- Yale Sleep Center8 Devine StreetNorth Haven, CT 06473
- Medical ICUSmilow Cancer Hospital at Yale New Haven35 Park StreetNew Haven, CT 06511
Andrey Zinchuk, MD, MHS
Biography
Andrey Zinchuk, MD, MHS, is a pulmonary, critical care and sleep physician.
In the hospital’s intensive care unit, he cares for people who are critically ill. In the clinic, he helps patients with sleep disorders, particularly those with complex sleep-disordered breathing. “My goal is to provide the kind of care that I would want for my own family,” Dr. Zinchuk says. “I believe in taking the time to hear the patient, and being a guide in their journey in health and illness.”
Before he decided to pursue medicine, Dr. Zinchuk worked as a chemical engineer, devising new ways to deliver medications to the right parts of the human body at the right time. “I loved the complexity of engineering and how physical systems interact, but I wanted to apply this passion for complex systems to directly improve people’s lives,” he says.
Both of Dr. Zinchuk’s parents were doctors, and he decided to follow in their footsteps. He began his training in neurology, but transitioned to internal medicine, ultimately specializing in pulmonary and sleep medicine. “I find sleep to be a perfect intersection between engineering, the science of breathing, neurology, and mental health.” He now directs the Advances Apnea Management Program (AAMP) at Yale, specializing in cutting-edge treatments for sleep apnea.
In addition to directly caring for patients, Dr. Zinchuk conducts research to help personalize therapy for sleep disorders. “We are finding that sleep apnea patients who have certain physiological characteristics (phenotypes) respond to some treatments but not others.” His most recent work describes how certain phenotypes may help predict whether a patient suffering from sleep apnea will succeed with continuous positive airway pressure (CPAP) or another sleep apnea therapy.
Titles
- Assistant Professor
- Director, Advanced Apnea Management Program
- Director, Yale Sleep Fellowship Didactic and Research Curriculum, Internal Medicine, PCCSM
- Director, Upper Airway Neurostimulation Program
- Section of Pulmonary, Critical Care and Sleep Medicine
Education & Training
- MHSYale University (2018)
- Fellow, Sleep MedicineYale University (2017)
- Fellow, Pulmonary & Critical CareYale University (2016)
- Chief Medical ResidentBeth Israel Deaconess Medical Center and Boston Veterans Affairs Medical Center (2013)
- Resident, Internal MedicineBeth Israel Deaconess Medical Center, Harvard University (2012)
- Resident, NeurologyBeth Israel Deaconess Medical Center, Harvard University (2010)
- Intern, Internal MedicineBeth Israel Deaconess Medical Center, Harvard University (2009)
- MDUniversity of Connecticut (2008)
- BSLehigh University (2000)
Languages Spoken
- English
- Русский (Russian)
- Українська (Ukrainian)
Additional Information
- Top Author for 2020 Review Articles, recognized for article: "Phenotypic Subtypes of OSA: A Challenge and Opportunity for Precision Medicine": CHEST Journal (2021)
- Most cited articles since 2017 for article “Phenotypes in obstructive sleep apnea: A definition, examples and evolution of approaches”: Sleep Medicine Reviews Journal (highest impact journal devoted to Sleep Medicine) (2020)
- Top-10 Paper in Sleep Medicine, "Cardiovascular phenotypes and their cardiovascular implication in Obstructive Sleep Apnoea.”: American Academy of Sleep Medicine (2018)
- Outstanding Early Investigator Award: Sleep Research Society (2018)
- Parker B. Francis Fellowship Career Development Award: Francis Family Foundation (2018)
- Highlighted paper, “Cardiovascular phenotypes and their cardiovascular implication in Obstructive Sleep Apnoea”: British Thoracic Society, London (2017)
- Sleep Research Society Trainee Merit Based Award: Associated Professional Sleep Societies Annual Meeting, Boston MA (2017)
- Award Winner and Grant Recipient for Clinical Research: 12th Annual Respiratory Disease Young Investigators Forum (2016)
- Fellowship in Clinical Research Grant Award: Robert E. Leet and Clara Guthrie Patterson Trust (2016)
- Yale Center for Clinical Investigation and Center for Biomedical and Interventional Technology Emerging Core Award: Yale University (2014)
- AB of Internal Medicine, Sleep Medicine (Internal Medicine) (2017)
- AB of Internal Medicine, Critical Care Medicine (Internal Medicine) (2016)
- AB of Internal Medicine, Pulmonary Disease (2015)
- Yale School of Medicine Physician Associate Thesis Readers (2020 - Present): Member
- Yale School of Medicine/Yale New Haven Hospital Internal Medicine Residency Mentor-Advisor-Coach committee (2020 - Present): Member
- Yale New Haven Hospital and Yale School of Medicine Focus group on Physician Burnout and Resilience (2019 - Present): Member
- Principles and Practice of Sleep Medicine (Seventh Edition), the authoritative reference book for sleep researchers and practitioners, Co-Editor for Sleep Disordered Breathing Section (2019 - Present): Associate Editor
- American Thoracic Society, Sleep Respiratory Neurobiology Program Committee, Scientific Session Co-chair and Poster Discussion Facilitator (2018 - 2020): Co-Chair
- Yale University and Yale New Haven Hospital, Advanced Apnea Management Program (2018 - Present): Director
- Yale Sleep Fellowship Program Clinical Competency Committee (2017 - Present): Member
- Yale University, Sleep Fellowship Didactic and Research Educational Curriculum (2017 - Present): Director
- American Academy of Sleep Medicine (SLEEP/APSS), Scientific Session Co-chair and Discussion Facilitator (2017 - Present): Co-Chair
- Sleep Research Society (2016 - Present): Member
- Zinchuk A, Kushida C, Walker A, Wellman A, Azarbarzin A, Alex R, Varga A, Sands S, Yaggi H. Arousal threshold modifies the effect of CPAP on executive function among individuals with obstructive sleep apnea. European Respiratory Journal 2024, 2401183. PMID: 39572221, DOI: 10.1183/13993003.01183-2024.
