PMCID: PMC10278836, DOI: 10.2215/cjn.0000000000000156.
- Vasquez-Rios G, Moledina D, Jia Y, McArthur E, Mansour S, Thiessen-Philbrook H, Shlipak M, Koyner J, Garg A, Parikh C, Coca S. Pre-operative kidney biomarkers and risks for death, cardiovascular and chronic kidney disease events after cardiac surgery: the TRIBE-AKI study. Journal Of Cardiothoracic Surgery 2022, 17: 338. PMID: 36567329, PMCID: PMC9790121, DOI: 10.1186/s13019-022-02066-4.
- Qian L, Menez S, Hu D, Weinstein J, Melchinger H, Thiessen-Philbrook H, Luciano R, Turner J, Perazella M, Villalobos C, Shaw M, Wilson F, Parikh C, Moledina D. Safety and Adequacy of Kidney Biopsy Procedure in Patients with Obesity. Kidney360 2022, 4: 98-101. PMID: 36700910, PMCID: PMC10101611, DOI: 10.34067/kid.0006602022.
- Chancay J, Liu C, Chauhan K, Andersen L, Harris C, Coca S, Delaney V, Tedla F, De Boccardo G, Sehgal V, Moledina D, Formica R, Reghuvaran A, Banu K, Florman S, Akalin E, Shapiro R, Salem F, Menon MC. Role of time from transplantation to biopsy in histologic ABMR: A single center report. Clinical Transplantation 2022, 36: e14802. PMID: 36069577, PMCID: PMC10211409, DOI: 10.1111/ctr.14802.
- Coca SG, Vasquez-Rios G, Mansour SG, Moledina DG, Thiessen-Philbrook H, Wurfel MM, Bhatraju P, Himmelfarb J, Siew E, Garg AX, Hsu CY, Liu KD, Kimmel PL, Chinchilli VM, Kaufman JS, Wilson M, Banks RE, Packington R, McCole E, Kurth MJ, Richardson C, Go AS, Selby NM, Parikh CR. Plasma Soluble Tumor Necrosis Factor Receptor Concentrations and Clinical Events After Hospitalization: Findings From the ASSESS-AKI and ARID Studies. American Journal Of Kidney Diseases 2022, 81: 190-200. PMID: 36108888, PMCID: PMC9868060, DOI: 10.1053/j.ajkd.2022.08.007.
- Xu L, Guo J, Moledina DG, Cantley LG. Immune-mediated tubule atrophy promotes acute kidney injury to chronic kidney disease transition. Nature Communications 2022, 13: 4892. PMID: 35986026, PMCID: PMC9391331, DOI: 10.1038/s41467-022-32634-0.
- Tran AC, Melchinger H, Weinstein J, Shaw M, Kent C, Perazella MA, Wilson FP, Parikh CR, Moledina DG. Urine testing to differentiate glomerular from tubulointerstitial diseases on kidney biopsy. Practical Laboratory Medicine 2022, 30: e00271. PMID: 35465621, PMCID: PMC9018443, DOI: 10.1016/j.plabm.2022.e00271.
- Wen Y, Thiessen-Philbrook H, Moledina DG, Kaufman JS, Reeves WB, Ghahramani N, Ikizler TA, Go AS, Liu KD, Siew ED, Himmelfarb J, Kimmel PL, Hsu CY, Parikh CR. Considerations in Controlling for Urine Concentration for Biomarkers of Kidney Disease Progression After Acute Kidney Injury. Kidney International Reports 2022, 7: 1502-1513. PMID: 35812275, PMCID: PMC9263319, DOI: 10.1016/j.ekir.2022.03.026.
- Moledina D, Herlitz L, Perazella M. Acute Interstitial Nephritis and Crystalline Nephropathies. Nephrology Self-Assessment Program 2022, 21: 50-70. DOI: 10.1681/nsap.2022.21.1.5.
- Mansour SG, Khoury N, Kodali R, Virmani S, Reese PP, Hall IE, Jia Y, Yamamoto Y, Thiessen-Philbrook HR, Obeid W, Doshi MD, Akalin E, Bromberg JS, Harhay MN, Mohan S, Muthukumar T, Singh P, Weng FL, Moledina DG, Greenberg JH, Wilson FP, Parikh CR. Clinically adjudicated deceased donor acute kidney injury and graft outcomes. PLOS ONE 2022, 17: e0264329. PMID: 35239694, PMCID: PMC8893682, DOI: 10.1371/journal.pone.0264329.
- Menez S, Moledina DG, Thiessen-Philbrook H, Wilson FP, Obeid W, Simonov M, Yamamoto Y, Corona-Villalobos CP, Chang C, Garibaldi BT, Clarke W, Farhadian S, Dela Cruz C, Coca SG, Parikh CR, Investigators T, Ko A, Iwasaki A, Farhadian S, Nelson A, Casanovas-Massana A, White E, Schulz W, Coppi A, Young P, Nunez A, Shepard D, Matos I, Strong Y, Anastasio K, Brower K, Kuang M, Chiorazzi M, Bermejo S, Vijayakumar P, Geng B, Fournier J, Minasyan M, Muenker M, Moore A, Nadkarni G. Prognostic Significance of Urinary Biomarkers in Patients Hospitalized With COVID-19. American Journal Of Kidney Diseases 2021, 79: 257-267.e1. PMID: 34710516, PMCID: PMC8542781, DOI: 10.1053/j.ajkd.2021.09.008.
- George S, Pal AC, Gagnon J, Timalsina S, Singh P, Vydyam P, Munshi M, Chiu JE, Renard I, Harden CA, Ott IM, Watkins AE, Vogels CBF, Lu P, Tokuyama M, Venkataraman A, Casanovas-Massana A, Wyllie AL, Rao V, Campbell M, Farhadian SF, Grubaugh ND, Dela Cruz CS, Ko AI, Perez A, Akaho EH, Moledina DG, Testani J, John AR, Ledizet M, Mamoun CB, Team A. Evidence for SARS-CoV-2 Spike Protein in the Urine of COVID-19 Patients. Kidney360 2021, 2: 924-936. PMID: 35373072, PMCID: PMC8791366, DOI: 10.34067/kid.0002172021.
- Moledina DG, Perazella MA. The Challenges of Acute Interstitial Nephritis: Time to Standardize. Kidney360 2021, 2: 1051-1055. PMID: 35373086, PMCID: PMC8791367, DOI: 10.34067/kid.0001742021.
