Brian B. Koo, MD
Biography
Brian B. Koo, MD, is an award-winning physician who combines his training in neurology and sleep medicine to treat patients with a wide variety of sleep disorders.
An internationally recognized expert in his field, Dr. Koo is the director of the Sleep Medicine Program at the Connecticut Veterans Affairs Healthcare System, as well as director of the Yale Medicine Program for Restless Legs Syndrome (RLS). He works with patients who suffer from sleep disorders, including narcolepsy, RLS, sleep apnea and sleep issues caused by neurological conditions. “Sleep disorders are very treatable and we are almost always able to provide simple, effective treatments that can significantly and positively impact quality of life,” he says.
An assistant professor of neurology at Yale School of Medicine, Dr. Koo is also an active researcher and author specializing in RLS, and one of the world’s foremost experts on the epidemiologic research that links periodic limb movements during sleep and cardiovascular disease.
Titles
- Associate Professor
- Director, Sleep Medicine Laboratory at Connecticut Veterans Affairs Healthcare System, Medicine
- Director, Yale Center for Restless Legs Syndrome
Education & Training
- FellowshipCase Western Reserve University (2008)
- FellowshipCleveland Clinic (2006)
- ResidencyLong Island Jewish Hospital (2005)
- MDTufts University School of Medicine (2001)
- BAUniversity of Pennsylvania, Biological Basis of Behavior (1995)
Additional Information
- Sleep Research Network Junior Investigator Travel Award: Sleep Research Network (2012)
- American Academy of Sleep Medicine, Sleep-Related Movement Disorders Section Investigator Award: American Academy of Sleep Medicine (2012)
- American Academy of Sleep Medicine Young Investigator Forum: American Academy of Sleep Medicine (2012)
- AB of Psychiatry & Neurology, Sleep Medicine (2007, recertified: 2017)
- AB of Psychiatry & Neurology, Neurology (2006, recertified: 2016)
- Restless Legs Syndrome Foundation (2015 - Present): Medical advisory board RLS Foundation
- American Academy of Sleep Medicine: Restless Legs Syndrome Quality Care Task Force (2013 - 2014): Restless Legs Syndrome Quality Care Task Force
- Sleep & Breathing (2013 - Present): Journal Editorial Board
- Sleep-Related Movement Disorders Steering Committee Member, American Academy of Sleep Medicine (2012 - 2015): Steering Committee
- Journal of Korean Sleep Research Society (2012 - Present): Journal Editorial Board
- Koo B, Abdelfattah A, Eysa A, Lu L. The Melanocortin and Endorphin Neuropeptides in Patients with Restless Legs Syndrome. Annals Of Neurology 2024, 95: 688-699. PMID: 38308537, DOI: 10.1002/ana.26876.
- Berkowski J, Koo B. Can tonic motor activation be the magical elixir for restless legs syndrome? Sleep 2023, 46: zsad230. PMID: 37671678, PMCID: PMC11240113, DOI: 10.1093/sleep/zsad230.
- Walters A, Li Y, Koo B, Ondo W, Weinstock L, Champion D, Afrin L, Karroum E, Bagai K, Spruyt K. Review of the role of the endogenous opioid and melanocortin systems in the restless legs syndrome. Brain 2023, 147: 26-38. PMID: 37633259, PMCID: PMC10796165, DOI: 10.1093/brain/awad283.
- de Figueiredo J, Zhu B, Patel A, Kohn R, Koo B, Louis E. Differential impact of resilience on demoralization and depression in Parkinson disease. Frontiers In Psychiatry 2023, 14: 1207019. PMID: 37559912, PMCID: PMC10408307, DOI: 10.3389/fpsyt.2023.1207019.
- Waddell K, Myers L, Perkins A, Sico J, Sexson A, Burrone L, Taylor S, Koo B, Daggy J, Bravata D. Development and validation of a model predicting mild stroke severity on admission using electronic health record data. Journal Of Stroke And Cerebrovascular Diseases 2023, 32: 107255. PMID: 37473533, DOI: 10.1016/j.jstrokecerebrovasdis.2023.107255.
- Koo B. You too can increase brain iron to treat restless legs syndrome. Sleep 2023, 46: zsad181. PMID: 37419490, DOI: 10.1093/sleep/zsad181.