- Ding Q, Wojeck B, Zinchuk A. Understanding the impact of night-to-night sleep variations on glucose regulation in healthy young adults: Insights from Ng et al. (2024). Sleep 2024, zsae253. PMID: 39460669, DOI: 10.1093/sleep/zsae253.
- BUNTAK V, INAYA A, ZINCHUK A. PERSONALIZED APPROACH IN TREATING CENTRAL SLEEP APNEA IN INDIVIDUALS WITH REDUCED EJECTION FRACTION. CHEST Journal 2024, 166: a6174-a6175. DOI: 10.1016/j.chest.2024.06.3656.
- BUNTAK V, INAYA A, ZINCHUK A. THE VALUE OF ADJUNCTIVE THERAPIES IN INDIVIDUALS WITH SEVERE OBSTRUCTIVE SLEEP APNEA TREATED WITH HYPOGLOSSAL NERVE STIMULATOR. CHEST Journal 2024, 166: a6173. DOI: 10.1016/j.chest.2024.06.3655.
- Adekolu O, Ahsan M, Anwar A, Zinchuk A. Sleep Deficiency in Obstructive Sleep Apnea. Sleep Medicine Clinics 2024, 19: 687-706. PMID: 39455186, PMCID: PMC11512702, DOI: 10.1016/j.jsmc.2024.08.002.
- Anwar A, Byrne S, Sharma A, Sands S, Wellman A, Redeker N, Yaggi H, Zinchuk A. Novel physiologic predictors of positive airway pressure effectiveness (NICEPAP) study: rationale, design and methods. Sleep And Breathing 2024, 28: 2005-2015. PMID: 38995327, DOI: 10.1007/s11325-024-03099-w.
- Peker Y, Zinchuk A, Celik Y, Sands S, Azarbarzin A. Hypoxic Burden but Not AHI Predicts Risk of Cardiovascular Events: A Secondary Analysis of the RICCADSA Clinical Trial. 2024, a4730-a4730. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a4730.
- Inaya A, Baldassarri S, Sands S, Yaggi H, Wellman A, Redeker N, Zinchuk A. 0495 Association of Cannabis Use and Symptoms Among Patients with Obstructive Sleep Apnea. Sleep 2024, 47: a213-a213. DOI: 10.1093/sleep/zsae067.0495.
- Chu Y, Zinchuk A. The Present and Future of the Clinical Use of Physiological Traits for the Treatment of Patients with OSA: A Narrative Review. Journal Of Clinical Medicine 2024, 13: 1636. PMID: 38541862, PMCID: PMC10970765, DOI: 10.3390/jcm13061636.
- Zinchuk A, Walker A, Kushida C, Wellman A, Yaggi H, Sands S. Arousal threshold modifies the effects of CPAP therapy on neurocognition in men and women in the APPLES study. Sleep Medicine 2024, 115: 324-325. DOI: 10.1016/j.sleep.2023.11.876.
- Zinchuk A, Srivali N, Qin L, Jeon S, Ibrahim A, Sands S, Koo B, Yaggi H. Association of Periodic Limb Movements and Obstructive Sleep Apnea With Risk of Cardiovascular Disease and Mortality. Journal Of The American Heart Association 2024, 13: e031630. PMID: 38240208, PMCID: PMC11056155, DOI: 10.1161/jaha.123.031630.
- Knauert M, Adekolu O, Xu Z, Deng A, Chu J, Baldassarri S, Kushida C, Yaggi H, Zinchuk A. Morning Chronotype Is Associated with Improved Adherence to Continuous Positive Airway Pressure among Individuals with Obstructive Sleep Apnea. Annals Of The American Thoracic Society 2023, 20: 1182-1191. PMID: 36917194, PMCID: PMC10405611, DOI: 10.1513/annalsats.202210-885oc.
- Srivali N, Thongprayoon C, Tangpanithandee S, Krisanapan P, Zinchuk A, Koo B, Cheungpasitporn W. 0872 Periodic limb movements during sleep and hypertension: A systematic review and meta-analysis. Sleep 2023, 46: a384-a384. DOI: 10.1093/sleep/zsad077.0872.
- Sun H, Zinchuk A, Locascio J, Kushida C, Thomas R, Westover M. 0522 CPAP Improves Cognition in Brain-Healthy Males: Secondary Analysis of a Randomized Trial. Sleep 2023, 46: a230-a231. DOI: 10.1093/sleep/zsad077.0522.
- Walker A, Baldassarri S, Chu J, Deng A, Xu Z, Blohowiak R, Byrne S, Kushida C, Yaggi H, Zinchuk A. 0480 Psychoactive Substance Use and Sleep Characteristics Among Individuals with Untreated Obstructive Sleep Apnea. Sleep 2023, 46: a213-a214. DOI: 10.1093/sleep/zsad077.0480.
- Baldassarri S, Chu J, Deng A, Xu Z, Blohowiak R, Byrne S, Kushida C, Yaggi H, Zinchuk A. Nicotine, alcohol, and caffeine use among individuals with untreated obstructive sleep apnea. Sleep And Breathing 2023, 27: 2479-2490. PMID: 37058215, PMCID: PMC10576010, DOI: 10.1007/s11325-023-02830-3.
- Srivali N, Thongprayoon C, Tangpanithandee S, Krisanapan P, Mao M, Zinchuk A, Koo B, Cheungpasitporn W. Periodic limb movements during sleep and risk of hypertension: A systematic review. Sleep Medicine 2023, 102: 173-179. PMID: 36701831, PMCID: PMC10388290, DOI: 10.1016/j.sleep.2023.01.008.
- Azarbarzin A, Zinchuk A, Wellman A, Labarca G, Vena D, Gell L, Messineo L, White DP, Gottlieb DJ, Redline S, Peker Y, Sands SA. Cardiovascular Benefit of Continuous Positive Airway Pressure in Adults with Coronary Artery Disease and Obstructive Sleep Apnea without Excessive Sleepiness. American Journal Of Respiratory And Critical Care Medicine 2022, 206: 767-774. PMID: 35579605, PMCID: PMC9799106, DOI: 10.1164/rccm.202111-2608oc.