- Ghazi L, Simonov M, Mansour SG, Moledina DG, Greenberg JH, Yamamoto Y, Biswas A, Wilson FP. Predicting patients with false negative SARS-CoV-2 testing at hospital admission: A retrospective multi-center study. PLOS ONE 2021, 16: e0251376. PMID: 33979353, PMCID: PMC8115794, DOI: 10.1371/journal.pone.0251376.
- Menez S, Ju W, Menon R, Moledina DG, Thiessen Philbrook H, McArthur E, Jia Y, Obeid W, Mansour SG, Koyner JL, Shlipak MG, Coca SG, Garg AX, Bomback AS, Kellum JA, Kretzler M, Parikh CR, . Urinary EGF and MCP-1 and risk of CKD after cardiac surgery. JCI Insight 2021, 6: e147464. PMID: 33974569, PMCID: PMC8262289, DOI: 10.1172/jci.insight.147464.
- Ferkowicz M, Winfree S, Sabo A, Kamocka M, Khochare S, Barwinska D, Eadon M, Cheng Y, Phillips C, Sutton T, Kelly K, Dagher P, El-Achkar T, Dunn K, Knight R, Lecker S, Stillman I, Mcmahon G, Waikar S, Weins A, Hacohen N, Hoover P, Aulisio M, Cooperman L, Herlitz L, O'toole J, Poggio E, Sedor J, Appelbaum P, Barasch J, Bomback A, D'agati V, Kiryluk K, Mehl K, Shang N, Weng C, Barisoni L, Alexandrov T, Ashkar T, Barwinska D, Dagher P, Dunn K, Eadon M, Ferkowicz M, Kelly K, Sutton T, Winfree S, Menez S, Parikh C, Rosenberg A, Villalobos P, Slack A, Rosas S, Williams M, Azeloglu E, He C, Iyengar R, Parikh S, Anderton C, Pasa-Tolic L, Velickovic D, Oliver G, Ardayfio J, Bebiak J, Brown K, Campbell T, Campbell C, Hayashi L, Jefferson N, Koewler R, Roberts G, Saul J, Shpigel A, Stutzke E, Wright L, Miegs L, Pinkeney R, Sealfon R, Troyanskaya O, Tuttle K, Goltsev Y, Lake B, Zhang K, Dobi D, Joanes M, Laszik Z, Nolan G, Schroeder A, Balis U, He O, Hodgin J, Kretzler M, Mariani L, Menon R, Otto E, Schaub J, Steck B, Elder M, Hall D, Kellum J, Kruth M, Murugan R, Palevsky P, Randhawa P, Rosengart M, Sims-Lucas S, Stefanick M, Stull S, Tublin M, Alpers C, Boer I, Fullerton M, Himmelfarb J, Mcclelland R, Mooney S, Shankland S, Williams K, Blank K, Dighe A, Carson J, Dowd F, Drager Z, Sharma K, Zhang G, Kermani A, Lee S, Lu C, Miller T, Moe O, Park H, Sambandam K, Sanchez F, Torrealba J, Robert T, Vazquez M, Wang N, Gaut J, Jain S, Vijayan A, Luciano R, Moledina D, Ugochukwu U, Wilson F. Large-scale, three-dimensional tissue cytometry of the human kidney: a complete and accessible pipeline. Laboratory Investigation 2021, 101: 661-676. PMID: 36775387, DOI: 10.1038/s41374-020-00518-w.
- Mansour SG, Malhotra D, Simonov M, Yamamoto Y, Arora T, Subair L, Alausa J, Moledina DG, Greenberg JH, Wilson FP, Marin EP. A Comparison Study of Coronavirus Disease 2019 Outcomes in Hospitalized Kidney Transplant Recipients. Kidney360 2021, 2: 494-506. PMID: 35369023, PMCID: PMC8786009, DOI: 10.34067/kid.0005652020.
- Nugent J, Aklilu A, Yamamoto Y, Simonov M, Li F, Biswas A, Ghazi L, Greenberg J, Mansour S, Moledina D, Wilson FP. Assessment of Acute Kidney Injury and Longitudinal Kidney Function After Hospital Discharge Among Patients With and Without COVID-19. JAMA Network Open 2021, 4: e211095. PMID: 33688965, PMCID: PMC7948062, DOI: 10.1001/jamanetworkopen.2021.1095.
- de Boer IH, Alpers CE, Azeloglu EU, Balis UGJ, Barasch JM, Barisoni L, Blank KN, Bomback AS, Brown K, Dagher PC, Dighe AL, Eadon MT, El-Achkar TM, Gaut JP, Hacohen N, He Y, Hodgin JB, Jain S, Kellum JA, Kiryluk K, Knight R, Laszik ZG, Lienczewski C, Mariani LH, McClelland RL, Menez S, Moledina DG, Mooney SD, O’Toole J, Palevsky PM, Parikh CR, Poggio ED, Rosas SE, Rosengart MR, Sarwal MM, Schaub JA, Sedor JR, Sharma K, Steck B, Toto RD, Troyanskaya OG, Tuttle KR, Vazquez MA, Waikar SS, Williams K, Wilson FP, Zhang K, Iyengar R, Kretzler M, Himmelfarb J, Project K, Knight R, Lecker S, Stillman I, Waikar S, Mcmahon G, Weins A, Short S, Hacohen N, Hoover P, Aulisio M, Cooperman L, Herlitz L, O’Toole J, Poggio E, Sedor J, Jolly S, Appelbaum P, Balderes O, Barasch J, Bomback A, Canetta P, d’Agati V, Kiryluk K, Kudose S, Mehl K, Radhakrishnan J, Weng C, Barisoni L, Alexandrov T, Ashkar T, Barwinska D, Dagher P, Dunn K, Eadon M, Ferkowicz M, Kelly K, Sutton T, Winfree S, Menez S, Parikh C, Rosenberg A, Villalobos P, Malik R, Fine D, Atta M, Trujillo J, Slack A, Rosas S, Williams M, Azeloglu E, He C, Iyengar R, Hansen J, Parikh S, Rovin B, Anderton C, Pasa-Tolic L, Velickovic D, Lukowski J, Oliver G, Ardayfio J, Bebiak J, Brown K, Campbell T, Campbell C, Hayashi L, Jefferson N, Koewler R, Roberts G, Saul J, Shpigel A, Stutzke E, Wright L, Miegs L, Pinkeney R, Sealfon R, Troyanskaya O, Tuttle K, Dobi D, Goltsev Y, Lake B, Zhang K, Joanes M, Laszik Z, Schroeder A, Sarwal M, Sigdel T, Balis U, Blanc V, He O, Hodgin J, Kretzler M, Mariani L, Menon R, Otto E, Schaub J, Steck B, Lienczewski C, Eddy S, Elder M, Hall D, Kellum J, Kruth M, Murugan R, Palevsky P, Randhawa P, Rosengart M, Sims-Lucas S, Stefanick M, Stull S, Tublin M, Alpers C, de Boer I, Dighe A, Himmelfarb J, Mcclelland R, Mooney S, Shankland S, Williams K, Blank K, Carson J, Dowd F, Drager Z, Park C, Sharma K, Zhang G, Bansal S, Venkatachalam M, Kermani A, Lee S, Lu C, Miller T, Moe O, Park H, Sambandam K, Sanchez F, Torrealba J, Robert T, Vazquez M, Wang N, Gaut J, Jain S, Vijayan A, Luciano R, Moledina D, Ugochukwu U, Wilson F, Alfano S. Rationale and design of the Kidney Precision Medicine Project. Kidney International 2021, 99: 498-510. PMID: 33637194, PMCID: PMC8330551, DOI: 10.1016/j.kint.2020.08.039.