- Sico J, Koo B, Perkins A, Burrone L, Sexson A, Myers L, Taylor S, Yarbrough W, Daggy J, Miech E, Bravata D. Impact of the coronavirus disease-2019 pandemic on Veterans Health Administration Sleep Services. SAGE Open Medicine 2023, 11: 20503121231169388. PMID: 37152838, PMCID: PMC10158800, DOI: 10.1177/20503121231169388.
- Koo B. Re-equip with opioids instead of dopamine agonists for the treatment of augmentation. Sleep 2022, 45: zsac115. PMID: 35556146, DOI: 10.1093/sleep/zsac115.
- Silber MH, Buchfuhrer MJ, Earley CJ, Koo BB, Manconi M, Winkelman JW. The Management of Restless Legs Syndrome: An Updated Algorithm. Mayo Clinic Proceedings 2021, 96: 1921-1937. PMID: 34218864, DOI: 10.1016/j.mayocp.2020.12.026.
- Ahmed N, Kandil M, Elfil M, Jamal A, Koo BB. Hypothyroidism in restless legs syndrome. Journal Of Sleep Research 2020, 30: e13091. PMID: 32483857, DOI: 10.1111/jsr.13091.
- Ahmed N, Kandil M, Elfil M, Jamal A, Koo B. 0795 The Relationship Between Restless Legs Syndrome and Hypothyroidism. Sleep 2020, 43: a302-a303. DOI: 10.1093/sleep/zsaa056.791.
- Elfil M, Eldokmak M, Baratloo A, Ahmed N, Amin H, Koo B. Neuroimaging-Guided Thrombolytic Treatment in Wake-Up Stroke: A Literature Review (127). Neurology 2020, 94 DOI: 10.1212/wnl.94.15_supplement.127.
- Elfil M, Kamel S, Kandil M, Ahmed N, Schaefer S, Koo B. Implications of Gut Microbiome Dysbiosis in Parkinson’s Disease: A Literature Review. (103). Neurology 2020, 94 DOI: 10.1212/wnl.94.15_supplement.103.
- Elfil M, Kamel S, Kandil M, Koo BB, Schaefer SM. Implications of the Gut Microbiome in Parkinson's Disease. Movement Disorders 2020, 35: 921-933. PMID: 32092186, DOI: 10.1002/mds.28004.
- Kim J, Azarbarzin A, Wang R, Djonlagic I, Punjabi N, Zee P, Koo B, Soliman E, Lederer D, Younes M, Redline S. Association of Novel Measures of Sleep Disturbances and Blood Pressure: The MESA Study. 2019, a7270-a7270. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a7270.
- May A, May R, Bena J, Wang L, Monahan K, Stone K, Barrett-Connor E, Koo B, Winkelman J, Redline S, Mittleman M, Mehra R. 0670 Sleep-Related Event Physiologic Timing for Triggering Nonsustained Ventricular Tachycardia: A Case-crossover Analysis. Sleep 2019, 42: a267-a268. DOI: 10.1093/sleep/zsz067.668.
- Koo B, Ahmed N, Alapati A, Bahekar R, Chilakamarri P, Elfil M, Nalamada K, SirDeshpande P, Louis E. Suicidal Behavior in Parkinson Disease (P2.8-025). Neurology 2019, 92 DOI: 10.1212/wnl.92.15_supplement.p2.8-025.
- Miner B, Jiwa N, Koo B. Chapter 4 Treatment of Sleep-Related Movement and Circadian Rhythm Disorders, Hypersomnolence, and Parasomnias. 2019, 77-95. DOI: 10.1016/b978-0-12-813014-8.00004-4.
- Para KS, Chow CA, Nalamada K, Kakade VM, Chilakamarri P, Louis ED, Koo BB. Suicidal thought and behavior in individuals with restless legs syndrome. Sleep Medicine 2018, 54: 1-7. PMID: 30529070, DOI: 10.1016/j.sleep.2018.09.019.
- Doan TT, Koo BB, Ogilvie RP, Redline S, Lutsey PL. Restless legs syndrome and periodic limb movements during sleep in the Multi-Ethnic Study of Atherosclerosis. Sleep 2018, 41: zsy106. PMID: 29860522, PMCID: PMC6093310, DOI: 10.1093/sleep/zsy106.
- Para K, Chow C, Kakade V, Nalamada K, Chilakamarri P, Louis E, KOO B. 0661 Suicidal Behavior in Restless Legs Syndrome. Sleep 2018, 41: a245-a245. DOI: 10.1093/sleep/zsy061.660.