- Adekolu O, Zinchuk A. Sleep Deficiency in Obstructive Sleep Apnea. Clinics In Chest Medicine 2022, 43: 353-371. PMID: 35659030, PMCID: PMC9351701, DOI: 10.1016/j.ccm.2022.02.013.
- Sharma A, Byrne S, Deng A, Chu J, Sands S, Wellman A, Redeke N, Yaggi H, Zinchuk A. 0158 Risk perception, outcome expectancy, and treatment self-efficacy among women and men with obstructive sleep apnea (OSA). Sleep 2022, 45: a73-a73. DOI: 10.1093/sleep/zsac079.156.
- Ding Q, Qin L, Wojeck B, Inzucchi SE, Ibrahim A, Bravata DM, Strohl KP, Yaggi HK, Zinchuk AV. Polysomnographic Phenotypes of Obstructive Sleep Apnea and Incident Type 2 Diabetes: Results from the DREAM Study. Annals Of The American Thoracic Society 2021, 18: 2067-2078. PMID: 34185617, PMCID: PMC8641817, DOI: 10.1513/annalsats.202012-1556oc.
- Zinchuk AV, Chu JH, Liang J, Celik Y, Op de Beeck S, Redeker NS, Wellman A, Yaggi HK, Peker Y, Sands SA. Physiological Traits and Adherence to Sleep Apnea Therapy in Individuals with Coronary Artery Disease. American Journal Of Respiratory And Critical Care Medicine 2021, 204: 703-712. PMID: 34156917, PMCID: PMC8521693, DOI: 10.1164/rccm.202101-0055oc.
- Ding Q, Qin L, Wojeck B, Inzucchi S, Ibrahim A, Bravata D, Strohl K, Yaggi H, Zinchuk A. Associations Between Polysomnographic Phenotypes of Obstructive Sleep Apnea and Incident Type 2 Diabetes. 2021, a4679-a4679. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4679.
- Azarbarzin A, Zinchuk A, Wellman D, Taranto Montemurro L, Vena D, Gell L, Messineo L, White D, Gottlieb D, Redline S, Peker Y, Sands S. Cardiovascular Benefit of CPAP Is Modified by the Sleep Apnea Related Pulse Rate Response in Coronary Artery Disease Patients with Nonsleepy OSA: Findings from the RICCADSA Randomized Controlled Trial. 2021, a1103-a1103. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a1103.
- Zinchuk A, Yaggi H. Treatment-Emergent Central Sleep Apnea. 2021, 85-102. DOI: 10.1007/978-3-030-57942-5_8.
- Baldassarri SR, Beitel M, Zinchuk A, Redeker NS, Oberleitner DE, Oberleitner LMS, Carrasco D, Madden LM, Lipkind N, Fiellin DA, Bastian LA, Chen K, Yaggi HK, Barry DT. Correlates of sleep quality and excessive daytime sleepiness in people with opioid use disorder receiving methadone treatment. Sleep And Breathing 2020, 24: 1729-1737. PMID: 32556918, PMCID: PMC7680294, DOI: 10.1007/s11325-020-02123-z.
- Leary EB, Zinchuk A, Stone KL, Mehra R. Update in Sleep in 2019. American Journal Of Respiratory And Critical Care Medicine 2020, 0: 1473-1479. PMID: 32293912, DOI: 10.1164/rccm.202003-0586up.
- Zinchuk AV, Redeker NS, Chu JH, Liang J, Stepnowsky C, Brandt CA, Bravata DM, Wellman A, Sands SA, Yaggi HK. Physiological Traits and Adherence to Obstructive Sleep Apnea Treatment in Patients with Stroke. American Journal Of Respiratory And Critical Care Medicine 2020, 0: 1568-1572. PMID: 32083949, PMCID: PMC7301748, DOI: 10.1164/rccm.201911-2203le.
- The Arousal Threshold as a Drug-Target to Improve CPAP Adherence: Secondary Analysis of a Randomized TrialZinchuk A. The Arousal Threshold as a Drug-Target to Improve CPAP Adherence: Secondary Analysis of a Randomized Trial. PracticeUpdate website. Available at: https://www.practiceupdate.com/content/the-arousal-threshold-as-a-drug-target-to-improve-cpap-adherence/103953/65/20/1. Aug 7, 2020
- Central Sleep Apnea: Diagnosis and TreatmentZinchuk, A., Thomas, R. “Central Sleep Apnea: Diagnosis and Treatment,“ in Principles and Practice of Sleep Medicine (Seventh Edition), Meir H. Kryger, Thomas Roth, and William C. Dement; Saunders, 2020
- Introduction to Sleep Breathing DisordersZinchuk, A., Thomas, R. “Introduction to Sleep Breathing Disorders,“ in Principles and Practice of Sleep Medicine (Seventh Edition), Meir H. Kryger, Thomas Roth, and William C. Dement; Saunders, 2020
- Zinchuk A, Yaggi HK. Phenotypic Subtypes of OSA A Challenge and Opportunity for Precision Medicine. CHEST Journal 2019, 157: 403-420. PMID: 31539538, PMCID: PMC7005379, DOI: 10.1016/j.chest.2019.09.002.
- Zinchuk A, Yaggi HK. Sleep Apnea Heterogeneity, Phenotypes, and Cardiovascular Risk. Implications for Trial Design and Precision Sleep Medicine. American Journal Of Respiratory And Critical Care Medicine 2019, 200: 412-413. PMID: 30916985, PMCID: PMC6701039, DOI: 10.1164/rccm.201903-0545ed.