- Wilson FP, Martin M, Yamamoto Y, Partridge C, Moreira E, Arora T, Biswas A, Feldman H, Garg AX, Greenberg JH, Hinchcliff M, Latham S, Li F, Lin H, Mansour SG, Moledina DG, Palevsky PM, Parikh CR, Simonov M, Testani J, Ugwuowo U. Electronic health record alerts for acute kidney injury: multicenter, randomized clinical trial. The BMJ 2021, 372: m4786. PMID: 33461986, PMCID: PMC8034420, DOI: 10.1136/bmj.m4786.
- Tian X, Inoue K, Zhang Y, Wang Y, Sperati CJ, Pedigo CE, Zhao T, Yan M, Groener M, Moledina DG, Ebenezer K, Li W, Zhang Z, Liebermann D, Greene L, Greer P, Parikh CR, Ishibe S. Inhibiting calpain 1 and 2 in cyclin G associated kinase–knockout mice mitigates podocyte injury. JCI Insight 2020, 5: e142740. PMID: 33208557, PMCID: PMC7710277, DOI: 10.1172/jci.insight.142740.
- Moledina DG, Belliveau O, Yamamoto Y, Arora T, Carey KA, Churpek M, Martin M, Partridge CM, Mansour SG, Parikh CR, Koyner JL, Wilson FP. Variation in Best Practice Measures in Patients With Severe Hospital-Acquired Acute Kidney Injury: A Multicenter Study. American Journal Of Kidney Diseases 2020, 77: 547-549. PMID: 33075389, PMCID: PMC8672301, DOI: 10.1053/j.ajkd.2020.08.013.
- Menez S, Moledina DG, Garg AX, Thiessen-Philbrook H, McArthur E, Jia Y, Liu C, Obeid W, Mansour SG, Koyner JL, Shlipak MG, Wilson FP, Coca SG, Parikh CR. Results from the TRIBE-AKI Study found associations between post-operative blood biomarkers and risk of chronic kidney disease after cardiac surgery. Kidney International 2020, 99: 716-724. PMID: 32721447, PMCID: PMC8077034, DOI: 10.1016/j.kint.2020.06.037.
- Ugwuowo U, Yamamoto Y, Arora T, Saran I, Partridge C, Biswas A, Martin M, Moledina DG, Greenberg JH, Simonov M, Mansour SG, Vela R, Testani JM, Rao V, Rentfro K, Obeid W, Parikh CR, Wilson FP. Real-Time Prediction of Acute Kidney Injury in Hospitalized Adults: Implementation and Proof of Concept. American Journal Of Kidney Diseases 2020, 76: 806-814.e1. PMID: 32505812, PMCID: PMC8667815, DOI: 10.1053/j.ajkd.2020.05.003.
- Sandokji I, Yamamoto Y, Biswas A, Arora T, Ugwuowo U, Simonov M, Saran I, Martin M, Testani JM, Mansour S, Moledina DG, Greenberg JH, Wilson FP. A Time-Updated, Parsimonious Model to Predict AKI in Hospitalized Children. Journal Of The American Society Of Nephrology 2020, 31: 1348-1357. PMID: 32381598, PMCID: PMC7269342, DOI: 10.1681/asn.2019070745.
- Bhatraju PK, Zelnick LR, Chinchilli VM, Moledina DG, Coca SG, Parikh CR, Garg AX, Hsu CY, Go AS, Liu KD, Ikizler TA, Siew ED, Kaufman JS, Kimmel PL, Himmelfarb J, Wurfel MM. Association Between Early Recovery of Kidney Function After Acute Kidney Injury and Long-term Clinical Outcomes. JAMA Network Open 2020, 3: e202682. PMID: 32282046, PMCID: PMC7154800, DOI: 10.1001/jamanetworkopen.2020.2682.
- Patel DM, Thiessen-Philbrook H, Brown JR, McArthur E, Moledina DG, Mansour SG, Shlipak MG, Koyner JL, Kavsak P, Whitlock RP, Everett AD, Malenka DJ, Garg AX, Coca SG, Parikh CR. Association of plasma-soluble ST2 and galectin-3 with cardiovascular events and mortality following cardiac surgery. American Heart Journal 2019, 220: 253-263. PMID: 31911262, PMCID: PMC7008086, DOI: 10.1016/j.ahj.2019.11.014.
- Moledina DG, Mansour SG, Jia Y, Obeid W, Thiessen-Philbrook H, Koyner JL, McArthur E, Garg AX, Wilson FP, Shlipak MG, Coca SG, Parikh CR, Consortium T. Association of T Cell–Derived Inflammatory Cytokines With Acute Kidney Injury and Mortality After Cardiac Surgery. Kidney International Reports 2019, 4: 1689-1697. PMID: 31844805, PMCID: PMC6895592, DOI: 10.1016/j.ekir.2019.09.003.
- Moledina DG, Parikh CR. Differentiating Acute Interstitial Nephritis from Acute Tubular Injury: A Challenge for Clinicians. Nephron 2019, 143: 211-216. PMID: 31203275, PMCID: PMC6821567, DOI: 10.1159/000501207.
- The Association of Angiogenesis Markers With Acute Kidney Injury and Mortality After Cardiac SurgeryMansour SG, Zhang WR, Moledina D, Coca SG, Jia Y, Thiessen-Philbrook H, McArthur E, Inoue K, Koyner JL, Shlipak MG, Wilson FP, Garg AX, Ishibe S, Parikh CR, Consortium T. The Association of Angiogenesis Markers With Acute Kidney Injury and Mortality After Cardiac Surgery. American Journal Of Kidney Diseases 2019, 74: 36-46. PMID: 30955944, PMCID: PMC6591032, DOI: 10.1053/j.ajkd.2019.01.028.