- May A, Koo B, Yaffe K, Leng Y, Cawthon P, Redline S, Stone K, Mehra R. 1015 Frequent Periodic Limb Movements During Sleep and Risk of Incident Stroke. Sleep 2018, 41: a376-a377. DOI: 10.1093/sleep/zsy061.1014.
- Koo BB, Chow CA, Shah DR, Khan FH, Steinberg B, Derlein D, Nalamada K, Para KS, Kakade VM, Patel AS, de Figueiredo JM, Louis ED. Demoralization in Parkinson disease. Neurology 2018, 90: e1613-e1617. PMID: 29618626, PMCID: PMC5931805, DOI: 10.1212/wnl.0000000000005425.
- Zinchuk AV, Jeon S, Koo BB, Yan X, Bravata DM, Qin L, Selim BJ, Strohl KP, Redeker NS, Concato J, Yaggi HK. Polysomnographic phenotypes and their cardiovascular implications in obstructive sleep apnoea. Thorax 2017, 73: 472. PMID: 28935698, PMCID: PMC6693344, DOI: 10.1136/thoraxjnl-2017-210431.
- May A, May R, Bena J, Wang L, Monahan K, Stone K, Cawthon P, Barrett-Connor E, Koo B, Winkelman J, Redline S, Mittleman M, Mehra R. 0720 ASSOCIATION OF INDIVIDUAL PERIODIC LIMB MOVEMENTS AND NON-SUSTAINED TACHYCARDIA DURING SLEEP: A CASE-CROSSOVER ANALYSIS. Sleep 2017, 40: a266-a267. DOI: 10.1093/sleepj/zsx050.719.
- Ferri R, Koo BB, Picchietti DL, Fulda S. Periodic leg movements during sleep: phenotype, neurophysiology, and clinical significance. Sleep Medicine 2016, 31: 29-38. PMID: 28341521, DOI: 10.1016/j.sleep.2016.05.014.
- Koo B, Bagai K, Walters A. Restless Legs Syndrome: Current Concepts about Disease Pathophysiology. Tremor And Other Hyperkinetic Movements 2016, 6: 401. DOI: 10.5334/tohm.322.
- Koo BB, Bagai K, Walters AS. Restless Legs Syndrome: Current Concepts about Disease Pathophysiology. Tremor And Other Hyperkinetic Movements 2016, 6: 401. PMID: 27536462, PMCID: PMC4961894, DOI: 10.7916/d83j3d2g.
- Selim BJ, Koo BB, Qin L, Jeon S, Won C, Redeker NS, Lampert RJ, Concato JP, Bravata DM, Ferguson J, Strohl K, Bennett A, Zinchuk A, Yaggi HK. The Association between Nocturnal Cardiac Arrhythmias and Sleep-Disordered Breathing: The DREAM Study. Journal Of Clinical Sleep Medicine 2016, 12: 829-37. PMID: 26951420, PMCID: PMC4877315, DOI: 10.5664/jcsm.5880.
- Koo BB, Blackwell T, Lee HB, Stone KL, Louis ED, Redline S, Group O. Restless Legs Syndrome and Depression: Effect Mediation by Disturbed Sleep and Periodic Limb Movements. American Journal Of Geriatric Psychiatry 2016, 24: 1105-1116. PMID: 27526989, PMCID: PMC5241001, DOI: 10.1016/j.jagp.2016.04.003.
- Koo B, Blackwell T, Lee H, Stone K, Louis E, Redline S. The Restless Legs Syndrome - Depression Relationship: Effect Mediation by Disturbed Sleep and Periodic Limb Movements (P1.149). Neurology 2016, 86 DOI: 10.1212/wnl.86.16_supplement.p1.149.
- Koo BB, Bravata DM, Tobias LA, Mackey JS, Miech EJ, Matthias MS, Stahl SM, Sico JJ, Fragoso C, Williams LS, Lampert R, Qin L, Yaggi HK. Observational Study of Obstructive Sleep Apnea in Wake-Up Stroke: The SLEEP TIGHT Study. Cerebrovascular Diseases 2016, 41: 233-241. PMID: 26811929, DOI: 10.1159/000440736.
- Koo BB, Won C, Selim BJ, Qin L, Jeon S, Redeker NS, Bravata DM, Strohl KP, Concato J, Zinchuk AV, Yaggi HK. The Determining Risk of Vascular Events by Apnea Monitoring (DREAM) study: design, rationale, and methods. Sleep And Breathing 2015, 20: 893-900. PMID: 26642771, DOI: 10.1007/s11325-015-1254-3.