- Treatment Emergent Central Sleep ApneaZinchuk, A. Yaggi, K. “Treatment Emergent Central Sleep Apnea” in Complex Sleep Breathing Disorders (1st Edition), edited by Christine Won; Springer Nature, 2019
- Zinchuk A, Edwards BA, Jeon S, Koo BB, Concato J, Sands S, Wellman A, Yaggi HK. Prevalence, Associated Clinical Features, and Impact on Continuous Positive Airway Pressure Use of a Low Respiratory Arousal Threshold Among Male United States Veterans With Obstructive Sleep Apnea. Journal Of Clinical Sleep Medicine 2018, 14: 809-817. PMID: 29734986, PMCID: PMC5940432, DOI: 10.5664/jcsm.7112.
- Brady VA, Zinchuk AV, Siegel MD, Possick JD. A Young Man With Hemoptysis and Cavitary Lung Lesions. CHEST Journal 2018, 153: e85-e88. PMID: 29626974, PMCID: PMC6026285, DOI: 10.1016/j.chest.2017.09.018.
- Zinchuk AV, Jeon S, Koo BB, Yan X, Bravata DM, Qin L, Selim BJ, Strohl KP, Redeker NS, Concato J, Yaggi HK. Polysomnographic phenotypes and their cardiovascular implications in obstructive sleep apnoea. Thorax 2017, 73: 472. PMID: 28935698, PMCID: PMC6693344, DOI: 10.1136/thoraxjnl-2017-210431.
- Zinchuk A, Thomas R. Chapter 110 Central Sleep Apnea Diagnosis and Management. 2017, 1059-1075.e6. DOI: 10.1016/b978-0-323-24288-2.00110-0.
- Zinchuk AV, Gentry MJ, Concato J, Yaggi HK. Phenotypes in obstructive sleep apnea: A definition, examples and evolution of approaches. Sleep Medicine Reviews 2016, 35: 113-123. PMID: 27815038, PMCID: PMC5389934, DOI: 10.1016/j.smrv.2016.10.002.
- Selim BJ, Koo BB, Qin L, Jeon S, Won C, Redeker NS, Lampert RJ, Concato JP, Bravata DM, Ferguson J, Strohl K, Bennett A, Zinchuk A, Yaggi HK. The Association between Nocturnal Cardiac Arrhythmias and Sleep-Disordered Breathing: The DREAM Study. Journal Of Clinical Sleep Medicine 2016, 12: 829-37. PMID: 26951420, PMCID: PMC4877315, DOI: 10.5664/jcsm.5880.
- Koo BB, Won C, Selim BJ, Qin L, Jeon S, Redeker NS, Bravata DM, Strohl KP, Concato J, Zinchuk AV, Yaggi HK. Erratum to: The Determining Risk of Vascular Events by Apnea Monitoring (DREAM) study: design, rationale, and methods. Sleep And Breathing 2016, 20: 901-901. PMID: 26971325, DOI: 10.1007/s11325-016-1329-9.
- Arts, Sleep and MedicineZinchuk, A., Kryger, M. “Arts, Sleep and Medicine,” American Thoracic Society Podcast Series, 2016, http://www.thoracic.org/about/ats-podcasts/interview-with-professor-dr-meir-h-kryger.php
- Central Sleep Apnea: Diagnosis and TreatmentZinchuk, A., Thomas, R. “Central Sleep Apnea: Diagnosis and Treatment,“ in Principles and Practice of Sleep Medicine (Sixth Edition), Meir H. Kryger, Thomas Roth, and William C. Dement; Saunders, 2016.
- Koo BB, Won C, Selim BJ, Qin L, Jeon S, Redeker NS, Bravata DM, Strohl KP, Concato J, Zinchuk AV, Yaggi HK. The Determining Risk of Vascular Events by Apnea Monitoring (DREAM) study: design, rationale, and methods. Sleep And Breathing 2015, 20: 893-900. PMID: 26642771, DOI: 10.1007/s11325-015-1254-3.
- Masha L, Zinchuk A, Boosalis V. Synchronous pulmonary malignancies: atypical presentation of mantle cell lymphoma masking a lung malignancy. Rare Tumors 2015, 7: 5929. PMID: 26500732, PMCID: PMC4600994, DOI: 10.4081/rt.2015.5929.
- Zinchuk A, Saukkonen J, Boosalis V, Brahma P. Simultaneous Mantle Cell Lymphoma and Undifferentiated Carcinoma Manifested by Pleural Studding and Effusion. CHEST Journal 2013, 144: 597a-597b. DOI: 10.1378/chest.1702019.
- Zinchuk AV, Flanagan EP, Tubridy NJ, Miller WA, McCullough LD. Attitudes of US medical trainees towards neurology education: "Neurophobia" - a global issue. BMC Medical Education 2010, 10: 49. PMID: 20573257, PMCID: PMC2900283, DOI: 10.1186/1472-6920-10-49.
- Govindarajan R, Zinchuk A, Hancock B, Shalaev E, Suryanarayanan R. Ionization States in the Microenvironment of Solid Dosage Forms: Effect of Formulation Variables and Processing. Pharmaceutical Research 2006, 23: 2454-2468. PMID: 16933092, DOI: 10.1007/s11095-006-9085-3.
- Zinchuk AV, Hancock BC, Shalaev EY, Reddy RD, Govindarajan R, Novak E. The influence of measurement conditions on the Hammett acidity function of solid pharmaceutical excipients. European Journal Of Pharmaceutics And Biopharmaceutics 2005, 61: 158-170. PMID: 16005194, DOI: 10.1016/j.ejpb.2005.04.008.
- Zinchuk AV, Mullarney MP, Hancock BC. Simulation of roller compaction using a laboratory scale compaction simulator. International Journal Of Pharmaceutics 2004, 269: 403-415. PMID: 14706252, DOI: 10.1016/j.ijpharm.2003.09.034.
- The relative density of pharmaceutical powders, blends, dry granulations and immediate release tabletsHancock, B.C., Colvin, J.T., Mullarney, M.P., Zinchuk, A.V., “The relative density of pharmaceutical powders, blends, dry granulations and immediate release tablets,” Pharmaceutical Technology, April 2003, 64-80
- Yale Sleep Center8 Devine StreetNorth Haven, CT 06473
- Medical ICUSmilow Cancer Hospital at Yale New Haven35 Park StreetNew Haven, CT 06511
Biography
Andrey Zinchuk, MD, MHS, is a pulmonary, critical care and sleep physician.