- Moledina DG. Penkid: A Novel Biomarker of Reduced GFR in Sepsis. Kidney International Reports 2018, 4: 17-19. PMID: 30596164, PMCID: PMC6308914, DOI: 10.1016/j.ekir.2018.11.002.
- Moledina DG, Perazella MA. Treatment of Drug-Induced Acute Tubulointerstitial Nephritis: The Search for Better Evidence. Clinical Journal Of The American Society Of Nephrology 2018, 13: 1785-1787. PMID: 30397028, PMCID: PMC6302332, DOI: 10.2215/cjn.12001018.
- Moledina DG, Luciano RL, Kukova L, Chan L, Saha A, Nadkarni G, Alfano S, Wilson FP, Perazella MA, Parikh CR. Kidney Biopsy–Related Complications in Hospitalized Patients with Acute Kidney Disease. Clinical Journal Of The American Society Of Nephrology 2018, 13: 1633-1640. PMID: 30348813, PMCID: PMC6237071, DOI: 10.2215/cjn.04910418.
- Moledina DG, Parikh CR. Phenotyping of Acute Kidney Injury: Beyond Serum Creatinine. Seminars In Nephrology 2018, 38: 3-11. PMID: 29291759, PMCID: PMC5753429, DOI: 10.1016/j.semnephrol.2017.09.002.
- Moledina DG, Cheung B, Kukova L, Luciano RL, Peixoto AJ, Wilson FP, Alfano S, Parikh CR. A Survey of Patient Attitudes Toward Participation in Biopsy-Based Kidney Research. Kidney International Reports 2017, 3: 412-416. PMID: 29725645, PMCID: PMC5932306, DOI: 10.1016/j.ekir.2017.11.008.
- Moledina DG, Perazella MA. Drug-Induced Acute Interstitial Nephritis. Clinical Journal Of The American Society Of Nephrology 2017, 12: 2046-2049. PMID: 28893923, PMCID: PMC5718279, DOI: 10.2215/cjn.07630717.
- Moledina DG, Hall IE, Thiessen-Philbrook H, Reese PP, Weng FL, Schröppel B, Doshi MD, Wilson FP, Coca SG, Parikh CR. Performance of Serum Creatinine and Kidney Injury Biomarkers for Diagnosing Histologic Acute Tubular Injury. American Journal Of Kidney Diseases 2017, 70: 807-816. PMID: 28844586, PMCID: PMC5701867, DOI: 10.1053/j.ajkd.2017.06.031.
- Coca SG, Nadkarni GN, Huang Y, Moledina DG, Rao V, Zhang J, Ferket B, Crowley ST, Fried LF, Parikh CR. Plasma Biomarkers and Kidney Function Decline in Early and Established Diabetic Kidney Disease. Journal Of The American Society Of Nephrology 2017, 28: 2786-2793. PMID: 28476763, PMCID: PMC5576932, DOI: 10.1681/asn.2016101101.
- Moledina DG, Isguven S, McArthur E, Thiessen-Philbrook H, Garg AX, Shlipak M, Whitlock R, Kavsak PA, Coca SG, Parikh CR, Consortium T. Plasma Monocyte Chemotactic Protein-1 Is Associated With Acute Kidney Injury and Death After Cardiac Operations. The Annals Of Thoracic Surgery 2017, 104: 613-620. PMID: 28223055, PMCID: PMC5588689, DOI: 10.1016/j.athoracsur.2016.11.036.
- Moledina D, Perazella M. Acute Interstitial Nephritis. DeckerMed Nephrology Dialysis And Transplantation 2017 DOI: 10.2310/nephro.12028.
- Parikh CR, Moledina DG, Coca SG, Thiessen-Philbrook HR, Garg AX. Application of new acute kidney injury biomarkers in human randomized controlled trials. Kidney International 2016, 89: 1372-1379. PMID: 27165835, PMCID: PMC4869991, DOI: 10.1016/j.kint.2016.02.027.
- Moledina DG, Perazella MA. Proton Pump Inhibitors and CKD. Journal Of The American Society Of Nephrology 2016, 27: 2926-2928. PMID: 27080978, PMCID: PMC5042680, DOI: 10.1681/asn.2016020192.
- Moledina DG, Perazella MA. PPIs and kidney disease: from AIN to CKD. Journal Of Nephrology 2016, 29: 611-616. PMID: 27072818, DOI: 10.1007/s40620-016-0309-2.
- Tucker B, Moledina DG. We Use Dialysate Potassium Levels That Are Too Low in Hemodialysis. Seminars In Dialysis 2016, 29: 300-302. PMID: 27061895, DOI: 10.1111/sdi.12495.
- Schaub JA, Coca SG, Moledina DG, Gentry M, Testani JM, Parikh CR. Amino-Terminal Pro-B-Type Natriuretic Peptide for Diagnosis and Prognosis in Patients With Renal Dysfunction A Systematic Review and Meta-Analysis. JACC Heart Failure 2015, 3: 977-989. PMID: 26671676, PMCID: PMC4683413, DOI: 10.1016/j.jchf.2015.07.014.
- Moledina DG, Parikh CR, Garg AX, Thiessen-Philbrook H, Koyner JL, Patel UD, Devarajan P, Shlipak MG, Coca SG, . Association of Perioperative Plasma Neutrophil Gelatinase-Associated Lipocalin Levels with 3-Year Mortality after Cardiac Surgery: A Prospective Observational Cohort Study. PLOS ONE 2015, 10: e0129619. PMID: 26053382, PMCID: PMC4460181, DOI: 10.1371/journal.pone.0129619.
- Moledina DG, Perry Wilson F. Pharmacologic Treatment of Common Symptoms in Dialysis Patients: A Narrative Review. Seminars In Dialysis 2015, 28: 377-383. PMID: 25913502, DOI: 10.1111/sdi.12378.
- Moledina DG, Perazella MA. Acute Kidney Injury and Mortality in the Elderly: Add Atypical Antipsychotics to the List. American Journal Of Kidney Diseases 2015, 65: 655-658. PMID: 25687262, DOI: 10.1053/j.ajkd.2015.01.005.
- Moledina D, Geller D. Is Low Dialysate Potassium Ever Indicated in Outpatient Hemodialysis? Seminars In Dialysis 2014, 27: 263-265. PMID: 24635442, DOI: 10.1111/sdi.12212.