- Koo B. Restless Legs Syndrome: Would You Like That with Movements or Without? Tremor And Other Hyperkinetic Movements 2015, 5: 316. DOI: 10.5334/tohm.280.
- Trotti LM, Goldstein CA, Harrod CG, Koo BB, Sharon D, Zak R, Chervin RD. Quality measures for the care of adult patients with restless legs syndrome. Journal Of Clinical Sleep Medicine 2015, 11: 293-310. PMID: 25700882, PMCID: PMC4346652, DOI: 10.5664/jcsm.4550.
- Koo BB, Sillau S, Dean DA, Lutsey PL, Redline S. Periodic Limb Movements During Sleep and Prevalent Hypertension in the Multi-Ethnic Study of Atherosclerosis. Hypertension 2014, 65: 70-77. PMID: 25287399, PMCID: PMC4268086, DOI: 10.1161/hypertensionaha.114.04193.
- Oyetakin‐White P, Suggs A, Koo B, Matsui M, Yarosh D, Cooper K, Baron E. Does poor sleep quality affect skin ageing? Clinical And Experimental Dermatology 2014, 40: 17-22. PMID: 25266053, DOI: 10.1111/ced.12455.
- Tanimoto A, Mehndiratta P, Koo BB. Characteristics of Wake-up Stroke. Journal Of Stroke And Cerebrovascular Diseases 2013, 23: 1296-1299. PMID: 24361192, DOI: 10.1016/j.jstrokecerebrovasdis.2013.10.021.
- Koo B. Sleep-Related Movement Disorders and Parasomnias. 2013, 187-209. DOI: 10.1007/978-1-4614-9065-4_12.
- Koo B, Strohl K. Interpretation of traces from polysomnography. 2012, 73-73. DOI: 10.1017/cbo9781139058490.061.
- Budhiraja P, Budhiraja R, Goodwin JL, Allen RP, Newman AB, Koo BB, Quan SF. Incidence of restless legs syndrome and its correlates. Journal Of Clinical Sleep Medicine : JCSM : Official Publication Of The American Academy Of Sleep Medicine 2012, 8: 119-24. PMID: 22505854, PMCID: PMC3311406, DOI: 10.5664/jcsm.1756.
- Koo B, Strohl K. An adult being assessed for obstructive sleep apnea. 2012, 74-74. DOI: 10.1017/cbo9781139058490.062.
- Koo BB. Restless legs syndrome: relationship between prevalence and latitude. Sleep And Breathing 2011, 16: 1237-1245. PMID: 22210354, DOI: 10.1007/s11325-011-0640-8.
- Koo BB, Blackwell T, Ancoli-Israel S, Stone KL, Stefanick ML, Redline S, Group F. Association of Incident Cardiovascular Disease With Periodic Limb Movements During Sleep in Older Men. Circulation 2011, 124: 1223-1231. PMID: 21859975, PMCID: PMC3265562, DOI: 10.1161/circulationaha.111.038968.
- Strohl K, Gillombardo C, Chai S, Moore M, Yamauchi M, Donovan L, Koo B, Dostal J, Adams M. A Quantitative Trait Locus On Mouse Chromosome 1 Influences The Expression Of Post-Hypoxic Spontaneous Apnea. 2011, a2465-a2465. DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a2465.
- Koo BB, Strohl KP, Gillombardo CB, Jacono FJ. Ventilatory patterning in a mouse model of stroke. Respiratory Physiology & Neurobiology 2010, 172: 129-135. PMID: 20472101, PMCID: PMC3698953, DOI: 10.1016/j.resp.2010.05.008.
- Koo BB, Patel SR, Strohl K, Hoffstein V. Rapid Eye Movement-Related Sleep-Disordered Breathing Influence of Age and Gender. CHEST Journal 2008, 134: 1156-1161. PMID: 18812455, PMCID: PMC7448537, DOI: 10.1378/chest.08-1311.
- Koo BB, Feng P, Dostal J, Strohl KP. α‐Melanocyte stimulating hormone and adrenocorticotropic hormone: An alternative approach when thinking about restless legs syndrome? Movement Disorders 2008, 23: 1234-1242. PMID: 18464280, PMCID: PMC7350876, DOI: 10.1002/mds.22035.