In the hospital’s intensive care unit, he cares for people who are critically ill. In the clinic, he helps patients with sleep disorders, particularly those with complex sleep-disordered breathing. “My goal is to provide the kind of care that I would want for my own family,” Dr. Zinchuk says. “I believe in taking the time to hear the patient, and being a guide in their journey in health and illness.”
Before he decided to pursue medicine, Dr. Zinchuk worked as a chemical engineer, devising new ways to deliver medications to the right parts of the human body at the right time. “I loved the complexity of engineering and how physical systems interact, but I wanted to apply this passion for complex systems to directly improve people’s lives,” he says.
Both of Dr. Zinchuk’s parents were doctors, and he decided to follow in their footsteps. He began his training in neurology, but transitioned to internal medicine, ultimately specializing in pulmonary and sleep medicine. “I find sleep to be a perfect intersection between engineering, the science of breathing, neurology, and mental health.” He now directs the Advances Apnea Management Program (AAMP) at Yale, specializing in cutting-edge treatments for sleep apnea.
In addition to directly caring for patients, Dr. Zinchuk conducts research to help personalize therapy for sleep disorders. “We are finding that sleep apnea patients who have certain physiological characteristics (phenotypes) respond to some treatments but not others.” His most recent work describes how certain phenotypes may help predict whether a patient suffering from sleep apnea will succeed with continuous positive airway pressure (CPAP) or another sleep apnea therapy.
Titles
- Assistant Professor
- Director, Advanced Apnea Management Program
- Director, Yale Sleep Fellowship Didactic and Research Curriculum, Internal Medicine, PCCSM
- Director, Upper Airway Neurostimulation Program
- Section of Pulmonary, Critical Care and Sleep Medicine
Education & Training
- MHSYale University (2018)
- Fellow, Sleep MedicineYale University (2017)
- Fellow, Pulmonary & Critical CareYale University (2016)
- Chief Medical ResidentBeth Israel Deaconess Medical Center and Boston Veterans Affairs Medical Center (2013)
- Resident, Internal MedicineBeth Israel Deaconess Medical Center, Harvard University (2012)
- Resident, NeurologyBeth Israel Deaconess Medical Center, Harvard University (2010)
- Intern, Internal MedicineBeth Israel Deaconess Medical Center, Harvard University (2009)
- MDUniversity of Connecticut (2008)
- BSLehigh University (2000)
Languages Spoken
- English
- Русский (Russian)
- Українська (Ukrainian)
Additional Information
- Top Author for 2020 Review Articles, recognized for article: "Phenotypic Subtypes of OSA: A Challenge and Opportunity for Precision Medicine": CHEST Journal (2021)
- Most cited articles since 2017 for article “Phenotypes in obstructive sleep apnea: A definition, examples and evolution of approaches”: Sleep Medicine Reviews Journal (highest impact journal devoted to Sleep Medicine) (2020)
- Top-10 Paper in Sleep Medicine, "Cardiovascular phenotypes and their cardiovascular implication in Obstructive Sleep Apnoea.”: American Academy of Sleep Medicine (2018)
- Outstanding Early Investigator Award: Sleep Research Society (2018)
- Parker B. Francis Fellowship Career Development Award: Francis Family Foundation (2018)
- Highlighted paper, “Cardiovascular phenotypes and their cardiovascular implication in Obstructive Sleep Apnoea”: British Thoracic Society, London (2017)
- Sleep Research Society Trainee Merit Based Award: Associated Professional Sleep Societies Annual Meeting, Boston MA (2017)
- Award Winner and Grant Recipient for Clinical Research: 12th Annual Respiratory Disease Young Investigators Forum (2016)
- Fellowship in Clinical Research Grant Award: Robert E. Leet and Clara Guthrie Patterson Trust (2016)
- Yale Center for Clinical Investigation and Center for Biomedical and Interventional Technology Emerging Core Award: Yale University (2014)
- AB of Internal Medicine, Sleep Medicine (Internal Medicine) (2017)
- AB of Internal Medicine, Critical Care Medicine (Internal Medicine) (2016)
- AB of Internal Medicine, Pulmonary Disease (2015)
- Yale School of Medicine Physician Associate Thesis Readers (2020 - Present): Member
- Yale School of Medicine/Yale New Haven Hospital Internal Medicine Residency Mentor-Advisor-Coach committee (2020 - Present): Member
- Yale New Haven Hospital and Yale School of Medicine Focus group on Physician Burnout and Resilience (2019 - Present): Member
- Principles and Practice of Sleep Medicine (Seventh Edition), the authoritative reference book for sleep researchers and practitioners, Co-Editor for Sleep Disordered Breathing Section (2019 - Present): Associate Editor
- American Thoracic Society, Sleep Respiratory Neurobiology Program Committee, Scientific Session Co-chair and Poster Discussion Facilitator (2018 - 2020): Co-Chair
- Yale University and Yale New Haven Hospital, Advanced Apnea Management Program (2018 - Present): Director
- Yale Sleep Fellowship Program Clinical Competency Committee (2017 - Present): Member
- Yale University, Sleep Fellowship Didactic and Research Educational Curriculum (2017 - Present): Director
- American Academy of Sleep Medicine (SLEEP/APSS), Scientific Session Co-chair and Discussion Facilitator (2017 - Present): Co-Chair
- Sleep Research Society (2016 - Present): Member
- Zinchuk A, Kushida C, Walker A, Wellman A, Azarbarzin A, Alex R, Varga A, Sands S, Yaggi H. Arousal threshold modifies the effect of CPAP on executive function among individuals with obstructive sleep apnea. European Respiratory Journal 2024, 2401183. PMID: 39572221, DOI: 10.1183/13993003.01183-2024.