- Shirazian S, Kline M, Sakhiya V, Schanler M, Moledina D, Patel C, Hazzan A, Fishbane S. Longitudinal Predictors of Uremic Pruritus. Journal Of Renal Nutrition 2013, 23: 428-431. PMID: 24209894, DOI: 10.1053/j.jrn.2013.08.002.
- Shirazian S, Wang R, Moledina D, Liberman V, Zeidan J, Strand D, Mattana J. A Pilot Trial of a Computerized Renal Template Note to Improve Resident Knowledge and Documentation of Kidney Disease. Applied Clinical Informatics 2013, 04: 528-540. PMID: 24454580, PMCID: PMC3885913, DOI: 10.4338/aci-2013-07-ra-0048.
Departments and Programs
Biography
Dennis Moledina, MD, PhD, is a nephrologist (kidney specialist) who directs the Yale Kidney BioBank, which collects samples of kidney tissue, DNA, plasma, and urine to better understand kidney diseases and develop treatments.
Dr. Moledina's work revolves around evaluating biomarkers for acute interstitial nephritis, a lesion that causes a decline in kidney function, and acute kidney injury. He is the recipient of several National Institutes of Health (NIH) research awards and enrolls study participants in NIH-funded consortia, including the Kidney Precision Medicine Program (KPMP) and care of outpatients with acute kidney injury (COPE-AKI).
He obtained clinical training through a clinical fellowship in nephrology and research training through postdoctoral fellowship and an investigative medicine doctorate at Yale University. Notably, his research experience includes leading the enrollment of a group of more than 750 participants concurrent with their kidney biopsy to create the Yale Kidney BioBank. In this group, he has identified diagnostic and prognostic biomarkers of acute interstitial nephritis.
Dr. Moledina is a fellow of the American Society of Nephrology. This designation honors members who have distinguished themselves through excellent work and clinical practice.
Titles
- Associate Professor of Medicine (Nephrology)
- Director, Kidney BioBank, Internal Medicine
Education & Training
- PhDYale Graduate School of Arts and Sciences, Investigative Medicine (2018)
- Postdoctoral FellowYale School of Medicine (2018)
- Clinical FellowYale School of Medicine (2015)
- Resident PhysicianNYU Grossman Long Island School of Medicine (2013)
- MDM.P. Shah Medical College (2009)
Languages Spoken
- English
- ગુજરાતી (Gujarati)
- हिन्दी (Hindi)
Additional Information
Honors & Recognitions
- Top -rated abstract: National Kidney Foundation (2024)
- Fellow: American Society of Nephrology (2021)
- K23 Mentored Patient-Oriented Career Development Award: NIH/NIDDK (2018)
- KPMP Opportunity Pool Travel Grant: Kidney Precision Medicine Program (KPMP) (2018)
- American Heart Association Career Development Award: (2018)
- Patterson Trust Mentored Research Award: (2017)
- Top Oral Abstract by a Trainee: American Society of Nephrology (2015)
- Outstanding Renal Fellow: Faculty and Fellows of Yale Nephrology (2015)
- John F Aloia Award for Academic Excellence: NYU Grossman Long Island School of Medicine (2013)
- Outstanding Second Year Medical Resident: NYU Grossman Long Island School of Medicine (2012)
Professional Service
- ASN Journals Editorial Board (2024 - 2026): Editorial Board Member
- National Kidney Foundation: 2025 Spring Clinical Meetings (2024 - 2025): Committee Member
- 2025 Patterson Mentored Research Review Committee (2024): Review Panel Member
- National Kidney Foundation Spring Clinical Meetings 2025 (2024): Abstract Reviewer
- National Institutes of Health (2024): Special Emphasis panel: Topics in Nephrology and Urology
- Fundamentals and Updates in Critical Care Nephrology and Acute Kidney Injury: National Kidney Foundation: Spring Clinical Meeting 2024 Planning Committee (2024): Chair
- AKI Syndromes: Special Considerations: National Kidney Foundation 2024 Spring Clinical Meetings (2024): Chair
- National Kidney Foundation: 2024 Spring Clinical Meetings (2023 - 2024): Committee Member
- National Kidney Foundation Spring Clinical Meeting 2024 (2023): Abstract Reviewer
- American Society of Nephrology: Kidney Week 2023 (2023): Coronavirus (COVID-19): 000 Coronavirus (COVID-19)
Publications
- Moledina D, Obeid W, Smith R, Rosales I, Sise M, Moeckel G, Kashgarian M, Kuperman M, Campbell K, Lefferts S, Meliambro K, Bitzer M, Perazella M, Luciano R, Pober J, Cantley L, Colvin R, Wilson F, Parikh C. Identification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis. Journal Of Clinical Investigation 2023, 133: e168950. PMID: 37395276, PMCID: PMC10313360, DOI: 10.1172/jci168950.
- Moledina DG, Wilson FP, Pober JS, Perazella MA, Singh N, Luciano RL, Obeid W, Lin H, Kuperman M, Moeckel GW, Kashgarian M, Cantley LG, Parikh CR. Urine TNF-α and IL-9 for clinical diagnosis of acute interstitial nephritis. JCI Insight 2019, 4: e127456. PMID: 31092735, PMCID: PMC6542610, DOI: 10.1172/jci.insight.127456.
- Moledina DG, Eadon MT, Calderon F, Yamamoto Y, Shaw M, Perazella MA, Simonov M, Luciano R, Schwantes-An TH, Moeckel G, Kashgarian M, Kuperman M, Obeid W, Cantley LG, Parikh CR, Wilson FP. Development and external validation of a diagnostic model for biopsy-proven acute interstitial nephritis using electronic health record data. Nephrology Dialysis Transplantation 2021, 37: 2214-2222. PMID: 34865148, PMCID: PMC9755995, DOI: 10.1093/ndt/gfab346.
- Baker ML, Yamamoto Y, Perazella MA, Dizman N, Shirali AC, Hafez N, Weinstein J, Simonov M, Testani JM, Kluger HM, Cantley LG, Parikh CR, Wilson FP, Moledina DG. Mortality after acute kidney injury and acute interstitial nephritis in patients prescribed immune checkpoint inhibitor therapy. Journal For ImmunoTherapy Of Cancer 2022, 10: e004421. PMID: 35354588, PMCID: PMC8968986, DOI: 10.1136/jitc-2021-004421.