Biography
Brian B. Koo, MD, is an award-winning physician who combines his training in neurology and sleep medicine to treat patients with a wide variety of sleep disorders.
An internationally recognized expert in his field, Dr. Koo is the director of the Sleep Medicine Program at the Connecticut Veterans Affairs Healthcare System, as well as director of the Yale Medicine Program for Restless Legs Syndrome (RLS). He works with patients who suffer from sleep disorders, including narcolepsy, RLS, sleep apnea and sleep issues caused by neurological conditions. “Sleep disorders are very treatable and we are almost always able to provide simple, effective treatments that can significantly and positively impact quality of life,” he says.
An assistant professor of neurology at Yale School of Medicine, Dr. Koo is also an active researcher and author specializing in RLS, and one of the world’s foremost experts on the epidemiologic research that links periodic limb movements during sleep and cardiovascular disease.
Titles
- Associate Professor
- Director, Sleep Medicine Laboratory at Connecticut Veterans Affairs Healthcare System, Medicine
- Director, Yale Center for Restless Legs Syndrome
Education & Training
- FellowshipCase Western Reserve University (2008)
- FellowshipCleveland Clinic (2006)
- ResidencyLong Island Jewish Hospital (2005)
- MDTufts University School of Medicine (2001)
- BAUniversity of Pennsylvania, Biological Basis of Behavior (1995)
Additional Information
- Sleep Research Network Junior Investigator Travel Award: Sleep Research Network (2012)
- American Academy of Sleep Medicine, Sleep-Related Movement Disorders Section Investigator Award: American Academy of Sleep Medicine (2012)
- American Academy of Sleep Medicine Young Investigator Forum: American Academy of Sleep Medicine (2012)
- AB of Psychiatry & Neurology, Sleep Medicine (2007, recertified: 2017)
- AB of Psychiatry & Neurology, Neurology (2006, recertified: 2016)
- Restless Legs Syndrome Foundation (2015 - Present): Medical advisory board RLS Foundation
- American Academy of Sleep Medicine: Restless Legs Syndrome Quality Care Task Force (2013 - 2014): Restless Legs Syndrome Quality Care Task Force
- Sleep & Breathing (2013 - Present): Journal Editorial Board
- Sleep-Related Movement Disorders Steering Committee Member, American Academy of Sleep Medicine (2012 - 2015): Steering Committee
- Journal of Korean Sleep Research Society (2012 - Present): Journal Editorial Board
- Koo B, Abdelfattah A, Eysa A, Lu L. The Melanocortin and Endorphin Neuropeptides in Patients with Restless Legs Syndrome. Annals Of Neurology 2024, 95: 688-699. PMID: 38308537, DOI: 10.1002/ana.26876.
- Berkowski J, Koo B. Can tonic motor activation be the magical elixir for restless legs syndrome? Sleep 2023, 46: zsad230. PMID: 37671678, PMCID: PMC11240113, DOI: 10.1093/sleep/zsad230.
- Walters A, Li Y, Koo B, Ondo W, Weinstock L, Champion D, Afrin L, Karroum E, Bagai K, Spruyt K. Review of the role of the endogenous opioid and melanocortin systems in the restless legs syndrome. Brain 2023, 147: 26-38. PMID: 37633259, PMCID: PMC10796165, DOI: 10.1093/brain/awad283.
- de Figueiredo J, Zhu B, Patel A, Kohn R, Koo B, Louis E. Differential impact of resilience on demoralization and depression in Parkinson disease. Frontiers In Psychiatry 2023, 14: 1207019. PMID: 37559912, PMCID: PMC10408307, DOI: 10.3389/fpsyt.2023.1207019.
- Waddell K, Myers L, Perkins A, Sico J, Sexson A, Burrone L, Taylor S, Koo B, Daggy J, Bravata D. Development and validation of a model predicting mild stroke severity on admission using electronic health record data. Journal Of Stroke And Cerebrovascular Diseases 2023, 32: 107255. PMID: 37473533, DOI: 10.1016/j.jstrokecerebrovasdis.2023.107255.
- Koo B. You too can increase brain iron to treat restless legs syndrome. Sleep 2023, 46: zsad181. PMID: 37419490, DOI: 10.1093/sleep/zsad181.