- Ding Q, Wojeck B, Zinchuk A. Understanding the impact of night-to-night sleep variations on glucose regulation in healthy young adults: Insights from Ng et al. (2024). Sleep 2024, zsae253. PMID: 39460669, DOI: 10.1093/sleep/zsae253.
- BUNTAK V, INAYA A, ZINCHUK A. PERSONALIZED APPROACH IN TREATING CENTRAL SLEEP APNEA IN INDIVIDUALS WITH REDUCED EJECTION FRACTION. CHEST Journal 2024, 166: a6174-a6175. DOI: 10.1016/j.chest.2024.06.3656.
- BUNTAK V, INAYA A, ZINCHUK A. THE VALUE OF ADJUNCTIVE THERAPIES IN INDIVIDUALS WITH SEVERE OBSTRUCTIVE SLEEP APNEA TREATED WITH HYPOGLOSSAL NERVE STIMULATOR. CHEST Journal 2024, 166: a6173. DOI: 10.1016/j.chest.2024.06.3655.
- Adekolu O, Ahsan M, Anwar A, Zinchuk A. Sleep Deficiency in Obstructive Sleep Apnea. Sleep Medicine Clinics 2024, 19: 687-706. PMID: 39455186, PMCID: PMC11512702, DOI: 10.1016/j.jsmc.2024.08.002.
- Anwar A, Byrne S, Sharma A, Sands S, Wellman A, Redeker N, Yaggi H, Zinchuk A. Novel physiologic predictors of positive airway pressure effectiveness (NICEPAP) study: rationale, design and methods. Sleep And Breathing 2024, 28: 2005-2015. PMID: 38995327, DOI: 10.1007/s11325-024-03099-w.
- Peker Y, Zinchuk A, Celik Y, Sands S, Azarbarzin A. Hypoxic Burden but Not AHI Predicts Risk of Cardiovascular Events: A Secondary Analysis of the RICCADSA Clinical Trial. 2024, a4730-a4730. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a4730.
- Inaya A, Baldassarri S, Sands S, Yaggi H, Wellman A, Redeker N, Zinchuk A. 0495 Association of Cannabis Use and Symptoms Among Patients with Obstructive Sleep Apnea. Sleep 2024, 47: a213-a213. DOI: 10.1093/sleep/zsae067.0495.
- Chu Y, Zinchuk A. The Present and Future of the Clinical Use of Physiological Traits for the Treatment of Patients with OSA: A Narrative Review. Journal Of Clinical Medicine 2024, 13: 1636. PMID: 38541862, PMCID: PMC10970765, DOI: 10.3390/jcm13061636.
- Zinchuk A, Walker A, Kushida C, Wellman A, Yaggi H, Sands S. Arousal threshold modifies the effects of CPAP therapy on neurocognition in men and women in the APPLES study. Sleep Medicine 2024, 115: 324-325. DOI: 10.1016/j.sleep.2023.11.876.
- Zinchuk A, Srivali N, Qin L, Jeon S, Ibrahim A, Sands S, Koo B, Yaggi H. Association of Periodic Limb Movements and Obstructive Sleep Apnea With Risk of Cardiovascular Disease and Mortality. Journal Of The American Heart Association 2024, 13: e031630. PMID: 38240208, PMCID: PMC11056155, DOI: 10.1161/jaha.123.031630.
- Knauert M, Adekolu O, Xu Z, Deng A, Chu J, Baldassarri S, Kushida C, Yaggi H, Zinchuk A. Morning Chronotype Is Associated with Improved Adherence to Continuous Positive Airway Pressure among Individuals with Obstructive Sleep Apnea. Annals Of The American Thoracic Society 2023, 20: 1182-1191. PMID: 36917194, PMCID: PMC10405611, DOI: 10.1513/annalsats.202210-885oc.
- Srivali N, Thongprayoon C, Tangpanithandee S, Krisanapan P, Zinchuk A, Koo B, Cheungpasitporn W. 0872 Periodic limb movements during sleep and hypertension: A systematic review and meta-analysis. Sleep 2023, 46: a384-a384. DOI: 10.1093/sleep/zsad077.0872.
- Sun H, Zinchuk A, Locascio J, Kushida C, Thomas R, Westover M. 0522 CPAP Improves Cognition in Brain-Healthy Males: Secondary Analysis of a Randomized Trial. Sleep 2023, 46: a230-a231. DOI: 10.1093/sleep/zsad077.0522.
- Walker A, Baldassarri S, Chu J, Deng A, Xu Z, Blohowiak R, Byrne S, Kushida C, Yaggi H, Zinchuk A. 0480 Psychoactive Substance Use and Sleep Characteristics Among Individuals with Untreated Obstructive Sleep Apnea. Sleep 2023, 46: a213-a214. DOI: 10.1093/sleep/zsad077.0480.
- Baldassarri S, Chu J, Deng A, Xu Z, Blohowiak R, Byrne S, Kushida C, Yaggi H, Zinchuk A. Nicotine, alcohol, and caffeine use among individuals with untreated obstructive sleep apnea. Sleep And Breathing 2023, 27: 2479-2490. PMID: 37058215, PMCID: PMC10576010, DOI: 10.1007/s11325-023-02830-3.
- Srivali N, Thongprayoon C, Tangpanithandee S, Krisanapan P, Mao M, Zinchuk A, Koo B, Cheungpasitporn W. Periodic limb movements during sleep and risk of hypertension: A systematic review. Sleep Medicine 2023, 102: 173-179. PMID: 36701831, PMCID: PMC10388290, DOI: 10.1016/j.sleep.2023.01.008.
- Azarbarzin A, Zinchuk A, Wellman A, Labarca G, Vena D, Gell L, Messineo L, White DP, Gottlieb DJ, Redline S, Peker Y, Sands SA. Cardiovascular Benefit of Continuous Positive Airway Pressure in Adults with Coronary Artery Disease and Obstructive Sleep Apnea without Excessive Sleepiness. American Journal Of Respiratory And Critical Care Medicine 2022, 206: 767-774. PMID: 35579605, PMCID: PMC9799106, DOI: 10.1164/rccm.202111-2608oc.