- Moledina DG, Wilson FP, Kukova L, Obeid W, Luciano R, Kuperman M, Moeckel GW, Kashgarian M, Perazella MA, Cantley LG, Parikh CR. Urine interleukin-9 and tumor necrosis factor-α for prognosis of human acute interstitial nephritis. Nephrology Dialysis Transplantation 2020, 36: 1851-1858. PMID: 33125471, PMCID: PMC8476079, DOI: 10.1093/ndt/gfaa169.
- Moledina DG, Simonov M, Yamamoto Y, Alausa J, Arora T, Biswas A, Cantley LG, Ghazi L, Greenberg JH, Hinchcliff M, Huang C, Mansour SG, Martin M, Peixoto A, Schulz W, Subair L, Testani JM, Ugwuowo U, Young P, Wilson FP. The Association of COVID-19 With Acute Kidney Injury Independent of Severity of Illness: A Multicenter Cohort Study. American Journal Of Kidney Diseases 2021, 77: 490-499.e1. PMID: 33422598, PMCID: PMC7791318, DOI: 10.1053/j.ajkd.2020.12.007.
- Melchinger H, Calderon-Gutierrez F, Obeid W, Xu L, Shaw MM, Luciano RL, Kuperman M, Moeckel GW, Kashgarian M, Wilson FP, Parikh CR, Moledina DG. Urine Uromodulin as a Biomarker of Kidney Tubulointerstitial Fibrosis. Clinical Journal Of The American Society Of Nephrology 2022, 17: 1284-1292. PMID: 35948365, PMCID: PMC9625093, DOI: 10.2215/cjn.04360422.
- Moledina D, Shelton K, Menez S, Aklilu A, Yamamoto Y, Kadhim B, Shaw M, Kent C, Makhijani A, Hu D, Simonov M, O'Connor K, Bitzel J, Thiessen-Philbrook H, Wilson F, Parikh C. External Validation of an Electronic Health Record-Based Diagnostic Model for Histological Acute Tubulointerstitial Nephritis. Journal Of The American Society Of Nephrology 2024 PMID: 39500309, DOI: 10.1681/asn.0000000556.
- Mistry K, Sadarangani S, Moreno D, Mejia S, Moledina D, Sise M. Novel Biomarkers and Imaging Tests for AKI Diagnosis in Patients with Cancer. Kidney360 2024 PMID: 39575585, DOI: 10.34067/kid.0000000660.
- Aklilu A, Menez S, Baker M, Brown D, Dircksen K, Dunkley K, Gaviria S, Farrokh S, Faulkner S, Jones C, Kadhim B, Le D, Li F, Makhijani A, Martin M, Moledina D, Coronel-Moreno C, O’Connor K, Shelton K, Shvets K, Srialluri N, Tan J, Testani J, Corona-Villalobos C, Yamamoto Y, Parikh C, Wilson F, Sundararajan A, Wang A, Schretlen C, Singel D, Moss E, Aune F, Iantosca G, Zou G, Chernova I, Bitzel J, Hernandez J, Lindsley J, Dane K, Orias M, Mehta P, Zassman-Isner S, Wen Y, Freeman N. Early, Individualized Recommendations for Hospitalized Patients With Acute Kidney Injury. JAMA 2024, 332 PMID: 39454050, DOI: 10.1001/jama.2024.22718.
- Schmidt I, Surapaneni A, Zhao R, Upadhyay D, Yeo W, Schlosser P, Huynh C, Srivastava A, Palsson R, Kim T, Stillman I, Barwinska D, Barasch J, Eadon M, El-Achkar T, Henderson J, Moledina D, Rosas S, Claudel S, Verma A, Wen Y, Lindenmayer M, Huber T, Parikh S, Shapiro J, Rovin B, Stanaway I, Sathe N, Bhatraju P, Coresh J, Rhee E, Grams M, Waikar S. Plasma proteomics of acute tubular injury. Nature Communications 2024, 15: 7368. PMID: 39191768, PMCID: PMC11349760, DOI: 10.1038/s41467-024-51304-x.
- D Souza S, Obeid W, Hernandez J, Hu D, Wen Y, Moledina D, Albert A, Gregg A, Wheeler A, Philbrook H, Parikh C. The development of lateral flow devices for urinary biomarkers to assess kidney health. Scientific Reports 2024, 14: 8516. PMID: 38609491, PMCID: PMC11014899, DOI: 10.1038/s41598-024-59104-5.
- Aklilu A, Kumar S, Nugent J, Yamamoto Y, Coronel-Moreno C, Kadhim B, Faulkner S, O’Connor K, Yasmin F, Greenberg J, Moledina D, Testani J, Wilson F. COVID-19−Associated Acute Kidney Injury and Longitudinal Kidney Outcomes. JAMA Internal Medicine 2024, 184: 414-423. PMID: 38407862, PMCID: PMC10897825, DOI: 10.1001/jamainternmed.2023.8225.
- de Cos M, Mosoyan G, Chauhan K, Troost J, Wong J, Lefferts S, Morgan P, Meliambro K, Egerman M, Ray J, Parker T, Levine D, Seshan S, Bardash Y, Horowitz B, Kent C, Shaw M, Perlman A, Moledina D, Coca S, Campbell K. Urinary Plasminogen as a Marker of Disease Progression in Human Glomerular Disease. American Journal Of Kidney Diseases 2024, 84: 205-214.e1. PMID: 38452919, PMCID: PMC11260534, DOI: 10.1053/j.ajkd.2024.01.520.
- Barsotti G, Luciano R, Kumar A, Meliambro K, Kakade V, Tokita J, Naik A, Fu J, Peck E, Pell J, Reghuvaran A, Tanvir E, Patel P, Zhang W, Li F, Moeckel G, Perincheri S, Cantley L, Moledina D, Wilson F, He J, Menon M. Rationale and Design of a Phase 2, Double-blind, Placebo-Controlled, Randomized Trial Evaluating AMP Kinase-Activation by Metformin in Focal Segmental Glomerulosclerosis. Kidney International Reports 2024, 9: 1354-1368. PMID: 38707807, PMCID: PMC11068976, DOI: 10.1016/j.ekir.2024.02.006.
- Krishnan N, Moledina D, Perazella M. Toxic Nephropathies of the Tubulointerstitium: Core Curriculum 2024. American Journal Of Kidney Diseases 2024, 83: 659-676. PMID: 38243994, DOI: 10.1053/j.ajkd.2023.09.017.
- Guo X, Blanc V, Davidson N, Velazquez H, Chen T, Moledina D, Moeckel G, Safirstein R, Desir G. APOBEC-1 deletion enhances cisplatin-induced acute kidney injury. Scientific Reports 2023, 13: 22255. PMID: 38097707, PMCID: PMC10721635, DOI: 10.1038/s41598-023-49575-3.