- Sico J, Koo B, Perkins A, Burrone L, Sexson A, Myers L, Taylor S, Yarbrough W, Daggy J, Miech E, Bravata D. Impact of the coronavirus disease-2019 pandemic on Veterans Health Administration Sleep Services. SAGE Open Medicine 2023, 11: 20503121231169388. PMID: 37152838, PMCID: PMC10158800, DOI: 10.1177/20503121231169388.
- Koo B. Re-equip with opioids instead of dopamine agonists for the treatment of augmentation. Sleep 2022, 45: zsac115. PMID: 35556146, DOI: 10.1093/sleep/zsac115.
- Silber MH, Buchfuhrer MJ, Earley CJ, Koo BB, Manconi M, Winkelman JW. The Management of Restless Legs Syndrome: An Updated Algorithm. Mayo Clinic Proceedings 2021, 96: 1921-1937. PMID: 34218864, DOI: 10.1016/j.mayocp.2020.12.026.
- Ahmed N, Kandil M, Elfil M, Jamal A, Koo BB. Hypothyroidism in restless legs syndrome. Journal Of Sleep Research 2020, 30: e13091. PMID: 32483857, DOI: 10.1111/jsr.13091.
- Ahmed N, Kandil M, Elfil M, Jamal A, Koo B. 0795 The Relationship Between Restless Legs Syndrome and Hypothyroidism. Sleep 2020, 43: a302-a303. DOI: 10.1093/sleep/zsaa056.791.
- Elfil M, Eldokmak M, Baratloo A, Ahmed N, Amin H, Koo B. Neuroimaging-Guided Thrombolytic Treatment in Wake-Up Stroke: A Literature Review (127). Neurology 2020, 94 DOI: 10.1212/wnl.94.15_supplement.127.
- Elfil M, Kamel S, Kandil M, Ahmed N, Schaefer S, Koo B. Implications of Gut Microbiome Dysbiosis in Parkinson’s Disease: A Literature Review. (103). Neurology 2020, 94 DOI: 10.1212/wnl.94.15_supplement.103.
- Elfil M, Kamel S, Kandil M, Koo BB, Schaefer SM. Implications of the Gut Microbiome in Parkinson's Disease. Movement Disorders 2020, 35: 921-933. PMID: 32092186, DOI: 10.1002/mds.28004.
- Kim J, Azarbarzin A, Wang R, Djonlagic I, Punjabi N, Zee P, Koo B, Soliman E, Lederer D, Younes M, Redline S. Association of Novel Measures of Sleep Disturbances and Blood Pressure: The MESA Study. 2019, a7270-a7270. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a7270.
- May A, May R, Bena J, Wang L, Monahan K, Stone K, Barrett-Connor E, Koo B, Winkelman J, Redline S, Mittleman M, Mehra R. 0670 Sleep-Related Event Physiologic Timing for Triggering Nonsustained Ventricular Tachycardia: A Case-crossover Analysis. Sleep 2019, 42: a267-a268. DOI: 10.1093/sleep/zsz067.668.
- Koo B, Ahmed N, Alapati A, Bahekar R, Chilakamarri P, Elfil M, Nalamada K, SirDeshpande P, Louis E. Suicidal Behavior in Parkinson Disease (P2.8-025). Neurology 2019, 92 DOI: 10.1212/wnl.92.15_supplement.p2.8-025.
- Miner B, Jiwa N, Koo B. Chapter 4 Treatment of Sleep-Related Movement and Circadian Rhythm Disorders, Hypersomnolence, and Parasomnias. 2019, 77-95. DOI: 10.1016/b978-0-12-813014-8.00004-4.
- Para KS, Chow CA, Nalamada K, Kakade VM, Chilakamarri P, Louis ED, Koo BB. Suicidal thought and behavior in individuals with restless legs syndrome. Sleep Medicine 2018, 54: 1-7. PMID: 30529070, DOI: 10.1016/j.sleep.2018.09.019.
- Doan TT, Koo BB, Ogilvie RP, Redline S, Lutsey PL. Restless legs syndrome and periodic limb movements during sleep in the Multi-Ethnic Study of Atherosclerosis. Sleep 2018, 41: zsy106. PMID: 29860522, PMCID: PMC6093310, DOI: 10.1093/sleep/zsy106.
- Para K, Chow C, Kakade V, Nalamada K, Chilakamarri P, Louis E, KOO B. 0661 Suicidal Behavior in Restless Legs Syndrome. Sleep 2018, 41: a245-a245. DOI: 10.1093/sleep/zsy061.660.