- Adekolu O, Zinchuk A. Sleep Deficiency in Obstructive Sleep Apnea. Clinics In Chest Medicine 2022, 43: 353-371. PMID: 35659030, PMCID: PMC9351701, DOI: 10.1016/j.ccm.2022.02.013.
- Sharma A, Byrne S, Deng A, Chu J, Sands S, Wellman A, Redeke N, Yaggi H, Zinchuk A. 0158 Risk perception, outcome expectancy, and treatment self-efficacy among women and men with obstructive sleep apnea (OSA). Sleep 2022, 45: a73-a73. DOI: 10.1093/sleep/zsac079.156.
- Ding Q, Qin L, Wojeck B, Inzucchi SE, Ibrahim A, Bravata DM, Strohl KP, Yaggi HK, Zinchuk AV. Polysomnographic Phenotypes of Obstructive Sleep Apnea and Incident Type 2 Diabetes: Results from the DREAM Study. Annals Of The American Thoracic Society 2021, 18: 2067-2078. PMID: 34185617, PMCID: PMC8641817, DOI: 10.1513/annalsats.202012-1556oc.
- Zinchuk AV, Chu JH, Liang J, Celik Y, Op de Beeck S, Redeker NS, Wellman A, Yaggi HK, Peker Y, Sands SA. Physiological Traits and Adherence to Sleep Apnea Therapy in Individuals with Coronary Artery Disease. American Journal Of Respiratory And Critical Care Medicine 2021, 204: 703-712. PMID: 34156917, PMCID: PMC8521693, DOI: 10.1164/rccm.202101-0055oc.
- Ding Q, Qin L, Wojeck B, Inzucchi S, Ibrahim A, Bravata D, Strohl K, Yaggi H, Zinchuk A. Associations Between Polysomnographic Phenotypes of Obstructive Sleep Apnea and Incident Type 2 Diabetes. 2021, a4679-a4679. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4679.
- Azarbarzin A, Zinchuk A, Wellman D, Taranto Montemurro L, Vena D, Gell L, Messineo L, White D, Gottlieb D, Redline S, Peker Y, Sands S. Cardiovascular Benefit of CPAP Is Modified by the Sleep Apnea Related Pulse Rate Response in Coronary Artery Disease Patients with Nonsleepy OSA: Findings from the RICCADSA Randomized Controlled Trial. 2021, a1103-a1103. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a1103.
- Zinchuk A, Yaggi H. Treatment-Emergent Central Sleep Apnea. 2021, 85-102. DOI: 10.1007/978-3-030-57942-5_8.
- Baldassarri SR, Beitel M, Zinchuk A, Redeker NS, Oberleitner DE, Oberleitner LMS, Carrasco D, Madden LM, Lipkind N, Fiellin DA, Bastian LA, Chen K, Yaggi HK, Barry DT. Correlates of sleep quality and excessive daytime sleepiness in people with opioid use disorder receiving methadone treatment. Sleep And Breathing 2020, 24: 1729-1737. PMID: 32556918, PMCID: PMC7680294, DOI: 10.1007/s11325-020-02123-z.
- Leary EB, Zinchuk A, Stone KL, Mehra R. Update in Sleep in 2019. American Journal Of Respiratory And Critical Care Medicine 2020, 0: 1473-1479. PMID: 32293912, DOI: 10.1164/rccm.202003-0586up.
- Zinchuk AV, Redeker NS, Chu JH, Liang J, Stepnowsky C, Brandt CA, Bravata DM, Wellman A, Sands SA, Yaggi HK. Physiological Traits and Adherence to Obstructive Sleep Apnea Treatment in Patients with Stroke. American Journal Of Respiratory And Critical Care Medicine 2020, 0: 1568-1572. PMID: 32083949, PMCID: PMC7301748, DOI: 10.1164/rccm.201911-2203le.
- The Arousal Threshold as a Drug-Target to Improve CPAP Adherence: Secondary Analysis of a Randomized TrialZinchuk A. The Arousal Threshold as a Drug-Target to Improve CPAP Adherence: Secondary Analysis of a Randomized Trial. PracticeUpdate website. Available at: https://www.practiceupdate.com/content/the-arousal-threshold-as-a-drug-target-to-improve-cpap-adherence/103953/65/20/1. Aug 7, 2020
- Central Sleep Apnea: Diagnosis and TreatmentZinchuk, A., Thomas, R. “Central Sleep Apnea: Diagnosis and Treatment,“ in Principles and Practice of Sleep Medicine (Seventh Edition), Meir H. Kryger, Thomas Roth, and William C. Dement; Saunders, 2020
- Introduction to Sleep Breathing DisordersZinchuk, A., Thomas, R. “Introduction to Sleep Breathing Disorders,“ in Principles and Practice of Sleep Medicine (Seventh Edition), Meir H. Kryger, Thomas Roth, and William C. Dement; Saunders, 2020
- Zinchuk A, Yaggi HK. Phenotypic Subtypes of OSA A Challenge and Opportunity for Precision Medicine. CHEST Journal 2019, 157: 403-420. PMID: 31539538, PMCID: PMC7005379, DOI: 10.1016/j.chest.2019.09.002.
- Zinchuk A, Yaggi HK. Sleep Apnea Heterogeneity, Phenotypes, and Cardiovascular Risk. Implications for Trial Design and Precision Sleep Medicine. American Journal Of Respiratory And Critical Care Medicine 2019, 200: 412-413. PMID: 30916985, PMCID: PMC6701039, DOI: 10.1164/rccm.201903-0545ed.
- Treatment Emergent Central Sleep ApneaZinchuk, A. Yaggi, K. “Treatment Emergent Central Sleep Apnea” in Complex Sleep Breathing Disorders (1st Edition), edited by Christine Won; Springer Nature, 2019
- Zinchuk A, Edwards BA, Jeon S, Koo BB, Concato J, Sands S, Wellman A, Yaggi HK. Prevalence, Associated Clinical Features, and Impact on Continuous Positive Airway Pressure Use of a Low Respiratory Arousal Threshold Among Male United States Veterans With Obstructive Sleep Apnea. Journal Of Clinical Sleep Medicine 2018, 14: 809-817. PMID: 29734986, PMCID: PMC5940432, DOI: 10.5664/jcsm.7112.