- Wen Y, Su E, Xu L, Menez S, Moledina D, Obeid W, Palevsky P, Mansour S, Devarajan P, Cantley L, Cahan P, Parikh C, Project K, Injury T. Analysis of the human kidney transcriptome and plasma proteome identifies markers of proximal tubule maladaptation to injury. Science Translational Medicine 2023, 15: eade7287. PMID: 38091407, PMCID: PMC11405121, DOI: 10.1126/scitranslmed.ade7287.
- Kiernan E, Hu D, Philbrook H, Ix J, Bonventre J, Coca S, Moledina D, Fried L, Shlipak M, Parikh C. Urinary Biomarkers and Kidney Injury in VA NEPHRON-D: Phenotyping Acute Kidney Injury in Clinical Trials. American Journal Of Kidney Diseases 2023, 83: 151-161. PMID: 37726051, PMCID: PMC10841767, DOI: 10.1053/j.ajkd.2023.07.012.
- Aklilu A, Kumar S, Yamamoto Y, Moledina D, Sinha F, Testani J, Wilson F. Outcomes Associated with Sodium-Glucose Cotransporter-2 Inhibitor Use in Acute Heart Failure Hospitalizations Complicated by AKI. Kidney360 2023, 4: 1371-1381. PMID: 37644648, PMCID: PMC10615381, DOI: 10.34067/kid.0000000000000250.
- Menez S, Wen Y, Xu L, Moledina D, Thiessen-Philbrook H, Hu D, Obeid W, Bhatraju P, Ikizler T, Siew E, Chinchilli V, Garg A, Go A, Liu K, Kaufman J, Kimmel P, Himmelfarb J, Coca S, Cantley L, Parikh C. The ASSESS-AKI Study found urinary epidermal growth factor is associated with reduced risk of major adverse kidney events. Kidney International 2023, 104: 1194-1205. PMID: 37652206, PMCID: PMC10840723, DOI: 10.1016/j.kint.2023.08.007.
- Reghuvaran A, Lin Q, Basgen J, Banu K, Shi H, Vashist A, Pell J, Perinchery S, He J, Moledina D, Wilson F, Menon M. Comparative evaluation of glomerular morphometric techniques reveals differential technical artifacts between focal segmental glomerulosclerosis and normal glomeruli. Physiological Reports 2023, 11: e15688. PMID: 37423891, PMCID: PMC10329935, DOI: 10.14814/phy2.15688.
- Menez S, Coca S, Moledina D, Wen Y, Chan L, Thiessen-Philbrook H, Obeid W, Garibaldi B, Azeloglu E, Ugwuowo U, Sperati C, Arend L, Rosenberg A, Kaushal M, Jain S, Wilson F, Parikh C, Consortium T, Deng J, Atta M, Bagnasco S, Ko A, Iwasaki A, Farhadian S, Nelson A, Casanovas-Massana A, White E, Schulz W, Coppi A, Young P, Nunez A, Shepard D, Matos I, Strong Y, Anastasio K, Brower K, Kuang M, Chiorazzi M, Bermejo S, Vijayakumar P, Geng B, Fournier J, Minasyan M, Muenker M, Moore A, Nadkarni G. Evaluation of Plasma Biomarkers to Predict Major Adverse Kidney Events in Hospitalized Patients With COVID-19. American Journal Of Kidney Diseases 2023, 82: 322-332.e1. PMID: 37263570, PMCID: PMC10229201, DOI: 10.1053/j.ajkd.2023.03.010.
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- Vasquez-Rios G, Oh W, Lee S, Bhatraju P, Mansour S, Moledina D, Gulamali F, Siew E, Garg A, Sarder P, Chinchilli V, Kaufman J, Hsu C, Liu K, Kimmel P, Go A, Wurfel M, Himmelfarb J, Parikh C, Coca S, Nadkarni G. Joint Modeling of Clinical and Biomarker Data in Acute Kidney Injury Defines Unique Subphenotypes with Differing Outcomes. Clinical Journal Of The American Society Of Nephrology 2023, 18: 716-726. PMID: 36975209, PMCID: PMC10278836, DOI: 10.2215/cjn.0000000000000156.
- Vasquez-Rios G, Moledina D, Jia Y, McArthur E, Mansour S, Thiessen-Philbrook H, Shlipak M, Koyner J, Garg A, Parikh C, Coca S. Pre-operative kidney biomarkers and risks for death, cardiovascular and chronic kidney disease events after cardiac surgery: the TRIBE-AKI study. Journal Of Cardiothoracic Surgery 2022, 17: 338. PMID: 36567329, PMCID: PMC9790121, DOI: 10.1186/s13019-022-02066-4.
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- Mansour SG, Khoury N, Kodali R, Virmani S, Reese PP, Hall IE, Jia Y, Yamamoto Y, Thiessen-Philbrook HR, Obeid W, Doshi MD, Akalin E, Bromberg JS, Harhay MN, Mohan S, Muthukumar T, Singh P, Weng FL, Moledina DG, Greenberg JH, Wilson FP, Parikh CR. Clinically adjudicated deceased donor acute kidney injury and graft outcomes. PLOS ONE 2022, 17: e0264329. PMID: 35239694, PMCID: PMC8893682, DOI: 10.1371/journal.pone.0264329.
- Menez S, Moledina DG, Thiessen-Philbrook H, Wilson FP, Obeid W, Simonov M, Yamamoto Y, Corona-Villalobos CP, Chang C, Garibaldi BT, Clarke W, Farhadian S, Dela Cruz C, Coca SG, Parikh CR, Investigators T, Ko A, Iwasaki A, Farhadian S, Nelson A, Casanovas-Massana A, White E, Schulz W, Coppi A, Young P, Nunez A, Shepard D, Matos I, Strong Y, Anastasio K, Brower K, Kuang M, Chiorazzi M, Bermejo S, Vijayakumar P, Geng B, Fournier J, Minasyan M, Muenker M, Moore A, Nadkarni G. Prognostic Significance of Urinary Biomarkers in Patients Hospitalized With COVID-19. American Journal Of Kidney Diseases 2021, 79: 257-267.e1. PMID: 34710516, PMCID: PMC8542781, DOI: 10.1053/j.ajkd.2021.09.008.
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- Wilson FP, Martin M, Yamamoto Y, Partridge C, Moreira E, Arora T, Biswas A, Feldman H, Garg AX, Greenberg JH, Hinchcliff M, Latham S, Li F, Lin H, Mansour SG, Moledina DG, Palevsky PM, Parikh CR, Simonov M, Testani J, Ugwuowo U. Electronic health record alerts for acute kidney injury: multicenter, randomized clinical trial. The BMJ 2021, 372: m4786. PMID: 33461986, PMCID: PMC8034420, DOI: 10.1136/bmj.m4786.