- May A, Koo B, Yaffe K, Leng Y, Cawthon P, Redline S, Stone K, Mehra R. 1015 Frequent Periodic Limb Movements During Sleep and Risk of Incident Stroke. Sleep 2018, 41: a376-a377. DOI: 10.1093/sleep/zsy061.1014.
- Koo BB, Chow CA, Shah DR, Khan FH, Steinberg B, Derlein D, Nalamada K, Para KS, Kakade VM, Patel AS, de Figueiredo JM, Louis ED. Demoralization in Parkinson disease. Neurology 2018, 90: e1613-e1617. PMID: 29618626, PMCID: PMC5931805, DOI: 10.1212/wnl.0000000000005425.
- Zinchuk AV, Jeon S, Koo BB, Yan X, Bravata DM, Qin L, Selim BJ, Strohl KP, Redeker NS, Concato J, Yaggi HK. Polysomnographic phenotypes and their cardiovascular implications in obstructive sleep apnoea. Thorax 2017, 73: 472. PMID: 28935698, PMCID: PMC6693344, DOI: 10.1136/thoraxjnl-2017-210431.
- May A, May R, Bena J, Wang L, Monahan K, Stone K, Cawthon P, Barrett-Connor E, Koo B, Winkelman J, Redline S, Mittleman M, Mehra R. 0720 ASSOCIATION OF INDIVIDUAL PERIODIC LIMB MOVEMENTS AND NON-SUSTAINED TACHYCARDIA DURING SLEEP: A CASE-CROSSOVER ANALYSIS. Sleep 2017, 40: a266-a267. DOI: 10.1093/sleepj/zsx050.719.
- Ferri R, Koo BB, Picchietti DL, Fulda S. Periodic leg movements during sleep: phenotype, neurophysiology, and clinical significance. Sleep Medicine 2016, 31: 29-38. PMID: 28341521, DOI: 10.1016/j.sleep.2016.05.014.
- Koo B, Bagai K, Walters A. Restless Legs Syndrome: Current Concepts about Disease Pathophysiology. Tremor And Other Hyperkinetic Movements 2016, 6: 401. DOI: 10.5334/tohm.322.
- Koo BB, Bagai K, Walters AS. Restless Legs Syndrome: Current Concepts about Disease Pathophysiology. Tremor And Other Hyperkinetic Movements 2016, 6: 401. PMID: 27536462, PMCID: PMC4961894, DOI: 10.7916/d83j3d2g.
- Selim BJ, Koo BB, Qin L, Jeon S, Won C, Redeker NS, Lampert RJ, Concato JP, Bravata DM, Ferguson J, Strohl K, Bennett A, Zinchuk A, Yaggi HK. The Association between Nocturnal Cardiac Arrhythmias and Sleep-Disordered Breathing: The DREAM Study. Journal Of Clinical Sleep Medicine 2016, 12: 829-37. PMID: 26951420, PMCID: PMC4877315, DOI: 10.5664/jcsm.5880.
- Koo BB, Blackwell T, Lee HB, Stone KL, Louis ED, Redline S, Group O. Restless Legs Syndrome and Depression: Effect Mediation by Disturbed Sleep and Periodic Limb Movements. American Journal Of Geriatric Psychiatry 2016, 24: 1105-1116. PMID: 27526989, PMCID: PMC5241001, DOI: 10.1016/j.jagp.2016.04.003.
- Koo B, Blackwell T, Lee H, Stone K, Louis E, Redline S. The Restless Legs Syndrome - Depression Relationship: Effect Mediation by Disturbed Sleep and Periodic Limb Movements (P1.149). Neurology 2016, 86 DOI: 10.1212/wnl.86.16_supplement.p1.149.
- Koo BB, Bravata DM, Tobias LA, Mackey JS, Miech EJ, Matthias MS, Stahl SM, Sico JJ, Fragoso C, Williams LS, Lampert R, Qin L, Yaggi HK. Observational Study of Obstructive Sleep Apnea in Wake-Up Stroke: The SLEEP TIGHT Study. Cerebrovascular Diseases 2016, 41: 233-241. PMID: 26811929, DOI: 10.1159/000440736.
- Koo BB, Won C, Selim BJ, Qin L, Jeon S, Redeker NS, Bravata DM, Strohl KP, Concato J, Zinchuk AV, Yaggi HK. The Determining Risk of Vascular Events by Apnea Monitoring (DREAM) study: design, rationale, and methods. Sleep And Breathing 2015, 20: 893-900. PMID: 26642771, DOI: 10.1007/s11325-015-1254-3.