- Brady VA, Zinchuk AV, Siegel MD, Possick JD. A Young Man With Hemoptysis and Cavitary Lung Lesions. CHEST Journal 2018, 153: e85-e88. PMID: 29626974, PMCID: PMC6026285, DOI: 10.1016/j.chest.2017.09.018.
- Zinchuk AV, Jeon S, Koo BB, Yan X, Bravata DM, Qin L, Selim BJ, Strohl KP, Redeker NS, Concato J, Yaggi HK. Polysomnographic phenotypes and their cardiovascular implications in obstructive sleep apnoea. Thorax 2017, 73: 472. PMID: 28935698, PMCID: PMC6693344, DOI: 10.1136/thoraxjnl-2017-210431.
- Zinchuk A, Thomas R. Chapter 110 Central Sleep Apnea Diagnosis and Management. 2017, 1059-1075.e6. DOI: 10.1016/b978-0-323-24288-2.00110-0.
- Zinchuk AV, Gentry MJ, Concato J, Yaggi HK. Phenotypes in obstructive sleep apnea: A definition, examples and evolution of approaches. Sleep Medicine Reviews 2016, 35: 113-123. PMID: 27815038, PMCID: PMC5389934, DOI: 10.1016/j.smrv.2016.10.002.
- Selim BJ, Koo BB, Qin L, Jeon S, Won C, Redeker NS, Lampert RJ, Concato JP, Bravata DM, Ferguson J, Strohl K, Bennett A, Zinchuk A, Yaggi HK. The Association between Nocturnal Cardiac Arrhythmias and Sleep-Disordered Breathing: The DREAM Study. Journal Of Clinical Sleep Medicine 2016, 12: 829-37. PMID: 26951420, PMCID: PMC4877315, DOI: 10.5664/jcsm.5880.
- Koo BB, Won C, Selim BJ, Qin L, Jeon S, Redeker NS, Bravata DM, Strohl KP, Concato J, Zinchuk AV, Yaggi HK. Erratum to: The Determining Risk of Vascular Events by Apnea Monitoring (DREAM) study: design, rationale, and methods. Sleep And Breathing 2016, 20: 901-901. PMID: 26971325, DOI: 10.1007/s11325-016-1329-9.
- Arts, Sleep and MedicineZinchuk, A., Kryger, M. “Arts, Sleep and Medicine,” American Thoracic Society Podcast Series, 2016, http://www.thoracic.org/about/ats-podcasts/interview-with-professor-dr-meir-h-kryger.php
- Central Sleep Apnea: Diagnosis and TreatmentZinchuk, A., Thomas, R. “Central Sleep Apnea: Diagnosis and Treatment,“ in Principles and Practice of Sleep Medicine (Sixth Edition), Meir H. Kryger, Thomas Roth, and William C. Dement; Saunders, 2016.
- Koo BB, Won C, Selim BJ, Qin L, Jeon S, Redeker NS, Bravata DM, Strohl KP, Concato J, Zinchuk AV, Yaggi HK. The Determining Risk of Vascular Events by Apnea Monitoring (DREAM) study: design, rationale, and methods. Sleep And Breathing 2015, 20: 893-900. PMID: 26642771, DOI: 10.1007/s11325-015-1254-3.
- Masha L, Zinchuk A, Boosalis V. Synchronous pulmonary malignancies: atypical presentation of mantle cell lymphoma masking a lung malignancy. Rare Tumors 2015, 7: 5929. PMID: 26500732, PMCID: PMC4600994, DOI: 10.4081/rt.2015.5929.
- Zinchuk A, Saukkonen J, Boosalis V, Brahma P. Simultaneous Mantle Cell Lymphoma and Undifferentiated Carcinoma Manifested by Pleural Studding and Effusion. CHEST Journal 2013, 144: 597a-597b. DOI: 10.1378/chest.1702019.
- Zinchuk AV, Flanagan EP, Tubridy NJ, Miller WA, McCullough LD. Attitudes of US medical trainees towards neurology education: "Neurophobia" - a global issue. BMC Medical Education 2010, 10: 49. PMID: 20573257, PMCID: PMC2900283, DOI: 10.1186/1472-6920-10-49.
- Govindarajan R, Zinchuk A, Hancock B, Shalaev E, Suryanarayanan R. Ionization States in the Microenvironment of Solid Dosage Forms: Effect of Formulation Variables and Processing. Pharmaceutical Research 2006, 23: 2454-2468. PMID: 16933092, DOI: 10.1007/s11095-006-9085-3.
- Zinchuk AV, Hancock BC, Shalaev EY, Reddy RD, Govindarajan R, Novak E. The influence of measurement conditions on the Hammett acidity function of solid pharmaceutical excipients. European Journal Of Pharmaceutics And Biopharmaceutics 2005, 61: 158-170. PMID: 16005194, DOI: 10.1016/j.ejpb.2005.04.008.
- Zinchuk AV, Mullarney MP, Hancock BC. Simulation of roller compaction using a laboratory scale compaction simulator. International Journal Of Pharmaceutics 2004, 269: 403-415. PMID: 14706252, DOI: 10.1016/j.ijpharm.2003.09.034.
- The relative density of pharmaceutical powders, blends, dry granulations and immediate release tabletsHancock, B.C., Colvin, J.T., Mullarney, M.P., Zinchuk, A.V., “The relative density of pharmaceutical powders, blends, dry granulations and immediate release tablets,” Pharmaceutical Technology, April 2003, 64-80
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- Yale Sleep Center8 Devine StreetNorth Haven, CT 06473
- Medical ICUSmilow Cancer Hospital at Yale New Haven35 Park StreetNew Haven, CT 06511