- Tian X, Inoue K, Zhang Y, Wang Y, Sperati CJ, Pedigo CE, Zhao T, Yan M, Groener M, Moledina DG, Ebenezer K, Li W, Zhang Z, Liebermann D, Greene L, Greer P, Parikh CR, Ishibe S. Inhibiting calpain 1 and 2 in cyclin G associated kinase–knockout mice mitigates podocyte injury. JCI Insight 2020, 5: e142740. PMID: 33208557, PMCID: PMC7710277, DOI: 10.1172/jci.insight.142740.
- Moledina DG, Belliveau O, Yamamoto Y, Arora T, Carey KA, Churpek M, Martin M, Partridge CM, Mansour SG, Parikh CR, Koyner JL, Wilson FP. Variation in Best Practice Measures in Patients With Severe Hospital-Acquired Acute Kidney Injury: A Multicenter Study. American Journal Of Kidney Diseases 2020, 77: 547-549. PMID: 33075389, PMCID: PMC8672301, DOI: 10.1053/j.ajkd.2020.08.013.
- Menez S, Moledina DG, Garg AX, Thiessen-Philbrook H, McArthur E, Jia Y, Liu C, Obeid W, Mansour SG, Koyner JL, Shlipak MG, Wilson FP, Coca SG, Parikh CR. Results from the TRIBE-AKI Study found associations between post-operative blood biomarkers and risk of chronic kidney disease after cardiac surgery. Kidney International 2020, 99: 716-724. PMID: 32721447, PMCID: PMC8077034, DOI: 10.1016/j.kint.2020.06.037.
- Ugwuowo U, Yamamoto Y, Arora T, Saran I, Partridge C, Biswas A, Martin M, Moledina DG, Greenberg JH, Simonov M, Mansour SG, Vela R, Testani JM, Rao V, Rentfro K, Obeid W, Parikh CR, Wilson FP. Real-Time Prediction of Acute Kidney Injury in Hospitalized Adults: Implementation and Proof of Concept. American Journal Of Kidney Diseases 2020, 76: 806-814.e1. PMID: 32505812, PMCID: PMC8667815, DOI: 10.1053/j.ajkd.2020.05.003.
- Sandokji I, Yamamoto Y, Biswas A, Arora T, Ugwuowo U, Simonov M, Saran I, Martin M, Testani JM, Mansour S, Moledina DG, Greenberg JH, Wilson FP. A Time-Updated, Parsimonious Model to Predict AKI in Hospitalized Children. Journal Of The American Society Of Nephrology 2020, 31: 1348-1357. PMID: 32381598, PMCID: PMC7269342, DOI: 10.1681/asn.2019070745.
- Bhatraju PK, Zelnick LR, Chinchilli VM, Moledina DG, Coca SG, Parikh CR, Garg AX, Hsu CY, Go AS, Liu KD, Ikizler TA, Siew ED, Kaufman JS, Kimmel PL, Himmelfarb J, Wurfel MM. Association Between Early Recovery of Kidney Function After Acute Kidney Injury and Long-term Clinical Outcomes. JAMA Network Open 2020, 3: e202682. PMID: 32282046, PMCID: PMC7154800, DOI: 10.1001/jamanetworkopen.2020.2682.
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- Moledina DG. Penkid: A Novel Biomarker of Reduced GFR in Sepsis. Kidney International Reports 2018, 4: 17-19. PMID: 30596164, PMCID: PMC6308914, DOI: 10.1016/j.ekir.2018.11.002.
- Moledina DG, Perazella MA. Treatment of Drug-Induced Acute Tubulointerstitial Nephritis: The Search for Better Evidence. Clinical Journal Of The American Society Of Nephrology 2018, 13: 1785-1787. PMID: 30397028, PMCID: PMC6302332, DOI: 10.2215/cjn.12001018.
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- Moledina DG, Perazella MA. Proton Pump Inhibitors and CKD. Journal Of The American Society Of Nephrology 2016, 27: 2926-2928. PMID: 27080978, PMCID: PMC5042680, DOI: 10.1681/asn.2016020192.
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- Tucker B, Moledina DG. We Use Dialysate Potassium Levels That Are Too Low in Hemodialysis. Seminars In Dialysis 2016, 29: 300-302. PMID: 27061895, DOI: 10.1111/sdi.12495.
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- Moledina DG, Parikh CR, Garg AX, Thiessen-Philbrook H, Koyner JL, Patel UD, Devarajan P, Shlipak MG, Coca SG, . Association of Perioperative Plasma Neutrophil Gelatinase-Associated Lipocalin Levels with 3-Year Mortality after Cardiac Surgery: A Prospective Observational Cohort Study. PLOS ONE 2015, 10: e0129619. PMID: 26053382, PMCID: PMC4460181, DOI: 10.1371/journal.pone.0129619.
- Moledina DG, Perry Wilson F. Pharmacologic Treatment of Common Symptoms in Dialysis Patients: A Narrative Review. Seminars In Dialysis 2015, 28: 377-383. PMID: 25913502, DOI: 10.1111/sdi.12378.
- Moledina DG, Perazella MA. Acute Kidney Injury and Mortality in the Elderly: Add Atypical Antipsychotics to the List. American Journal Of Kidney Diseases 2015, 65: 655-658. PMID: 25687262, DOI: 10.1053/j.ajkd.2015.01.005.
- Moledina D, Geller D. Is Low Dialysate Potassium Ever Indicated in Outpatient Hemodialysis? Seminars In Dialysis 2014, 27: 263-265. PMID: 24635442, DOI: 10.1111/sdi.12212.
- Shirazian S, Kline M, Sakhiya V, Schanler M, Moledina D, Patel C, Hazzan A, Fishbane S. Longitudinal Predictors of Uremic Pruritus. Journal Of Renal Nutrition 2013, 23: 428-431. PMID: 24209894, DOI: 10.1053/j.jrn.2013.08.002.
- Shirazian S, Wang R, Moledina D, Liberman V, Zeidan J, Strand D, Mattana J. A Pilot Trial of a Computerized Renal Template Note to Improve Resident Knowledge and Documentation of Kidney Disease. Applied Clinical Informatics 2013, 04: 528-540. PMID: 24454580, PMCID: PMC3885913, DOI: 10.4338/aci-2013-07-ra-0048.
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