- Koo B. Restless Legs Syndrome: Would You Like That with Movements or Without? Tremor And Other Hyperkinetic Movements 2015, 5: 316. DOI: 10.5334/tohm.280.
- Trotti LM, Goldstein CA, Harrod CG, Koo BB, Sharon D, Zak R, Chervin RD. Quality measures for the care of adult patients with restless legs syndrome. Journal Of Clinical Sleep Medicine 2015, 11: 293-310. PMID: 25700882, PMCID: PMC4346652, DOI: 10.5664/jcsm.4550.
- Koo BB, Sillau S, Dean DA, Lutsey PL, Redline S. Periodic Limb Movements During Sleep and Prevalent Hypertension in the Multi-Ethnic Study of Atherosclerosis. Hypertension 2014, 65: 70-77. PMID: 25287399, PMCID: PMC4268086, DOI: 10.1161/hypertensionaha.114.04193.
- Oyetakin‐White P, Suggs A, Koo B, Matsui M, Yarosh D, Cooper K, Baron E. Does poor sleep quality affect skin ageing? Clinical And Experimental Dermatology 2014, 40: 17-22. PMID: 25266053, DOI: 10.1111/ced.12455.
- Tanimoto A, Mehndiratta P, Koo BB. Characteristics of Wake-up Stroke. Journal Of Stroke And Cerebrovascular Diseases 2013, 23: 1296-1299. PMID: 24361192, DOI: 10.1016/j.jstrokecerebrovasdis.2013.10.021.
- Koo B. Sleep-Related Movement Disorders and Parasomnias. 2013, 187-209. DOI: 10.1007/978-1-4614-9065-4_12.
- Koo B, Strohl K. Interpretation of traces from polysomnography. 2012, 73-73. DOI: 10.1017/cbo9781139058490.061.
- Budhiraja P, Budhiraja R, Goodwin JL, Allen RP, Newman AB, Koo BB, Quan SF. Incidence of restless legs syndrome and its correlates. Journal Of Clinical Sleep Medicine : JCSM : Official Publication Of The American Academy Of Sleep Medicine 2012, 8: 119-24. PMID: 22505854, PMCID: PMC3311406, DOI: 10.5664/jcsm.1756.
- Koo B, Strohl K. An adult being assessed for obstructive sleep apnea. 2012, 74-74. DOI: 10.1017/cbo9781139058490.062.
- Koo BB. Restless legs syndrome: relationship between prevalence and latitude. Sleep And Breathing 2011, 16: 1237-1245. PMID: 22210354, DOI: 10.1007/s11325-011-0640-8.
- Koo BB, Blackwell T, Ancoli-Israel S, Stone KL, Stefanick ML, Redline S, Group F. Association of Incident Cardiovascular Disease With Periodic Limb Movements During Sleep in Older Men. Circulation 2011, 124: 1223-1231. PMID: 21859975, PMCID: PMC3265562, DOI: 10.1161/circulationaha.111.038968.
- Strohl K, Gillombardo C, Chai S, Moore M, Yamauchi M, Donovan L, Koo B, Dostal J, Adams M. A Quantitative Trait Locus On Mouse Chromosome 1 Influences The Expression Of Post-Hypoxic Spontaneous Apnea. 2011, a2465-a2465. DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a2465.
- Koo BB, Strohl KP, Gillombardo CB, Jacono FJ. Ventilatory patterning in a mouse model of stroke. Respiratory Physiology & Neurobiology 2010, 172: 129-135. PMID: 20472101, PMCID: PMC3698953, DOI: 10.1016/j.resp.2010.05.008.
- Koo BB, Patel SR, Strohl K, Hoffstein V. Rapid Eye Movement-Related Sleep-Disordered Breathing Influence of Age and Gender. CHEST Journal 2008, 134: 1156-1161. PMID: 18812455, PMCID: PMC7448537, DOI: 10.1378/chest.08-1311.
- Koo BB, Feng P, Dostal J, Strohl KP. α‐Melanocyte stimulating hormone and adrenocorticotropic hormone: An alternative approach when thinking about restless legs syndrome? Movement Disorders 2008, 23: 1234-1242. PMID: 18464280, PMCID: PMC7350876, DOI: 10.1002/mds.22035.